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873
datasets available to search
ShareScore release 0.9.0
Dataset results
873 results for “ligands”
Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling
GEO Series GSE280470. Homo sapiens. 39 samples. Type: Expression profiling by array.
The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells
GEO Series GSE89897. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Discovery of a small-size imidazole-benzoindolium ligand for binding to KRAS promoter G-quadruplex that inhibits cancer growth with enhanced immunomodulation
GEO Series GSE280939. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Responsiveness of a frog cell line to the AHR ligands FICZ and TCDD
GEO Series GSE16670. Xenopus laevis. 9 samples. Type: Expression profiling by array.
Interphase condensins regulate ligand-depedent enhancer activation (ChIP-seq)
GEO Series GSE62222. Homo sapiens. 39 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Peripheral Nerve Single-Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth (injured sciatic nerve microarray data)
GEO Series GSE146883. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation
GEO Series GSE279769. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
[Bulk RNA-seq]: Characterization of transcriptional and chromatin accessibility landscape of human bronchial epithelial cells treated with synergistic immunostimulatory ligands.
GEO Series GSE299678. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
DNA damage induced by G-quadruplex ligand PyBI and its synthetic lethality with DNA repair inhibitors in cancer cells
GEO Series GSE270287. Homo sapiens. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Phase Separation of Ligand-Activated Enhancers Licenses Cooperative Chromosomal Enhancer Assembly
GEO Series GSE99544. Mus musculus; Homo sapiens. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing.
Effect of interferon-gamma on macrophage differentiation and response to Toll-like receptor ligands
GEO Series GSE11864. Homo sapiens. 10 samples. Type: Expression profiling by array.
Indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
GEO Series GSE51834. Homo sapiens. 6 samples. Type: Expression profiling by array.
Interphase condensins regulate ligand-depedent enhancer activation (GRO-seq)
GEO Series GSE62228. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Functional TRIM24 degraders via conjugation of ineffectual bromodomain and VHL ligands [ChIP-seq]
GEO Series GSE100571. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages [GRO-Seq]
GEO Series GSE110464. Mus musculus. 5 samples. Type: Other.
Identification of gene expression changes induced by ligands for RXR and its partners in differentiating human monocyte-derived dendritic cells
GEO Series GSE48573. Homo sapiens. 30 samples. Type: Expression profiling by array.
Deep Learning-Ready Voxel Representation of Protein-Ligand Complexes from an Enhanced PBDbind v.2020 Dataset
<p>A critical aspect of successful deep learning (DL) modelling in computer-aided drug discovery (CADD) is the representation of biomolecular data. Voxel grid representations have emerged as a straightforward method for depicting 3D molecular structures of protein-ligand complexes. Proper structural preparation of these complexes is also crucial, particularly in models where the orientation of hydrogen atoms and the accurate assignment of protonation/tautomeric states are vital. The PDBbind, a widely used dataset, can be improved in this regard. This work presents an enhanced version of the PDBbind v.2020 refined set concerning structural preparation, a voxel representation of these structures suitable for DL model training and a diverse set of docking-generated poses that could be used to develop new scoring functions for pose prediction. With this dataset, we aim to provide the CADD community with high-quality, accessible resources to facilitate the development of DL models for drug discovery.</p>
Selective ligand removal to improve accessibility of active sites in hierarchical MOFs for heterogeneous photocatalysis
<p>This file includes the source data for all experimental and theoretical data of the publication.</p>
Data for Ligand exchange provides new insight into the role of humic substances in the marine iron cycle
<p>This repository contains (i) all the data included in the study "Ligand exchange provides new insight into the role of humic substances in the marine iron cycle" in seven XSLX files, and (ii) twelve scripts and eight CSV files used to model the data with Dynafit software (http://www.biokin.com/dynafit/). A readme file is included to guide the calculations.</p> <p>The data sets originated when iron-saturated complexes of humic substances (fulvic acid and humic acid from the International Humic Substances Society) in seawater were subjected to iron ligand exchange after addition of an iron-free competing ligand, in most cases desferrioxamine B. In four cases EDTA and protoporphyrin IX were used as competing ligands to understand the effect of the chemical nature of the competing ligand. Additionally, reversibility was also tested. The concentration of the Fe-humic complexes was monitored by catalytic cathodic stripping voltammetry (10.4319/lo.2009.54.2.0610), a method not sensitive to the other iron species and free iron present.</p>
Fig. 5 in Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity
Fig. 5. Effect of 1 on lipid accumulation in 3T3-L1 adipocytes. Subconfluent 3T3-L1 preadipocytes in the basal medium were treated in the presence or absence of 5 μM of 1 for 96 h 3T3-L1 cells treated in the differentiation-inducing medium are shown as a positive control. Intracellular lipid was stained with Oil Red O. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.