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12,662 results for “linking”
Data sets for Shiburah et al., "The absence of the Leishmania major telomerase TERT component links telomeres and cell homeostasis with infectivity"
<p>These files correspond to the figures and information contained in Shiburah et al., "The absence of the <em>Leishmania major</em> telomerase TERT component links telomeres and cell homeostasis with infectivity"</p>
Data for: A histone demethylase links the loss of plasticity to nongenetic inheritance and morphological change
<p class="MsoNormal"><span>Plasticity is a widespread feature of development, enabling phenotypic change based on the environment. Although the evolutionary loss of plasticity has been linked both theoretically and empirically to increased rates of phenotypic diversification, molecular insights into how this process might unfold are generally lacking. Here, we show that a regulator of nongenetic inheritance links evolutionary loss of plasticity in nature to changes in plasticity and morphology as selected in the laboratory. Across nematodes of Diplogastridae, which ancestrally had a polyphenism, or discrete plasticity, in their feeding morphology, we use molecular evolutionary analyses to screen for change associated with independent losses of plasticity. Having inferred a set of ancestrally polyphenism-biased genes from phylogenetically informed gene-knockouts and gene-expression comparisons, selection signatures associated with plasticity's loss identify the histone H3K4 di/monodemethylase gene <em>spr-5</em>/<em>LSD1</em>/<em>KDM1A</em>. Manipulations of this gene affect both sensitivity and variation in plastic morphologies, and artificial selection of manipulated lines drives multigenerational shifts in these phenotypes. Our findings thus give mechanistic insight into how traits are modified as they traverse the continuum of greater to lesser environmental sensitivity.</span></p>
Public funding accountability: a linked open data-based methodology for analysing the scientific productivity and influence of funded projects. Dataset
<p>Tables containing the information about the projects funded by the Spanish AEI and publications acknowledging funding from Funder Registry. Both datasets where used in our publication: <em>Public funding accountability: a linked open data-based methodology for analysing the scientific productivity and influence of funded projects</em>.</p>
Chain Link Fence
A chain linked fence, and old rusted fence that is relitively reasonably priced to build and classic look. Made in Blender and Textured in Quixel Mixer Made for Unreal Engine 5 Source: Objaverse 1.0 / Sketchfab
2 Epitaphe, links Konrad von Kuehedorf († 1428)
Zwei Epitaphe, links Konrad d. Ae. von Kuehedorf († 1428), rechts eine nicht zuweisbare Grabplatte der Herren von Kuehedorf; zu besichtigen in Kuehedorf vor dem ehemaligen Burgareal. Two epitaphs, on the left Konrad the Elder of Kuehedorf († 1428), on the right the grave slab of an unidentified knight, also from the Kuehedorf family; Kuehedorf, district Roth, Bavaria, Germany. Source: Objaverse 1.0 / Sketchfab
Bronze Age House at Links of Noltland Orkney
Mid-ex of Structure 17, Bronze Age House at the Links of Noltland, Westray, Orkney. This structure is currently under excavation. Source: Objaverse 1.0 / Sketchfab
Bronze Age House & Paving Links of Noltland
Bronze Age House with stone lined tank and external paving at Links of Noltland, Westray Source: Objaverse 1.0 / Sketchfab
1860s' cuff links
Discover the [Ballarat Town Hall collection](http://www.hulballarat.org.au/cb_pages/rediscovering_town_hall_vaults.php) today. Model developed by  [Digital Heritage Australia ](http://digitalheritageaustralia.com) Source: Objaverse 1.0 / Sketchfab
Data from: Anti-predator defenses are linked with high levels of genetic differentiation in frogs
<p>Predator-prey interactions have been suggested as drivers of diversity in different lineages, and the presence of anti-predator defences in some clades is linked to higher rates of diversification. Warning signals are some of the most widespread defenses in the animal world, and there is evidence of higher diversification rates in aposematic lineages. The mechanisms behind such species richness, however, are still unclear. Here, we test whether lineages that use aposematism as anti-predator defense exhibit higher levels of genetic differentiation between populations, leading to increased opportunities for divergence. We collated from the literature > 3,000 pairwise genetic differentiation values across more than 700 populations from over 60 amphibian species. We find evidence that, given the same geographic distance, populations of species of aposematic lineages exhibit greater genetic divergence relative to species that are not aposematic. Our results support a scenario where the use of warning signals could restrict gene flow, and suggest that anti-predator defences could impact divergence between populations and potentially have effects at a macro-evolutionary scale.</p>
Output data from "Emissions leakage and economic losses could limit the effectiveness of deforestation-linked oil crop import restrictions"
<p>Contains a .dat file with queried output from scenario runs used in the paper, Yarlagadda, B., X. Zhao, G. Iyer, T. Wild, N. Hultman and J. Lamontagne, "Emissions leakage and economic losses could limit the effectiveness of deforestation-linked oil crops". This output can be run with the workflow in <a href="https://github.com/brinday/oilcrop-trade-deforestation-leakage">https://github.com/brinday/oilcrop-trade-deforestation-leakage</a> to generate the figures presented in the paper.</p>
Links between mathematical software (swMATH) and publications (zbMATH Open)
<p>software.csv: (List of software)</p> <p>id: Unique identifier from swMATH. Prefix with <a href="https://swmath.org/software/" rel="nofollow">https://swmath.org/software/</a> to visit resolve. For example, 4503 is associated with <a href="https://swmath.org/software/4503" rel="nofollow">https://swmath.org/software/4503</a> . API <a href="https://api.zbmath.org/v1/software/4503" rel="nofollow">https://api.zbmath.org/v1/software/4503</a>. Corresponding Wikidata Property <a href="https://www.wikidata.org/wiki/Property:P6830" rel="nofollow">https://www.wikidata.org/wiki/Property:P6830</a></p> <p>name: Name (curated) homepage: Website with a software description (curated)</p> <p>vcs: Link to a version control system, as manually extracted from the homepage authors: Plain text author information (name formats vary)</p> <p>soft_article: (Links between software and publications)</p> <p>software_id: (Foreign key to id in software.csv)</p> <p>zbl: Unique identifier from zbMATH Open. Prefix with <a href="https://zbmath.org/" rel="nofollow">https://zbmath.org/</a> to visit additional information on the article. For example, 5635019 is associated with <a href="https://zbmath.org/5635019" rel="nofollow">https://zbmath.org/5635019</a> . API <a href="https://api.zbmath.org/v1/document/5635019" rel="nofollow">https://api.zbmath.org/v1/document/5635019</a>. Corresponding Wikidata Property <a href="https://www.wikidata.org/wiki/Property:P6830" rel="nofollow">https://www.wikidata.org/wiki/Property:P6830</a></p> <p>mention_type: either mention or creation (curated)</p>
Climate biogeography of Arabidopsis thaliana: Linking distribution models and individual variation
<p>Patterns of individual variation are key to testing hypotheses about the mechanisms underlying biogeographic patterns. If species distributions are determined by environmental constraints, then populations near range margins may have reduced performance and be adapted to harsher environments. Model organisms are potentially important systems for biogeographical studies, given the available range‐wide natural history collections, and the importance of providing biogeographical context to their genetic and phenotypic diversity. We fit occurrence records to climate data and then projected the distribution of <em>Arabidopsis</em> under the last glacial maximum, current, and future climates. We confronted model predictions with individual performance measured on 2194 herbarium specimens, and we asked whether predicted suitability was associated with life history and genomic variation measured on ~900 natural accessions. The most important climate variables constraining the <em>Arabidopsis</em> distribution were winter cold in northern and high-elevation regions and summer heat in southern regions. Herbarium specimens from regions with lower habitat suitability in both northern and southern regions were smaller, supporting the hypothesis that the distribution of <em>Arabidopsis</em> is constrained by climate‐associated factors. Climate anomalies partly explained interannual variation in herbarium specimen size, but these did not closely correspond to local limiting factors identified in the distribution model. Late‐flowering genotypes were absent from the lowest suitability regions, suggesting slower life histories are only viable closer to the centre of the realized niche. We identified glacial refugia farther north than previously recognized, as well as refugia concordant with previous population genetic findings. Lower latitude populations, known to be genetically distinct, are most threatened by future climate change. The recently colonized range of Arabidopsis was well‐predicted by our native‐range model applied to certain regions but not others, suggesting it has colonized novel climates. Integration of distribution models with performance data from vast natural history collections is a route forward for testing biogeographical hypotheses about species distributions and their relationship with evolutionary fitness across large scales.</p>
Phenotypic plasticity in tropical butterflies is linked to climatic seasonality on a macroevolutionary scale
<p>Phenotypic plasticity can be adaptive in fluctuating environments by providing rapid environment-phenotype matching and this applies particularly in seasonal environments. African <em>Bicyclus</em> butterflies have repeatedly colonized seasonal savannahs from ancestral forests around the Late Miocene and many species now exhibit seasonal polyphenism. On a macroevolutionary scale, it can be expected that savannah species will exhibit higher plasticity due to them experiencing stronger environmental seasonality than forest species. We quantified seasonality using environmental niche modelling, and surveyed the degree of plasticity in a key wing pattern element (eyespot size) using museum specimens. We show that species occurring in highly seasonal environments display strong plasticity, while species in less seasonal or aseasonal environments exhibit surprisingly variable degrees of plasticity, including strong to no plasticity. Furthermore, eyespot size plasticity has a moderate phylogenetic signal and the ancestral <em>Bicyclus</em> likely exhibited some degree of plasticity. We propose hypotheses to explain the range of plasticity patterns seen in less seasonal environments, and generate testable predictions for the evolution of plasticity in <em>Bicyclus</em>. Our study provides one of the most compelling cases showing links between seasonality and phenotypic plasticity on a macroevolutionary scale and the potential role of plasticity in facilitating the colonization of novel environments.</p>
A phased genome of the highly heterozygous 'Texas' almond uncovers patterns of allele-specific expression linked to heterozygous structural variants
<h2># Genomic datasets associated to the publication: </h2> <h3># Gene-ID conversion with previous genome version</h3> <p>Texasv3_vs_Texasv2_GeneID.txt -- gene ID conversion between Texasv3 and Texasv2 (https://www.rosaceae.org/analysis/295)</p> <p>pdulcis26_to_F1_liftoff_polished.gff3 -- Texasv2 gene annotation liftoff on Phase-1 assembly (Phase-1 coordinates)</p> <h3># Phase-1</h3> <p>Texas_F1_K80_chr.fasta -- genome asssembly, phase-1 <br>Texas_F1_gene_models.gff3 -- phase-1 gene annotation (de novo annotation)<br>Functional_annotation_TexasF1.csv -- phase-1 gene functions <br>Texas_F1_ref_SV.vcf --- Structural variations relative to phase-0 (This file uses Phase-1 as reference)</p> <h3># Phase-0</h3> <p>Texas_F0_K80_chr.fasta -- genome asssembly, phase-0 <br>Texas_F0_gene_models.gff3 -- phase-0 gene annotation (liftoff from Phase-1)<br>Functional_annotation_TexasF0.csv -- phase-0 gene functions <br>Texas_F0_ref_SV.vcf --- Structural variations relative to phase-1 (This file uses Phase-0 as reference)</p> <h3># Transposable element annotation</h3> <p>Texas_F0_HiConf_TE_v3.gff3 --- TE annotation in Phase-0<br>Texas_F1_HiConf_TE_v3.gff3 --- TE annotation in Phase-1<br>Texasv3_TElib.fa --- TE library of TexasV3 (non-redundant repeat consensuses taking the account the two genome phases)</p> <h3># Gene sequences in fasta</h3> <p>Transcript, CDS and protein sequences in fasta format for phase-0 (F0) and phase-1 (F1) </p>
Promptuarium genealogicum by Carl Keller-Escher: Transcription Full Texts and Image File Links
<div> <div>This dataset contains image links, full texts, and metadata of the seven volumes of the *Promptuarium genealogicum* by Carl Keller-Escher (1851–1916). This genealogical work, spanning approximately 2,800 pages, provides information on members of 258 historical Zurich families, some dating back to the 16th century.</div> </div>
A Functional Response in Resource Selection Links Multi-Scale Responses of a Large Carnivore to Human Mortality Risk
<p>This repository contains code and data to reproduce results from the manuscript 'A Functional Response in Resource Selection Links Multi-Scale Responses of a Large Carnivore to Human Mortality Risk'. </p>
Recovering Trace Links In Software Architecture Documentation
<p>Replication Package for the dissertation "Recovering Trace Links In Software Architecture Documentation" by Jan Keim.</p> <p>The ZIP-file contains the replication package. Additionally, there is the OVA-file, which is a file to be imported as virtual machine (e.g., in VirtualBox). The virtual machine contains the replication package and everything required to run the experiments like Java, maven, dependencies etc. is installed.</p>
Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism
<p>Motion tracking dataset used for the paper "<strong><em>Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism</em></strong>", by Joeri Bordes et al.</p> <p><strong><span>Abstract</span></strong></p> <p>Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation. Employing innovative unsupervised behavioral classification, the current study reveals distinct behavioral patterns associated with fear acquisition and retrieval in male and female mice following ELS. Females exposed to LBN display heightened active fear responses, contrasting with males. Furthermore, the study examined the crucial link between behavioral regulation and cellular metabolism in key brain regions involved in fear and stress processing. Sex-specific and stress-dependent alterations were observed in purine, pyrimidine, and glutamate metabolism within the basolateral amygdala, the dorsal hippocampus, and the ventral hippocampus. These findings provide crucial insights into the complex interplay between metabolic pathways, the neurobiological underpinnings of fear memory, and stress responses. Importantly, they emphasize the significance of considering sex-specific metabolic alterations when investigating stress-related disorders, opening potential avenues for the development of targeted interventions.</p>
ISPRA Linked Open Dataset part of the WHOW-KG
<p>This linked open dataset contains Italian data for:</p> <ul> <li>soil consumption (soilc);</li> <li>spread in water of Ostreopsis ovata (ostreopsis);</li> <li>environmental protection interventions (dissesto);</li> <li>Italian national tide gauge network (rmn);</li> <li>Italian National Wave Network (ron);</li> <li>bathing waters (bathw).</li> </ul>
Novel Macrophage Subpopulation Linked to CAD: raw and processed data files
<div> <p>This directory contains all single-cell datasets analyzed in the "Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying increased genetic risk of coronary artery disease". Associated scripts are available at https://github.com/jhjiang2020/multiome_paper. </p> <p><strong>Jan 2025 updates</strong>: include the 10x Cell Ranger ARC output for the scATAC-seq assay. <em>Please note that 10x peaks were not used for downstream analyses. Instead, we trimmed the atac-seq fragments to retain the 9bp Tn5 cut sites at both ends and aggregated into one consensus bed file. We then recalled peaks using `MACS3 --qvalue 1e-5 --nomodel --shift -50 --extsize 100 --broad` (see discussion in https://github.com/stuart-lab/signac/issues/682). </em></p> <p> </p> </div>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.