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984
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ShareScore release 0.9.0
Dataset results
984 results for “Cell stress”
Toxin-antitoxin deletions in Legionella pneumophila reveal unusual cell death and contact-dependent survival responses during genotoxic stress [Lp_cipro_RNAseq]
GEO Series GSE278701. Legionella pneumophila. 12 samples. Type: Expression profiling by high throughput sequencing.
Affinity purification of ribosomes and associated RNAs from stress-treated cells using tagged Rpl16a and Rpl16b
GEO Series GSE13682. Saccharomyces cerevisiae. 60 samples. Type: Expression profiling by array; Other.
Changes in Gene expression mediated by Cyclic Mechanical Stress in Trabecular Meshwork Cells
GEO Series GSE14768. Homo sapiens. 6 samples. Type: Expression profiling by array.
Impact of curcumin on human monocytes (U937 cells) exposed to oxidative stress
GEO Series GSE10896. Homo sapiens. 24 samples. Type: Expression profiling by array.
ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress
GEO Series GSE151058. Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells
GEO Series GSE79694. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Nucleotide stress induction of HEXIM1 suppresses melanoma by modulating cancer cell-specific gene transcription [RNA-Seq2]
GEO Series GSE68040. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Direct cell-to-cell transfer in stressed tumor microenvironment aggravates tumorigenic or metastatic potential in pancreatic cancer
GEO Series GSE201876. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
NsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus
GEO Series GSE27061. Staphylococcus aureus. 4 samples. Type: Expression profiling by array.
FoxO are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
GEO Series GSE6623. Mus musculus. 12 samples. Type: Expression profiling by array.
Renal Cell Carcinomas in Vinylidene Chloride Exposed Male B63FC1 Mice Are Characterized by Oxidative Stress and TP53 Overexpression
GEO Series GSE67320. Mus musculus. 18 samples. Type: Expression profiling by array.
Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"
<p>This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims</p> <p>Calcific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-stenosis">aortic valve stenosis</a> (CAVS) is the most frequent manifestation of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-disease">aortic valve disease</a> and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-oxidation">oxidation</a> leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premolar">bicuspid</a> (BAV) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve">aortic valve</a> deterioration are considered to differ only by shear stress. We hypothesized that <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/endothelial-cell">endothelial cells</a> (EC) derived from BAV and TAV patients have different <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNA</a> expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients.</p> <p>Methods and results</p> <p>We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNAs</a> between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress">oxidative stress</a> and DNA damage stimulus <em>via</em> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-p53">p53</a> and alteration in the intrinsic apoptotic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction">signaling pathway</a>. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/gpx3">GPX3</a> and SRXN1 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/messenger-rna">mRNA</a> were express at lower levels in BAV compared to TAV ECs, leading to an increment of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/double-stranded-dna">DNA double-strand</a> breaks. BAV ECs had a sustained <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/programmed-cell-death">apoptosis</a> activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition.</p> <p>Conclusion</p> <p>The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.</p>
A screen for cell envelope stress uncovers a novel small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli
<p>Whole genome sequencing data of MAC-0452936 resistance isolates.</p>
Fig. 11 in Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress
Fig. 11. Effects of verniciflavanol A (9) on IL-6/Src-STAT3 pathway. (A) The protein levels of IL-6/Src-Stat3 pathway in SH-SY5Y cells are analyzed by Western Blot. (B) Grey intensity analysis of IL-6, p-Src, p-STAT3. Data are presented as the mean ±SD of three independent experiments. *p <0.05 and ***p <0.001 ompared with indicated control. &p <0.05, &&p <0.01, and &&&p <0.001 compared with the H O -treated group.
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
ClinicalTrials.gov study NCT06686069. IPD Sharing: NO. Countries: 0. Publications: 0.
SIRT1 and H1AcK26 promoter-association in mouse ES cells changes upon oxidative stress
GEO Series GSE13075. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by array.
Analysis of micro-RNA expression profiles in human islets and islet-derived exosomes during cytokine mediated β cell stress and death
GEO Series GSE160391. Homo sapiens. 48 samples. Type: Non-coding RNA profiling by high throughput sequencing.
IRE1-dependent transcriptome remodelling upon ER stress in human glioma cells
GEO Series GSE27306. Homo sapiens. 10 samples. Type: Expression profiling by array.
Chronic stress-driven glucocorticoid receptor activation programs key cell phenotypes and functional epigenomic patterns in human fibroblasts
GEO Series GSE210304. Homo sapiens. 68 samples. Type: Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Cell-specific Studies Through Novel Mouse Model Reveal the Transcriptomic Response of Retinal Müller Glia to Acute and Chronic Stress [ONC]
GEO Series GSE197507. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.