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126,115 results for “Patients”
Epigenetic clock estimations in patients with isolated REM Sleep Behavior Disorder
<p>Isolated REM Sleep Behavior Disorder (iRBD) is the strongest prodromal marker for conversion to α-synucleinopathies. A continuum between aging and neurodegeneration has been proposed, but this hypothesis has not been tested in iRBD so far. Here we used epigenetic clocks, estimated from DNA methylation arrays using the DNA Methylation Age Calculator available at https://dnamage.genetics.ucla.edu/home, to measure biological aging in videopolysomnography-confirmed iRBD patients (iRBDs, n=28), videopolysomnography-negative controls (CTR_neg; n=57), and controls from the general population (CTR_pop; n=31)<strong>.</strong></p>
Erythrocyte sedimentation rate in the evolution of covid -19 patients attended at the CLAS health center, Nuevo Lurin-2021
<p>Abstract</p> <p><strong>Background:</strong> To determine the values of the erythrocyte sedimentation rate in the evolution of patients with COVID -19 with treatment attended at the CLAS Health Center, Nuevo Lurín.</p> <p><strong>Methods:</strong> The research was applied with an observational and descriptive method. The approach was quantitative, applied and cross-sectional. The study population was 13,000 patients in the CLAS center in Nuevo Lurin. After applying the inclusion and exclusion criteria, there were only 45 male and female patients attended at the CLAS Health Center in Nuevo Lurin between February and June 2021, to whom the capillary method was applied in order to determine the values of the erythrocyte sedimentation rate in the evolution of COVID-19 patients. The data collection instrument was a record card.</p> <p><strong>Results:</strong> It was compared that between male and female sex, there are statistically significant differences between the 45 COVID-19 patients evaluated. Higher values were identified in 7 male patients, while in women there was 1 patient with elevated values of erythrocyte sedimentation rate. This shows that there is a higher incidence of erythrocyte sedimentation rate in males.</p> <p><strong>Conclusion: </strong>Values of erythrocyte sedimentation rate were determined in 45 patients with COVID-19 evolution with treatment attended at the CLAS Health Center in Nuevo Lurin and confirming that erythrocyte sedimentation rate evolves significantly in COVID-19 patients.</p>
Characteristics of medical marijuana dispensary patients
<p><strong>Introduction</strong>: <span>Despite the rising availability and use of medical marijuana (MM) in the U.S., little is known about the demographics, clinical characteristics, or quality of life of MM patients. This study describes the demographic characteristics and health-related quality of life (HRQoL) of MM patients who are initiating treatment in Pennsylvania.</span></p> <p><strong>Methods</strong>: Two hundred<span> adults naive to MM and referred for any of the 23 state-approved qualifying conditions were recruited at three MM dispensaries in Pennsylvania between September 2020 and March 2021. All participants consented to the study, completed semi-structured interviews that included demographic questionnaires, the Short Form-36 (SF-36), and Generalized Anxiety Disorder-7 (GAD-7), provided height and weight measurements, and allowed access to their dispensary medical records. </span></p> <p><strong>Results</strong>: <span>Participants had a mean age of 48.5 ±15.6 years, predominantly identified as female (67.5 %), and were most commonly referred for chronic pain (63.5%) and/or anxiety (58.5%). Additionally, 46.0% were living with obesity as determined by Body Mass Index (BMI). Relative to a normative sample, participants reported diminished HRQoL in several domains, most notably in role limitations due to physical health (M = 46.0 ± 42.0), role limitations due to emotional problems (M = 52.5 ± 42.3), energy and fatigue (M = 39.8 ± 20.2), and pain (M = 49.4 ± 26.0).</span></p> <p><strong>Discussion/Conclusion</strong>: <span>Patients initiating MM treatment experienced low HRQoL in multiple domains. Future studies could evaluate the relationship between HRQoL and patients' decisions to pursue MM treatment, as well as changes in HRQoL with MM use over time.</span></p>
A gene variation at the ZPR1 locus (rs964184) interacts with the type of diet to modulate postprandial triglycerides in patients with coronary artery disease: From the Cordioprev Study
<p>Background and Aims: rs964184 variant in the ZPR1 gene has been associated with blood lipids levels both in fasting and postprandial state and with the risk of myocardial<br>infarction in high-risk cardiovascular patients. However, whether this association is modulated by diet has not been studied.</p> <p>Objective: To investigate whether the type of diet (low-fat or Mediterranean diets) interacts with genetic variability at this loci to modulate fasting and postprandial lipids in<br>coronary patients.</p> <p>Materials and Methods: The genotype of the rs964184 polymorphism was determined in the Cordioprev Study population (NCT00924937). Fasting and Postprandial triglycerides were assessed before and after 3 years of dietary intervention with either a Mediterranean or a low-fat diet. Postprandial lipid assessment was done by a 4-h oral fat tolerance test (OFTT). Differences in triglycerides levels were identified using repeated-measures ANCOVA.</p> <p>Results: From 523 patients (85% males, mean age 59 years) that completed the OFTT at baseline and after 3 years of intervention and had complete genotype information, 125<br>of them were carriers of the risk allele G. At the start of the study, these patients showed a higher fasting and postprandial triglycerides (TG) plasma levels. After 3 years of dietary<br>intervention, G-carriers following a Mediterranean Diet maintained higher fasting and postprandial triglycerides, while those on the low-fat diet reduced their postprandial<br>triglycerides to similar values to the population without the G-allele.</p> <p>Conclusion: After 3 years of dietary intervention, the altered postprandial triglyceride response induced by genetic variability in the rs964184 polymorphism of the ZPR1 gene<br>can be modulated by a low-fat diet, better than by a Mediterranean diet, in patients with coronary artery disease.</p>
Multishell Diffusion MR Tractography Yields Morphological and Microstructural Information of the Anterior Optic Pathway: A Proof-of-Concept Study in Patients with Leber's Hereditary Optic Neuropathy. RAW DATA
<p>Raw data used to prepare Figures and Tables in article "Multishell Diffusion MR Tractography Yields Morphological and Microstructural Information of the Anterior Optic Pathway: A Proof-of-Concept Study in Patients with Leber’s Hereditary Optic Neuropathy", accepted for publication at International Journal of Environmental Research and Public Health, 27 May 2022.</p>
Prescribing trends in older patients with multimorbidity and significant polypharmacy recruited to the SPPiRE trial
<p><strong>Aims</strong></p> <p>Medication count and appropriateness are often used as outcome measures to evaluate the effectiveness of deprescribing interventions. The aim of this study was to evaluate changes in prescribing, potentially inappropriate prescriptions (PIP) and use of low value medicines during the SPPiRE trial.</p> <p><strong>Methods</strong></p> <p>We retrospectively analysed trial prescription data from 51 general practices with 404 participants aged ≥65 years and prescribed ≥15 repeat medicines. A dataset was created with 7,051 ATC coded medicines at baseline. Outcomes were the most commonly prescribed and potentially inappropriately prescribed drug groups, the most frequently stopped or started drug groups and the number of changes per person between baseline and follow-up.</p> <p><strong>Results </strong></p> <p>There were 7,051 medicines prescribed to 404 participants at baseline. The most commonly prescribed drug group were proton pump inhibitors (82% participants) and statins (77%). There was a median of 17 medicines (IQR 15-19) at baseline and 16 (IQR 14-19) at follow-up. PIP represented 17.1% of prescriptions at baseline and 15.7% (n=6,777) at follow-up. There were reductions in the prescription of most drug groups with the largest reduction in antiplatelet prescriptions. Considering medication discontinuations, initiations and switches, there was a median of five medication changes per person (range 0-30, IQR 3-9) by follow-up. There were 95 low value prescriptions at baseline reducing to 78 at follow-up.</p> <p><strong>Conclusions</strong></p> <p>The number of medication changes per person was not reflected by summarising medication count at two time points, highlighting the need for repeated measurements of prescribing outcomes especially for populations with high degrees of polypharmacy.</p>
Dataset related to the article :"Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting"
<p>This record contains raw data related to the article:" Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting" </p> <p>Abstract</p> <p>Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants.<strong> </strong>In a nested case–control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG.<strong> </strong>We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.</p>
Longitudinal trends of EHR concepts in pediatric patients
<p>The longitudinal nature of the data motivated temporal trend identification in the pediatric EHR datatypes. Over the past three decades (1980-2018), we identified and quantified the temporal trend of 16,460 EHR concepts across measurement, visit, diagnosis, drug, and procedure datatypes. </p>
Data set from "Absolute Treatment Effects for the Primary Outcome and All-cause Mortality in the Cardiovascular Outcome Trials of New Antidiabetic Drugs – A Meta-Analysis of Digitalized Individual Patient Data"
<p>This data set contains the complete digitalized individual patient data that are used in the manuscript "Absolute Treatment Effects for the Primary Outcome and All-cause Mortality in the Cardiovascular Outcome Trials of New Antidiabetic Drugs – A Meta-Analysis of Digitalized Individual Patient Data", which is accepted from "Acta Diabetologica".<br> The data file is in CSV format and contains the five variables "OutcomeType" (with values "AllcauseMortality" or "PrimaryOutcome"), "Study" (denoting the respective cardiovascular outcome trial), "Treatment" (denoting the respective study treatment or placebo), "Event" (denoting if the respective has been observed (Event=1) or not (Event=0)), and "SurvivalTimeMonths" (denoting the respective time to the event or censoring in months).</p>
The profile of the gut microbiome in gliomas patients
<p>Through 16S rRNA sequecing of fecal samples from gliomas patients, we found the characteristics of the gut microbiome proflie.</p>
Factors related to the implementation of patient safety culture in prehospital emergency services
<p><span>Background</span><span>: Prehospital emergency services are one of the main areas of health care, which provide emergency services for patients who experience acute, critical illness or injury outside the hospital. Prehospital services are more often carried out by the Emergency Medical Services (EMS) team, as one of the health service providers who come to the scene more quickly, both in daily emergencies.</span></p> <p><span>Purpose</span><span>: </span><span>This study aims to determine the factors related to the application of patient safety culture and determine the most dominant factors in the application of patient safety culture at </span><span>the prehospital emergency service in Bantaeng.</span></p> <p><span>Results:</span><span> The results showed that all domains of patient safety culture had a significant effect (p<0.05) namely teamwork 0.000, safety climate 0.000, management perception and support 0.000, job satisfaction 0.019, work environment 0.000 and stress recognition 0.000. The most influential domain is stress recognition 1.116 and Adjust R Square value of 69.7%.</span></p> <p><span>Conclusion:</span><span> Patient safety needs to be a priority in handling and organizations must continue to evaluate the application of patient safety culture in PSC 119 setting in Bantaeng. Nurses are responsible for improving services that prioritize patient safety by understanding all factors related to the implementation of patient safety culture.</span></p>
MALDI-MS raw files of primary human lung cancer samples, lung cancer patient derived xenografts and lung cancer mouse models
<p>Human primary lung cancer samples, patient derived lung cancer xenografts and lung tumors from the TetO-KRASG12D mouse model were analyzed using MALDI-MS. We determined the spatial distribution and relative abundance of lipids of interest. </p>
The validity and reliability test of the leprosy life quality questionnaire in leprosy patients
<p>This is underlying data for study titled<strong> The validity and reliability test of the leprosy life quality questionnaire in leprosy patients</strong></p> <p> </p>
PD1+CD8+ cells are an independent prognostic marker in patients with head and neck cancer
<p><strong>Data open:</strong> file with parametres used for the multivariate evaluation. </p>
The visualization of the collected data corresponding to the following paper: "The development of a Self-Rated ICF-based questionnaire (HEAR-COMMAND Tool) to evaluate Hearing, Communication, and Conversation disability: multinational experts' and patients' perspectives"
<p>These two PDF files include the data collected for a study conducted by Afghah et.al, 2022. They include the responses of the participant in this study to a newly developed self-rated ICF-based questionnaire. One file includes the responses to 30 demographic questions and the other one 88 ICF-based questions. The presented data were collected in Germany, the USA, and Egypt as well as overall data.</p> <p>The design of the questionnaire is described here:<br> Afghah, T., Alfakir, R., Meis, M., van Leeuwen, L. M., Kramer, S. E., Hammady, M., Youssif, M., & Wagener, K. C. (2021). The development of a Self-Rated ICF-based questionnaire (HEAR-COMMAND Tool) to evaluate hearing, communication, and conversation disability: multinational experts' and patients' perspectives. Zenodo. https://doi.org/10.5281/zenodo.5534360.</p> <p>This study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project ID: 352015383 – SFB 1330, C4.</p>
Machine learning methods detect arm movement impairments in a patient with parieto-occipital lesion using only early kinematic information.
<p>This depository contains the data and codes of the paper: </p> <p>Bosco, A., Bertini C., Filippini M., Foglino C., Fattori P (2022). Machine learning methods detect arm movement impairments in a patient with parieto-occipital lesion using only early kinematic information. <em>Journal of Vision</em>, in press. </p> <p>Data are provided in mat-file, codes is provided in m-files (Matlab).</p>
: Enzobiotics –A Novel Therapy For Elimination Of Uremic Toxins In Ckd Patients (EETOX Study)–Multicentric Double-Blinded Randomised Controlled Trial
<p>Supplementary file for <strong>: </strong><strong>Enzobiotics –A Novel Therapy For </strong><strong>Elimination Of Uremic Toxins In Ckd Patients (EETOX Study)–Multicentric Double-Blinded Randomised Controlled Trial</strong></p>
Sex-related differences in symptom presentation of patients with aneurysmal subarachnoid hemorrhage
<p>Retrospective study regarding sex-related differences in symptom presentation of patients with aneurysmal subarachnoid hemorrhage.</p>
Gastric Residual Volume, Safety and Effectiveness of Drinking 250ml Glucose Solution 2-3 Hours before Surgery in Gastric Cancer Patients: A Multicenter, Single-blind, Randomized Controlled Trial
<p><strong>Supplementary Figure 1</strong></p> <p> </p> <p>A. Change of QUICKI level after surgery</p> <p>Post-OP: right after operation; POD: post-operation day; Mixed linear model statistics showed that the effect of time ( p=0.004) was significant, but no significant differences were noted for group(P=0.600) or group*time(P=0.963).</p> <p>B. Change of Recovery Level of QUICKI after surgery</p> <p>Post-OP: right after operation; POD: post-operation day; Mixed linear model statistics showed that no significant differences were noted for group(P=0.600) ,time (P=0.235) or group×time(P=0.963).</p> <p>C. Change of WBC level after surgery</p> <p>Post-OP: right after operation; POD: post-operation day; Mixed linear model statistics showed that the effect of time ( p<0.001) was significant, and no significant differences were noted for group(P=0.392) or group×time(P=0.314).</p> <p>D. Change of CRP level after surgery</p> <p>Post-OP: right after operation; POD: post-operation day; Mixed linear model statistics showed that the effect of time ( p<0.001) was significant, but no significant differences were noted for group(P=0.312) or group × time(P=0.826).</p>
Safety of ChAdOx1 nCoV-19 vaccination in patients with end-stage renal disease on hemodialysis
<p>This dataset was the minimal dataset of the research article entitle 'Safety of ChAdOx1 nCoV-19 vaccination in patients with end-stage renal disease on hemodialysis'. The study aims to investigate the localized and systemic adverse effects (AEs) within 30-days after the first dose of ChAdOx1 nCoV19 (Oxford-AstraZeneca) vaccination in end-stage renal disease (ESRD) patients receiving hemodialysis (HD). The first dataset is the raw data for logistic regression analyses examining the risk factors in association with AEs, another dataset contains the second- and the seventh- day incidences of various AEs depicted in bar graphs. It comprises variables recording the status of patient-reported local and systemic AEs in questionnaire on the second and seventh days after vaccination as well as patients' baseline demographic and clinical characteristics.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.