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12,871 results for “aging;”
Data from: Biological clocks as age estimation markers in animals: a review and meta-analysis
<p>Complete dataset of Methylation and Telomere studies searched, retrieved, analysed, extracted and compared in the review and meta-analysis "<strong>Biological clocks as age estimation markers in animals: a review and meta-analysis".</strong></p>
Meta-GWAS of Age at Type 1 Diabetes Diagnosis
<p>7,923 subjects with type 1 diabetes from five studies (SDRNT1BIO, DCCT, CACTI, WESDR and EDC) were included in this analysis. This dataset includes summary stats for 8,154,711 autosomal SNPs.</p>
Carbon storage and carbon-equivalent albedo impact for US forests, by age and forest type
<p>These tables document estimates of carbon storage (Mg/ha +/- Standard Error) and carbon-equivalent albedo impacts (same units) of US forests by age and forest type (Healey et al., in review). Carbon estimates are derived from field measurements made by the USDA Forest Service on approximately 125,000 forested field plots (Domke et al., 2022). Soil organic carbon is omitted from these estimates, but all other above- and below-ground pools are included. Albedo impacts (time-dependent emissions equivalent, TDEE; Bright et al., 2016) were developed by applying atmospheric kernels (Bright and O'Halloran) to a new Landsat blue sky albedo product for the Landsat archive (Erb et al., 2022), as described by Healey et al. (in review). Standard error is supplied for each age/forest type bin for carbon storage, but upper and lower standard error bounds are specified for TDEE because log transformation creates an asymmetrical uncertainty envelope. </p> <p> </p> <p>Bright, Bogren, Bernier, Astrup, (2016). Carbon-equivalent metrics for albedo changes in land management contexts: Relevance of the time dimension. <em>Ecol. Appl.</em> 26, 1868–1880</p> <p>Bright, R. M., & O'Halloran, T. L. (2019). Developing a monthly radiative kernel for surface albedo change from satellite climatologies of Earth's shortwave radiation budget: CACK v1. 0. <em>Geoscientific Model Development, </em>12(9), 3975-3990.</p> <p>Domke, Walters, Nowak, Greenfield, Smith, Nichols, Ogle, Coulston, Wirth (2022). Greenhouse Gas Emissions and Removals From Forest Land, Woodlands, Urban Trees, and Harvested Wood Products in the United States, 1990–2020. (US Dept. Ag. For. Service, Madison, WI; <a href="https://doi.org/10.2737/FS-RU-382">https://doi.org/10.2737/FS-RU-382</a>).</p> <p>Erb, Li, Sun, Paynter, Wang, & Schaaf, (2022). Evaluation of the Landsat-8 Albedo Product across the Circumpolar Domain. <em>Remote Sensing</em>, <em>14</em>(21), 5320.</p> <p>Healey, Yang, Erb, Bright, Domke, Frescino, Schaaf, (in review) New satellite observations expose albedo dynamics offsetting half of carbon storage benefits in US forests.</p>
Resilin distribution and abundance in Apis mellifera across biological age classes and castes
<p>The presence of resilin, an elastomeric protein, in insect vein joints provides the flexible, passive deformations that are crucial to flapping flight. This study investigated the resilin gene expression and autofluorescence dynamics among <em>Apis</em> <em>mellifera</em> (honey bee) worker age classes and drone honey bees. Resilin gene expression was determined via ddPCR on whole honey bees and resilin autofluorescence was measured in the 1m-cu, 2m-cu, Cu-V, and Cu2-V joints on the forewing and the Cu-V joint of the hindwing. Resilin gene expression varied significantly with age, with resilin activity being highest in the pupae. Autofluorescence of the 1m-cu and the Cu-V joints on the ventral forewing and the Cu-V joint on the ventral hindwing varied significantly between age classes on the left and right sides of the wing, with the newly emerged honey bees having the highest level of resilin autofluorescence compared to all other groups. The results of this study suggest that resilin gene expression and deposition on the wing is age-dependent and may inform us more about the physiology of aging in honey bees.</p> <p> </p>
Age and geochemistry of High Arctic Large Igneous Province tholeiitic magmatism in NW Axel Heiberg Island, Canada
<p>Original data presented in Excel format to accompany the paper "Age and geochemistry of High Arctic Large Igneous Province tholeiitic magmatism in NW Axel Heiberg Island, Canada" by Deegan et al. (2023), published in <em>Geochemistry, Geophysics, Geosystems </em>in the special collection on Arctic magmatism ("Through the Arctic Lens: Progress in Understanding the Arctic Ocean, Margins and Landmasses").</p> <p>The file contains major and trace element data, Sr-Nd-Pb isotope data, and Ar-Ar dates for a suite of mafic rocks (lavas, dikes, and sills) from Bukken Fiord, NW Axel Heiberg Island, Canadian Arctic Islands.</p>
Mosquito aging modulates the development, virulence and transmission potential of pathogens
<p>Host age variation is a striking source of heterogeneity that can shape the evolution and transmission dynamic of pathogens. Compared to vertebrate systems, our understanding of the impact of host age on invertebrate-pathogen interactions remains limited. We examined the influence of mosquito age on key life-history traits driving human malaria transmission. Females of <em>Anopheles coluzzii</em>, a major malaria vector, belonging to three age classes (4, 8, and 12 day-old), were experimentally infected with <em>Plasmodium falciparum</em> field isolates. Our findings revealed reduced competence in 12-day-old mosquitoes, characterized by lower oocyst/sporozoite rates and intensities compared to younger mosquitoes. Despite shorter median longevities in older age classes, infected 12-day-old mosquitoes exhibited improved survival, suggesting that the infection might act as a fountain of youth for older mosquitoes specifically. The timing of sporozoite appearance in the salivary glands remained consistent across mosquito age classes, with an extrinsic incubation period of approximately 13 days. Integrating these results into an epidemiological model revealed a lower vectorial capacity for older mosquitoes compared to younger ones, albeit still substantial due to extended longevity in the presence of infection. Considering age heterogeneity provides valuable insights for ecological and epidemiological studies, informing targeted control strategies to mitigate pathogen transmission.</p>
Figure 5 in Age and growth of Conger conger (Congridae) from the north coast of Tunisia
Figure 5. – Vertebra of Conger conger observed under a binocular microscope (×10) in reflected light (Six annuli can be seen). Scale bar = 1 cm.
Figure 2 in Age and growth of Muraena helena (Muraenidae) from the north coast of Tunisia
Figure 2. - Length-frequency distribution of females, males and combined sexes for the Muraena helena sampled from the north coast of Tunisia.
Figure 1 in Age and growth of Muraena helena (Muraenidae) from the north coast of Tunisia
Figure 1. - Map of the study area, indicating the three sampling locations (✶) (North coast of Tunisia, central Mediterranean).
Figure 4 in Age and growth of Muraena helena (Muraenidae) from the north coast of Tunisia
Figure 4. - Seasonal mean marginal increment observed from sagittae sections of ages 2 to 10 Muraena helena specimens.
Study of Recombinant Protein Vaccines With Adjuvant as a Primary Series and as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older
ClinicalTrials.gov study NCT04762680. IPD Sharing: YES. Countries: 7. Publications: 2.
Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia
ClinicalTrials.gov study NCT01254422. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Efficacy Study in Preschool Children Aged 4-5 Years With Attention-deficit/Hyperactivity Disorder (ADHD)
ClinicalTrials.gov study NCT03260205. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Test if Fremanezumab is Effective in Preventing Episodic Migraine in Patients 6 to 17 Years of Age
ClinicalTrials.gov study NCT04458857. IPD Sharing: YES. Countries: 9. Publications: 1.
Study With Quadrivalent Recombinant Influenza Vaccine (RIV4) in Participants 9 Through 49 Years of Age.
ClinicalTrials.gov study NCT05513053. IPD Sharing: YES. Countries: 4. Publications: 1.
Study to Evaluate the Effectiveness of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Adults 65 Years of Age and Older
ClinicalTrials.gov study NCT04137887. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Assess the Effects of Brolucizumab in Adult Patients With Neovascular Age Related Macular Degeneration
ClinicalTrials.gov study NCT04239027. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India
ClinicalTrials.gov study NCT01550289. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency
ClinicalTrials.gov study NCT02292654. IPD Sharing: YES. Countries: 6. Publications: 1.
The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age
ClinicalTrials.gov study NCT03760458. IPD Sharing: YES. Countries: 4. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.