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906
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ShareScore release 0.9.0
Dataset results
906 results for “atherosclerosis”
Macrophage extracellular traps originated from the vascular smooth muscle cells play key roles in atherosclerosis progression.
GEO Series GSE197075. Mus musculus; Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
High Glucose Macrophage Exosomes Enhance Atherosclerosis by Driving Cellular Proliferation & Hematopoiesis
GEO Series GSE162962. Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Treml4 promotes inflammatory programs in human and murine macrophages and alters atherosclerosis lesion composition in the Apolipoprotein E deficient mouse
GEO Series GSE145384. Homo sapiens; Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis"
<p>This record contains raw data related to the article "Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis".</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims: Aortic valve sclerosis (AVSc), a non-uniform thickening of leaflets with an unrestricted opening, is characterized by inflammation, lipoprotein deposition, and matrix degradation. In the general population, AVSc predicts long-term cardiovascular mortality (+50%) even after adjustment for vascular risk factors and clinical atherosclerosis. We have hypothesized that AVSc is a risk-multiplier able to predict even short-term mortality. To address this issue, we retrospectively analyzed 90-day mortality of all patients who underwent isolated coronary artery bypass grafting (CABG) at Centro Cardiologico Monzino over a ten-year period (2006–2016). Methods: We analyzed 2246 patients and 90-day all-cause mortality was 1.5% (31 deaths). We selected only patients deceased from cardiac causes (n = 29) and compared to alive patients (n = 2215). A cardiologist classified the aortic valve as no-AVSc (n = 1352) or AVSc (n = 892). Cox linear regression and integrated discrimination improvement (IDI) analyses were used to evaluate AVSc in predicting 90-day mortality. Results: AVSc 90-day survival (97.6%) was lower than in no-AVSc (99.4%; p < 0.0001) with a hazard ratio (HR) of 4.0 (95%CI: 1.78, 9.05; p < 0.0001). The HR for AVSc, adjusted for propensity score, was 2.7 (95%CI: 1.17, 6.23; p = 0.02) and IDI statistics confirmed that AVSc significantly adds (p < 0.001) to the identification of high-risk patients than EuroSCORE II alone. Conclusion: Our data supports the hypothesis that a risk stratification strategy based on AVSc, added to ESII, may allow better recognition of patients at high-risk of short-term mortality after isolated surgical myocardial revascularization. Results from this study warrant further confirmation.</p>
Dataset related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"
<p>This record contains raw data related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aortic valve sclerosis (AVSc) is characterized by non-uniform thickening of the leaflets without hemodynamic changes. Endothelial dysfunction, also caused by dysregulation of glutathione homeostasis expressed as ratio between its reduced (GSH) and its oxidised form (GSSG), could represent one of the pathogenic triggers of AVSc. We prospectively enrolled 58 patients with overt atherosclerosis and requiring coronary artery bypass grafting (CABG). The incidence of AVSc in the studied population was 50%. The two groups (No-AVSc and AVSc) had similar clinical characteristics. Pre-operatively, AVSc group showed significantly lower GSH/GSSG ratio than No-AVSc group (<em>p = </em>0.02). Asymmetric dimethylarginine (ADMA) concentration was significantly higher in AVSc patients compared to No-AVSc patients (<em>p < </em>0.0001). Explanted sclerotic aortic valves presented a significantly increased protein glutathionylation (Pr-SSG) than No-AVSc ones (<em>p = </em>0.01). In vitro, inhibition of glutathione reductase caused β-actin glutathionylation, activation of histone 2AX, upregulation of α2 smooth muscle actin (<em>ACTA2</em>), downregulation of platelet and endothelial cell adhesion molecule 1 (<em>PECAM1</em>) and cadherin 5 (<em>CDH5</em>). In this study, we showed for the first time that the dysregulation of glutathione homeostasis is associated with AVSc. We found that Pr-SSG is increased in AVSc leaflets and it could lead to EndMT via DNA damage. Further studies are warranted to elucidate the causal role of Pr-SSG in aortic valve degeneration.</p>
Training dataset for Carotid Vessel Wall Segmentation and Atherosclerosis Diagnosis Challenge, MICCAI 2022
<p>Training dataset for <strong>Carotid Vessel Wall Segmentation and Atherosclerosis Diagnosis Challenge, MICCAI 2022</strong>. </p> <p>Please refer to our website: <strong>https://vessel-wall-segmentation-2022.grand-challenge.org/</strong>.</p>
A Randomized, Double Blind Study To Compare The Effects Of Olmesartan Medoxomil Versus Placebo In Patients With Established Atherosclerosis
ClinicalTrials.gov study NCT00382213. IPD Sharing: Not stated. Countries: 0. Publications: 0.
TMAO and Atherosclerosis in HIV
ClinicalTrials.gov study NCT03416257. IPD Sharing: NO. Countries: 0. Publications: 0.
Study to Evaluate Subclinical Atherosclerosis (an Early Sign of Heart Disease) in Healthy Adult Immigrant Asian Indians
ClinicalTrials.gov study NCT01104597. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Epidemiology of Vascular Inflammation & Atherosclerosis
ClinicalTrials.gov study NCT00087893. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED)
ClinicalTrials.gov study NCT00804843. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Randomized Controlled Trial on Carotid Atherosclerosis Screening in Asymptomatic Smokers and Hypertensive Adults: Prevalence and Impact on Cardiovascular Prevention
ClinicalTrials.gov study NCT06848283. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Atherosclerosis, Plaque and CVD in Communities
ClinicalTrials.gov study NCT00091754. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Pathological Crystallization of Cholesterol in Atherosclerosis
ClinicalTrials.gov study NCT04257942. IPD Sharing: YES. Countries: 0. Publications: 0.
Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms
ClinicalTrials.gov study NCT02977351. IPD Sharing: NO. Countries: 0. Publications: 0.
Cysteinyl Leukotriene Antagonist in Atherosclerosis Inhibition in Patients After Endovascular Treatment Due to Peripheral Arterial Disease
ClinicalTrials.gov study NCT04277702. IPD Sharing: YES. Countries: 0. Publications: 0.
The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray
ClinicalTrials.gov study NCT06301009. IPD Sharing: YES. Countries: 0. Publications: 0.
Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.
ClinicalTrials.gov study NCT07266220. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of a Dipeptidyl Peptidase-4 Inhibitor Sitagliptininsulin on the Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT03602638. IPD Sharing: NO. Countries: 0. Publications: 0.
Proof of Concept Study of BMS-823778 to Assess the Effects on Atherosclerosis
ClinicalTrials.gov study NCT01666704. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.