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Dataset results
818 results for “atrophy”
Identification of genes that elicit disuse muscle atrophy via the transcription factors p50 and Bcl-3
GEO Series GSE23497. Mus musculus. 24 samples. Type: Expression profiling by array.
Endogenous Muscle Atrophy F-box is Involved in the Development of Cardiac Rupture After Myocardial Infarction
GEO Series GSE97494. Mus musculus. 8 samples. Type: Expression profiling by array.
Endogenous Muscle Atrophy F-box Regulates Pressure Overload-Induced Cardiac Hypertrophy
GEO Series GSE24372. Mus musculus. 4 samples. Type: Expression profiling by array.
Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy
GEO Series GSE240814. Mus musculus. 80 samples. Type: Expression profiling by high throughput sequencing.
Delayed denervation-induced muscle atrophy in Opg knockout mice
GEO Series GSE220152. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Discovery of novel differentially expressed genes related to interstitial fibrosis and tubular atrophy among kidney transplantation recipients by mRNA-sequencing
GEO Series GSE218048. Homo sapiens. 82 samples. Type: Expression profiling by high throughput sequencing.
Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents via Effects on Estrogen Receptor-α.
GEO Series GSE77121. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
GEO Series GSE4492. Rattus norvegicus. 23 samples. Type: Expression profiling by array.
Jakyak-gamcho-tang ameliorates dexamethasone-induced muscle atrophy and muscle dysfunction
GEO Series GSE227496. Mus musculus. 101 samples. Type: Expression profiling by high throughput sequencing.
Differentially expressed genes during disuse atrophy.
GEO Series GSE40578. Mus musculus. 8 samples. Type: Expression profiling by array.
microRNA data from atrophied rat gastrocnemius of 5 days post denervation versus sham control
GEO Series GSE81914. synthetic construct; Rattus norvegicus. 8 samples. Type: Non-coding RNA profiling by array.
Increased global DNA methylation by Dnmt3a disrupts skeletal muscle homeostasis, promotes age-related muscle atrophy, and reduces muscle metabolic elasticity
GEO Series GSE262342. Mus musculus. 20 samples. Type: Methylation profiling by high throughput sequencing.
Muscle transcriptome response to 84-day bed rest with and without resistance exercise in men: the search for the residual signature of muscle atrophy
GEO Series GSE148152. Homo sapiens. 41 samples. Type: Expression profiling by array.
KLF5 on dexamethasone-mediated atrophy in mouse satellite cells
GEO Series GSE165072. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
NAD+ enhanced mesenchymal stromal cells effect on muscle atrophy by improving SIRT1/PGC-1α-mediated mitochondrial function via NAMPT
GEO Series GSE304351. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A Non-invasive Mouse Model That Recapitulates Disuse-Induced Muscle Atrophy in Immobilized Patients
GEO Series GSE237537. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Determining the mechanism of ATF4-mediated myofiber atrophy
GEO Series GSE20104. Mus musculus. 16 samples. Type: Expression profiling by array.
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy
GEO Series GSE23802. Drosophila melanogaster. 54 samples. Type: Expression profiling by array.
Quantitative Cervical Cord MRI in Spinal Muscular Atrophy: a sensitive imaging biomarker of Disease Evolution and Treatment
<p>Background Nusinersen is a promising therapy for spinal muscular atrophy (SMA), a rare disease characterized by the degeneration of alpha motor neurons in the spinal cord (SC), leading to progressive muscle atrophy and paralysis. This study aimed to validate cervical SC MRI as an imaging biomarker for assessing SMA severity, progression, and response to nusinersen treatment.</p> <p>Methods Five pediatric patients and three adult patients with SMA underwent clinical assessment and SC MRI at multiple time points during treatment with nusinersen. Total cord area (TCA), grey matter area (GMarea), and magnetization transfer saturation (MTsat) were measured at cervical SC levels.</p> <p>Results In pediatric patients, TCA increased significantly at all cervical levels during the observation period (C4-C5, p<0.001), whereas GMarea showed a significant increase only at the C3-C4 level (p=0.043). TCA was found to correlate with motor scales, particularly with measures of upper limb motor function.<span> </span>Pediatric patients demonstrated higher TCA values compared to the SC growth rates reported in healthy controls in the literature, especially during the early part of the observation period. GM MTsat values correlated with clinical scores. In adults, TCA and GMarea strongly correlated with clinical measures.</p> <p>Conclusion This study demonstrates that nusinersen has a positive effect on both adult and pediatric patients, with more pronounced effects in the latter, improving motor function and SC growth. SC MRI metrics reflect disease severity and correlate strongly with clinical scales, providing a valuable imaging marker for monitoring treatment response in SMA and evaluating emerging therapies.</p>
Database of publication "Diagnostic accuracy of Quantitative Susceptibility Mapping in Multiple System Atrophy: the impact of echo time and the potential of histogram analysis". NeuroImage: Clinical, 2022, 102989.
<p>The file data_MSA_NICL2022.mat contains the data from Lancione et al., NeuroImage: Clinical 2022.</p> <p>If you use these data, please cite:</p> <p>Lancione, M., et al. Diagnostic accuracy of Quantitative Susceptibility Mapping in Multiple System Atrophy: the impact of echo time and the potential of histogram analysis. NeuroImage: Clinical, 2022, 102989.</p> <p><br> The data are structured as follows:</p> <p>- age: age in years of all 44 subjects<br> - sex: "1": male; "-1": female<br> - diagnosis: "HC": healthy controls; "MSAp": Multiple System Atrophy with Parkinsonian phenotype; "MSAc": Multiple System Atrophy with cerebellar phenotype<br> - roi_name: names of the 20 ROIs; the abbreviations are defined in the original paper<br> - stats_name: names of the 9 histogram features<br> - stats: [9 histogram features x 44 subjects x 20 ROIs x 5 TEs (4 acquired TEs + the average of all TEs)]</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.