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12,662 results for “linking”
Linking temperature dependence in fitness effects of mutations to thermal niche adaptation
<p>Fitness effects of mutations may generally depend on temperature that influences all rate-limiting biophysical and biochemical processes. Earlier studies suggested that high temperatures may increase the availability of beneficial mutations ("more beneficial mutations"), or allow beneficial mutations to show stronger fitness effects ("stronger beneficial mutation effects"). The "more beneficial mutations" scenario would inevitably be associated with increased proportion of conditionally beneficial mutations at higher temperatures. This in turn predicts that populations in warm environments show faster evolutionary adaptation but suffer fitness loss when faced with cold conditions, and those evolving in cold environments become thermal-niche generalists ("hotter is narrower"). Under the "stronger beneficial mutation effects" scenario, populations evolving in warm environments would show faster adaptation without fitness costs in cold environments, leading to a "hotter is (universally) better" pattern in thermal niche adaptation. We tested predictions of the two competing hypotheses using an experimental evolution study in which populations of two model bacterial species, <em>Escherichia coli</em> and <em>Pseudomonas fluorescens</em>, evolved for 2,400 generations at three experimental temperatures. Results of reciprocal transplant experiments with our <em>P. fluorescens</em> populations were largely consistent with the "hotter is narrower" prediction. Results from the <em>E. coli</em> populations clearly suggested stronger beneficial mutation effects at higher assay temperatures, but failed to detect faster adaptation in populations evolving in warmer experimental environments (presumably because of limitation in the supply of genetic variation). Our results suggest that the influence of temperature on mutational effects may provide insight into the patterns of thermal niche adaptation and population diversification across thermal conditions.</p>
Modeling flexible protein structure with AlphaFold2 and cross-linking mass spectrometry
<p>Ensembles of models predicted by AlphaFold for the proteins C3 (Complement component 3), luciferase and QBP (glutamine-binding periplasmic protein). Models interpolated between two conformations of C3, and luciferase are also included. This dataset is cited in the following paper: https://www.biorxiv.org/content/10.1101/2023.09.11.557128v1</p>
Links between personality, reproductive success and re-pairing patterns in a long-lived seabird
<p>In long-lived monogamous species, the trigger of costly re-pairing is not always clear. Limited research suggests that within-pair behavioural compatibility may be an important driver of partnership success, as cooperation should be enhanced when pair members' decisions complement one another. Animals' decision-making processes are influenced by personality traits – defined as individual differences in behaviour that are stable in time. Despite the potential for the personality trait 'boldness' to a) directly impact individual willingness to re-pair and b) indirectly impact re-pairing choices via reproductive success, there is currently little work exploring how re-pairing decisions might be impacted by the pair members' personalities. Using a 13-year dataset, we investigated whether within-pair boldness and its relationship with breeding success explained re-pairing patterns of black-legged kittiwakes (<em>Rissa</em> <em>tridactyla</em>), breeding in two Arctic colonies. We found that pairs with dissimilar boldness levels were more likely to experience breeding failure and that failed pairs were more likely to re-pair the following year. Despite this, only one colony displayed evidence of assortative mating by boldness, and there was no indication that re-pairing impacted reproductive success the following season. Neither individual nor pair boldness directly influenced re-pairing probability, however, in both colonies, re-pairing birds chose partners that were slightly more similar to themselves in boldness than their previous mates. These results imply an indirect pathway by which poorer behavioural compatibility within pairs may lead to breeding failure and ultimately re-pairing. Our findings highlight the importance of behavioural compatibility, and possibly personality, in mitigating sexual conflict and its population-specific drivers.</p>
Population links between an insectivorous bird and moths disentangled through national scale monitoring data
<p>Code in support of "Population links between an insectivorous bird and moths disentangled through national scale monitoring data"</p> <p>Luke Christopher Evans, Malcolm D. Burgess, Simon G. Potts, William E. Kunin, Tom H. Oliver</p>
Neolithic Settlement, Links of Noltland, Westray
Neolithic Settlement after 2017 excavation showing enclosure wall, four interior and two outlying structures. Source: Objaverse 1.0 / Sketchfab
A Key Link for Transmission Prevention
ClinicalTrials.gov study NCT01450189. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services
ClinicalTrials.gov study NCT04155502. IPD Sharing: YES. Countries: 1. Publications: 2.
An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia
ClinicalTrials.gov study NCT01571596. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Study of KRN23 (Burosumab), a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH)
ClinicalTrials.gov study NCT02163577. IPD Sharing: Not stated. Countries: 4. Publications: 3.
Group Antenatal Care: Effectiveness and Contextual Factors Linked to Implementation Success in Malawi
ClinicalTrials.gov study NCT03673709. IPD Sharing: NO. Countries: 1. Publications: 3.
Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients
ClinicalTrials.gov study NCT06394934. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)
ClinicalTrials.gov study NCT02537431. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) - Retinitis Pigmentosa GTPase Regulator (RPGR)
ClinicalTrials.gov study NCT03252847. IPD Sharing: NO. Countries: 2. Publications: 1.
Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria or X-Linked Protoporphyria
ClinicalTrials.gov study NCT04402489. IPD Sharing: UNDECIDED. Countries: 10. Publications: 1.
Linking Infectious and Narcology Care-Part II
ClinicalTrials.gov study NCT03290391. IPD Sharing: NO. Countries: 1. Publications: 4.
DHA and X-Linked Retinitis Pigmentosa
ClinicalTrials.gov study NCT00100230. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Testing "Doula Link", a Multi-Component Intervention to Improve Perinatal Mental Health
ClinicalTrials.gov study NCT07217561. IPD Sharing: NO. Countries: 1. Publications: 11.
Prospective Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria
ClinicalTrials.gov study NCT05686837. IPD Sharing: YES. Countries: 1. Publications: 6.
Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector
ClinicalTrials.gov study NCT01129544. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
ClinicalTrials.gov study NCT02107976. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.