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8,038 results for “Validity”
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland transcriptomic, proteomic, and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
GPM Ground Validation Doppler on Wheels (DOW) OLYMPEX V2
The GPM Ground Validation Doppler on Wheels (DOW) OLYMPEX V2 dataset was obtained by a dual-polarization and dual-frequency X-band mobile radar operated by the Center for Severe Weather Research (CSWR) during the Olympic Mountain Experiment (OLYMPEX) campaign. The DOW was deployed in the Chehalis Valley for the OLYMPEX field campaign with the goal of obtaining radar reflectivity and Doppler velocity observations in order to better understand the orographic enhancement of precipitation during frontal passages over mountain ranges. The DOW radar uses two 250 kW transmitters with a measurement range of roughly 60 km. These data are available in CFradial netCDF-4 format from November 6, 2015 through January 15, 2016.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver tissues from RR-1 mice (female C57BL/6J 16wk old at time of launch). From each group two liver samples were collected and frozen immediately after euthanasia. The rest of the liver samples from each group were collected from frozen carcasses dissected post-flight. RNA-Seq whole genome and RNA BS-Seq (bisulfite sequencing) and proteomic expression profiling were performed. xc2 xa0RNA extracted from these tissues was re-sequenced; these data are available as part of GLDS-168 (https://genelab-data.ndc.nasa.gov/genelab/accession/GLDS-168). xc2 xa0
GPM Ground Validation NASA ER-2 Navigation Data OLYMPEX V1
The GPM Ground Validation NASA ER-2 Navigation Data OLYMPEX dataset supplies navigation data collected by the NASA ER-2 aircraft for flights that occurred during November 9, 2015 through December 15, 2015 for one of the GPM Ground Validation field campaigns called the Olympic Mountains Experiment (OLYMPEX). This navigation dataset consists of multiple altitude, pressure, temperature parameters, airspeed, and ground speed measurements in ASCII, ASCII-IWG1, and XML data file formats.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse left gastrocnemius muscle transcriptomic, proteomic, and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment (RR-1), a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
GPM GROUND VALIDATION OKLAHOMA CLIMATOLOGICAL SURVEY MESONET MC3E V1
The GPM Ground Validation Oklahoma Climatological Survey Mesonet MC3E data were collected during the Midlatitude Continental Convective Clouds Experiment (MC3E) in central Oklahoma during the April-June 2011 period. The overarching goal was to provide the most complete characterization of convective cloud systems, precipitation, and the environment that has ever been obtained, providing constraints for model cumulus parameterizations and space-based rainfall retrieval algorithms over land that had never before been available. Collected by a network of weather stations, this dataset is composed of 15 minute and 5 minute files with one file per site per day in mts format. Data can be read as ASCII text. Multiple parameters found in this dataset include relative humidity, air temperature, wind speed and direction, precipitation and calibrated soil moisture. More information on the contents and data format can be found at http://www.mesonet.org/index.php/site/about/mdf_mts_files.
East China Sea validation measurements for GOCI instrument
Measurements made in the East China Sea in 2013 to validate the South Korean GOCI instrument.
High-latitude Intercomparison and Validation Experiment (HIVE)
Measurements taken in the Gulf of Alaska and Bering Sea during 1997 and 1998.
GPM Ground Validation NASA ER-2 Navigation Data IPHEx V1
The GPM Ground Validation NASA ER-2 Navigation Data IPHEx dataset was gathered during the GPM Ground Validation Integrated Precipitation and Hydrology Experiment (IPHEx) in North Carolina. The ER-2 Aircraft flew during the IPHEx field campaign to aid in GPM validation. The science instruments onboard the aircraft acted as a proxy for GPM satellite instruments. Twenty-one ER-2 flights occurred during May 1, 2014 through June 14, 2014. The dataset consists of navigation data, as well as meteorological parameters collected by an on-board navigation recorder every second of the flight. The data are available in ASCII and XML formats.
GPM GROUND VALIDATION NASA MICRO RAIN RADAR (MRR) MC3E V1
The GPM Ground Validation NASA Micro Rain Radar (MRR) MC3E dataset was collected by a Micro Rain Radar (MRR), which is a vertically pointing Doppler radar which provides measurements of vertical velocity, drop size distribution, rainfall rate, attenuation, liquid water content, and reflectivity factor obtained during the Midlatitude Continental Convective Clouds Experiment (MC3E), which took place in Oklahoma during the Spring of 2011. The MRR is a frequency-modulated continuous wave (FMCW) vertically pointing Doppler radar, which operates at 24.24GHz, and is the second generation of the instrument manufactured by METEK (URL: http://metek.de/product/mrr-2/).
GPM GROUND VALIDATION ENVIRONMENT CANADA (EC) PASSIVE MICROWAVE RADIOMETER AND SOIL MOISTURE-TEMPERATURE DATA GCPEX V1
The GPM Ground Validation Environment Canada (EC) Passive Microwave Radiometer and Soil Moisture-Temperature Data GCPEx dataset is consisted of data during the GPM Cold-season Precipitation Experiment (GCPEx) at the Centre for Atmospheric Research Experiments (CARE) site in Ontario, Canada during the winter season 2011-2012. GCPEx addressed shortcomings in the GPM snowfall retrieval algorithm by collecting microphysical properties, associated remote sensing observations, and coordinated model simulations of precipitating snow. Data collected includes microwave brightness temperatures, snow and soil/snow-air interface (ground surface temperatures), soil surface temperatures, and soil volumetric water content. These data were acquired by multiple instruments: a passive microwave radiometer, a water content reflectometer, thermistors, soil moisture probe.
Prognostics of Power Electronics, methods and validation testbeds
An overview of the current results of prognostics for DC- DC power converters is presented, focusing on the output filter capacitor component. The electrolytic capacitor used typically as fileter capacitor is one of the components of the power supply with higher failure rate, hence the effort in devel- oping component level prognostics methods for capacitors. An overview of prognostics algorithms based on electrical overstress and thermal overstress accelerated aging data is presented and a discussion on the current efforts in terms of validation of the algorithms is included. The focus of current and future work is to develop a methodology that allows for algoritm development using accelerated aging data and then transform that to a valid algorithm on the real usage time scale.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse kidney transcriptomic, proteomic, and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
New Horizons Solar Wind Around Pluto (SWAP) Pick-Up Ions, Validated Summary Data (VS), Daily Data
Solar WInd Pick-Up Ion Plasma Moment Validated Summary (VS) Data from the New Horizons Solar Wind Around Pluto (SWAP) Instrument. Elliott, H.A., D.J. McComas, P. Valek, G. Nicolaou, S. Weidner, and G. Livadiotis (2016), ApJS, 223(2), 1-21, doi:10.3847/0067-0049/223/2/19. McComas, D.J., et al., (2008), The Solar Wind Around Pluto (SWAP) Instrument Aboard New Horizons, Space Sci Rev, 140(1), 261-313, doi:10.1007/s11214-007-9205-3.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse adrenal gland transcriptomic proteomic and epigenomic data
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS) it is imperative to use crew time efficiently while maximizing high-quality science return. NASA s GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics systems biology-based approach and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA DNA and protein extracted from archived RR-1 tissue samples for epigenomic transcriptomic and proteomic assays. During the first RR spaceflight experiment a variety of tissue types were harvested from subjects snap-frozen or RNAlater-preserved and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands quadriceps gastrocnemius tibialis anterior extensor digitorum longus soleus eye and kidney. We report here protocols for and results of these tissue extractions and thus the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
VIIRS validation measurements made in the Florida Keys
Measurements made in the Florida Keys as part of efforts to Validate the VIIRS instrument.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver tissues from RR-1 mice (female C57Bl6/J 16wk old at time of launch) including eight from the Flight group and eight from the Ground Control group. From each group two liver samples were collected and frozen immediately after euthanasia (Flight mice dissected on-orbit after total 37 days after launch Samples FLT-M21 M22 and corresponding Ground Control samples GC-M31,M32). An additional six samples from each group were collected from frozen carcasses dissected post-flight (Samples FLT-M25,M26,M27,M28,M29,M30 and corresponding Ground Control samples GC-M35,M36,M37,M38,M39,M40). RNA-Seq whole genome and RNA BS-Seq (bisulfite sequencing) and proteomic expression profiling were performed.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse kidney transcriptomic proteomic and epigenomic data
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS) it is imperative to use crew time efficiently while maximizing high-quality science return. NASA s GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics systems biology-based approach and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA DNA and protein extracted from archived RR-1 tissue samples for epigenomic transcriptomic and proteomic assays. During the first RR spaceflight experiment a variety of tissue types were harvested from subjects snap-frozen or RNAlater-preserved and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands quadriceps gastrocnemius tibialis anterior extensor digitorum longus soleus eye and kidney. We report here protocols for and results of these tissue extractions and thus the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic, proteomic, epigenomic and histology data
Translating fundamental biological discoveries from NASA Space Biology program into health risk from space flights has been an ongoing challenge. We propose to use NASA GeneLab database to gain new knowledge on potential systemic responses to space. Unbiased systems biology analysis of transcriptomic data from seven different rodent datasets reveals for the first time the existence of potential 'master regulators' coordinating a systemic response to microgravity and/or space radiation with TGF-β1 being the most common regulator. We hypothesized the space environment leads to the release of biomolecules circulating inside the blood stream. Through datamining we identified 13 candidate microRNAs (miRNA) which are common in all studies and directly interact with TGF-β1 that can be potential circulating factors impacting space biology. This study exemplifies the utility of the GeneLab data repository to aid in the process of performing novel hypothesis-based research.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse eye transcriptomic and epigenomic data
NASA's Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASA's GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.