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1,036
datasets available to search
ShareScore release 0.9.0
Dataset results
1,036 results for “Cell mechanics”
The RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism
GEO Series GSE249809. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells [HG-U133_Plus_2]
GEO Series GSE85732. Homo sapiens. 8 samples. Type: Expression profiling by array.
Pericytes promote more vascularization than stromal cells via an interleukin-6-dependent mechanism in microfluidic chips
GEO Series GSE287099. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments
GEO Series GSE309016. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology.
GEO Series GSE236905. Gallus gallus. 37 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments
GEO Series GSE309015. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Decreased TGFBR3/Betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-b-dependent and independent mechanisms
GEO Series GSE106719. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells
GEO Series GSE125617. Mus musculus. 78 samples. Type: Expression profiling by high throughput sequencing.
Molecular Atlas of HER2+ Breast Cancer Cells Stimulated with EGF and HRG: Temporal Insights into Mechanisms in Trastuzumab Resistance
GEO Series GSE237607. Homo sapiens. 80 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Effect of mechanically responsive miRNAs on biomechanical properties of airway smooth muscle cells and their related drug development studies
GEO Series GSE206435. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Changes in Gene expression mediated by Cyclic Mechanical Stress in Trabecular Meshwork Cells
GEO Series GSE14768. Homo sapiens. 6 samples. Type: Expression profiling by array.
Heart failure patients' peripheral blood mononuclear cell gene expression profiles before mechanical circulatory support
GEO Series GSE104423. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Dissecting molecular mediators of TGFb- and HGF-induced cell mechanical enhancement in NSCLC
GEO Series GSE98979. Homo sapiens. 45 samples. Type: Expression profiling by array.
Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells
GEO Series GSE62721. Homo sapiens; synthetic construct. 18 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Mechanism of Enhancing Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma with Paricalcitol and Hydroxychloroquine: A Single Cell RNA Sequencing - Part1
<p><span>Pancreatic ductal adenocarcinoma (PDAC) boasts a dismal five-year survival rate of less than 15%, mainly due to therapy resistance. Recent studies have highlighted hydroxychloroquine (H) and paricalcitol (P), reducing stromal density and enhancing PDAC sensitivity to chemotherapy. This investigation aimed to elucidate the molecular impacts of combining H and P, focusing on their ability to sensitize PDAC to chemotherapy. <em>In vitro</em> and <em>in vivo</em> experiments demonstrated that the HP combination significantly (p<0.001) enhanced gemcitabine (G) effects, validated in orthotopic mouse models and patient-derived xenografts (PDX). Mechanistically, GPH induced cell death via the vitamin D receptor pathway upregulated autophagy and ER stress-related transcripts and suppressed mTOR signaling. Single-cell (sc) RNAseq analyses showed GPH increased quiescent cancer associated fibroblasts and reduced autophagy related transcripts. GPH treatment modulated T-cell populations favoring antitumor immunity. Findings from clinical trial patient biopsies underscored these effects, highlighting GPH's potential as a therapeutic adjunct in PDAC management (NCT04524702).</span></p>
Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia
ClinicalTrials.gov study NCT02565849. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Multi-omics Analysis of Renal Cell Carcinoma Mechanisms; Drug Sensitivity Testing in Patient-Derived Cell-based Microtumors
ClinicalTrials.gov study NCT07351266. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Explore the Mechanisms Underlying Disease Resistance and Potential Primary Resistance Mechanism of Induction Therapy Lorlatinib in Resectable Non-small Cell Lung Cancer (NSCLC) Harboring ALK Positive
ClinicalTrials.gov study NCT06893354. IPD Sharing: NO. Countries: 0. Publications: 0.
The Immune Tolerance Mechanism Induced by IL-17-producing Regulatory T Cells in the Orthotopic Liver Transplant Recipients With Aspergillosis
ClinicalTrials.gov study NCT01117077. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant
ClinicalTrials.gov study NCT01558778. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.