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54,099 results for “Expression”
Modulation of gene expression in immune related organs by in-ovo stimulation with probiotics and prophybiotics in broiler chickens
<p><span>The current study was performed to further investigate the tissue specific immune modulation and metabolic gene regulation of these <em>in-ovo</em> stimulated chickens. Accordingly, the expression of immune related genes was determined in the secondary immune organs, cecal tonsils and the spleen as well as the liver which is an important organ for both the immune system and metabolism. Additionally, the expression of the genes related to metabolism was also analyzed in the liver.</span></p>
RatXcan: A framework for cross-species integration of genome-wide association and gene expression data
<p>Data for paper</p> <p><span>RatXcan: A framework for cross-species integration of genome-wide association and gene expression data</span></p> <p><span>Natasha Santhanam</span><span><span>1</span></span><span><span>†</span></span><span>, Sandra Sanchez-Roige</span><span><span>2,3,4</span></span><span><span>†</span></span><span>, Sabrina Mi</span><span><span>2</span></span><span>, Yanyu Liang</span><span><span>1</span></span><span>, Apurva S. Chitre</span><span><span>2</span></span><span>, Daniel Munro</span><span><span>2</span></span><span>, Denghui Chen</span><span><span>2</span></span><span>, Riyan Cheng</span><span><span>2</span></span><span>, Jianjun Gao</span><span><span>2</span></span><span>, Angel Garcia-Martinez</span><span><span>6</span></span><span>, Anthony M. George</span><span><span>5</span></span><span>, Alexander F. Gileta</span><span><span>2</span></span><span>, Wenyan Han</span><span><span>6</span></span><span>, Katie Holl</span><span><span>7</span></span><span>, Alesa Hughson</span><span><span>8</span></span><span>, Christopher P. King</span><span><span>9</span></span><span>, Alexander C. Lamparelli</span><span><span>9</span></span><span>, Connor D. Martin</span><span><span>5</span></span><span>, Festus Nyasimi</span><span><span>1</span></span><span>, Celine L. St. Pierre</span><span><span>2</span></span><span>, Sarah Sumner</span><span><span>1</span></span><span>, Jordan Tripi</span><span><span>9</span></span><span>, Tengfei Wang</span><span><span>6</span></span><span>, Hao Chen</span><span><span>6</span></span><span>, Shelly Flagel</span><span><span>8</span></span><span>, Keita Ishiwari</span><span><span>5,10</span></span><span>, Paul Meyer</span><span><span>5,9</span></span><span>, Oksana Polesskaya</span><span><span>2</span></span><span>, Laura Saba</span><span><span>11</span></span><span>, Leah C. Solberg Woods</span><span><span>12</span></span><span>, Abraham A. Palmer</span><span><span>2,3</span></span><span>*, Hae Kyung Im</span><span><span>1</span></span><span>*</span></p> <p><span> </span></p> <p><span>[1] Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, 60637, USA</span></p> <p><span>[2] Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA</span></p> <p><span>[3] Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA</span></p> <p><span>[4] Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA</span></p> <p><span>[5] University at Buffalo, Clinical and Research Institute on Addictions University at Buffalo, Buffalo, NY, 14203, USA</span></p> <p><span>[6] University of Tennessee Health Science Center, Department of Pharmacology, Addiction Science and Toxicology, Memphis, TN, 38120, USA</span></p> <p><span>[7] Medical College of Wisconsin, Department of Pediatrics, Milwaukee, WI, 53226, USA</span></p> <p><span>[8] University of Michigan, Department of Psychiatry, Ann Arbor, MI, 48109, USA</span></p> <p><span>[9] University at Buffalo, Department of Psychology, Buffalo, NY, 14260, USA</span></p> <p><span>[10] University at Buffalo, Pharmacology and Toxicology University at Buffalo, Buffalo, NY, 14203, USA</span></p> <p><span>[11] University of Colorado Anschutz Medical Campus, Department of Pharmaceutical Sciences, Aurora, CO 80045, USA</span></p> <p><span>[12] Wake Forest University School of Medicine, Department of Internal Medicine, Winston-Salem, NC, 27157, USA</span></p>
Gene Expression Transcriptomics Data for benchmarking Perturbation Models - Part 2
Open the record for dataset details and reuse information.
RNA-Seq analysis to identify differentially expressed genes in top and bottom leaves under Alternaria brassicicola infection
<p>The broccoli plants were infected with Alternaria brassicicola and RNA samples were extracted for control and inoculated plants at 10 days post inoculation. </p>
Comprehensive Transcriptomic Analysis of Spodoptera Frugi-perda Reveals Stage-Specific Gene Expression and P450-Mediated Adaptation Mechanisms
<p><em><span>Spodoptera frugiperda</span></em><span> is a highly adaptable agricultural pest with a complex life cycle, posing significant challenges to pest control. This study conducted a transcriptomic analysis across nine developmental stages, identifying 6,834 differentially expressed genes (DEGs) and 3,072 stage-specific genes (SSGs) critical for their development and adaptability. Significant gene expression shifts were observed during the transition from late larval stages to adulthood. Notably, a high number of SSGs in 6th instar larvae and adult males were enriched in pathways related to oxidative phosphorylation and neural signaling, indicating high metabolic and reproductive demands. Widely shared DEGs associated with ecdysone signaling and detoxification processes underscore robust adaptation mechanisms.</span></p>
Data sets of the analysis of 1sg and 2sg subject expression with the verbs 'creer' and 'saber' in a corpus of spoken Spanish
<p>These are the two data sets used for the quantitative analysis in the paper "“Perspectival factors and <em>pro</em>-drop – A corpus study of speaker/addressee pronouns with <em>creer </em>‘think/believe’ and <em>saber </em>‘know’ in spoken Spanish” (Peter Herbeck;<em> to appear </em>in <em>Glossa – a journal of general linguistics</em>). It contains the values of the annotation of null and overt speaker/addressee pronouns in the Madrid and Alcalá samples of the corpus PRESEEA (2014-). The first data set was used for the quantitative analysis of subject expression (null/overt) with the verbs <em>creer </em>and <em>saber </em>according to person (1sg vs. 2sg) and polarity (negative vs. positive verb forms). The second data set was used for the analysis of 1sg subject expression according to the complement type of <em>creer </em>and <em>saber</em>.</p>
Data from: Convergent changes in gene expression associated with repeated transitions between hummingbird and bee pollinated flowers
<p>Transcriptomic data for 6 Gesneriaceae species (<strong><em>Nemathanthus albus </em>-NA-,<em> N. fritchii </em>-NF-<em>, Sinningia eumorpha </em>-SE-<em>, S. magnifica </em>-SM-<em>, Vanhouttea calcarata </em>-VC-<em>, Paliavana tenuiflora </em>-PV-</strong>), presented in "Convergent changes in gene expression associated with repeated transitions between hummingbird and bee pollinated flowers". For each species, transcriptomes were obtained from RNA collected from flowers at three different developmental stages.</p> <p>The following files are availables:</p> <p><strong>Trimmed_Species_Trinity.fasta:</strong> Transcriptome assembly of the species in fasta format. The transcriptomes were obtained from RNA-Seq (Illumina paired-end reads) of three different floral developmental stages. For more information, please refer to the publication.</p> <p><strong>ORF_AllSpecies_Pep.fasta</strong>: Predicted protein sequences for each transcript of each species.</p> <p><strong>ORF_AllSpecies_CDS.fasta</strong>: Predicted coding sequences (CDS) for each transcript of each species.</p> <p><strong>BLASTP_allgenes6species.FINAL.txt</strong>: Blastp annotation for each transcript of each species.</p> <p><strong>BLASTX_allgenes6species.FINAL.txt: </strong>Blastx annotation for each transcript of each species.</p> <p><strong>groups.txt </strong>: Orthologous groups (OG) between the six species obtained with OrthoMCL. For more information, please refer to the publication.</p> <p><strong>1to1_OG.txt</strong>: Obtained single-copy orthologs (1-to-1 orthologous groups) between the six species</p> <p><strong>OG_and_genes.txt : </strong>link between orthologous groups and genes ID for each species.</p> <p>For more information, please refer to the publication.</p>
RNA-seq reveals altered gene expression levels in proximal tubular cell cultures compared to renal cortex but not during early glucotoxicity
AbstractCell cultures are often used to study physiological processes in health and disease. It is well-known that cells change their gene expression in vitro compared to in vivo, but it is rarely experimentally addressed. High glucose is a known trigger of apoptosis in proximal tubular cells (PTC). Here we used RNA-seq to detect differentially expressed genes in cultures of primary rat PTC, 3 days old, compared to cells retrieved directly from rat outer renal cortex and between PTC exposed to 15 mM glucose and control for 8 h. The expression of 6,174 genes was significantly up- or downregulated in the cultures of PTC compared to the cells in the outer renal cortex. Most altered were mitochondrial and metabolism related genes. Gene expression of proapoptotic proteins were upregulated and gene expression of antiapoptotic proteins were downregulated in PTC. Expression of transporter related genes were generally downregulated. After 8 h, high glucose had not altered the gene expression in PTC. The current study provides evidence that cells alter their gene expression in vitro compared to in vivo and suggests that short-term high glucose exposure can trigger apoptosis in PTC without changing the gene expression levels of apoptotic proteins.
Data from: Transcriptional remodeling upon light removal in a model cnidarian: losses and gains in gene expression
Organismal responses to light:dark cycles can result from two general processes: (i) direct response to light or (ii) a free-running rhythm (i.e., a circadian clock). Previous research in cnidarians has shown that candidate circadian clock genes have rhythmic expression in the presence of diel lighting, but these oscillations appear to be lost quickly after removal of the light cue. Here, we measure whole-organism gene expression changes in 136 transcriptomes of the sea anemone Nematostella vectensis, entrained to a light:dark environment and immediately following light cue removal to distinguish two broadly defined responses in cnidarians: light entrainment and circadian regulation. Direct light exposure resulted in significant differences in expression for hundreds of genes, including more than 200 genes with rhythmic, 24-hour periodicity. Removal of the lighting cue resulted in the loss of significant expression for 80% of these genes after one day, including most of the hypothesized cnidarian circadian genes. Further, 70% of these candidate genes were phase shifted. Most surprisingly, thousands of genes, some of which are involved in oxidative stress, DNA damage response, and chromatin modification, had significant differences in expression in the 24 hours following light removal, suggesting that loss of the entraining cue may induce a cellular stress response. Together, our findings suggest that a majority of genes with significant differences in expression for anemones cultured under diel lighting are largely driven by the primary photoresponse rather than a circadian clock when measured at the whole animal level. These results provide context for the evolution of cnidarian circadian biology and help to disassociate two commonly confounded factors driving oscillating phenotypes.
Vertical temperature profiles obtained from Venus Express and Akatsuki radio occultation data using FSI
<p>Vertical temperature profiles of Venusian atmosphere obtained from selected radio occultation data taken in ESA's Venus Express and JAXA's Akatsuki missions. The temperatures were retrieved using a radio holographic method, Full Spectrum Inversion (FSI). The data list and format are given in two Excel files and the data are given in text files with an extension ".dat".</p>
Dataset for "Plasma biochemistry, gene expression and liver histomorphology in common carp (Cyprinus carpio) fed with different dietary fat sources. Food and Chemical Toxicology, 139, 111300"
<p>Dataset for "<em>Eljasik P, Panicz R, Sobczak M, Sadowski J, Barbosa V, Marques A, Dias J. (2020). </em><strong><em>Plasma biochemistry, gene expression and liver histomorphology in common carp (</em></strong><em>Cyprinus carpio</em><strong><em>) fed with different dietary fat sources. Food and Chemical Toxicology, 139, 111300. </em></strong><em>DOI:<a href="https://doi.org/10.1016/j.fct.2020.111300"> doi.org/10.1016/j.fct.2020.111300</a>"</em></p>
A small vocal repertoire during the breeding season expresses complex behavioral motivations and individual signature in the Common Coot
<p><b>Backgroun</b><b>d:</b> Although acoustic communication plays an essential role in the social interactions of Rallidae, our knowledge of how Rallidae encode diverse types of information using simple vocalizations is limited. We recorded and examined the vocalizations of a Common Coot (<i>Fulica atra</i>) population during the breeding season to test the hypotheses that 1) different call types can be emitted under different behavioral contexts, and 2) variation in the vocal structure of a single call type may be influenced both by behavioral motivations and individual signature. We measured a total of 61 recordings of 30 adults while noting the behavioral activities in which individuals were engaged. We compared several acoustic parameters of the same call type emitted under different behavioral activities to determine how frequency and temporal parameters changed depending on behavioral motivations and individual differences.</p> <p><b>Results: </b>We found that adult Common Coots had a small vocal repertoire, including 4 types of call, composed of a single syllable that was used during 9 types of behaviors. The 4 calls significantly differed in both frequency and temporal parameters and can be clearly distinguished by discriminant function analysis. Minimum frequency of fundamental frequency (F<sub>0min</sub>) and duration of syllable (T) contributed the most to acoustic divergence between calls. Call <i>a</i> was the most commonly used (in 8 of the 9 behaviors detected), and maximum frequency of fundamental frequency (F<sub>0max</sub>) and interval of syllables (TI) contributed the most to variation in call <i>a</i>. Duration of syllable (T) in a single call <i>a</i> can vary with different behavioral motivations after individual vocal signature being controlled.</p> <p><b>Conclusions:</b> These results demonstrate that several call types of a small repertoire, and a single call with function-related changes in the temporal parameter in Common Coots could potentially indicate various behavioral motivations and individual signature. This study advances our knowledge of how Rallidae use "simple" vocal systems to express diverse motivations and provides new models for future studies on the role of vocalization in avian communication and behavior.</p>
Resource limitation, intragroup aggression, and brain neuropeptide expression in a social wasp
<p>1. Nourishment can have profound effects on social behavior, including aggressive interactions between individuals. However, how nutritional resource availability and limitation affects intraspecific aggression remains somewhat contested. The prevailing theoretical and empirical understanding is that when nutritional resources are limited, inter-individual competition and aggression will increase. However, findings from several social animals suggest that limited nutrition can lead to increased cooperation, including by a reduction in inter-individual aggression.</p> <p>2. We suggest that in social insect colonies, where nourishment is often important in determining differences between the reproductive and non-reproductive worker behavioral castes, the link between an individual's nourishment and their future reproductive potential may be a key missing element of models that predict how nutritional resource availability affects inter-individual aggression.</p> <p>3. We investigated how nourishment influenced intra-colony aggression and its molecular correlates in colonies of the social paper wasp <i>Polistes fuscatus</i>, which workers that maintain flexible reproductive potential as adults. We subjected colonies to either a high or low feeding treatment, and examined subsequent effects on behavior, physiology, and brain gene expression.</p> <p>4. We found that nutritional restriction reduced aggressive interactions, suggesting increased social cohesion when resources are limiting. Thus, individual worker paper wasps appear to have the capacity to adjust their behavior (e.g., reduced aggression) in response to nutritional stress, investing nutritional resources in the colony when resources are limiting, and in the self when resources are abundant.</p> <p>5. Differential brain gene expression results implicate two well-known neuropeptides associated with aggression and/or nutrient signaling across taxa, <i>Tachykinin </i>and <i>Neuropeptide-F</i>, as possible mediators of nutritionally-dependent intra-colony aggression. This adds to a growing understanding that deeply conserved genes associated with core, conserved behaviors such as feeding and aggression in solitary insects can play a role in the regulation of social plasticity in more highly social species.</p>
wild_expression: gene expression data on wildlife hosts of emerging infectious diseases
<p>Publicly accessible data and code supporting the manuscript:</p> <p>"Host gene expression in wildlife disease: making sense of species-level responses"</p>
Clinical outcome prediction in COVID-19 patients by lymphocyte subsets analysis and monocytes' iTNF-α expression
<p>Raw Box & Whiskers plot related to a manuscript submitted to "Biology" journal - MDPI - https://www.mdpi.com/journal/biology - https://doi.org/10.3390/biology10080735</p> <p><strong>Manuscript Title</strong>: Clinical outcome prediction in COVID-19 patients by lymphocyte subsets analysis and monocytes’ iTNF-α expression</p> <p><strong>Authors: G</strong>abriele Madonna <sup>1†</sup>, Silvia Sale <sup>2†</sup>, Mariaelena Capone <sup>1</sup>, Chiara De Falco <sup>2</sup>, Valentina Santocchio <sup>2</sup>, Tiziana Di Matola <sup>2</sup>, Giuseppe Fiorentino <sup>3</sup>, Caterina Pirozzi <sup>2</sup>, Anna D’Antonio <sup>2</sup>, Rocco Sabatino <sup>2</sup>, Lidia Atripaldi<sup>4</sup>, Umberto Atripaldi <sup>4</sup>, Marcello Raffone <sup>5</sup>, Marcello Curvietto<sup> 1</sup>, Antonio Maria Grimaldi <sup>1</sup>, Vito Vanella <sup>1</sup>, Lucia Festino <sup>1</sup>, Luigi Scarpato <sup>1</sup>, Marco Palla <sup>1</sup>, Michela Spatarella <sup>6</sup>, Francesco Perna <sup>7</sup>, Pellegrino Cerino <sup>8</sup>, Gerardo Botti <sup>9</sup>, Roberto Parrella <sup>10</sup>, Vincenzo Montesarchio <sup>11</sup>, Paolo Antonio Ascierto <sup>1††* </sup>and Luigi Atripaldi <sup>2††</sup></p> <p><strong>Affiliations:</strong></p> <p>1 Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy</p> <p>2 UOC Biochimica Clinica, AORN Ospedali dei Colli - Monaldi – Cotugno - CTO, Napoli, Italy</p> <p>3 UOC Fisiopatologia e Riabilitazione respiratoria, AORN Ospedali dei Colli - Monaldi – Cotugno - CTO, Napoli, Italy</p> <p>4 University of Campania "Luigi Vanvitelli", Naples, Italy</p> <p>5 UOC Microbiologia e Virologia, AORN Ospedali dei Colli - Monaldi – Cotugno - CTO, Napoli, Italy</p> <p>6 UOSD di Farmacia, AORN Ospedali dei Colli - Monaldi – Cotugno - CTO, Napoli, Italy</p> <p>7 Università degli Studi di Napoli "Federico II", Naples, Italy.</p> <p>8 Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici (Na), Italy.</p> <p>9 Scientific Direction, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy</p> <p>10 UOC Malattie Infettive ad Indirizzo Respiratorio, AORN Ospedali dei Colli - Monaldi – Cotugno -CTO, Napoli, Italy</p> <p>11 UOC Oncologia, AORN Ospedali dei Colli - Monaldi – Cotugno - CTO, Napoli, Italy</p> <p>†These authors have contributed equally to this work and share first authorship</p> <p>††These authors have contributed equally to this work and share senior authorship</p> <p>*Correspondence:</p> <p><strong>Abstract of submitted Manuscript:</strong> T</p> <p>In December 2019 a novel coronavirus, “SARS-CoV-2”, was recognized as the cause of Coronavirus disease-2019 (COVID-19-disease). Several studies have explored the changes and the role of inflammatory cells and cytokines in the immunopathogenesis of disease, but until today the results have been controversial. Based on these premises, we carried out a retrospective assessment of monocytes’ intracellular TNF-α expression (iTNF-α) and on frequencies of lymphocyte sub-populations in twenty-five patients with moderate/severe COVID-19-disease. We found lymphopenia in all COVID-19 infected subjects compared with healthy subjects. On initial observation, in patients with favorable outcome we detected high absolute eosinophils count and high CD4+/CD8+ T lymphocytes ratio, while in the exitus group we observed high neutrophils and CD8+ T lymphocytes counts. During infection, in patients with favorable outcome we observed a rise in lymphocyte count, in monocytes and in Treg lymphocytes counts, in CD4+ and in CD8+ T lymphocytes count but a reduction in CD4+/CD8+ T lymphocytes ratio. Instead, in the exitus group we observed a reduction in Treg lymphocytes counts and a decrease in iTNF-α expression. Our preliminary findings point to a modulation of the different cellular mediators of immune system, which probably have a key role in the outcome of the COVID-19-disease.</p> <p><strong>Funding:</strong> This work was supported by Grants from “Regione Campania” through “POR FESR CAMPANIA 2014-2020”, CUP H64I20000300002.</p> <p><strong>Cite</strong>: Madonna, G.; Sale, S.; Capone, M.; De Falco, C.; Santocchio, V.; Di Matola, T.; Fiorentino, G.; Pirozzi, C.; D’Antonio, A.; Sabatino, R.; Atripaldi, L.; Atripaldi, U.; Raffone, M.; Curvietto, M.; Grimaldi, A.M.; Vanella, V.; Festino, L.; Scarpato, L.; Palla, M.; Spatarella, M.; Perna, F.; Cerino, P.; Botti, G.; Parrella, R.; Montesarchio, V.; Ascierto, P.A.; Atripaldi, L. Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes’ iTNF-α Expression. <em>Biology</em> <strong>2021</strong>, <em>10</em>, 735. doi: <a href="https://doi.org/10.3390/biology10080735">10.3390/biology10080735</a></p> <p> </p>
Data manuscript: Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension
<p>Supporting Information files of manuscript: Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension </p> <p> </p> <p>The values behind the means, standard deviations and values used to build graphs; </p>
Repression precedes independent evolutionary gains of a highly specific gene expression pattern
<p>Dataset for Repression precedes independent evolutionary gains of a highly specific gene expression pattern</p>
Expression levels and activities of energy-yielding ATPases in the oligohaline neritid snail Theodoxus fluviatilis under changing environmental salinities
<p>The aquatic gastropod Theodoxus fluviatilis occurs in Europe and adjacent areas of Asia. The snail species has formed two genetically closely related subgroups, the freshwater ecotype (FW) and the brackish water ecotype (BW). Other than individuals of the FW ecotype, those of the BW ecotype survive in salinities of up to 28‰. Coastal aquatic ecosystems may be affected by climate change due to salinization. Thus, we investigated how the two Theodoxus ecotypes adjust to changes in environmental salinity focussing on the question whether Na+ /K+ -ATPase or V-ATPase are regulated on the transcriptional, the translational or at the activity level under changing external salinities. Animals were gradually adjusted to extreme salinities in containers under long-day conditions and constant temperature. Whole body RNA- or protein extracts were prepared. Semi-quantitative PCR and Western Blot-analyses did not reveal major changes in transcript or protein abundances for the two transporters under low or high salinity conditions. No significant changes in ATPase activities in whole body extracts of animals adjusted to high or low salinity conditions were detected. We conclude that constitutive expression of ATPases is sufficient to support osmotic and ion regulation in this species under changing salinities given the high level of tolerance with respect to changes in body fluid volume.</p>
Data from: Hybridization alters growth and migratory life history expression of native trout
<p><span><span><span><span><span><span><span><span><span><span><span>Human-mediated hybridization threatens many native species, but the effects of introgressive hybridization on life history expression are rarely quantified, especially in vertebrates. We quantified the effects of non-native rainbow trout admixture on important life history traits including growth and partial migration behavior in three populations of westslope cutthroat trout over five years. Rainbow trout admixture was associated with increased summer growth rates in all populations, and decreased spring growth rates in two populations with cooler spring temperatures. These results indicate that non-native admixture may increase growth under warmer conditions, but cutthroat trout have higher growth rates during cooler periods. Non-native admixture consistently increased expression of migratory behavior, suggesting that there is a genomic basis for life history differences between these species. Our results show that effects of interspecific hybridization on fitness traits can be the product of genotype-by-environment interactions even when there are minor differences in environmental optima between hybridizing species. These results also indicate that while environmentally mediated traits like growth may play a role in population-level consequences of admixture, strong genetic influences on migratory life history differences between these species likely explains the continued spread of non-native hybridization at the landscape-level, despite selection against hybrids at the population-level.</span></span></span></span></span></span></span></span></span></span></span></p>
Expression and Purification of DNA-binding domain of T-box Transcription Factor TBXTA-c021
<p>A detailed protocol for the expression and purification of G177D variant of TBXT DNA-binding domain.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.