Find research datasets worth reusing

opencc-by-4.0Sep 2022View details →

Satisfaction with Telemedicine for Cancer Pain Management: A Model of Care and Cross-Sectional Patient Satisfaction Study

Background: Since cancer pain requires complex modalities of care, the proper strategy for addressing its telemedicine-based management should be better defined. This study aimed to trace a pathway for a progressive implementation of the telemedicine process for the treatment of pain in the setting of cancer patients. Methods: The features of the model were investigated to dissect the dropout from the telemedicine pathway. A cross-sectional patient satisfaction study was conducted. The degree of satisfaction was evaluated through a developed 22-item questionnaire (Likert scale 0–7). Results: A total of 375 video consultations for 164 patients (mean age 62.9 years) were performed through remote consultations for cancer pain management between March 2021 and February 2022. After the exclusion of 72 patients, 92 (56.1%) were included in the analysis. The dropout ratio was 8.7%. The number of visits and pharmacological therapies for neuropathic pain correlated with the risk for readmission (p < 0.05). Overall, the satisfaction was very high (mean > 5.5 for all items). Conclusion: Feedback from patients reflected high satisfaction rates with the care provided. A methodological approach based on the degree of satisfaction combined with the analysis of the pathways can help to implement the quality of a service provided through telemedicine. While not without limitations, our hybrid protocol can be useful for addressing cancer pain through a patient-centered approach.

opencc-by-4.0Sep 2022View details →

Impact of a pulmonary rehabilitation program on social disadvantage and physical activity data of postCOVID19 patients: A North-African pilot study

WHAT IS ALREADY KNOWN <ul> <li>In post-acute COVID19, many patients still manifest symptoms for weeks and months.</li> <li>Psychological manifestations are prevalent and persisting in recovered COVID19 patients.</li> <li>Indeed, COVID19 was reported to possibly lead to symptoms of depression and anxiety, and to alter health-related quality of life (HRQoL).</li> <li>Physical activity has been proven to be effective in improving both mental and physical health.</li> <li>Thus, COVID19 patients could benefit from pulmonary rehabilitation program (PRP).</li> <li>Many studies related the effects of a standard PRP on physical activity and HRQoL in post COVID19 patients. However, to the best of the authors’ knowledge, no study evaluated the physical activity and social disadvantage of patients who were hospitalized for COVID19 in a low income country.</li> <li>This paper is the second part of a cross sectional study that aimed to evaluate the impact of a PRP on social disadvantage (physical activity, hospital anxiety and depression (HAD), HRQoL) data of Tunisian patients with postCOVID19.</li> </ul> WHAT THIS PAPER ADDS <ul> <li>The present North African study demonstrated that a PRP improved HRQoL, HAD, and physical activity data of Tunisian COVID19 patients.</li> <li>For instance, the means of the functional, psychological and relation dimensions, and the VQ11 total score (ie; main outcome) decreased significantly by 1.79, 2.00, 1.57, and 5.36 points. In addition, the means of the HAD anxiety and depression scores decreased significantly by 2.07, and 2.57 points, respectively, and the means of the physical activity and total scores improved significantly by 1.75 and 1.78 points, respectively.</li> <li>To the best of the authors’ knowledge, this is the first African and Arab study investigating the impact of a PRP on postcovid19 patients in terms of social disadvantages and physical activity.</li> <li> </li> </ul> <ul> <li>This study confirms that an outpatient PRP program improves physical activity, psychological status and HRQoL in the management of postCOVID19 patients.</li> </ul>

Frequency, types, and factors associated with Complementary and Alternative Medicine use among patients on Maintenance Haemodialysis

Objective: This study aims to determine the prevalence, types, indications, and factors associated with CAM use by patients on maintenance haemodialysis (MHD) in Cameroon.

An ssGSEA Based Immune-related Gene Prognostic Signature Combining Immune Infiltration and Immune Checkpoint for Breast Cancer Patients

This is the gene expression and related clinical data of breast cancer patients obtained from TCGA. Original codes and data from GEO database could be found in GitHub via link "https://github.com/Grevilblois/R-codes-for-manuscript".

Bacteria-Derived Extracellular Vesicle Microbiome in NAFLD Patients With and Without Obstructive Sleep Apnea

These are the supplementary figures.

Pancreas patients dicom

This dataset contains the dicom data for 6 pancreas patients. Images and annotations are included. For details, please refer to https://github.com/xuqifan897/EndtoEnd

opencc-zeroOct 2022View details →

dryad36/100

Patient-reported outcomes via electronic health record portal vs. telephone: process and retention data in a pilot trial of anxiety or depression symptoms in epilepsy

Objective: To close gaps between research and clinical practice, tools are needed for efficient pragmatic trial recruitment and patient-reported outcome(PROM) collection. The objective was to assess feasibility and process measures for patient-reported outcome collection in a randomized trial comparing electronic health record(EHR) patient portal questionnaires to telephone interview among adults with epilepsy and anxiety or depression symptoms. Results: Participants were 60% women, 77% White/non-Hispanic, with mean age 42.5 years. Among 15 individuals randomized to EHR portal, 10(67%, CI 41.7-84.8%) met the 6-month retention endpoint, versus 100%(CI 79.6-100%) in the telephone group(p=0.04). EHR outcome collection at 6 months required 11.8 minutes less research staff time per participant than telephone (5.9, CI 3.3-7.7 vs. 17.7, CI 14.1-20.2). Subsequent telephone contact after unsuccessful EHR attempts enabled near complete data collection and still saved staff time. Discussion: Data from this randomized pilot study of pragmatic outcome collection methods for patients with anxiety or depression symptoms in epilepsy includes baseline participant characteristics, recruitment flow resulting from a novel EHR-based, care-embedded recruitment process, and data on retention along with various process measures at 6-months.

dryad36/100

Patient preferences for HIV service delivery models: A discrete choice experiment in Kisumu, Kenya

Background: Novel "differentiated service delivery" models for HIV treatment that reduce clinic visit frequency, minimize waiting time, and deliver treatment in the community promise retention improvement for HIV treatment in Sub-Saharan Africa. Quantitative assessments of differentiated service delivery (DSD) feature most preferred by patient populations do not widely exist but could inform the selection and prioritization of different types of DSD models. Methods: We used a discrete choice experiment (DCE) to elicit patient preferences for HIV treatment services and how they differ across DSD models. We surveyed adults aged >18 years, enrolled in HIV care for >6 months between February and March 2019 at four facilities in Kisumu County, Kenya. DCE offered patients a series of comparisons between three treatment models, each of which varied in seven attributes: ART refill location, the quantity of ART dispensed at each refill, medication pick-up hours, type of adherence support, clinical visit frequency, staff attitude, and professional cadre of the person providing ART refills. We used a hierarchical Bayesian model to estimate attribute importance and the relative desirability of care characteristics, latent class analysis (LCA) for groups of preferences, and mixed logit model for willingness to trade analysis. Results: Of 242 patients, 128 (53.8%) were females and 150 (62.8%) lived in rural areas. Patients placed the greatest importance on ART refill location [19.5% (95%CI 18.4, 20.6)] and adherence support [19.5% (95%CI 18.7, 20.3)], followed by staff attitude [16.1% (95%CI 15.1, 17.2)]. In the mixed logit, patients preferred the nice attitude of the staff (coefficient=1.60), refill ART health center (Coeff=1.58), and individual adherence support (Coeff=1.54), 3 or 6 months for ART refill (Coeff=0.95 & 0.80, respectively) and pharmacists (instead of lay health workers) providing ART refill (Coeff=0.64). No differences were observed by gender or urbanicity. LCA revealed two distinct groups (59.5% vs.40.5%). Conclusions: Participants preferred 3 to 6-month refill intervals or clinic visit spacing, which DSD provides for stable patients. While DSD has also encouraged community ART group options, our results suggest strong patient preferences for ART refills from health centers or by pharmacists over lay caregivers or community members. These preferences held across gender and urban/rural subpopulations.

opencc-zeroOct 2022View details →

opencc-by-4.0Mar 2017View details →

Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases - Individual patient data

This dataset contains individual subject data for hemodynamic measurements assessed in the present study.

opencc-by-sa-4.0Oct 2017View details →

CHQ Score patient 1

Cluster Headache Quality of life scale (CHQ) for a patient affected by Cluster Headache before and after the theraphy with high dose thiamine.

opencc-by-4.0Dec 2017View details →

ROS-specific Huntingtin Interactions: GFP reactivation assay in HD patient fibroblasts

Optimization step in the lead up to phenotypic analysis of ROS-dependent huntingtin interacting proteins.

opencc-by-4.0Jan 2018View details →

Generation of fluorescently labelled OP9 stromal cells for growing patient leukemic cells

We added fluorescent labels to OP9 stromal cells to allow us to easily distinguish stromal cells from primary leukemia cells in co-culture growth conditions.

opencc-by-4.0Oct 2023View details →

Mutational Profiling in Epithelial Ovarian Cancer: A Meta-Analysis of 435 Patients Dataset

Data Description 0 represents no mutation, 1 represents a mutation Survive relates to the survival outcome of the patient. SurviveTime is in days (7300 chosen for alive patients). Ovarian Cancer Patients <ul> <li>361 count</li> <li>TP53, BRCA1, BRCA2, KMT2C, CDK12, CSMD3, TTN, MUC16, NF1, PALB2, RB1, PTEN, FOXM1, BRIP1, KRAS, RASA1, CHEK2, RAD50, RAD51C/D, MRE11A, NBN, FANCE, FANCD2, ATR, ATM, MSH2, PMS2, MLH1, MSH6, FAT1, FAT2, FAT3, FAT4</li> </ul> Uterine Cancer Patients <ul> <li>437 count</li> <li>MSH6, CDK12, PMS2, BRIP1, FAT1, CSMD3, FAT4, BRCA2, MUC16, PALB2, KRAS, BRCA1, MSH2, PTEN, TP53, NF1, KMT2C, FAT3, FANCD2, ATM, NBN, ATR, CHEK2, FANCE, MLH1</li> </ul> Cervical Cancer Patients <ul> <li>174 count</li> <li>CSMD3, CDK12, FAT1, BRIP1, RB1, FAT4, BRCA2, MUC16, PALB2, KRAS, TP53, PTEN, KMT2C, FAT3, BRCA1, NF1, ATM, FANCD2, NBN, ATR, MLH1</li> </ul>

opencc-by-4.0Oct 2023View details →

Dataset on computational and experimental external dose rates from nuclear medicine patients.

A journal paper published in EJNMMI Physics details the method to create the data, which support also the results described in the paper. The paper describes the development and validation of an advanced computational framework for the assessment of external dose rates from nuclear medicine patients.

opencc-by-4.0May 2024View details →

Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance

Resistance to targeted therapy remains a major clinical challenge in melanoma patients. To uncover resistance mechanisms, we performed single cell RNA sequencing of fine needle aspirates from resistant and responding tumors from melanoma patients before and during BRAFi/MEKi treatment. Among the genes most differentially expressed between malignant cells from resistant vs. responding tumors was POSTN encoding the secreted factor periostin. POSTN was predicted to predominantly signal to a macrophage population associated with targeted therapy resistance (TTR). Accordingly, tumors from patients with fast disease progression after targeted therapy exhibited high POSTN expression levels as well as high numbers of TTR macrophages, and POSTN was able to polarize macrophages towards a TTR phenotype. In a mouse model in vivo, POSTN expression protected melanoma from targeted therapy, which was associated with a phenotype change of intratumroal macrophages. Finally, polarized TTR macrophages protected melanoma cells from MEKi-induced killing through CD44 receptor expression on melanoma cells. Thus, interfering with the protective activity of TTR macrophages might represent a strategy to overcome resistance to targeted therapy in melanoma.

opencc-by-4.0May 2024View details →

Supplementary data to "High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach"

Compressed ".feather" files including the entire dataset of 319 Raman maps of the same number of cells from 19 patients affected by nine distinct leukemia subtypes. Raw data have been pre-processed as follows using custom software (LabVIEW, National Instruments Corp., TX):  a) cosmic rays removal by singular value decomposition (SVD); b) camera offset subtraction; c) CCD response correction (intensity and etaloning) using a tungsten halogen light with known emission (Avalight-HAL, Avantes BV, NL)); d) wavenumber calibration using the zero-wavenumber laser line, toluene and argon-mercury emission (CAL-2000, Ocean Optics, Germany); e) denoising by SVD. More details in the open access published article and supplementary material (10.1021/acs.analchem.4c00787).

KIR2DL2/DL3+NKs and Helios+Tregs in peripheral blood predict nivolumab response in patients with metastatic renal cell cancer

Purpose: To identify predictive factors of nivolumab sensitivity, peripheral blood NKs and Tregs were evaluated in patients with metastatic renal cancer (mRCC) enrolled in the REVOLUTION trial. Experimental design: 57 mRCCs being treated with nivolumab, as at least second-line of therapy (REV), and 62 healthy donors (HDs) were longitudinally evaluated (0-1-3-6-12 months) for peripheral NKs and Tregs, phenotype and function. Multivariable logistic regression were conducted to identify the independent predictors. The .632+ internal cross-validation was used to avoid overfitting. The best cut-off value based on three-months clinical-response was applied to progression-free survival (PFS) and overall survival (OS). Kaplan-Meier curves for PFS and OS were produced. Results: At pre-treatment, mRCCs displayed high frequency of NKp46+NKs, NKp30+NKs, KIR2DL1+NKs, KIR2DL2/DL3+NKs, and PD-1+NKs with reduced NK degranulation; as well as high frequency of Tregs, PD-1+Tregs, Helios+Tregs and ENTPD-1+Tregs. Responder patients (R), identified as a clinical response after three-months of treatment, presented at pre-treatment significantly low CD3+, high KIR2DL2/DL3+NKs, high PD-1+Tregs and high Helios+Tregs. Upon multivariate analysis, only KIR2DL2/DL3NKs and Helios+Tregs held as independent predictors of nivolumab responsiveness. The KIR2DL2/DL3+NKs >35.3% identified patients with longer OS while the Helios+Tregs >34.3% displayed significantly longer PFS. After 1-month of nivolumab, R patients showed low CD3+, high NKs, KIR2DL2/DL3+NKs and ICOS+Tregs. Among these subpopulations, CD3+ and KIR2DL2/DL3+NKs held as independent predictors of nivolumab efficacy. Low CD3+ (≤71%) significantly associated with longer PFS while high KIR2DL2/DL3+NKs (>23.3%) associated with both PFS and OS. Conclusions: Pre-treatment evaluation of Helios+Tregs/KIR2DL2/DL3+NKs and one-month post-treatment CD3+/ KIR2DL2/DL3+NKs will predict nivolumab response in mRCCs.

EFFECTIVENESS OF PELVIC FLOOR EXERCISE TO PREVENT LARS (LOW ANTERIOR RESECTION SYNDROME) AFTER MINI-INVASIVE LOW ANTERIOR RESECTION IN PATIENTS WITH RECTAL CANCER. Adherence to prescribed home exercise. Quality of life after low anterior resection.

Advances in the surgical treatment of rectal diseases lead to better oncological results, a higher chance of preserving the sphincters, and thus a lower number of permanent stomas. However, the preserved anus does not always have to perform its original function fully. All patients after a low anterior resection are at risk of developing functional disorders - low anterior resection syndrome (LARS). The prevalence of LARS ranges from 41-80% and is a significant factor in reducing the quality of life. According to the available data, it is possible to prevent LARS through postoperative pelvic floor exercises, however, relevant studies are missing. The pelvic floor is a ligament-muscle system that provides dynamic support for the organ systems located in the small pelvis. Strengthening the muscles can serve as a follow-up treatment after surgical procedures including prevention of LARS. The main goal of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LARS in patients after mini-invasive rectal resection. Secondary goal is to identify the adherence of patients to prescribed home exercise and quality of life.  Researchers will compare the group of patients with pelvic floor exercises to those without. Under the professional guidance of a physiotherapist, participants will be educated the day before surgery and in the first 4 postoperative days to exercise the pelvic floor exercise and continue at home for a month. The resulting knowledge will have a fundamental impact on clinical practice and patient management.

COMMUNI.CARE (Communication and Patient Engagement at Diagnosis of Pancreatic Cancer): Study Protocol

<div> <div> <div> <div> Consecutive PDAC patients were enrolled at the time of diagnosis after obtaining informed consent in a single-center study for a total of 32 doctor-patient interactions. Data were audio-recorded, fully anonymized, and then transcribed. All data are in Italian. </div> </div> </div> </div>

Peripheral blood TCRseq data in AIRR-C format for cancer patients who received either photon or proton based radiation therapy

These are the AIRR-C format converted data from the original Adaptive ImmunoSEQ v2 data format. See the analysis repo for more information: <a href="https://github.com/JamieHeather/radiation-induced-lymphopenia-paper-analysis" target="_blank" rel="noopener">https://github.com/JamieHeather/radiation-induced-lymphopenia-paper-analysis</a>.