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12,455 results for “Promoters”
Promoting photoswitching in mismatching mixed-linker multivariate Zr6 MOFs
<p>This is the data that accompanies the article ''Promoting photoswitching in mismatching mixed-linker multivariate Zr6 MOFs''. <a title="Link to landing page via DOI" href="https://doi.org/10.1039/D4RA07366E">https://doi.org/10.1039/D4RA07366E</a></p> <p>Information of data collection and treatment can be found in the supporting information of the article. </p>
Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters - segmented EM density used in integrative modeling
<p>segmented cryoEM map and derived gaussian mixture model used in the integrative modeling of the human SNAPc complex </p>
Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Dataset
<p>Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Dataset</p> <p>R19111110_BKDL192544031-Sham 1</p> <p>R19111110_BKDL192544032-Sham 2</p> <p>R19111110_BKDL192544033-Sham 3</p> <p>R19111110_BKDL192544034-Sham 4</p> <p>R19111110_BKDL192544035-Model 2</p> <p>R19111110_BKDL192544036-Model 3</p> <p>R19111110_BKDL192544037-Model 4</p> <p>R19111110_BKDL192544038-Model 5</p> <p>R19111110_BKDL192544039-Model 1</p> <p>R19111119_BKDL192544040-Model+Drug 1</p> <p>R19111119_BKDL192544041-Model+Drug 2</p> <p>R19111119_BKDL192544042-Model+Drug 3</p> <p>R19111119_BKDL192544043-Model+Drug 4</p> <p>R19111119_BKDL192544044-Model+Drug 5</p> <p> </p>
Supplementary information for Paleoceanographic changes in the late Pliocene promoted rapid diversification in pelagic seabirds
<p><b>Aim: </b>Paleoceanographic changes can act as drivers of diversification and speciation, even in highly mobile marine organisms. Shearwaters are a group of globally distributed and highly mobile pelagic seabirds. Despite a recent well resolved phylogeny, shearwaters have controversial species limits, and show periods of both slow and rapid diversification. Here, we explore the role of paleoceanographic changes on the diversification and speciation in these highly mobile pelagic seabirds. We investigate shearwater biogeography and the evolution of a key phenotypic trait, body size, and we assess the validity of the current taxonomy of the group.</p> <p><b>Location:</b> Worldwide.</p> <p><b>Taxa:</b> Shearwaters (Order Procellariiformes, Family Procellariidae, Genera <i>Ardenna</i>, <i>Calonectris</i> and <i>Puffinus</i>).</p> <p><b>Methods: </b>We generated genomic data (double-digest restriction site-associated DNA) for almost all extant shearwater species to infer a time-calibrated species tree. We estimated ancestral ranges and evaluated the roles of founder events, vicariance and surface ocean currents in driving shearwater diversification. We performed phylogenetic generalized least squares to identify potential predictors of variability in body size along the phylogeny. To assess the validity of the current taxonomy of the group, we analysed genomic patterns of recent shared ancestry and differentiation among shearwater taxa.</p> <p><b>Results:</b> We identified a period of high dispersal and rapid speciation during the Late Pliocene - early Pleistocene. Species dispersal appears to be favoured by surface ocean currents, and biogeographic reconstructions support founder events as the main mode of speciation in these highly mobile pelagic seabirds. Body mass shows significant associations with life strategies and local conditions. The current taxonomy shows some incongruences with the patterns of genomic divergence.</p> <p><b>Main Conclusions: </b>A reduction of neritic areas during the Pliocene seems to have driven global extinctions of shearwater species, followed by a subsequent burst of speciation and dispersal probably promoted by Plio-Pleistocene climatic shifts. Our findings extend our understanding on the drivers of speciation and dispersal of highly mobile pelagic seabirds and shed new light on the important role of paleoceanographic events.</p>
Finite Mixture Models for Clustering Sales Series Data in the Presence of Promotions
<pre> 131 sales data where promotion causes volatility over the entire time series</pre>
Downregulation of ST6GAL1 promotes liver inflammation and predicts adverse prognosis in hepatocellular carcinoma
<p>Original file of <em>Downregulation of ST6GAL1 promotes liver inflammation and predicts adverse prognosis in hepatocellular carcinoma.</em></p>
Identification of a 41-bp Embryonic Cell-Specific Region within the Pineapple SERK1 Promoter
<p>Plant regeneration via somatic embryogenesis (SE) is a key step during genetic engineering. <em>AcSERK1</em> is a gene specifically expressed in the early stage of SE in pineapple (<em>Ananas comosus</em>), suggesting that the promoter of <em>SERK1</em> might contain specific cis-acting element to regulate SE.</p>
Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure
<p>Spheroids of different composition (100% sensitive, 50% sensitive – 50% resistant, 100% resistant) were initiated from Venus-labeled CAMA-1 and mCherry-labeled CAMA-1_ribociclib_resistant cells and were subjected to 1 uM ribociclib treatment. After 11 days, speroids were harvested, washed and cell suspensions were viably frozen for single cell RNA-seq analysis. </p>
Data from: Floral resource diversification promotes solitary bee reproduction and may offset insecticide effects – evidence from a semi-field experiment
<p class="HeadingFK">Pollinator declines in agricultural landscapes are driven by multiple stressors, but potential interactions of these remain poorly studied. Using a highly replicated semi-field study with 56 mesocosms of varying wild plant diversity (2-16 species) and oilseed rape treated with a neonicotinoid, we tested the interacting effects of resource diversity and insecticides on reproduction of a solitary wild bee. Compared to mesocosms with oilseed rape monocultures, availability of resources from wild plants complementing oilseed rape doubled brood cell production. In addition, bee reproduction increased due to plant diversity and identity effects. Exposure to neonicotinoid-treated oilseed rape reduced bee larval to adult development by 69%, but only in mesocosms with oilseed rape monocultures. Availability of complementary flower resources can thus offset negative effects of neonicotinoid-treated oilseed rape on wild bee reproduction. Policy should encourage the implementation of diverse floral resources mitigating negative effects of crop monocultures and insecticides, thereby sustaining solitary bee populations in agricultural landscapes.</p>
The ecological stage maintains preference differentiation and promotes speciation
<p>Influential models of speciation by sexual selection posit either a single shared preference for a universal display, expressed only when males are locally adapted and hence in high condition, or that shared loci evolve population-specific alleles for displays and preferences. However, many closely related species instead show substantial differences across categorically different traits. We present a model of secondary contact whereby females maintain preferences for distinct displays that indicate both male condition and their match to distinct environments, fostering reproductive isolation among diverging species. This occurs even with search costs and with independent preference loci targeting independent displays. Such preferences can also evolve from standing variation. Divergence occurs because condition-dependent display and female preference depend on local ecology, and females obtain different benefits of choice. Given the ubiquity of ecological differences among environments, our model could help explain the evolution of striking radiations of displays seen in nature.</p>
Foreshock Activity Promoted by Locally Elevated Loading Rate on a 4-meter-long Laboratory Fault
<p>Experimental data and event catalog used for the study "Foreshock Activity Promoted by Locally Elevated Loading Rate on a 4-meter-long Laboratory Fault"</p>
Social Media data and sales for promotional product
<p>Social Media data and sales for promotional product from 2017-2019</p>
Multiple diversity facets of crucial microbial groups in biological soil crusts promote soil multifunctionality
<p>Aim: Microbial diversity is one of the most important factors for maintaining the performance of multiple functions in soils (multifunctionality). However, existing studies typically consider taxonomic richness or Shannon diversity of the entire community. We know little about the connection network of taxonomic and phylogenetic diversity facets and their collective impact on multifunctionality. In this study, the linkages of diversity effects within functional groups were disentangled in drylands.</p> <p>Location: The central Tibetan Plateau.</p> <p>Time period: Present.</p> <p>Major taxa studied: Phototrophs and diazotrophs (mainly cyanobacteria).</p> <p>Methods: Given the carbon- and nitrogen-limited nature of drylands, we conducted a high throughput sequencing of C/N-fixing functional groups from biocrusts and evaluated multiple diversity facets (i.e., richness, evenness, and phylogeny-related trait dissimilarity), together with seven crucial variables of soil functioning to calculate multifunctionality. The relations between multifaceted diversity and abundance with individual functions and multifunctionality were validated by a set of solid statistical analyses.</p> <p>Results: We found that the integrated biodiversity index was a stronger predictor of multifunctionality than richness. The divergent performance of different diversity facets determined the idiosyncratic effect of each functional group on soil multifunctionality. Moreover, the evaluation of functional significance at the species level gave important clues on the trade-offs and redundancy in each functional group, explaining the distinct patterns of diversity effects. Namely, richness was the dominant factor for diazotrophs to maximize multifunctionality, whereas phylogenetic dissimilarity was the essential one for phototrophs.</p> <p>Main conclusions: our study demonstrated that multiple diversity facets should be considered when grasping the biodiversity effects. In contrast with the community level, within-functional group measures may adequately capture the features of diversity that are most correlated with soil multifunctionality. Our results provided a perspective to bridge the gap between taxonomic and trait-based approaches for elucidating the biodiversity-ecosystem function relationship.</p>
Data from: The rising moon promotes mate finding in moths
<p><span>To counteract insect decline, it is essential to understand the underlying causes, especially for key pollinators such as nocturnal moths whose ability to orientate can easily be influenced by ambient light conditions. These comprise natural light sources as well as artificial light, but their specific relevance for moth orientation is still unknown. We investigated the influence of moonlight on the reproductive behavior of privet hawkmoths (<em>Sphinx ligustri</em>) at a relatively dark site where the Milky Way was visible while the horizon was illuminated by distant light sources and skyglow. We show that male moths use the moon for orientation and reach females significantly faster with increasing moon elevation. Furthermore, the choice of flight direction depended on the cardinal position of the moon but not on the illumination of the horizon caused by artificial light, indicating that the moon plays a key role in the orientation of male moths.</span></p>
Dietary flexibility promotes range expansion: the case of golden jackals in Eurasia
<p class="MsoNormal"><strong><span>Aim: </span></strong><span>Exploring the drivers of the successful ongoing expansion of the golden jackal across Europe is essential to understand the species' trophic ecology. We analysed which climatic and environmental factors affected the dietary composition of golden jackals and compared these drivers in the species' historic and recently colonised distribution ranges</span><span>.</span></p> <p class="MsoNormal"><strong><span>Location:</span></strong><span> Eurasia.</span></p> <p class="MsoNormal"><strong><span>Taxon</span></strong><span>: golden jackal (<em>Canis aureus</em>).</span></p> <p class="MsoNormal"><strong><span>Methods:</span></strong><span> Using 40 published data sets, we modelled the diet composition using 13 food categories based on the relative frequency of occurrence of food items and trophic niche breadth (B<sub>A</sub>) against climatic and environmental factors from throughout the jackals' recently colonised (22 studies) and historic range (18 studies).</span></p> <p class="MsoNormal"><strong><span>Results:</span></strong><span> The proportion of small mammals in golden jackal diet decreased with annual mean temperature, whereas the consumption of wild ungulates increased with environmental productivity. Increasing temperature and environmental productivity positively influenced niche breadth, while increasing precipitation negatively affected it. The recently colonised distribution range of golden jackals in Europe had a lower mean temperature but higher environmental productivity compared to the species' historic range in Eurasia. In the recently-colonised range, jackals consumed small mammals and/or wild ungulates (mostly from scavenging) more frequently, and fewer plants and/or domestic animals (again, mostly from scavenging). </span></p> <p><strong><span>Main Conclusions:</span></strong><span><strong> </strong>The golden jackal is an opportunistic, omnivorous carnivore with high dietary flexibility</span> <span>and biogeographical variation. Climatic and environmental factors shape the species' diet composition, which, in a changing environment, greatly enhances the opportunities for golden jackals to colonise new areas successfully. Golden jackals will likely continue to expand their range in the foreseeable future. The species' trophic niche is expected to broaden with predictions of overall increasing temperatures and reduced precipitation.</span></p>
FURIN promoter methylation predicts the risk of incident diabetes: A prospective analysis in the Gusu cohort
<p><strong>Background:</strong> Furin has been associated with diabetes but the underlying mechanisms are unclear. As a mediator linking fixed genome and dynamic environment, DNA methylation of its coding gene FURIN may be involved. Here, we aimed to examine the prospective association between DNA methylation in FURIN promoter and incident diabetes during 4 years of follow-up in Chinese adults.</p> <p><strong>Methods:</strong> DNA methylation levels in FURIN promoter were quantified by target bisulfite sequencing using peripheral blood from 1836 participants in the Gusu cohort who were free of diabetes at baseline. To examine the association between DNA methylation levels in FURIN promoter and incident diabetes, we constructed a logistic regression model adjusting for the conventional factors. Multiple testing was controlled by adjusting for the total number of CpG sites assayed using the false-discovery rate approach.</p> <p><strong>Results:</strong> Among the 1836 participants free of diabetes at baseline, 109 (5.94%) participants developed diabetes during the average of 4 years of follow-up. Hypermethylation at two of the eight CpG sites assayed in the FURIN promoter was associated with an increased risk of diabetes, after multivariable adjustment and multiple testing correction. Every 5% increment in methylation levels at CpG1 and CpG2 were associated with a 22% (OR=1.22, 95%CI: 1.05-1.43, P=0.009, q=0.038) and 39% (OR=1.39, 95%CI: 1.08-1.77, P=0.009, q=0.038) higher risk of incident diabetes, respectively. The gene-based association analysis revealed that DNA methylation at multiple CpG loci was jointly associated with incident diabetes (P<0.001). Using the average methylation level of the 8 CpG loci in FURIN promoter revealed a similar association (OR=1.28, 95% CI: 1.02–1.62, P=0.037).</p> <p><strong>Conclusions:</strong> These results suggested that the hypermethylation levels in FURIN promoter were associated with an increased risk for incident diabetes in Chinese adults.</p>
Richness, not evenness, of invasive plant species promotes invasion success into native plant communities via selection effects
<p>Native plant communities are often invaded by multiple alien species. It is still unclear how increasing diversity of alien invasive species suppresses the growth of native species and thus contributes to invasion success. In the subtropical monsoon region of Southeast China, we experimentally created a native plant community with 18 herbaceous species. One week later, we let it be invaded by either zero (controls without invasion), one, two, four or eight alien plant species, with either high or low species evenness. After a four-month growth period we harvested the aboveground biomass of each species. We found that increasing invasive species richness significantly increased invasive plant biomass, the biomass of all invasive and native plant species within the community, and invasion success (the ratio of invasive plant biomass to the biomass of all native and invasive plants), but it did not significantly reduce native plant biomass. Experimentally manipulating invasive species evenness did not influence invasion success and did not show any differential suppression effects on native plants. One invasive species, Sesbania cannabina, became dominant in terms of plant biomass, irrespective of its proportion in the alien plant mixtures. Throughout this experiment, effects of invasive species richness on invasion success were mainly due to such selection effects among the invasive species. On the other hand, the unchanged biomass of native species under increasing invasive plant richness suggests the presence of at least partly complementary resource niches between invasive and native species.</p>
Data from: Irregular forest structures originating after fire: an opportunity to promote alternatives to even-aged management in boreal forests
<p><span>1. Even-aged silviculture based on short-rotation clearcuts had severely altered boreal forests. Silvicultural alternatives (e.g., continuous cover or retention forestry) has the potential to restore and protect the habitats and functions of boreal forests. These alternatives are however often restricted to structurally complex old-growth forest, which are particularly threatened by anthropogenic disturbances. Increasing the use of alternatives to even-aged silviculture in early-successional stands could help recruit more structurally complex forests, with characteristics closer to the old-growth. In this article, we therefore evaluate the potential for silvicultural alternatives to even-aged management in boreal forests that burned less than a century ago.</span></p> <p><span>2. We analyzed 1085 field plots in a 243000 km<sup>2</sup> area situated in the boreal forest of eastern Canada. These plots burned 30 to 100 years before the survey and had not been subjected to previous or subsequent anthropogenic disturbance; they hence represent young primary forests. The main patterns of tree diameter distribution variation within the plots were identified using k-means clustering. Stand structure, tree species composition, and environmental variables that most explained the differences among the clusters were identified with a random forest model, and then compared using Kruskal-Wallis and Fisher's exact tests.</span></p> <p><span>3.</span> <span>The majority (>75 %) of the plots presented an irregular structure of stem diameters (i.e., non-normally distributed, with many small diameter trees). The understorey was generally dominated by black spruce (<em>Picea mariana</em> [Mill.] BSP), a shade-tolerant species. Irregular structures were observed in both forests of high and low productivity, implying that different processes (e.g., early regeneration, variable tree growth) can lead to observed early irregular structure. Regular structures were generally characterized by a higher productivity and abundance in hardwood species compared to the irregular structures. </span></p> <p><span>4. <em>Synthesis and application</em>: Many boreal forests of eastern Canada progress towards an irregular structure in the decades following the last stand-replacing fire. A substantial part of these early-successional forests may be suitable for alternatives to even-aged silviculture that better maintains habitats and functions of preindustrial boreal forests. </span></p>
Do habitat and elevation promote hybridization during secondary contact between three genetically distinct groups of warbling vireo (Vireo gilvus)?
<p>Following postglacial expansion, secondary contact can occur between genetically distinct lineages. These genetic lineages may be associated with specific habitat or environmental variables and therefore, their distributions in secondary contact could reflect such conditions within these areas. Here we used mtDNA, microsatellite, and morphological data to study three genetically distinct groups of warbling vireo (Vireo gilvus) and investigate the role that elevation and habitat play in their distributions. We studied two main contact zones and within each contact zone, we examined two separate transects. Across the Great Plains contact zone, we found that hybridization between eastern and western groups occurs along a habitat and elevational gradient, whereas hybridization across the Rocky Mountain contact zone was not as closely associated with habitat or elevation. Hybrids in the Great Plains contact zone were more common in transitional areas between deciduous and mixed-wood forests, and at lower elevations (<1000 m). Hybridization patterns were similar along both Great Plains transects indicating that habitat and elevation play a role in hybridization between distinct eastern and western genetic groups. The observed patterns suggest adaptation to different habitats, perhaps originating during isolation in multiple Pleistocene refugia, is facilitating hybridization in areas where habitat types overlap.</p>
Dataset for the research article "Direct evidence supporting Darwin's hypothesis of cross-pollination promoted by sex organ reciprocity"
<p>Data for experimental populations of Narcissus papyraceus exposed to two different pollination environments:</p> <p>SSR genotypes for parental individuals and seedlings</p> <p>Number of seeds produced by each combination of mating individuals, and spatial distance between individuals</p> <p>Data on floral traits and female and male fitness of parental individuals</p> <p>Data on floral traits measured at two flowers within each inflorescence, in a control group of 71 inflorescences.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.