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10,812 results for “novels”
Dataset for Sulfidation of air-stable iron nanoparticles: A novel strategy how to boost their reactivity demonstrated on Cr(VI) reduction
<p><strong>This repository contains data from the manuscript:</strong></p> <p>Víchová, V., Oborná, J. K., Petr, M., Soukupová, J., Pechancová, R., Pluháček, T., & Filip, J. (2024). Sulfidation of air-stable iron nanoparticles: A novel strategy how to boost their reactivity demonstrated on Cr (VI) reduction. <em>Journal of Water Process Engineering</em>, <em>67</em>, 106246. <a title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.jwpe.2024.106246" target="_blank" rel="noreferrer noopener">https://doi.org/10.1016/j.jwpe.2024.106246</a></p> <p><strong>Abstract of the manuscript:</strong></p> <p>Sulfidated zero-valent iron nanoparticles (S-nZVI) have been extensively studied as environmentally promising<br>alternative material, which enables reduction of variety of extremely dangerous pollutants directly in the<br>environment. However, synthesis and manipulation with these extremely reactive/pyrophoric nZVI particles<br>represents a challenge and requires special precautions. In this study, we report a synthesis of S-nZVI from airstable<br>core-shell nZVI, which reactivity with contaminants and properties are comparable with the commonly<br>prepared S-nZVI particles (where the precursor was bare/pyrophoric nZVI particles). The undeniable novelty<br>dwells in the simplicity of the synthetic process, which ensures consequential safe and easy handling, manipulation,<br>and application of S-nZVI particles. This material, especially highly effective against halogenated organic<br>compounds and heavy metals, was characterized in detail and its advanced characteristics were evaluated in the<br>process of hexavalent chromium (Cr(VI)) reduction from model aqueous solutions and polluted groundwater.<br>The results offer valuable insights into the preparation of a novel nanomaterial with high application potential in<br>the effective degradation of heavy metals in polluted water. Overall, the novel way prepared S-nZVI particles,<br>designed for the potential large-scale production, eliminates the drawbacks of S-nZVI synthesized from bare nZVI<br>particles and offers the effective material suitable for any on-site application.</p>
Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery
<p>Understanding transcriptional responses to chemical perturbations is central to drug discovery, but exhaustive experimental screening of diseasecompound combinations is unfeasible. To overcome this limitation, here we introduce PRnet, a perturbation-conditioned deep generative model that predicts transcriptional responses to novel chemical perturbations that have never experimentally perturbed at bulk and single-cell levels. Evaluations indicate that PRnet outperforms alternative methods in predicting responses across novel compounds, pathways, and cell lines. PRnet enables gene-level response interpretation and in-silico drug screening for diseases based on gene signatures. PRnet further identifies and experimentally validates novel compound candidates against small cell lung cancer and colorectal cancer. Lastly, PRnet generates a large-scale integration atlas of perturbation profiles, covering 88 cell lines, 52 tissues, and various compound libraries. PRnet provides a robust and scalable candidate recommendation workflow and successfully recommends drug candidates for 233 diseases. Overall, PRnet is an effective and valuable tool for gene-based therapeutics screening.</p>
Efficient Implementation of a Novel Decomposition Approach for the Hazmat Network Design Problem with Capacity Constraints in Java Including Computational Results
<p>Supplementary material for the Publication "Solving Multi-Follower Mixed-Integer Bilevel Problems with Binary Linking Variables"</p>
Dataset for Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic
<p><strong>Dataset for Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic</strong></p> <p>Code used for plotting of main figures and quantifying allelic shifts attached in the GitHub repository CareyMetheringham/MardenPark. Additional files for analysis of GEBV shifts between adults and juveniles, estimation of heritability, trends in green up and simulations of allelic shifts included as:</p> <ul> <li>GEBV-regression.Rmd</li> <li>heritabilityEst.R</li> <li>GreeningAnalysis.R</li> <li>Simulated_selection_analysis.Rmd</li> <li>Distinguishing the effects of selection from genetic drift.pdf</li> </ul> <p>Data files:</p> <ul> <li>S1 - phenotypic measurements for adult and juvenile trees</li> <li>S2 - Effect sizes for SNPs used to calculate GEBV</li> <li>S3 - Allelic frequencies of sites used to calculate GEBV</li> <li>related_trees.csv - Predicted parentage of trees</li> <li>gebv_model_df.csv - Data used for greenup calculations in GreeningAnalysis.R</li> <li>maf1.pass2.miss25.snps.only.LD.vcf - Filtered file of high MAF SNPs used for parentage estimation</li> <li>unlinked_sites.csv - unlinked sites used in GEBV-regression.Rmd</li> <li>ebv_table_10000_250 - table of estimated breeding values in field trial populatio, used for heritability estimation</li> <li>MP_eefects_MIA_and_MAA.csv - Data for plotting Figure 3 - Estimated effect size of the major and minor allele, plus standard error on the estimate</li> </ul>
Forest Fire Clustering: A Novel Tool for Identifying Star Members of Clusters
<p>In Tables 4 and 5, the <strong>Cluster</strong> column represents the name of the cluster. </p> <p><strong>Table 4</strong>: The columns <strong>ra</strong>, <strong>dec</strong>, <strong>pmra</strong>, <strong>pmdec</strong>, and <strong>parallax</strong> correspond to the median values for the cluster's position, parallax, and proper motions, respectively. The <strong>[Fe/H]</strong> and <strong>[Fe/H]_err</strong> columns indicate the cluster's [Fe/H] and its associated error. The <strong>logt</strong> and <strong>log_t_err</strong> columns represent the logarithmic age and its error, while the <strong>m-M</strong> and <strong>m-M_err</strong> columns denote the distance modulus and its error. Additionally, the <strong>E(BP-RP)</strong> and <strong>E(BP-RP)_err</strong> columns specify the cluster's reddening and its error, and the <strong>A_V</strong> and <strong>A_V_err</strong> columns represent the extinction and its error.</p> <p><strong>Table 5</strong>: The <strong>rc_pc</strong> and <strong>e_rc_pc</strong> columns indicate the core radius and its error, while the <strong>rt_pc</strong> and <strong>e_rt_pc</strong> columns represent the tidal radius and its error. The <strong>rh_pc</strong> column provides the radius containing half of the total number of stars in the cluster, and the <strong>rhm_pc</strong> column gives the half-mass radius. The <strong>R_J</strong> and <strong>R_J_err</strong> columns represent the Jacobi radius and its error. The <strong>mass</strong> and <strong>mass_err</strong> columns show the total mass of the cluster and its error, and the <strong>fb</strong> column denotes the binary fraction of the cluster. Finally, the <strong>trlx</strong> and <strong>trlx_err</strong> columns represent the relaxation time and its error. The units of<strong> trlx</strong> and <strong>trlx_err</strong> are Myr</p> <p>Note: NULL values for <strong>rc_pc, e_rc_pc, rt_pc, </strong>and <strong>e_rt_pc </strong>indicate the inapplicability of the RDP method. For <strong>Bootes I, NGC 104, NGC 3201, NGC 6121, NGC 6544, </strong>and <strong>NGC 6656</strong>, the parameters listed as “N/A”—including <strong>rhm, rJ, rJ_err, mass, mass_err, fb, trlx_Myr,</strong> and<strong> trlx_err</strong>—cannot be determined using our methods due to their faint magnitudes. This limitation arises because Gaia’s observational capacity extends only to 21 mag.</p> <p> </p>
Novel Macrophage Subpopulation Linked to CAD: raw and processed data files
<div> <p>This directory contains all single-cell datasets analyzed in the "Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying increased genetic risk of coronary artery disease". Associated scripts are available at https://github.com/jhjiang2020/multiome_paper. </p> <p><strong>Jan 2025 updates</strong>: include the 10x Cell Ranger ARC output for the scATAC-seq assay. <em>Please note that 10x peaks were not used for downstream analyses. Instead, we trimmed the atac-seq fragments to retain the 9bp Tn5 cut sites at both ends and aggregated into one consensus bed file. We then recalled peaks using `MACS3 --qvalue 1e-5 --nomodel --shift -50 --extsize 100 --broad` (see discussion in https://github.com/stuart-lab/signac/issues/682). </em></p> <p> </p> </div>
Single-cell RNA-Seq-based deconvolution of hairy cell leukemia reveals novel disease drivers and identifies DUSP1 as potential therapeutic target
<p>Microwell-based (BD Rhapsody) scRNA-seq of Hairy Cell Leukemia Patients published in </p> <blockquote> <p><strong>Single-cell RNA-Seq-based deconvolution of hairy cell leukemia reveals novel disease drivers and identifies DUSP1 as potential therapeutic target, Jan-Paul Bohn et al. Submitted.</strong></p> </blockquote> <p>The files will be made available upon publication. <br></p> <h4><strong>Description of the files</strong></h4> <ul> <li><strong>01_raw_counts: </strong>count matrices as CSV as generated by the BD Rhapsody WTA analysis pipeline</li> <li><strong>10_prepare_adata</strong>: Load BD Rhapsody WTA analysis pipeline outputs into AnnData objects and add metadata.</li> <li><strong>20_scrnaseq_qc</strong>: Use a nextflow pipeline (stored in lib/single-cell-analysis-nf) to perform threshold-based filtering of single-cell data and apply SOLO for doublet detection.</li> <li><strong>30_merge_adata</strong>: Merge samples into a single AnnData object, train a scVI model for batch effect removal, and annotate cell-types based on unsupervised clustering</li> <li><strong>40_cluster_analysis</strong>: Identify and investigate subclusters representing cell-states that go beyond the major cell-types</li> <li><strong>50_de_analysis</strong>: Generate pseudobulk and perform differential gene expression analysis using DESeq2 (based on a wrapper script stored in lib/deseq2_workflow)</li> <li><strong>70_downstream_analysis</strong>: Perform pathway analyses and generate figures for publication based on the data generated in the previous steps</li> <li><strong>containers:</strong> Conda environments used for the analysis packed up as singularity containers. </li> </ul>
Genome of a novel phenui-like virus in Morus alba
<p>SY_1.fq.gz and SY_1.fq.gz are transcriptome sequencing raw data files.</p> <p>SY_siRNA.fq.gz is the siRNA sequencing raw data file.</p> <p>trinity.Morus.Trinity.fasta is the Trinity assembly result.</p> <p>trinity.Morus.Trinity.re.fasta is the same as the Trinity assembly result except that we reoriented the novel virus genome segments, so all the segments are on their negative strand.</p> <p>trinity.nr.Morus is the DIAMOND BLASTX result</p> <p>Supplementary material.zip Includes the Ma phenui-like virus genome (RNA1_re.fasta, RNA2.fasta, RNA3_re.fasta), Sanger sequencing data, and the host's <em>matK</em> gene.</p>
Emerging Resistance to Novel b-Lactam b-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants
<p><em><span><span>Klebsiella pneumoniae</span></span></em><span><span> carbapenemase (KPC) variants, predominantly KPC-2 and KPC-3, are a significant global resistance mechanism in <em><span>K. pneumoniae</span></em>. KPC-2 and KPC-3 confer resistance to a broad range of β-lactams, including carbapenems, while remaining susceptible to ceftazidime-avibactam (CZA). Lately, new KPC variants have emerged and developed resistance to CZA, often through mutations, insertions, or deletions in key regions such as the Omega loop, the 237–243 loop, and the 266–275 loop. In the present work we aim to understand the role of these mutations in KPC in the emergence of cross-resistance to last-resort antibiotics like cefiderocol (FDC) and cefepime/zidebactam (FPZ). Fifteen clinical isolates of KPC-producing <em><span>Klebsiella</span></em> spp. were analyzed, representing 15 distinct KPC variants. CZA resistance was confirmed in 12 of the 15 KPC variants tested. Cross-resistance to FDC was observed in eight isolates, with five of these exhibiting spontaneous resistant subpopulations, including one originally categorized as FDC-susceptible. Six FDC-resistant strains carried mutations in the 266–275 loop. Cross-resistance to FPZ was observed in five KPC variants, particularly those with mutations in the 266–275 loop, although many omega loop and 237–243 loop mutants remained susceptible to FPZ. WGS of FDC-resistant subpopulations revealed additional mutations in genes such as <em><span>ompC</span></em>, <em><span>rpoC</span></em>, <em><span>dksA</span></em>, and <em><span>cirA</span></em>.<br>This study demonstrates that KPC variants show resistance to both CZA and FDC, with cross-resistance to FPZ observed to a lesser degree. The emergence of cross-resistance in strains that had not been exposed to these antibiotics raises concerns about the spread of resistance. The identification of mutations in <em><span>bla</span></em><sub>KPC</sub>, <em><span>cirA</span></em>, and other novel genes highlights the importance of understanding the molecular mechanisms driving resistance to develop effective therapeutic strategies. </span></span></p>
BioMates - WP1: Novel pyrolysis oil from non-food/feed biomass - Data sheet: Identifiers for samples and blends
<p>Ablative fast pyrolysis (AFP) is the first step in the BioMates-concept for producing bio-based intermediates (BioMates) with reliable properties from stalk-type biomass. These intermediates are designed for co-processing within conventional refineries. The H2020-project BioMates validates the process concept (<a href="http://www.biomates.eu">www.biomates.eu</a>).</p> <p>AFP produces bio-oil to be mildly hydrotreated towards said intermediates afterwards. This document provides identifiers for samples and blends produced in TRL4 via AFP from wheat-barley-straw and Miscanthus within the BioMates-project.</p>
Using CSA Cement for Novel Waterway Repair Materials
<p>Many maritime structures (e.g., locks, dams, ports) in the US are either reaching or are past their design lives, and there are limited funds for necessary maintenance activities which can often lead to closures. These structures are not easy to detour and often require dewatering before repairs can be made. Closures can cause delays and business-related losses which can have a large economic effect. Thus, it is advantageous to reduce the repair time for maritime structures. BCSA (belitic calcium sulfoaluminate) cement is a promising repair material due to its properties. BCSA cement is a fast-setting hydraulic cement capable of reaching compressive strengths greater than 4000 psi (27.6 MPa) in less than 2 hours. BCSA also has low shrinkage and good long-term strengths. This research consisted of developing an optimal rapid-setting underwater repair mortar mixture design using BCSA cement. Properties such as compressive strength and workability were tested to select the best mix design. Additionally, soil-cements made with BCSA cement were compared to portland cement-based soil-cements. These soil cements have applications for the rapid repair of levees and earthen dams, but also for rapid soil stabilization. The results obtained proved that BCSA cement is a promising material for rapid underwater repairs and repairs of soil-based waterway structures.</p>
Summary Statistics from "Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis"
<p>Summary statistics of meta GWAS of phytosterols.</p>
Support for a novel, simple method for calculating word frequency of output on language production tasks
<p>Pre-recorded presentation for the International Workshop on Language Production 2021</p>
Specimens from Brand et al. 2021, "Large-scale phylogenomics of the genus Macrostomum (Platyhelminthes) reveals cryptic diversity and novel sexual traits"
<p>The deposited folders contain image and video material of free-living flatworm specimens that were documented in vivo. These data support the following publication:</p> <p>Jeremias N. Brand, Gudrun Viktorin, R. Axel W. Wiberg, Christian Beisel, Lukas Schärer.<br> Large-scale phylogenomics of the genus<em> Macrostomum</em> (Platyhelminthes) reveals cryptic diversity and novel sexual traits.<br> Molecular Phylogenetics and Evolution. Volume 166. 2022. <a href="https://doi.org/10.1016/j.ympev.2021.107296">https://doi.org/10.1016/j.ympev.2021.107296</a></p> <p>For more information about these specimens see also http://macrostomorpha.info.</p>
French Novel Collection (ELTeC-fra) for TXM
<p>TXM annotated binary corpus of the French Novel Collection (ELTeC-fra) in the "European Literary Text Collection" (ELTeC) produced by the COST Action "Distant Reading for European Literary History" (CA16204). The current version is based on v1.0.0 of the French Novel Collection (ELTeC-fra).</p> <p>Authors represented in this collection (see metadata table for details): Amédée Achard; Juliette Adam; Gustave Aimard; Alphonse Allais; Marguerite Audoux; Honoré de Balzac; Henri Barbusse; Maurice Barrès; René Bazin; Stella Blandy; Adèle Blondel; Fortuné du Boisgobey; Paul Bourget; Zulma Carraud; Claide de Chandeneux; Michel Corday; Georges Darien; Comtesse Dash; Alphonse Daudet; Lucie de Delarue-Mardrus; Xavier de Montépin; Roger Dombre; Alexandre (père) Dumas; Georges Eekhoud; Émile Erckmann; Octave Feuillet; Paul Henri Corentin Féval; Gustave Flaubert; Zénaïde Fleuriot; Anatole France; Émile Gaboriau; Arnould Galopin; Judith Gautier; Théophile Gautier; Marie Françoise Sophie Gay; Jehan Gilbert; Delphine de Girardin; Julie Gouraud; Henry Gréville; Gyp (Sibylle Riquetti de Mirabeau); Paul de Kock; Maurice Leblanc; Jules Lermina; Gustave Le Rouge; Gaston Leroux; Daniel Lesueur; Pierre Loti; Hector Malot; Auguste Maquet; Guy de Maupassant; Catulle Mendès; Pierre Mille; Octave Mirbeau; Édouard Montagne; Emile Moselly; Anna de Noailles; Georges Ohnet; Joséphin Péladan; Pierre Alexis Ponson du Terrail; Marcel Proust; Marie Rattazzi; Hugues Rebell; Fanny Reybaud; Romain Rolland; Jules Sandeau; George Sand; Daniel Stern; Madame de Stolz; Mario Uchard; Victor Vaillant; Cécile de Valgand; Jules Verne; Horace de Viel-Castel; Claude Vignon.</p>
OPT data from: A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint
<p><span>The acquisition of movable jaws was a major event during vertebrate evolution. The role of NK3 homeobox 2 (Nkx3.2) transcription factor in patterning the primary jaw joint of gnathostomes (jawed vertebrates) is well known, however, knowledge about its regulatory mechanism is lacking. In this study, we report a proximal enhancer element of <em>Nkx3.2</em> that is deeply conserved in most gnathostomes but undetectable in the jawless hagfish and lamprey. This enhancer is active in the developing jaw joint region of the zebrafish <em>Danio rerio</em>, and was thus designated as <em>jaw joint regulatory sequence 1</em> (JRS1). We further show that JRS1 enhancer sequences from a range of gnathostome species, including a chondrichthyan and mammals, have the same activity in the jaw joint as the native zebrafish enhancer, indicating a high degree of functional conservation despite the divergence of cartilaginous and bony fish lineages or the transition of the primary jaw joint into the middle ear of mammals. Finally, we show that deletion of JRS1 from the zebrafish genome using CRISPR/Cas9 results in a significant reduction of early gene expression of <em>Nkx3.2</em> and leads to transient jaw joint deformation and partial fusion. The emergence of this <em>Nkx3.2 </em>enhancer in early gnathostomes may have contributed to the origin and shaping of the articulating surfaces of vertebrate jaws.</span></p>
Experimental evidence that novel land management interventions inspired by history enhance biodiversity
<p>To address biodiversity declines within semi-natural habitats, land-management must cater for diverse taxonomic groups. Integrating our understanding of the ecological requirements of priority (rare, scarce or threatened) species through 'biodiversity auditing', with that of the intensity and complexity of historical land-use, encourages novel forms of management. Experimental confirmation is needed to establish whether this enhances biodiversity conservation relative to routine management.</p> <p>Biodiversity auditing and historical land-use of dry-open terrestrial habitats in Breckland (Eastern England) both encourage management incorporating ground-disturbance and spatio-temporal variability. To test biodiversity conservation outcomes, we developed 40 4-ha management complexes over three successive winters, of which 20 were shallow-cultivated (rotovation) and 20 deep-cultivated (ploughing), stratified across 3,850-ha of closed-sward dry grassland and lowland heathland (collectively 'dry grassland'). Complexes comprised four 1-ha sub-treatments: repeat-cultivation, first-time-cultivation, one-year-old fallow and two-year-old fallow. We examined responses of vascular plants; spiders; true bugs; ground, rove and 'other' beetles; bees and wasps; ants; and true flies on treatment complexes and 21 4-ha untreated controls. Sampling gave 132,251 invertebrates from 877 species and 28,846 plant observations from 167 species.</p> <p>Resampling and rarefaction analyses showed shallow- and deep-cultivation both doubled priority species richness (pooling sub-treatments within complexes) compared to controls. Priority spider, ground beetle, other beetle, and true bug richness were greater on both treatments than controls. Responses were strongest for those priority dry-open-habitat associated invertebrates initially predicted (by biodiversity auditing) to benefit from heavy physical-disturbance.</p> <p>Assemblage composition (pooling non-priority and priority species) varied between sub-treatments for plants, ants, true bugs, spiders, ground, rove and other beetles; but only one-year-old fallowed deep-cultivation increased priority richness across multiple taxa.</p> <p>Treatments produced similar biodiversity responses across various dry grassland 'habitats' that differed in plant composition, allowing simplified management guidance.</p> <p><em>Synthesis and applications</em>. Our landscape-scale experiment confirmed the considerable biodiversity value of interventions inspired by history and informed by systematic multi-taxa analysis of ecological requirements across priority biota. Since assemblage composition varied between sub-treatments, providing heterogeneity in management will support the widest suite of species. Crucially, the intended recipients responded most strongly, suggesting biodiversity audits could successfully inform interventions within other systems.</p>
NOVEL MOLECULAR TARGETS FOR HEPATOCELLULAR CARCINOMA
<p><strong>Abstract: </strong>Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer globally. Indeed, only few treatments are available, most of which are effective only for the early stages of the disease. Therefore, there is an urgent needing of potential markers for a specifically targeted therapy. Candidate proteins were selected from datasets of The Human Protein Atlas, in order to identify specific tumor-associated proteins overexpressed in HCC samples associated with poor prognosis. Potential epitopes were predicted from such proteins and homology with peptides derived from viral proteins was assessed. A multiparametric validation was performed, including recognition by PBMCs from HCC-patients and healthy donors, showing a T cell cross-reactivity with paired epitopes. These results provide novel HCC-specific Tumor-associated antigens (TAAs)TAAs for immunotherapeutic anti-HCC strategies potentially able to expand pre-existing virus-specific CD8<sup>+</sup> T cells with superior anti-cancer efficacy.</p>
The impact of life stage and pigment source on the evolution of novel warning signal traits
<p><span><span><span><span><span><span><span><span><span><span><span>Our understanding of how novel warning color traits evolve in natural populations is largely based on studies of reproductive stages and organisms with endogenously produced pigmentation. In these systems, genetic drift is often required for novel alleles to overcome strong purifying selection stemming from frequency-dependent predation and positive assortative mating. Here, we integrate data from field surveys, predation experiments, population genomics, and phenotypic correlations to explain the origin and maintenance of geographic variation in a diet-based larval pigmentation trait in the redheaded pine sawfly (<i>Neodiprion lecontei</i>), a pine-feeding hymenopteran. Although our experiments confirm that <i>N. lecontei</i><i> </i>larvae are indeed aposematic—and therefore likely to experience frequency-dependent predation—our genomic data do not support a historical demographic scenario that would have facilitated the spread of an initially deleterious allele via drift. Additionally, significantly elevated differentiation at a known color locus suggests that geographic variation in larval color is currently maintained by selection. Together, these data suggest that the novel white morph likely spread via selection. However, white body color does not enhance aposematic displays, nor is it correlated with enhanced chemical defense or immune function. Instead, the derived white-bodied morph is disproportionately abundant on a pine species with a reduced carotenoid content relative to other pine hosts, suggesting that bottom-up selection via host plants may have driven divergence among populations. Overall, our results suggest that life stage and pigment source can have a substantial impact the evolution of novel warning signals, highlighting the need to investigate diverse aposematic taxa to develop a comprehensive understanding of color variation in nature.</span></span></span></span></span></span></span></span></span></span></span></p>
A novel UPLC-MS metabolomic analysis-based strategy to monitor the course and extent of iPSC differentiation to hepatocytes
<p>ms2 raw data, peak tables generated in Quantitative Analysis Software from Agilent and Matlab functions for QC-SVRC, data clean-up and analysis for the publication with title "Monitoring the differentiation of iPSC to hepatocytes by means of UPLC-MS metabolomics".</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.