Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,920
datasets available to search
ShareScore release 0.9.0
Dataset results
7,920 results for “implications”
Figure 1 in New material of Pepesuchus (Crocodyliformes; Mesoeucrocodylia) from the Bauru Group: implications about its phylogeny and the age of the Adamantina Formation
Figure 1. Map of the Bauru Group (modified from Fernandes & Coimbra, 1996).
Historical patterns and sustainability implications in worldwide bicycle ownership and use
<p>This dataset is for the paper "Historical patterns and sustainability implications in worldwide bicycle ownership and use" published on communication earth & environment.</p>
Database of the integrated model, used for the material and climate implication of car transition in China
<p>Database of the integrated model, used for the material and climate implication of China car transition. All excel files are the parameter settings used in that case. All csv files are results under all scenarios.</p>
Simulations of PKA RIα Homodimer Reveal cAMP-coupled Conformational Dynamics of Each Protomer and the Dimer Interface with Functional Implications
<p>Protein kinase A (PKA) is a ubiquitous cAMP-dependent enzyme in mammalian tissues. The inactive PKA holoenzyme disassociates into a homodimer of regulatory (R) subunits and two active catalytic (C) subunits upon cAMP binding to two tandem domains (termed <span>CBD-A</span> <span>and</span> <span>CBD</span>-<span>B</span>) in R subunits. The release of cAMP facilitates reassociation of R and C subunits<span>,</span> resetting PKA to its basal state. The cAMP-mediated structural changes in the activation-termination cycle <span>remain</span> <span>partially</span> <span>understood</span>. The multimeric states of PKA complicate the issue and are particularly <span>less</span> <span>studied</span>. Therefore, we computationally investigate the conformational dynamics of PKA <span>RI</span>a homodimer in different cAMP-bound states. The absence of cAMP in two CBDs affect differently the <span>conformational</span> <span>dynamics</span> of protomers. Moreover, <span>such</span> disparate <span>responses</span> are extended to the dimer interface <span>constituted</span> <span>by</span> <span>the</span> <span>N</span>-<span>terminal</span> <span>helical</span> <span>sub-domains</span> termed N3A motifs. T<span>he removal of cAMP from CBD-A induces large-scale structure</span> changes <span>of individual </span>R subunits <span>towards the holoenzyme state,</span> consist with previous simulations of a single R subunit. <span>Meanwhile</span> <span>it</span> <span>keeps the structural heterogeneity of the </span>N3A-N3A' <span>dimer interface observed in the fully bound state.</span> By contrast, the removal of cAMP from CBD-B does not affect <span>individual </span>R subunits but alters the conformational space of the N3A-N3A' dimer interface. The cAMP-coupled s<span>tructural</span> <span>changes</span> <span>of</span> <span>each</span> <span>protomer</span> <span>and</span> conserved conformational space of <span>the</span> N3A-N3A' <span>dimer</span> <span>interface</span> are essential for t<span>he</span> <span>transition</span> <span>between</span> the fully cAMP-bound R<sub>2</sub> homodimer and the R<sub>2</sub>C<sub>2</sub> holoenzyme as suggested by their crystal structures. Our work provides structural insights into <span>the</span> regulatory mechanism of cAMP in PKA signaling. </p>
Age-related dynamics and spectral characteristics of the TCRβ repertoire in healthy children: implications for immune aging
<p><strong><span>Background: </span></strong><span>The T cell receptor (TCR) is crucial for adaptive immunity, providing a diverse repertoire for antigen response. However, despite its clinical importance, baseline characterization of the TCR in the pediatric population remains limited.</span></p> <p><strong><span>Methods:</span></strong><span> We conducted TCR<span>β</span> sequencing on 325 healthy Chinese children aged 0-18 years, categorized into six age groups, to understand dynamic changes and establish a reference database of TCR<span>β</span> rearrangements for this demographic. Furthermore, we used cell sorting on 81 samples with flow cytometry to analyze cellular composition and associations, focusing specifically on age-related variations in the TCRβ repertoire.</span></p> <p><strong><span>Results: </span></strong><span>Our study revealed an age-related decline in TCRβ repertoire diversity, marked by increased high-frequency and in-frame clonotypes. This shift in diversity is likely due to age-related variations in CDR3 length and V(D)J gene usage. The analysis of dynamic clonal changes in TCRβ, especially in public clones, suggests a link to perinatal influences and the immune system's evolving personalization. Early-life vaccinations and antigen exposures play a pivotal role in shaping this immune evolution. Notably, a significant association was found between the decrease of CD4<sup>+</sup> T naive cells and the diminishing TCRβ repertoire diversity along with age. Furthermore, our predictive models highlight specific TCRβ features as potential biomarkers for biological age, supported by their significant correlation.</span></p> <p><strong><span>Conclusion: </span></strong><span>This study provides essential insights into age-related variations in the TCRβ repertoire among children, enriching our understanding of pediatric immune system evolution and informing potential disease prevention strategies.</span></p>
Fig. 6 Paracontias fasika n in Systematics of limbless scincid lizards from northern Madagascar: morphology, phylogenetic relationships and implications for classification (Squamata: Scincidae)
Fig. 6 Paracontias fasika n. sp. (holotype, ZSM 2256/2007) in life; dorsolateral view
Dataset related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"
<p>This record contains raw data related to article "Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications"</p> <p>AIMS:</p> <p>Nodule-in-nodule (N/N) hepatocellular carcinoma (HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer, more differentiated, tumour, which can be rapidly taken over by the former so that N/N HCC is rarely detected.</p> <p>METHODS AND RESULTS:</p> <p>Ten resected N/N HCCs arising in cirrhotic background and characterized: (i) as outer lesions by early (n = 3) and G1 (n = 7) HCC; (ii) as inner lesions by G1 (n = 3) and G2 (n = 7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 mm and 16/4 mm. We investigated vascular (CD34 and endocan), hepatocellular VEGF, GS, GPC3, HSP70 and CHC) and molecular (TERT promoter and β-catenin) changes taking place from the outer neoplastic compartment to the inner neoplastic compartment (INC). A diffuse pattern of CD34+ capillarized vessels and focal endocan immunoreactivity were major distinctive features acquired in the INC; VEGF immunoreactivity was inversely related to CD34 staining. A gain in the number of cells immunoreactive for GPC3, HSP70, and CHC, but not of GS-immunoreactive cells, also occurred in the INC. TERT promoter mutations were seen in half of the cases in both compartments, whereas β-catenin mutations were more rarely detectable.</p> <p>CONCLUSIONS:</p> <p>Major phenotypic changes take place in the INC of N/N HCC. TERT promoter mutations take place frequently and very early, and, in contrast to β-catenin mutations, do not appear to be acquired during N/N growth. These findings suggest that inner nodules represent a step further along the pathway of tumour progression, in contrast to earlier, simply initiated, lesions, and that complete neovascularisation predicts a change in HCC biology.</p>
Data from "Implications of mistletoe parasitism for the host metabolome: a new plant identity in the forest canopy"
<p>Field-collected data that support the findings of the study Lázaro-González et al. 2021.</p> <p>Lázaro-González A., Gargallo-Garriga A., Hódar J.A., Sardans J., Oravec M., Urban O., Peñuelas J. & Zamora R. (2021) Implications of mistletoe parasitism for the host metabolome: a new plant identity in the forest canopy. Plant Cell & Environment.</p>
Text-fig. 1. Map of Turkey showing the localities Keseköy, Yapıntı and Horlak. in An Exceptional Large Sample Of The Early Miocene Ctenodactyline Rodent Sayimys Giganteus, Specific Variation And Taxonomic Implications
Text-fig. 1. Map of Turkey showing the localities Keseköy, Yapıntı and Horlak.
Dataset related to article "Arteriovenous fistula creation with VasQ device: A feasibility study to reveal hemodynamic implications"
<p>The dataset contains two folders: 1) Imaging, and 2) Post-processing, each containing data from individual patients (C1, C2, V1, and V2).</p> <p>In details:</p> <p>- the Imaging folder contains MRI DICOM data at different time points (3 days, 3 weeks, and 1 year) and US data used as boundary conditions for CFD simulations</p> <p>- the Post-processing folder contains .vtp files of both morphology (CSA.vtp) and hemodynamics (hemo.vtp) at different time points</p>
Fig. 4. Possible biogenetic pathway for taipainine D in Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity
Fig. 4. Possible biogenetic pathway for taipainine D (4).
FIGURE 2 in Mitochondrial genomes of three Mylabris (Pseudabris) species (Coleoptera: Meloidae, Mylabrini) and their phylogenetic implications
FIGURE 2. The guanine-cytosine contents of each gene fragment in different species.
In vivo selection reveals long non-coding RNAs implicated in colon to liver metastasis
GEO Series GSE145749. Homo sapiens. 6 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
The Role of CDCP1 in Carotid Artery Stenosis: Implications for Mitochondrial Autophagy and Therapeutic Potential of 8-isopentenylnaringenin
GEO Series GSE285538. Rattus. 6 samples. Type: Expression profiling by high throughput sequencing.
Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation
GEO Series GSE310786. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Loss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies
GEO Series GSE145314. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
NUSAP1 regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Phenotypes Implicated in Joint Damage, and a cancer-associated transcriptomic signature.
GEO Series GSE276772. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Differentiation-dependent changes in the epigenomic landscape of human myeloid leukemia cells implicate signaling pathways and highlight chromosomal amplifications
GEO Series GSE66765. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
Small noncoding RNA Dysregulation is Implicated in Manganism in a Rat Model of Methylcyclopentadienyl Manganese Tricarbonyl-Induced Unrepaired Striatum Damage
GEO Series GSE227299. Rattus norvegicus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts
GEO Series GSE36454. Schizosaccharomyces pombe. 8 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.