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7,920 results for “implications”
Expression analysis in multiple muscle groups and serum reveals complexity in the microRNA transcriptome of the mdx mouse and implications for therapy
GEO Series GSE36257. synthetic construct; Mus musculus. 24 samples. Type: Non-coding RNA profiling by array.
Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation
GEO Series GSE132437. Rattus norvegicus. 22 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Aberrant differentiation of glioma stem cells: Implications for therapeutic targeting
GEO Series GSE58924. Homo sapiens. 33 samples. Type: Expression profiling by array.
Molecular genomic studies of the obesogenic effects of tributyltin during adipogenic differentiation implicate a primary role for cytoskeletal damage [ATAC-seq]
GEO Series GSE207039. Homo sapiens. 50 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic insights into GABAergic development in Dravet Syndrome iPSC and therapeutic implications
GEO Series GSE274660. Homo sapiens. 56 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Aberrant differentiation of glioma stem cells: Implications for therapeutic targeting (shift)
GEO Series GSE58922. Homo sapiens. 4 samples. Type: Expression profiling by array.
Implication of an Immune Score in Molecular Subtypes and Distant Metastasis of Breast Cancer: Comparison between Western and Chinese Han Patients
GEO Series GSE87377. Homo sapiens. 71 samples. Type: Expression profiling by array.
Deciphering the novel regulatory mechanisms and biological implications of ARID1A C-terminal missense mutations in cancer [ATAC-Seq]
GEO Series GSE254864. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Deciphering the novel regulatory mechanisms and biological implications of ARID1A C-terminal missense mutations in cancer [ChIP-Seq]
GEO Series GSE254865. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide mapping of nucleosome positioning in Toxoplasma gondii implicates nucleosome-free regions as the major gene regulatory regions
GEO Series GSE86620. Toxoplasma gondii. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Aberrant differentiation of glioma stem cells: Implications for therapeutic targeting [Xenograph]
GEO Series GSE58923. Homo sapiens. 12 samples. Type: Expression profiling by array.
dataset related to the article "Biological profile of monocyte-derived macrophages in coronary heart disease patients: implications for plaque morphology"
<p>This record contains row data related to the article "Biological profile of monocyte-derived macrophages in coronary heart disease patients: implications for plaque morphology"</p> <p>Abstract: The prevalence of a macrophage phenotype in atherosclerotic plaque may drive its progression and/or instability. Macrophages from coronary plaques are not available, and monocyte-derived macrophages (MDMs) are usually considered as a surrogate. We compared the MDM profile obtained from coronary artery disease (CAD) patients and healthy subjects, and we evaluated the association between CAD MDM profile and in vivo coronary plaque characteristics assessed by optical coherence tomography (OCT). At morphological analysis, MDMs of CAD patients had a higher prevalence of round than spindle cells, whereas in healthy subjects the prevalence of the two morphotypes was similar. Compared to healthy subjects, MDMs of CAD patients had reduced efferocytosis, lower transglutaminase-2, CD206 and CD163 receptor levels, and higher tissue factor (TF) levels. At OCT, patients with a higher prevalence of round MDMs showed more frequently a lipid-rich plaque, a thin-cap fibroatheroma, a greater intraplaque macrophage accumulation, and a ruptured plaque. The MDM efferocytosis correlated with minimal lumen area, and TF levels in MDMs correlated with the presence of ruptured plaque. MDMs obtained from CAD patients are characterized by a morpho-phenotypic heterogeneity with a prevalence of round cells, showing pro-inflammatory and pro-thrombotic properties. The MDM profile allows identifying CAD patients at high risk.</p>
Data set from Ciconte G, Santinelli V, Vicedomini G, Borrelli V, Monasky MM, Micaglio E, Giannelli L, Negro G, Giordano F, Mecarocci V, Mazza BC, Locati E, Anastasia L, Calovic Z, Pappone C. Non-invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal-averaged electrocardiogram: clinical implications from a prospective clinical trial. Europace. 2019 Dec 1;21(12):1900-1910. doi: 10.1093/europace/euz295. PMID: 31647530.
<p>Data set from Ciconte G, Santinelli V, Vicedomini G, Borrelli V, Monasky MM, Micaglio E, Giannelli L, Negro G, Giordano F, Mecarocci V, Mazza BC, Locati E, Anastasia L, Calovic Z, Pappone C. Non-invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal-averaged electrocardiogram: clinical implications from a prospective clinical trial. Europace. 2019 Dec 1;21(12):1900-1910. doi: 10.1093/europace/euz295. PMID: 31647530.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aims: </strong> Brugada syndrome (BrS) represents a major cause of sudden cardiac death in young individuals. The risk stratification to forecast future life-threatening events is still controversial. Non-invasive assessment of late potentials (LPs) has been proposed as a risk stratification tool. However, their nature in BrS is still undetermined. The purpose of this study is to assess the electrophysiological determinants of non-invasive LPs.</p> <p><strong>Methods and results: </strong> Two hundred and fifty consecutive patients with (Group 1, n = 96) and without (Group 2, n = 154) BrS-related symptoms were prospectively enrolled in the registry. Signal-averaged electrocardiogram (SAECG) was performed in all subjects before undergoing epicardial mapping. Group 1 patients exhibited larger arrhythmogenic substrates (AS; 5.8 ± 2.8 vs. 2.6 ± 2.1 cm2, P < 0.001) with more delayed potentials (220.4 ± 46.0 vs. 186.7 ± 42.3 ms, P < 0.001). Late potentials were present in 82/96 (85.4%) Group 1 and in 31/154 (20.1%) Group 2 individuals (P < 0.001). Patients exhibiting LPs had more frequently a spontaneous Type 1 pattern (30.1% vs. 10.9%, P < 0.001), SCN5A mutation (34.5% vs. 21.2%, P = 0.02), and exhibited a larger AS with longer potentials (5.8 ± 2.7 vs. 2.2 ± 1.7 cm2; 231.2 ± 37.3 vs. 213.8 ± 39.0 ms; P < 0.001, respectively). Arrhythmogenic substrate dimension was the strongest predictor of the presence of LPs (odds ratio 1.9; P < 0.001). An AS area of at least 3.5 cm2 identified patients with LPs (area under the curve 0.88, 95% confidence interval 0.843-0.931; P < 0.001) with a sensitivity of 86%, specificity 88%, positive predictive value 85%, and negative predictive value 89%.</p> <p><strong>Conclusion: </strong> The results of this study support the role of the epicardial AS as an electrophysiological determinant of non-invasive LPs, which may serve as a tool in the non-invasive assessment of the BrS substrate, as SAECG-LPs could be considered an expression of the abnormal epicardial electrical activity.</p> <p>ClinicalTrials.gov number (<a href="http://clinicaltrials.gov/show/NCT02641431">NCT02641431</a>; <a href="http://clinicaltrials.gov/show/NCT03106701">NCT03106701</a>).</p> <p> </p>
Matching genes, phylotypes and morphotypes to invertebrate taxonomic assignments: implications for metagenetic surveys in terrestrial Antarctica
<p>Data and analysis scripts associated with manuscript "Matching genes, phylotypes and morphotypes to invertebrate taxonomic assignments: implications for metagenetic surveys in terrestrial Antarctica".</p> <p> </p>
Characteristics of oxygenated volatile organic compounds in Zurich, Switzerland: Sources, composition, and implication for secondary aerosol formation
Open the record for dataset details and reuse information.
Impact of respiratory protective devices on respiration: Implications for panic vulnerability during the COVID-19 pandemic
<p>Impact of respiratory protective devices on respiration: Implications for<br> panic vulnerability during the COVID-19 pandemic</p> <p>Background: The wearing of respiratory protective devices (RPDs) correctly and continually in situations where<br> people are at risk of respiratory infections is crucial for infection prevention. Certain people are poorly compliant<br> with RPDs due to RPD-related annoyance, including respiratory discomfort. We hypothesized that individuals<br> vulnerable to panic attacks are included in this group. No published studies on this topic are available. The<br> evidence for our hypothesis was reviewed in this study as a starting point for future research.<br> Methods: We selected a set of experimental studies that measured the respiratory physiological burden in RPD<br> wearers through objective and validated methods. We conducted a bibliographic search of publications in the<br> PubMed database (January 2000–May 2020) to identify representative studies that may be of interest for panic<br> respiratory pathophysiology.<br> Results: Five studies were included. Wearing RPDs exerted significant respiratory effects, including increased<br> breathing resistance, CO2 rebreathing due to CO2 accumulation in the RPD cavity, and decreased inhaled O2<br> concentration. We discussed the implications of these effects on the respiratory pathophysiology of panic.<br> Limitations: Most studies had a small sample size, with a preponderance of young participants. Different<br> methodologies were used across the studies. Furthermore, differences in physical responses between wearing<br> RPDs in experimental settings or daily life cannot be excluded.<br> Conclusions: This research supports the idea that panic-prone individuals may be at higher risk of respiratory<br> discomfort when wearing RPDs, thereby reducing their tolerance for these devices. Strategies to decrease discomfort<br> should be identified to overcome the risk of poor compliance.</p>
Poor concordance between definitions of type III arch and implications for risk prediction and assessment for carotid artery stenting
<p>Dataset from Marrocco-Trischitta MM, Vitale R, Nava G, Baroni I, Boveri S, Nano G, Secchi F. Poor concordance between definitions of type III arch and implications for risk prediction and assessment for carotid artery stenting. J Vasc Surg. 2021 Apr;73(4):1277-1281. doi: 10.1016/j.jvs.2020.08.142. Epub 2020 Sep 25. PMID: 32987147.</p> <p>Abstract</p> <p><strong>Objective: </strong>The type III arch configuration has been inconsistently reported as a stroke risk factor during carotid artery stenting. However, at least three different methods for the definition of type III arch can be identified in the literature, related to the level of the origin of the innominate artery (IA). According to Casserly's definition, a type III arch presents with an origin of the IA below the horizontal plane of the inner curvature. According to Madhwal's definition, a type III arch has a distance greater than twice the diameter of the left common carotid artery between the highest point of the arch and the origin of the IA. According to MacDonald's definition, a type III arch presents with a distance of ≥2 cm between the highest point of the arch and the origin of the IA. Our aim was to assess the level of concordance between these different methods.</p> <p><strong>Methods: </strong>Anonymized thoracic computed tomography scans of 100 healthy patients were reviewed. Two of us independently stratified the selected cases as a type I to III arch, according to the three considered definitions. The interobserver level of concordance for each type III arch classification and level of concordance among the three definitions were assessed.</p> <p><strong>Results: </strong>The 100 selected patients (64% male) were 76 ± 7 years old. For each definition, the interobserver repeatability was almost perfect for all three (Madhwal, κ = 0.81; 95% confidence interval [CI], 0.71-0.99; MacDonald, κ = 0.82; 95% CI, 0.72-0.92; Casserly, κ = 0.84; 95% CI, 0.74-0.93). The level of concordance among the different definitions was very low (Madhwal vs MacDonald, 85% [P = .002]; 33% for type III arch; Madhwal vs Casserly, 60% [P < .0001]; 12% for type III arch; MacDonald vs Casserly, 75% [P < .0001]; 12% for type III arch).</p> <p><strong>Conclusions: </strong>The three definitions of the type III arch have a very low level of concordance, which might account for the varying clinical relevance of this configuration. Our findings have relevant implications for risk prediction for carotid artery stenting based on the presence of a type III arch, for comparisons of the results from different studies, and for comparisons of different datasets from multicenter trials.</p>
Poor concordance between definitions of type III arch and implications for risk prediction and assessment for carotid artery stenting
<p>Dataset from Marrocco-Trischitta MM, Vitale R, Nava G, Baroni I, Boveri S, Nano G, Secchi F. Poor concordance between definitions of type III arch and implications for risk prediction and assessment for carotid artery stenting. J Vasc Surg. 2021 Apr;73(4):1277-1281. doi: 10.1016/j.jvs.2020.08.142. Epub 2020 Sep 25. PMID: 32987147.</p> <p>Abstract</p> <p><strong>Objective: </strong>The type III arch configuration has been inconsistently reported as a stroke risk factor during carotid artery stenting. However, at least three different methods for the definition of type III arch can be identified in the literature, related to the level of the origin of the innominate artery (IA). According to Casserly's definition, a type III arch presents with an origin of the IA below the horizontal plane of the inner curvature. According to Madhwal's definition, a type III arch has a distance greater than twice the diameter of the left common carotid artery between the highest point of the arch and the origin of the IA. According to MacDonald's definition, a type III arch presents with a distance of ≥2 cm between the highest point of the arch and the origin of the IA. Our aim was to assess the level of concordance between these different methods.</p> <p><strong>Methods: </strong>Anonymized thoracic computed tomography scans of 100 healthy patients were reviewed. Two of us independently stratified the selected cases as a type I to III arch, according to the three considered definitions. The interobserver level of concordance for each type III arch classification and level of concordance among the three definitions were assessed.</p> <p><strong>Results: </strong>The 100 selected patients (64% male) were 76 ± 7 years old. For each definition, the interobserver repeatability was almost perfect for all three (Madhwal, κ = 0.81; 95% confidence interval [CI], 0.71-0.99; MacDonald, κ = 0.82; 95% CI, 0.72-0.92; Casserly, κ = 0.84; 95% CI, 0.74-0.93). The level of concordance among the different definitions was very low (Madhwal vs MacDonald, 85% [P = .002]; 33% for type III arch; Madhwal vs Casserly, 60% [P < .0001]; 12% for type III arch; MacDonald vs Casserly, 75% [P < .0001]; 12% for type III arch).</p> <p><strong>Conclusions: </strong>The three definitions of the type III arch have a very low level of concordance, which might account for the varying clinical relevance of this configuration. Our findings have relevant implications for risk prediction for carotid artery stenting based on the presence of a type III arch, for comparisons of the results from different studies, and for comparisons of different datasets from multicenter trials.</p>
Identity construction among remotely acculturated non-migrant Africans: Psychological and social Implications.
<p>The data was collected among 504 young adults. 90 of the respondents were excluded because they did not complete the survey thereby bringing the number to 414 which was analyzed in the study. Participants had been informed ahead of time a week before the administration of the questionnaire. The sample was drawn among first year students of a university in south west Nigeria. All the students who showed interest in the research through their class representatives participated in the study. The students were sufficiently briefed before the study and were assured on confidentiality and anonymity during and after the study. The number of students who showed interest at first were 120 in all, The link to the survey was subsequently sent to them and were encouraged to share the link with at least two of their colleagues and friends who may also be interested. The questionnaire was completed online through a secure survey system hosted and maintained by Sosci Survey with the website address httpp//www.sosci/survey.den/. Participants who presented the screenshots of the last page of the completed survey and that of the shared and completed survey of more than five friends in the faculty got an internet data of $1 on their phones as a compensation for the cost of data used to complete the survey and share with others.</p>
Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis
<p>Angiotensin-converting enzyme 2 (ACE2) is a receptor for the spike protein of SARS-COV-2 that allows viral binding and entry and is expressed on the surface of several pulmonary and non-pulmonary cell types, with induction of a "cytokine storm" upon binding. Other cell types present the receptor and can be infected, including cardiac, renal, intestinal, and endothelial cells. High ACE2 levels protect from inflammation. Despite the relevance of ACE2 levels in COVID-19 pathogenesis, experimental studies to comprehensively address the question of ACE2 regulations are still limited. A relevant observation from the clinic is that, besides the pro-inflammatory cytokines, such as IL-6 and IL-1β, the anti-inflammatory cytokine IL-10 is also elevated in worse prognosis patients. This could represent somehow a "danger signal", an alarmin from the host organism, given the immuno-regulatory properties of the cytokine. Here, we investigated whether IL-10 could increase ACE2 expression in the lung-derived Calu-3 cell line. We provided preliminary evidence of ACE2 mRNA increase in cells of lung origin <em>in vitro</em>, following IL-10 treatment. Endothelial cell infection by SARS-COV-2 is associated with vasculitis, thromboembolism, and disseminated intravascular coagulation. We confirmed ACE2 expression enhancement by IL-10 treatment also on endothelial cells. The sartans (olmesartan and losartan) showed non-statistically significant ACE2 modulation in Calu-3 and endothelial cells, as compared to untreated control cells. We observed that the antidiabetic biguanide metformin, a putative anti-inflammatory agent, also upregulates ACE2 expression in Calu-3 and endothelial cells. We hypothesized that IL-10 could be a danger signal, and its elevation could possibly represent a feedback mechanism fighting inflammation. Although further confirmatory studies are required, inducing IL-10 upregulation could be clinically relevant in COVID-19-associated acute respiratory distress syndrome (ARDS) and vasculitis, by reinforcing ACE2 levels.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.