Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,920
datasets available to search
ShareScore release 0.9.0
Dataset results
7,920 results for “implications”
Heart Rate Variability from Wearable Photoplethysmography Systems: Implications in Sleep Studies at High Altitude (dataset)
<p>public anonymized dataset of the main findings of the study</p> <p>Abstract:</p> <p>The interest in photoplethysmography (PPG) for sleep monitoring is increasing because PPG may allow assessing the heart rate variability (HRV), which is particularly important in breathing disorders. Thus, we aim to evaluate how PPG wearable systems measure HRV during sleep at high altitudes, where hypobaric hypoxia induces respiratory disturbances. We considered PPG and electrocardiographic recordings in 21 volunteers sleeping at 4554m asl (as a model of sleep breathing disorder), and 5 alpine guides sleeping at sea level, 6000m and 6800m asl. Power spectra, multiscale entropy, and self-similarity were calculated for PPG tachograms and electrocardiography R-R intervals (RRI). Results demonstrated that wearable PPG devices provide HRV measures even at extremely high altitudes. However, the comparison between PPG tachograms and RRI showed discrepancies in the faster spectral components and at the shorter scales of self-similarity and entropy (TABLE 1). Furthermore, the changes in sleep HRV from sea level to extremely high altitudes quantified by RRI and PPG tachograms in the 5 alpine guides tended to be different at the faster frequencies and shorter scales (TABLE 2). Discrepancies may be explained by modulations of pulse wave velocity and should be considered to interpret correctly autonomic alterations during sleep from HRV analysis.</p>
Safety Implications of Modulating Nuclear Receptors: A Comprehensive Analysis from Non-Clinical and Clinical Perspectives" Mohan Rao*!, Eric McDuffie!, Sanjay Srivastava+ and Warren Plaisted$ and Clifford Sachs!
Open the record for dataset details and reuse information.
Morphometry and Evolution of Sinkholes on the Western Shore of the Dead Sea. Implications for Spatial Prediction
<p>Dataset of the paper titled: Morphometry and Evolution of Sinkholes on the Western Shore of the Dead Sea. Implications for Spatial Prediction</p>
Does the Synergy Model Implementation Improve the Transition from In-Hospital to Primary Care? The Experience from an Italian Cardiac Surgery Unit, Perspectives, and Future Implications
<p>Dellafiore F, Caruso R, Nania T, Pittella F, Fiorini T, Caruso MP, Zaffino G, Stievano A, Arrigoni C. Does the Synergy Model Implementation Improve the Transition from In-Hospital to Primary Care? The Experience from an Italian Cardiac Surgery Unit, Perspectives, and Future Implications. Int J Environ Res Public Health. 2022 May 5;19(9):5624. doi: 10.3390/ijerph19095624. PMID: 35565012; PMCID: PMC9105911.</p> <p>Abstract</p> <p>The demand for care services in the healthcare system has changed and is triggering a smooth transition from in-hospital to primary care. In this regard, patient-centered-care models of care delivery might provide a framework to follow patients' journeys throughout their transition between different levels of care. Accordingly, an Italian research group at a cardiac hospital in Northern Italy implemented the Synergy Model in a Cardiac Surgery Unit, a patient-centered-care model, and is using the framework of the model to guide a smooth transition of patients towards rehabilitation and primary care after their hospitalization. This discursive paper is focused on the experience, perspectives, and future implications of adopting the Synergy Model to facilitate the transition from in-hospital to primary care. The presented experience and discussion might be helpful to the international debate regarding the strategies to boost a smooth transition from in-hospital to primary care.</p>
Endothelial cells present an innate resistance to glucocorticoid treatment: implications for therapy of primary vasculitis
GEO Series GSE25269. Homo sapiens. 4 samples. Type: Expression profiling by array.
Focal amplification of HOXD-harboring chromosome region is implicated in multiple-walled carbon nanotubes-induced carcinogenicity
GEO Series GSE46542. Homo sapiens. 14 samples. Type: Expression profiling by array.
Systematic mapping of 2’-O-methylation sites in rRNAs implicates new strategy for ribose methylation in Arabidopsis [20ME]
GEO Series GSE150455. Arabidopsis thaliana. 8 samples. Type: Expression profiling by high throughput sequencing.
Pathway based integrative analysis reveals a key role for the hexosamine biosynthetic pathway in prostate cancer progression with therapeutic implications
GEO Series GSE50661. Homo sapiens. 16 samples. Type: Expression profiling by array.
Cambrian–Silurian sedimentary processes and provenance with basin shift in southeastern Qilian Orogenic Belt: implications for crustal and tectonic evolution in northern Proto-Tethyan realm
<p>This datatset contains detrital zircon U-Pb-Hf isotope, whole-rock major and trace elemental, and Nd isotopic data of the Cambrian to Silurian sedimentary rocks in the southeastern Qilian Orogenic Belt.</p>
Mothers' and fathers' early tactile contact behaviors during triadic and dyadic parent-infant interactions immediately after birth and at 3-months postpartum: Implications for early care behaviors and intervention
<p>Raw data of the study "Mothers’ and fathers’ early tactile contact behaviors during triadic and dyadic parent-infant interactions immediately after birth and at 3-months postpartum: Implications for early care behaviors and intervention" :Mothers’ and fathers’ touch were investigated during their first naturalistic interaction with their newborns, and maternal touch was predicted from newborn to 3-months postpartum during the Still-Face (SF) procedure. Both parents displayed more nurturing types of touch when interacting with their infants for the first time. Maternal touch at newborn predicted maternal touch after, but not before, the SF 3-months later; more touch after birth was associated with more soothing, regulating, types of maternal touch following the SF, suggesting that the nature of these interactive contexts (post-birth, post-SF) may be parallel</p>
Interactions Between Antiepileptic and Antibiotic Drugs: A Systematic Review and Meta-Analysis with Dosing Implications.
<p>Raw data. Contains clinical, pharmacological, epileptological and microbiological data analyzed in the article.</p>
Lithospheric structure of the southern Amazonian Craton from multiple-frequency seismic tomography: Preliminary insights on tectonic and metallogenic implications
<p>Multiple-frequency tomographic model database for the Amazonian craton submitted to Geophysical Journal International</p>
Supplemental Material for Leite et al: Duodenal microbiome changes in postmenopausal women: effects of hormone therapy and implications for cardiovascular risk
<p>Supplemental Material for Leite et al: Duodenal microbiome changes in postmenopausal women: effects of hormone therapy and implications for cardiovascular risk</p>
Progressive failure analysis of slip zone soils with strain-softening behavior and implications for landslide triggering mechanisms
<p>Figure for paper entitled “Progressive failure analysis of slip zone soils with strain-softening behavior and implications for landslide triggering mechanisms”</p>
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD
<p><em>C9ORF72</em>-derived dipeptide repeat proteins have emerged as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). However, the mechanisms underlying their expression are not fully understood. Here, we demonstrate that ZNF598, the rate-limiting factor for ribosome-associated quality control (RQC), co-translationally titrates the expression of <em>C9ORF72</em>-derived poly(GR) protein. A <em>Drosophila</em> genetic screen identified key RQC factors as potent modifiers of poly(GR)-induced neurodegeneration. ZNF598 overexpression in human neuroblastoma cells inhibited the nuclear accumulation of poly(GR) protein and decreased its cytotoxicity, whereas <em>ZNF598</em> deletion had opposing effects. Poly(GR)-encoding sequences in the reporter RNAs caused translational stalling and generated ribosome-associated translation products, sharing molecular signatures with canonical RQC substrates. Furthermore, ZNF598 and listerin 1, the RQC E3 ubiquitin-protein ligase, promoted poly(GR) degradation via the ubiquitin-proteasome pathway. An ALS-relevant ZNF598<sup>R69C</sup> mutant displayed loss-of-function effects on poly(GR) expression, as well as on general RQC. Moreover, RQC function was impaired in C9-ALS patient-derived neurons, whereas lentiviral overexpression of ZNF598 lowered their poly(GR) expression and suppressed proapoptotic caspase-3 activation. Taken together, we propose that an adaptive nature of the RQC-relevant ZNF598 activity allows the co-translational surveillance to cope with the atypical expression of pathogenic poly(GR) protein, thereby acquiring a neuroprotective function in C9-ALS/FTD.</p>
Nitrogen retention in feldspar: Implications for nitrogen transport in subduction zones
<p>This is the research data for Figures 2, 3 and 4.</p>
New paleomagnetic results of the Upper Cretaceous to Lower Eocene sedimentary rocks from the Xigaze forearc basin and their tectonic implications
<p>This is a Supplementary Information for a manuscript submitted to JGR: Solid Earth entitled "New paleomagnetic results of the Upper Cretaceous to Lower Eocene sedimentary rocks from the Xigaze forearc basin and their tectonic implications".</p>
Dataset related to article"THE SPTLC1 P.S331 MUTATION BRIDGES SENSORY NEUROPATHY AND MOTOR NEURON DISEASE AND HAS IMPLICATIONS FOR TREATMENT"
<p><strong>cmt gene panel data of SPTLC1 case</strong></p>
Data from: Conservation implications of sex-specific landscape suitability for a large generalist carnivore
Aim: Terrestrial mammal distribution models typically do not differentiate between sexes when making spatial predictions, which could have important conservation implications. As male carnivores are usually more risk tolerant and travel longer distances, male potential range should be larger and include more human modified areas than female range. To evaluate if differences between females and males could influence their conservation planning, we quantified sex-specific suitable range for a recolonizing population of American black bears (Ursus americanus). Location: We applied this method in Missouri, USA. Methods: We collected telemetry data from 57 females and 43 male bears from 2010 to 2018. We used three machine-learning methods (generalized boosted regression, random forest, and Maximum entropy) to develop sex-specific distribution models, which were combined into a weight-averaged ensemble model, and converted into a binary (presence/absence) model using an optimized threshold. We used 80% of individuals for each sex as training data, and 20% as evaluation data. Results: All models had high predictive performance; the greatest uncertainty in model predictions corresponded with the periphery of the distributions, whereas there was high agreement in the core distribution. Male suitable range was 66% larger than female range, and males were predicted to occur in more human-modified areas and more likely to be present in developed land and agriculture. Main conclusions: Distribution models based on data from both sexes, or that is male-biased, could overestimate the female (i.e. reproductive) range and potentially misrepresent the biologically relevant species distribution. This bias can potentially lead to misguided decisions and suboptimal use of resources. By improving models when sex-specific data is available, we can better focus resources in areas where there is reproductive potential, leading to more accurate assessments of species' conservation status and better identifying areas vital for species persistence.
Re-evaluating the genetic variation of the COI gene of Insecta: Implications for DNA barcoding, metabarcoding and species delimitation studies
<p>To analyze the genetic variation of the <i>cytochrome c oxidase subunit I</i> (<i>COI</i>) gene of Insecta, the <i>COI</i> data of Insecta was downloaded from GenBank and the intraspecific Kimura-2 -parameter (K2P) distance of 40,782 species was calculated (each species with three or more sequences). Our result indicated that the maximum intraspecific genetic distance of 8,928 (21.89%) species was over 3%. Using a threshold of 3% in the clustering analysis, 7,123 (17.47%) species can be divided into two or more clusters. We also analyzed 3,189 genera with over three species (25,283 species) and found that the optimal thresholds for these genera ranged from 0.1%-15.7% (average value: 0.03531, median value: 0.02900). In clustering analysis, if the threshold values were set to 0.01, 0.02, 0.022, and 0.03, the numbers of clusters were 39,860, 31,024, 29,954, and 26,527, respectively. In metabarcoding studies, a threshold of 0.03 was recommended to estimate the species diversity of insects in a certain environment. However, using the empirical thresholds mentioned above for operational taxonomic unit (OTU) picking, the average match ratios of the 3,189 genera were 0.5137, 0.6338, 0.6440, and 0.6587. By contrast, if the possible thresholds from the distance matrix, the minimum interspecific genetic distance of congeneric species, and the optimal thresholds were used in clustering analysis, the average match ratios of them were 0.6626 0.7530, and 0.7549. Herein, we recommended the utilizations of the minimum interspecific genetic distance (when it was greater than or equal to 2%) and the optimal thresholds for OTU picking in DNA barcoding and species delimitation studies based on the <i>COI</i> gene of insects.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.