Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,224
datasets available to search
ShareScore release 0.9.0
Dataset results
1,224 results for “1-1”
Kinesin-1 activity recorded in living cells with a precipitating dye FIB-SEM data 1
<p>Kinesin-1 activity recorded in living cells with a precipitating dye</p> <p>FIB-SEM dataset 1 - QPDTf precipitating dye with HeLa cells</p> <p> </p>
Dataset for paper "1-to-1 or 1-to-n? Investigating the effect of function inlining on binary similarity analysis"
<p>This is the dataset constructed and used in the paper "1-to-1 or 1-to-n? Investigating the effect of function inlining on binary similarity analysis". </p> <p>We release it with its ground truth labels to facilitate further research in binary similarity analysis under function inlining. Besides, we also welcome others to find miss-labeling in this dataset and fix them. We hope our dataset could help researchers conduct their studies and improve the binary similarity analysis techniques.</p> <p>Binaries of dataset-I can also be accessed from https://github.com/SoftSec-KAIST/BinKit. It is named the "normal dataset".</p> <p>Any miss-labeling can be reported at https://github.com/island255/TOSEM2022.</p> <p>Using this dataset, please cite our paper, "1-to-1 or 1-to-n? Investigating the effect of function inlining on binary similarity analysis".</p>
Coordinates and output files for stationary points determined for the reaction between 1,4-ditrimethylsilyl-1,4-dihydropyridine and unsaturated nitriles.
<p>The .zip folder contains coordinates and output files (containing energies and frequencies) of the different stationary points found for the analyzed reactions, all of them in .xyz format. IRC output files are also included.</p>
Figure 1 in Quantitative phosphoproteomic analysis of chicken DF-1 cells infected with Eimeria tenella, using tandem mass tag (TMT) and parallel reaction monitoring (PRM) mass spectrometry
Figure 1. Proportion of serine, threonine, and tyrosine in phosphorylation sites.
Figure 1. Motorised fishing boat near Bally-1 in Notes on the record of Gymnothorax pseudotile Mohapatra et al., 2017 (Muraenidae: Muraeninae) from the Sundarbans, West Bengal, India
Figure 1. Motorised fishing boat near Bally-1 Island, buffer area of STR.
Fig. 1 in Isotopic discrimination and persistence of the C marker in adults of Anastrepha fraterculus (Diptera: Tephritidae) Brazilian-1 morphotype
Fig. 1. Schematic view of the diet switching experiments.
Role of supraspinal sphingosine-1-phosphate receptor 1 in neuropathic pain
<p><span>An unbiased transcriptomic analysis of the RVM was used to identify genes affected by nerve injury and the impact of S1PR1 antagonism. </span></p>
Single-cell RNA-Seq and TCR-Seq analysis of PD-1+ CD8+ T-cells responding to anti-PD-1 and anti-PD-1/CTLA-4 immunotherapy in melanoma
<p><strong>This dataset details the scRNASeq and TCR-Seq analysis of sorted PD-1+ CD8+ T cells from patients with melanoma treated with checkpoint therapy (anti-PD-1 monotherapy and anti-PD-1 & anti-CTLA-4 combination therapy) at baseline and after the first cycle of therapy. A major publication using this dataset is accessible here: (reference) </strong></p> <p> </p> <p><strong>*experimental design</strong></p> <p> Single-cell RNA sequencing was performed using 10x Genomics with feature barcoding technology to multiplex cell samples from different patients undergoing mono or dual therapy so that they can be loaded on one well to reduce costs and minimize technical variability. Hashtag oligomers (oligos) were obtained as purified and already oligo-conjugated in TotalSeq-C format from BioLegend. Cells were thawed, counted and 20 million cells per patient and time point were used for staining. Cells were stained with barcoded antibodies together with a staining solution containing antibodies against CD3, CD4, CD8, PD-1/IgG4 and fixable viability dye (eBioscience) prior to FACS sorting. Barcoded antibody concentrations used were 0.5 µg per million cells, as recommended by the manufacturer (BioLegend) for flow cytometry applications. After staining, cells were washed twice in PBS containing 2% BSA and 0.01% Tween 20, followed by centrifugation (300 xg 5 min at 4 °C) and supernatant exchange. After the final wash, cells were resuspended in PBS and filtered through 40 µm cell strainers and proceeded for sorting. Sorted cells were counted and approximately 75,000 cells were processed through 10x Genomics single-cell V(D)J workflow according to the manufacturer’s instructions. Gene expression, hashing and TCR libraries were pooled to desired quantities to obtain the sequencing depths of 15,000 reads per cell for gene expression libraries and 5,000 reads per cell for hashing and TCR libraries. Libraries were sequenced on a NovaSeq 6000 flow cell in a 2X100 paired-end format.</p> <p> </p> <p><strong>*extract protocol</strong></p> <p> PBMCs were thawed, counted and 20 million cells per patient and time point were used for staining. Cells were stained with barcoded antibodies together with a staining solution containing antibodies against CD3, CD4, CD8, PD-1/IgG4 and fixable viability dye (eBioscience) prior to FACS sorting. Barcoded antibody concentrations used were 0.5 µg per million cells, as recommended by the manufacturer (BioLegend) for flow cytometry applications. After staining, cells were washed twice in PBS containing 2% BSA and 0.01% Tween 20, followed by centrifugation (300 xg 5 min at 4 °C) and supernatant exchange. After the final wash, cells were resuspended in PBS and filtered through 40 µm cell strainers and proceeded for sorting. Sorted cells were counted and approximately 75,000 cells were processed through 10x Genomics single-cell V(D)J workflow according to the manufacturer’s instructions.</p> <p> </p> <p><strong>*library construction protocol</strong></p> <p> Sorted cells were counted and approximately 75,000 cells were processed through 10x Genomics single-cell V(D)J workflow according to the manufacturer’s instructions. Gene expression, hashing and TCR libraries were pooled to desired quantities to obtain the sequencing depths of 15,000 reads per cell for gene expression libraries and 5,000 reads per cell for hashing and TCR libraries. Libraries were sequenced on a NovaSeq 6000 flow cell in a 2X100 paired-end format.</p> <p> </p> <p><strong>*library strategy</strong></p> <p> scRNA-seq and scTCR-seq</p> <p> </p> <p><strong>*data processing step</strong></p> <p> Pre-processing of sequencing results to generate count matrices (gene expression and HTO barcode counts) was performed using the 10x genomics Cell Ranger pipeline.</p> <p> Further processing was done with Seurat (cell and gene filtering, hashtag identification, clustering, differential gene expression analysis based on gene expression).</p> <p> </p> <p> <strong>*genome build/assembly</strong></p> <p> Alignment was performed using prebuilt Cell Ranger human reference GRCh38.</p> <p> </p> <p><strong>*processed data files format and content</strong></p> <p> RNA counts and HTO counts are in sparse matrix format and TCR clonotypes are in csv format.</p> <p>Datasets were merged and analyzed by Seurat and the analyzed objects are in rds format.</p> <p> </p> <table> <tbody> <tr> <td> <p><strong>file name</strong></p> </td> <td> <p><strong>file checksum</strong></p> </td> </tr> <tr> <td> <p>PD1CD8_160421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>da2e006d2b39485fd8cf8701742c6d77</p> </td> </tr> <tr> <td> <p>PD1CD8_190421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>e125fc5031899bba71e1171888d78205</p> </td> </tr> <tr> <td> <p>PD1CD8_160421_filtered_contig_annotations.csv</p> </td> <td> <p>927241805d507204fbe9ef7045d0ccf4</p> </td> </tr> <tr> <td> <p>PD1CD8_190421_filtered_contig_annotations.csv</p> </td> <td> <p>8ca544d27f06e66592b567d3ab86551e</p> </td> </tr> </tbody> </table> <p> </p> <table> <tbody> <tr> <td> <p><strong>*processed data file </strong></p> </td> <td> <p><strong>antibodies/tags</strong></p> </td> </tr> <tr> <td> <p>PD1CD8_160421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>none</p> </td> </tr> <tr> <td> <p>PD1CD8_160421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>TotalSeq™-C0251 anti-human Hashtag 1 Antibody - (HASH_1) - M1_base_monotherapy<br>TotalSeq™-C0252 anti-human Hashtag 2 Antibody - (HASH_2) - M1_post_monotherapy<br>TotalSeq™-C0253 anti-human Hashtag 3 Antibody - (HASH_3) - C1_base_combined_therapy<br>TotalSeq™-C0254 anti-human Hashtag 4 Antibody - (HASH_4) - C1_post_combined_therapy<br>TotalSeq™-C0255 anti-human Hashtag 5 Antibody - (HASH_5) - C2_base_combined_therapy<br>TotalSeq™-C0256 anti-human Hashtag 6 Antibody - (HASH_6) - C2_post_combined_therapy</p> </td> </tr> <tr> <td> <p>PD1CD8_160421_filtered_contig_annotations.csv</p> </td> <td> <p>none</p> </td> </tr> <tr> <td> <p>PD1CD8_190421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>none</p> </td> </tr> <tr> <td> <p>PD1CD8_190421_filtered_feature_bc_matrix.zip</p> </td> <td> <p>TotalSeq™-C0251 anti-human Hashtag 1 Antibody - (HASH_1) - M2_base_monotherapy<br>TotalSeq™-C0252 anti-human Hashtag 2 Antibody - (HASH_2) - M2_post_monotherapy<br>TotalSeq™-C0253 anti-human Hashtag 3 Antibody - (HASH_3) - M3_base_monotherapy<br>TotalSeq™-C0254 anti-human Hashtag 4 Antibody - (HASH_4) - M3_post_monotherapy<br>TotalSeq™-C0255 anti-human Hashtag 5 Antibody - (HASH_5) - C3_base_combined_therapy<br>TotalSeq™-C0256 anti-human Hashtag 6 Antibody - (HASH_6) - C3_post_combined_therapy</p> </td> </tr> <tr> <td> <p>PD1CD8_190421_filtered_contig_annotations.csv</p> </td> <td> <p>none</p> </td> </tr> </tbody> </table> <p> </p>
Raw, unprocessed SEM data images for: Figure 1: Scanning electron microscope images of "type-1 bone collagen" demineralized bone matrix fibrils
<p>Raw, unprocessed SEM data images for Figure 1 of the manuscript: Scanning electron microscope images of "type-1 bone collagen" demineralized bone matrix fibrils. (A) Fibrils from the <em>B</em>. <em>taurus</em> extant long bone control. Prominent banding (~67nm) is present that is characteristic of type-1 collagen protein fibrils (Boatman et al., 2019; Gottardi et al., 2016; Lin et al., 1993; Rabotyagova et al., 2008; Tzaphlidou, 2005). (B) Permafrost YG 610.2397 <em>M</em>. <em>primigenius</em> demineralized bone matrix fibrils. An ~67nm banding pattern on the fibrils is also observed but is somewhat less distinct in comparison to that of the extant <em>B</em>. <em>taurus</em> specimen. (C) Observed fibril structures in the temperate MOR 91.72 <em>M</em>. <em>columbi</em> specimen. Fibril banding is generally absent, suggesting the original chemical state of the type-1 collagen fibrils/sequences is substantially altered.</p>
2DeteCT - A large 2D expandable, trainable, experimental Computed Tomography dataset for machine learning: Slices 1-1,000
<p>This upload contains slices 1 – 1,000 from the data collection described in</p> <p>Maximilian B. Kiss, Sophia B. Coban, K. Joost Batenburg, Tristan van Leeuwen, and Felix Lucka “"2DeteCT - A large 2D expandable, trainable, experimental Computed Tomography dataset for machine learning", <a href="https://doi.org/10.1038/s41597-023-02484-6"><em>Sci Data</em> <strong>10</strong>, 576 (2023)</a> or <a href="https://arxiv.org/abs/2306.05907">arXiv:2306.05907 (2023)</a></p> <p>Abstract:<br> "Recent research in computational imaging largely focuses on developing machine learning (ML) techniques for image reconstruction, which requires large-scale training datasets consisting of measurement data and ground-truth images. However, suitable experimental datasets for X-ray Computed Tomography (CT) are scarce, and methods are often developed and evaluated only on simulated data. We fill this gap by providing the community with a versatile, open 2D fan-beam CT dataset suitable for developing ML techniques for a range of image reconstruction tasks. To acquire it, we designed a sophisticated, semi-automatic scan procedure that utilizes a highly-flexible laboratory X-ray CT setup. A diverse mix of samples with high natural variability in shape and density was scanned slice-by-slice (5000 slices in total) with high angular and spatial resolution and three different beam characteristics: A high-fidelity, a low-dose and a beam-hardening-inflicted mode. In addition, 750 out-of-distribution slices were scanned with sample and beam variations to accommodate robustness and segmentation tasks. We provide raw projection data, reference reconstructions and segmentations based on an open-source data processing pipeline."</p> <p>The data collection has been acquired using a highly flexible, programmable and custom-built X-ray CT scanner, the FleX-ray scanner, developed by <a href="https://info.tescan.com/micro-ct">TESCAN-XRE NV,</a> located in the FleX-ray Lab at the <a href="https://www.cwi.nl/en/">Centrum Wiskunde & Informatica (CWI)</a> in Amsterdam, Netherlands. It consists of a cone-beam microfocus X-ray point source (limited to 90 kV and 90 W) that projects polychromatic X-rays onto a 14-bit CMOS (complementary metal-oxide semiconductor) flat panel detector with CsI(Tl) scintillator (Dexella 1512NDT) and 1536-by-1944 pixels, <span class="math-tex">\(74.8\mu m^2\)</span> each. To create a 2D dataset, a fan-beam geometry was mimicked by only reading out the central row of the detector. Between source and detector there is a rotation stage, upon which samples can be mounted. The machine components (i.e., the source, the detector panel, and the rotation stage) are mounted on translation belts that allow the moving of the components independently from one another.</p> <p>Please refer to the paper for all further technical details.</p> <p>The complete dataset can be found via the following links: <a href="https://doi.org/10.5281/zenodo.8014758">1-1000</a>, <a href="https://doi.org/10.5281/zenodo.8014766">1001-2000</a>, <a href="https://doi.org/10.5281/zenodo.8014787">2001-3000</a>, <a href="https://doi.org/10.5281/zenodo.8014829">3001-4000</a>, <a href="https://doi.org/10.5281/zenodo.8014874">4001-5000</a>, <a href="https://doi.org/10.5281/zenodo.8014907">OOD</a>.<br> The reference reconstructions and segmentations can be found via the following links: <a href="https://doi.org/10.5281/zenodo.8017583">1-1000</a>, <a href="https://doi.org/10.5281/zenodo.8017604">1001-2000</a>, <a href="https://doi.org/10.5281/zenodo.8017612">2001-3000</a>, <a href="https://doi.org/10.5281/zenodo.8017618">3001-4000</a>, <a href="https://doi.org/10.5281/zenodo.8017624">4001-5000</a>, <a href="https://doi.org/10.5281/zenodo.8017653">OOD</a>.</p> <p>The corresponding Python scripts for loading, pre-processing, reconstructing and segmenting the projection data in the way described in the paper can be found on <a href="https://github.com/mbkiss/2DeteCTcodes">github</a>. A machine-readable file with the used scanning parameters and instrument data for each acquisition mode as well as a script loading it can be found on the GitHub repository as well.</p> <p>Note: It is advisable to use the graphical user interface when decompressing the .zip archives. If you experience a zipbomb error when unzipping the file on a Linux system rerun the command with the UNZIP_DISABLE_ZIPBOMB_DETECTION=TRUE environment variable by setting in your .bashrc “export UNZIP_DISABLE_ZIPBOMB_DETECTION=TRUE”.</p> <p>For more information or guidance in using the data collection, please get in touch with</p> <p> Maximilian.Kiss [at] cwi.nl</p> <p> Felix.Lucka [at] cwi.nl</p>
2DeteCT - A large 2D expandable, trainable, experimental Computed Tomography dataset for machine learning: Slices 1-1,000 (reference reconstructions and segmentations)
<p>This upload contains the reference reconstructions and segmentation of slices 1 – 1,000 from the data collection described in</p> <p>Maximilian B. Kiss, Sophia B. Coban, K. Joost Batenburg, Tristan van Leeuwen, and Felix Lucka “"2DeteCT - A large 2D expandable, trainable, experimental Computed Tomography dataset for machine learning", <a href="https://doi.org/10.1038/s41597-023-02484-6"><em>Sci Data</em> <strong>10</strong>, 576 (2023)</a> or <a href="https://arxiv.org/abs/2306.05907">arXiv:2306.05907 (2023)</a></p> <p>Abstract:<br> "Recent research in computational imaging largely focuses on developing machine learning (ML) techniques for image reconstruction, which requires large-scale training datasets consisting of measurement data and ground-truth images. However, suitable experimental datasets for X-ray Computed Tomography (CT) are scarce, and methods are often developed and evaluated only on simulated data. We fill this gap by providing the community with a versatile, open 2D fan-beam CT dataset suitable for developing ML techniques for a range of image reconstruction tasks. To acquire it, we designed a sophisticated, semi-automatic scan procedure that utilizes a highly-flexible laboratory X-ray CT setup. A diverse mix of samples with high natural variability in shape and density was scanned slice-by-slice (5000 slices in total) with high angular and spatial resolution and three different beam characteristics: A high-fidelity, a low-dose and a beam-hardening-inflicted mode. In addition, 750 out-of-distribution slices were scanned with sample and beam variations to accommodate robustness and segmentation tasks. We provide raw projection data, reference reconstructions and segmentations based on an open-source data processing pipeline."</p> <p>The data collection has been acquired using a highly flexible, programmable and custom-built X-ray CT scanner, the FleX-ray scanner, developed by <a href="https://info.tescan.com/micro-ct">TESCAN-XRE NV,</a> located in the FleX-ray Lab at the <a href="https://www.cwi.nl/en/">Centrum Wiskunde & Informatica (CWI)</a> in Amsterdam, Netherlands. It consists of a cone-beam microfocus X-ray point source (limited to 90 kV and 90 W) that projects polychromatic X-rays onto a 14-bit CMOS (complementary metal-oxide semiconductor) flat panel detector with CsI(Tl) scintillator (Dexella 1512NDT) and 1536-by-1944 pixels, <span class="math-tex">\(74.8\mu m^2\)</span> each. To create a 2D dataset, a fan-beam geometry was mimicked by only reading out the central row of the detector. Between source and detector there is a rotation stage, upon which samples can be mounted. The machine components (i.e., the source, the detector panel, and the rotation stage) are mounted on translation belts that allow the moving of the components independently from one another.</p> <p>Please refer to the paper for all further technical details.</p> <p>The complete dataset can be found via the following links: <a href="https://doi.org/10.5281/zenodo.8014758">1-1000</a>, <a href="https://doi.org/10.5281/zenodo.8014766">1001-2000</a>, <a href="https://doi.org/10.5281/zenodo.8014787">2001-3000</a>, <a href="https://doi.org/10.5281/zenodo.8014829">3001-4000</a>, <a href="https://doi.org/10.5281/zenodo.8014874">4001-5000</a>, <a href="https://doi.org/10.5281/zenodo.8014907">OOD</a>.<br> The reference reconstructions and segmentations can be found via the following links: <a href="https://doi.org/10.5281/zenodo.8017583">1-1000</a>, <a href="https://doi.org/10.5281/zenodo.8017604">1001-2000</a>, <a href="https://doi.org/10.5281/zenodo.8017612">2001-3000</a>, <a href="https://doi.org/10.5281/zenodo.8017618">3001-4000</a>, <a href="https://doi.org/10.5281/zenodo.8017624">4001-5000</a>, <a href="https://doi.org/10.5281/zenodo.8017653">OOD</a>.</p> <p>The corresponding Python scripts for loading, pre-processing, reconstructing and segmenting the projection data in the way described in the paper can be found on <a href="https://github.com/mbkiss/2DeteCTcodes">github</a>. A machine-readable file with the used scanning parameters and instrument data for each acquisition mode as well as a script loading it can be found on the GitHub repository as well.</p> <p>Note: It is advisable to use the graphical user interface when decompressing the .zip archives. If you experience a zipbomb error when unzipping the file on a Linux system rerun the command with the UNZIP_DISABLE_ZIPBOMB_DETECTION=TRUE environment variable by setting in your .bashrc “export UNZIP_DISABLE_ZIPBOMB_DETECTION=TRUE”.</p> <p>For more information or guidance in using the data collection, please get in touch with</p> <p> Maximilian.Kiss [at] cwi.nl</p> <p> Felix.Lucka [at] cwi.nl</p>
Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-1).
ClinicalTrials.gov study NCT03478254. IPD Sharing: YES. Countries: 1. Publications: 6.
Study to Evaluate the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
ClinicalTrials.gov study NCT01095796. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Anti-MART-1 F5 Cells Plus ALVAC MART-1 Vaccine to Treat Advanced Melanoma
ClinicalTrials.gov study NCT00612222. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Bone Mineral Density in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Adult Subjects Switching From a Tenofovir Regimen to a Dolutegravir Plus Rilpivirine Regimen
ClinicalTrials.gov study NCT02478632. IPD Sharing: YES. Countries: 6. Publications: 1.
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail
ClinicalTrials.gov study NCT02340338. IPD Sharing: NO. Countries: 1. Publications: 1.
Study to Evaluate the Safety and Efficacy of Stribild Versus Ritonavir-Boosted Atazanavir Plus Truvada in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
ClinicalTrials.gov study NCT01106586. IPD Sharing: Not stated. Countries: 17. Publications: 3.
Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)
ClinicalTrials.gov study NCT03661541. IPD Sharing: NO. Countries: 1. Publications: 1.
Orbital Radiotherapy in Grave's Ophthalmopathy 1 Week vs 2 Weeks (OraGO-1 Trial)
ClinicalTrials.gov study NCT06392906. IPD Sharing: YES. Countries: 1. Publications: 11.
Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
ClinicalTrials.gov study NCT00233519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.