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185 results for “Anthracyclines”
Data from: Anthracycline drugs on modified surface of quercetin-loaded polymer nanoparticles: a dual drug delivery model for cancer treatment
Polymer nanoparticles are vehicles used for delivery of hydrophobic anti-cancer drugs, like doxorubicin, paclitaxel or chemopreventors like quercetin (Q). The present study deals with the synthesis and characterisation of nano formulations (NFs) from Q loaded PLGA (poly lactic-co-glycolic acid) nano particles (NPs) by surface modification. The surface of Q-loaded (NPs) is modified by coating with biopolymers like bovine serum albumin (BSA) or histones (His). Conventional chemotherapeutic drugs adriamycin (ADR) and mitoxantrone (MTX) are bound to BSA and His respectively before being coated on Q-loaded NPs to nano formulate NF1 and NF2 respectively. The sizes of these NFs are in the range 400-500 nm as ascertained by SEM and DLS measurements. Encapsulation of Q in polymer NPs is confirmed from shifts in FT-IR, TGA and DSC traces of Q-loaded NPs compared to native PLGA and Q. Surface modification in NFs is evidenced by three distinct regions in their TEM images; the core, polymer capsule and the coated surface. Negative zeta potential of Q-loaded NPs shifted to positive potential on surface modification in NF1 and NF2. In vitro release of Q from the NFs lasted up to twenty days with an early burst release. NF2 is better formulation than NF1 as loading of MTX is 85% compared to 23% loading of ADR. Such NFs are expected to overcome multi-drug resistance (MDR) by reaching and treating the target cancerous cells by virtue of size, charge and retention.
Treatment of Patients With Diffuse Large B Cell Lymphoma Who Are Not Suitable for Anthracycline Containing Chemotherapy
ClinicalTrials.gov study NCT01679119. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin
ClinicalTrials.gov study NCT02096588. IPD Sharing: NO. Countries: 1. Publications: 0.
Enalapril After Anthracycline Cardiotoxicity
ClinicalTrials.gov study NCT00000547. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dapagliflozin to Prevent Anthracycline-Induced Cardiotoxicity
ClinicalTrials.gov study NCT06888505. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomised,Multi-Center Study of Docetaxol Plus Capecitabine or Cisplatin in Anthracycline-Pretreated Patients With Advanced Breast Cancer
ClinicalTrials.gov study NCT00717951. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Gemcitabine Monotherapy for Metastatic Breast Cancer After Anthracycline and Taxane Regimen
ClinicalTrials.gov study NCT00191269. IPD Sharing: Not stated. Countries: 1. Publications: 0.
GIMEMA LAL 0496: High-dose Anthracycline in the Induction Regimen for the Treatment of Adult ALL.
ClinicalTrials.gov study NCT00439920. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Natriuretic Peptide Concentrations of B-type (BNP) During Anesthesia in Patients Previously Sensitized to Anthracyclines
ClinicalTrials.gov study NCT01754597. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of QL1706 Combined With Short-Cycle Anthracyclines or Taxanes for the Treatment of Early-Stage TNBC
ClinicalTrials.gov study NCT07178171. IPD Sharing: YES. Countries: 1. Publications: 0.
A Phase I/II Study of KDX-0811(Dexrazoxane) in the Treatment of Accidental Extravasation of Anthracycline Anti-cancer Agents
ClinicalTrials.gov study NCT01596088. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations
ClinicalTrials.gov study NCT04216472. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chloroquine With Taxane Chemotherapy for Advanced or Metastatic Breast Cancer After Anthracycline Failure (CAT)
ClinicalTrials.gov study NCT01446016. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevention of Anthracycline or Trastuzumab Induced Cardiomyopathy by Metoprolol
ClinicalTrials.gov study NCT00806390. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of NOX66 Plus Doxorubicin in Anthracycline-naïve, Adult Patients With Soft Tissue Sarcoma
ClinicalTrials.gov study NCT05100628. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Data from: Anthracycline drugs on modified surface of quercetin-loaded polymer nanoparticles: a dual drug delivery model for cancer treatment
Open the record for dataset details and reuse information.
Anthracycline treatment and resistance in four human cancer cell lines (HGU133A)
GEO Series GSE3926. Homo sapiens. 12 samples. Type: Expression profiling by array.
Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer
GEO Series GSE6448. Homo sapiens. 185 samples. Type: Genome variation profiling by array.
Anthracycline treatment and resistance in four human cancer cell lines
GEO Series GSE3929. Homo sapiens. 20 samples. Type: Expression profiling by array.
Multifactorial Approach to Predicting Resistance to Anthracyclines
GEO Series GSE16446. Homo sapiens. 120 samples. Type: Expression profiling by array.
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