Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
763
datasets available to search
ShareScore release 0.9.0
Dataset results
763 results for “Antioxidant”
Table 3 in Phytochemical characterization, and antioxidant and antibacterial activities of the hydroethanolic extract of Anadenanthera peregrina stem bark
<p><b>Table 3.</b> Diameter of the inhibitory zone of the hydroethanolic extract of <i>Anadenanthera peregrina</i> stem bark against <i>Staphylococcus aureus</i> (ATCC 25923) and <i>Escherichia coli</i> (ATCC 25922).</p><table><tbody><tr><th></th><th><b>A. peregrina extract concentration</b></th><th></th><th></th></tr></tbody><tbody><tr><th><b>Strain</b></th><td></td><td></td><td></td><td><b>C +</b></td><td><b>C -</b></td></tr><tr><th></th><td><b>50 µL</b></td><td><b>100 µL</b></td><td><b>200 µL</b></td><td></td><td></td></tr><tr><th><i>E. coli</i></th><td>-</td><td>-</td><td>-</td><td>29 mm</td><td>-</td></tr><tr><th><i>S. aureus</i></th><td>10 mm</td><td>16 mm</td><td>20 mm</td><td>35 mm</td><td>-</td></tr></tbody></table>
Table 2 in Phytochemical characterization, and antioxidant and antibacterial activities of the hydroethanolic extract of Anadenanthera peregrina stem bark
<p><b>Table 2.</b> Physicochemical properties,antioxidant activity,and total phenolic content of the hydroethanolic extract of <i>A.peregrina</i> stem bark.</p><table><tbody><tr><th>Sample</th><th>pH</th><th>Density (g cm 3)</th><th>DPPH (IC 50)</th><th><b>Total Phenolics (g GAE 100 g-</b> 1)</th></tr></tbody><tbody><tr><th><b>A. peregrina extract</b></th><td>5.21 ± 0.01</td><td>0.956</td><td>44.13 mg mL-1</td><td>6.40 ± 0.08</td></tr></tbody></table>
Table 1 in Phytochemical characterization, and antioxidant and antibacterial activities of the hydroethanolic extract of Anadenanthera peregrina stem bark
<p><b>Table 1.</b> Phytochemical prospecting of the main secondary metabolite groups of the hydroethanolic extract of <i>A. peregrina</i> stem bark.</p><table><tbody><tr><th><b>Secondary metabolite</b></th><th><b>Hydroethanolic extract of A. peregrina</b></th></tr><tr><th><b>Cardiac glycosides</b></th></tr></tbody><tbody><tr><th>Kedd reagent test</th><td>++</td></tr><tr><th>Keller–Kiliani reagent test</th><td>++</td></tr><tr><th>Baljet reagent test</th><td>-</td></tr><tr><th>Raymond–Marthoud reagent test</th><td>+++</td></tr><tr><th><b>Alkaloids</b></th></tr><tr><th>Libermann–Bouchardat reagent test</th><td>-</td></tr><tr><th>Wagner reagent test</th><td>-</td></tr><tr><th>Mayer’s reagent test</th><td>-</td></tr><tr><th><b>Organic acids</b></th></tr><tr><th>Pascová reagent test</th><td>++</td></tr><tr><th><b>Reducing sugars</b></th></tr><tr><th>Fehling reagent test</th><td>++</td></tr><tr><th><b>Non-reducing sugars</b></th></tr><tr><th>Fehling + HCl test</th><td>-</td></tr><tr><th><b>Coumarins</b></th></tr><tr><th>UV light 254 and 365 nm</th><td>+</td></tr><tr><th><b>Saponins</b></th></tr><tr><th>Foamy</th><td>-</td></tr><tr><th>Haemolytic</th><td>+++</td></tr><tr><th><b>Polysaccharides</b></th></tr><tr><th>Reactive lugol</th><td>-</td></tr><tr><th><b>Phenols</b></th></tr><tr><th>FeCl 3 <b>Tannins</b></th><td>+++</td></tr><tr><th>FeCl3 <b>Flavonoids</b></th><td>Gr</td></tr><tr><th>Pb(C2 H 3O2)2</th><td>++</td></tr><tr><th><b>Purines</b></th><td><b>-</b></td></tr><tr><th><b>Catechins</b></th><td>+++</td></tr><tr><th><b>Benzoquinone derivatives</b></th><td>+++</td></tr><tr><th><b>Depsids and depsidones</b></th><td>+++</td></tr><tr><th><b>Steroids and triterpenoids</b></th><td><b>-</b></td></tr><tr><th><b>Sesquiterpenolactones</b></th><td>-</td></tr></tbody></table>
Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants
<p>Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of PKD1 mutation, PKD1RC/null and PKD1RC/RC. Mouse kidneys with PKD1 mutation have decreased mitochondrial complexes activity. Targeted proteomics analysis shows a significant decrease in proteins involved in the TCA cycle, fatty acid oxidation (FAO), respiratory complexes, and endogenous antioxidants. Overexpressing mitochondrial-targeted catalase (mCAT) using adeno-associated virus reduces mitochondrial ROS, oxidative damage, ameliorates the progression of PKD and partially restores expression of proteins involved in FAO and the TCA cycle. In human ADPKD cells, inducing mitochondrial ROS increased ERK1/2 phosphorylation and decreased AMPK phosphorylation, whereas the converse was observed with increased scavenging of ROS in the mitochondria. Treatment with the mitochondrial protective peptide, SS31, recapitulates the beneficial effects of mCAT, supporting its potential application as a novel therapeutic for ADPKD.</p>
Data for: Innate immune function and antioxidant capacity of nestlings of an African raptor co-vary with the level of urbanization around breeding territories
<p>Urban areas provide breeding habitats for many species. However, animals raised in urban environments face challenges such as altered food availability and quality, pollution, and pathogens assemblages. These challenges can affect physiological processes like immune function and antioxidant defences which are important for fitness.</p> <p>Here, we explore how levels of urbanisation influence innate immune function, immune response to a mimicked bacterial infection and antioxidant capacity of nestling Black Sparrowhawks <em>Accipiter melanoleucus</em> in South Africa. We also explore the effect of timing of breeding and rainfall on physiology since both can influence the environmental condition under which nestlings are raised. Finally, because urbanisation can influence immune function indirectly, we use path analyses to explore direct and indirect associations between urbanisation, immune function, and oxidative stress.</p> <p>We obtained measures of innate immunity (haptoglobin, lysis, agglutination and bactericidal capacity), indices of antioxidant capacity (total non-enzymatic antioxidant capacity (tAOX), and total glutathione from nestlings from 2015 - 2019. In addition, in 2018 and 2019, we mimicked a bacterial infection by injecting nestlings with lipopolysaccharide and quantified their immune response.</p> <p>Increased urban cover was associated with an increase in lysis and a decrease in tAOX, but not with any of the other physiological parameters. Furthermore, except for agglutination, no physiological parameters were associated with the timing of breeding. Lysis and bactericidal capacity, however, varied consistently with the annual rainfall pattern. Immune response to a mimicked a bacterial infection decreased with urban cover but not with the timing of breeding nor rainfall. Our path analyses suggested indirect associations between urban cover and some immune indices via tAOX but not via the timing of breeding.</p> <p>Our results show that early-life development in an urban environment is associated with variation in immune and antioxidant functions. The direct association between urbanisation and antioxidant capacity and their impact on immune function is likely an important factor mediating the impact of urbanisation on urban-dwelling animals. Future studies should explore how these results are linked to fitness and whether the responses are adaptive for urban-dwelling species.</p>
Green synthesis of ZnO nanoparticles using Cocos nucifera leaf extract: Characterization, antimicrobial, antioxidant, and photocatalytic activity
<p>Zinc oxide nanoparticles (ZnO NPs) have been successfully prepared using <em>Cocos nucifera</em> leaf extract and investigated with their antimicrobial, antioxidant, and photocatalytic activity. The structural, compositional, and morphological properties of the NPs were recorded and studied systematically to confirm the synthesis. The aqueous suspension of NPs showed a UV-Vis. absorption maxima of 370 nm indicating primarily its formation. The XRD analysis identified the NPs with hexagonal wurtzite structure with an average particle size of 16.6 nm. The FTIR analysis identified some biomolecules and functional groups in the leaf extract as responsible for the encapsulation and stabilization of ZnO NPs. The EDX analysis showed the desired elemental compositions in the material. A flower-shaped morphology of ZnO NPs was observed by SEM with a grain size of around 15 nm. The optical properties of the NPs were studied by UV-Vis spectroscopy and the bandgap was calculated as 3.37 eV. The Prepared ZnO NPs have demonstrated antimicrobial activity against <em>T. harzianum</em>, and <em>S. aureus</em> with a ZOI (zone of inhibition) of 14 and 10 mm, respectively. The photocatalytic behavior of ZnO NPs showed absorbance degradation at around 640 nm and discolored methylene blue dye after one hour with a degradation maximum of 84.29 %. Thus, the prepared ZnO NPs could be used potentially in antibiotic development, pharmaceutical industries, and as photocatalysts. </p>
Antioxidant Therapy in RYR1-Related Congenital Myopathy
ClinicalTrials.gov study NCT02362425. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma
ClinicalTrials.gov study NCT01897792. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Fruit and Vegetable Juice Concentrate Effects on RBP4 and Antioxidant Capacity in Lean and Overweight 6-10 Year Old Boys
ClinicalTrials.gov study NCT00842543. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients
ClinicalTrials.gov study NCT00133978. IPD Sharing: Not stated. Countries: 5. Publications: 5.
Males, Antioxidants, and Infertility Trial
ClinicalTrials.gov study NCT02421887. IPD Sharing: YES. Countries: 1. Publications: 2.
Relationship Between Some Vitamins and Antioxidants With in Vitro Fertilization Outcomes
ClinicalTrials.gov study NCT05393011. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Antioxidation Medication for Noise-induced Hearing Loss
ClinicalTrials.gov study NCT00552786. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
ClinicalTrials.gov study NCT01322009. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis
ClinicalTrials.gov study NCT01859390. IPD Sharing: NO. Countries: 1. Publications: 4.
Memory and Antioxidants in Vascular Impairment Trial
ClinicalTrials.gov study NCT03306979. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Antioxidant Juice Intake on Brain Injury and Placental Pathology in Infants With Intrauterine Growth Restriction (IUGR)
ClinicalTrials.gov study NCT04394910. IPD Sharing: NO. Countries: 1. Publications: 1.
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1
ClinicalTrials.gov study NCT04481035. IPD Sharing: NO. Countries: 1. Publications: 27.
Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
ClinicalTrials.gov study NCT00135707. IPD Sharing: YES. Countries: 1. Publications: 18.
The Effect of High Antioxidant Cacao on Behaviors in Children With Autism Spectrum Disorder
ClinicalTrials.gov study NCT03195465. IPD Sharing: NO. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.