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891 results for “Apoptosis”
Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes
ClinicalTrials.gov study NCT02880033. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Dapagliflozin Administration on the Apoptosis Levels of Patients With Acute Myocardial Infarction
ClinicalTrials.gov study NCT06615674. IPD Sharing: NO. Countries: 1. Publications: 7.
Use of the MiCK Assay for Apoptosis in AML
ClinicalTrials.gov study NCT00286845. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Smoking Influence on Apoptosis in Periodontitis
ClinicalTrials.gov study NCT02111005. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Apoptosis Markers in Aggressive Periodontitis
ClinicalTrials.gov study NCT04984031. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Data from: Thyroid hormone protects primary cortical neurons exposed to hypoxia by reducing DNA methylation and apoptosis
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Stochastic fluctuations in apoptotic threshold of tumor cells can enhance apoptosis and combat fractional killing
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Data from: A novel triptolide analog downregulates NF-kB and induces mitochondrial apoptosis pathways in human pancreatic cancer
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A novel mitochondrial Kv1.3-caveolin axis controls cell survival and apoptosis
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Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment
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Data from: Effect of Ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells
Chili peppers are an important constituent of many foods and contain medicinally valuable compounds, such as capsaicin and dihydrocapsaicin. As various dietary botanicals have anticancer properties, this study was aimed to examine the effect of Ghost pepper (Bhut Jolokia), one of the hottest chili peppers in the world, on cell proliferation, apoptosis, senescence and the global proteomic profile in human renal cell adenocarcinoma in vitro. 769-P human renal adenocarcinoma cells were cultured on RPMI-1640 media supplemented with fetal bovine serum (10%) and antibiotic-antimycotic solution (1%). Treatment stock solutions were prepared in ethanol. Cell proliferation was tested with phenol red-free media with capsaicin (0–400 μM), dihydrocapsaicin (0–400 μM), capsaicin + dihydrocapsaicin (5:1), and dry Ghost peppers (0–3 g L-1) for 24, 48 and 72 h. Polycaspase and senescence associated-beta-galactosidase (SA-beta-gal) activities were tested with capsaicin (400 μM), dihydrocapsaicin (400 μM), capsaicin (400 μM) + dihydrocapsaicin (80 μM), and ghost pepper (3 g L-1) treatments. Global proteomic profile of cells in control and ghost pepper treatment (3 g L-1) was analyzed after 6 h by a shotgun proteomic approach using tandem mass spectrometry. At 24 h after treatment (24 HAT), relative to control, cell proportion with capsaicin (400 μM), dihydrocapsaicin (400 μM), capsaicin (400 μM) + dihydrocapsaicin (80 μM), and ghost pepper (3 g L-1) treatments was reduced to 36%, 18%, 33% and 20%, respectively, and further reduced at 48 and 72 HAT. All treatments triggered an early polycaspase response. SA-beta-gal activity was normal or suppressed with all treatments. About 68,220 protein isoforms were identified by shotgun proteomic approach. Among these, about 8.2% were significantly affected by ghost pepper. Ghost pepper regulated various proteins involved in intrinsic and extrinsic apoptotic pathways, Ras, Rb/E2F, p53, TGF-beta, WNT-beta catenin, and calcium induced cell death pathways. Ghost pepper also induced changes in proteins related to methylation, acetylation, genome stability, cell cycle check points, carbohydrate, protein and other metabolism and cellular mechanisms. Ghost pepper exhibited antiproliferation activity by inducing apoptosis through a complex network of proteins in human renal cell adenocarcinoma in vitro.
Data from: Synthesis of gypsogenin derivatives with capabilities to arrest cell cycle and induce apoptosis in human cancer cells
Thirty-two gypsogenin derivatives were synthesized and screened for their cytotoxic activities. Their structures were established using IR, 1H NMR, 13C NMR, and LC-MS spectroscopic data. In MTT assays nearly all the compounds displayed good cytotoxicity in the low μM range for several human tumour cell lines (A549, LOVO, SKOV3 and HepG2). Low IC50 values were obtained especially for the carboxamides 7a–7j, for an oxime derivative 3 and a (2,4-dinitrophenyl)hydrazono derivative 4. In particular, the IC50 values of compounds 4 (IC50 = 2.97 ± 1.13 µΜ) and 7 g (IC50 = 3.59 ± 2.04 µΜ) against LOVO cells were found to be much lower than those of the other derivatives and parent compound. These compounds were submitted to an extensive biological testing and proved compounds 4 and 7 g to act mainly by an arrest of the tumour cells in the S phase of the cell cycle. In addition, compounds 4 and 7 g triggered the apoptotic pathway in cancer cells, showing high apoptosis ratios.
Data from: Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts
The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the uterine and fetal placental tissues during the experimental type 2 PRRS virus (PRRSV) infection and determine associations between apoptosis at the MFI, PRRSV RNA concentration and antigen staining intensity, PRRSV-induced microscopic lesions, and fetal preservation status. A total of 114 naïve, high-health pregnant gilts were inoculated with type 2 PRRSV on gestation day 85±1 with euthanasia 21 days later; 19 sham-inoculated gilts served as controls. Two hundred and fifty samples of uterine tissue with fetal placenta were selected based on negative, low PRRSV RNA, and high PRRSV RNA concentration (0, < or > 2.7 log10 copies/mg, respectively). TUNEL assay was used to detect apoptosis in the endometrium and at the MFI. PRRSV RNA concentration and numbers of PRRSV immunopositive cells in uterine and placental tissue were positively associated with the severity of apoptosis in the endometrium and the MFI (P<0.001, P<0.05 and P<0.001, respectively). The number of TUNEL positive cells at the MFI was also positively associated with the severity (P<0.001) of vasculitis, but not total numbers of inflammatory cells in the endometrium. Increased numbers of TUNEL positive cells at the MFI were associated with PRRSV load in the fetal thymus, and greater odds of meconium staining of the fetus at 21 days post infection (P<0.001 for both). These findings suggest an important role of apoptosis in the pathogenesis of uterine epithelial and trophoblastic cell death at the MFI. Moreover, apoptosis at the MFI is significantly associated with fetal demise during in utero type 2 PRRSV infection.
Data from: Stabilization of primary cilia reduces abortive cell cyle re-entry to protect injured adult CNS neurons from apoptosis
Abortive cell cycle (ACC) re-entry of apoptotic neurons is a recently characterized phenomenon that occurs after central nervous system (CNS) injury or over the course of CNS disease. Consequently, inhibiting cell cycle progression is neuroprotective in numerous CNS pathology models. Primary cilia are ubiquitous, centriole-based cellular organelles that prevent cell cycling, but their ability to modulate abortive cell cycle has not been described. Here, we show that neuronal cilia are ablated in-vitro and in-vivo following injury by hypoxia or optic nerve transection (ONT), respectively. Furthermore, forced cilia resorption sensitized neurons to these injuries and enhanced cell death. In contrast, pharmacological inhibition or shRNA knockdown of the proteins that disassemble the cilia increased neuron survival and decreased the phosphorylation of retinoblastoma (Rb), a master switch for cell cycle re-entry. Our findings show that the stabilization of neuronal primary cilia inhibits apoptotic cell cycling, which has implications for future therapeutic strategies that halt or slow the progression of neurodegenerative diseases and acute CNS injuries.
CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting
<p><strong>Data Description:</strong></p> <ul> <li>Two cell death modalities are considered in this study: apoptosis and ferroptosis. The treatments and their cell death types used in these experiments are shown in Figure 1 in the paper. In total we have seven apoptosis and seven ferroptosis inducers. They target specific cell organelles and components. Besides, active treatments there are negative controls DMSO and untreated wells.</li> <li>Every image has a resolution of 1360 x 1024. These four channels were imaged in the experiments. For every well multiple images (fields) are taken typically ten fields.</li> <li>Three plates with four different settings were imaged. 20x non-confocal (very fast [1.5h]), 20x confocal (fast [2.5h]), 40x non-confocal (slow [5h]), 40x confocal (very slow [8h]). All for one time point 28h (incubation time).</li> </ul>
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-Induced p53-dependent apoptosis in NPTr cells
<p>The rawdata supporting the results or analyses</p>
Computational dataset, scripts and models for 'Lipid unsaturation promotes BAX and BAK pore activity during apoptosis'
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Figure 2 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 2. Effect of Hyp on brain antioxidant profile in rat: A) superoxide dismutase (SOD), B) glutathione peroxidase (GPx), C) catalase (CAT), and D) thiobarbituric acid reactive substances (TBARS). Data are presented as mean ± SEM (n = 7). a Significant differences between other groups studied and control (a1 P <0.05, a3 P <0.001, a4 P <0.0001). b Significant differences between other groups studied and Hyp group (b1 P <0.05, b2 P <0.01, b3 P <0.001, b4 P <0.0001). c Significant differences between other groups studied and Ni + Hyp group (c2 P <0.01, c3 P <0.001, c4 P <0.0001) by Tukey's multiple range tests.
Figure 6 in Evaluation of nickel-induced brain injuries in rats via oxidative stress and apoptosis: attenuating effects of hyperoside
Figure 6. (A) Neurons of brain tissue of control group (arrows). (B) Mild positive signs in neurons of Hyp-treated group (arrows). (C) Severe positive signs in neurons of Ni-treated group (arrows). (D) Mild positive signs in neurons of Ni + Hyptreated group (arrows) (IF, 20 µm).
Fig. 6 in Cytotoxicity of methanolic extract of Swertia petiolata against gastric cancer cell line SNU-5 is via induction of apoptosis ⁎
Fig. 6. LC–MS chromatogram of methanolic extract of S. petiolata.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.