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423
datasets available to search
ShareScore release 0.9.0
Dataset results
423 results for “Brain aging”
Active Gains in Brain Using Exercise During Aging
ClinicalTrials.gov study NCT05186090. IPD Sharing: NO. Countries: 1. Publications: 6.
Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality
ClinicalTrials.gov study NCT06170073. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Effects of a Multidomain Lifestyle Intervention on Brain Functioning and Its Relation With Immunometabolic Markers in Ageing
ClinicalTrials.gov study NCT05777863. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder
ClinicalTrials.gov study NCT02592564. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Randomized Control Trial to Compare Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In 64 Severe Traumatic Brain Injury Patients, Aged 18 to 60 Years Old Undergoing Eme
ClinicalTrials.gov study NCT04664699. IPD Sharing: NO. Countries: 1. Publications: 15.
The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
ClinicalTrials.gov study NCT03679533. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Age-at-injury influences the glial response to traumatic brain injury in the cortex of male juvenile rats
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Supplemental Data to: Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age
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Data from: Circulating cortisol and cognitive and structural brain measures in a middle-aged cohort: the Framingham Heart Study
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Data from: Cognition at age 70: life course predictors and associations with brain pathologies
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Age and social experience induced plasticity across brain regions of the paper wasp Polistes fuscatus
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Data from: Decreased brain levels of vitamin B12 in aging, autism and schizophrenia
Many studies indicate a crucial role for the vitamin B12 and folate-dependent enzyme methionine synthase (MS) in brain development and function, but vitamin B12 status in the brain across the lifespan has not been previously investigated. Vitamin B12 (cobalamin, Cbl) exists in multiple forms, including methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), serving as cofactors for MS and methylmalonylCoA mutase, respectively. We measured levels of five Cbl species in postmortem human frontal cortex of 43 control subjects, from 19 weeks of fetal development through 80 years of age, and 12 autistic and 9 schizophrenic subjects. Total Cbl was significantly lower in older control subjects (> 60 yrs of age), primarily reflecting a >10-fold age-dependent decline in the level of MeCbl. Levels of inactive cyanocobalamin (CNCbl) were remarkably higher in fetal brain samples. In both autistic and schizophrenic subjects MeCbl and AdoCbl levels were more than 3-fold lower than age-matched controls. In autistic subjects lower MeCbl was associated with decreased MS activity and elevated levels of its substrate homocysteine (HCY). Low levels of the antioxidant glutathione (GSH) have been linked to both autism and schizophrenia, and both total Cbl and MeCbl levels were decreased in glutamate-cysteine ligase modulatory subunit knockout (GCLM-KO) mice, which exhibit low GSH levels. Thus our findings reveal a previously unrecognized decrease in brain vitamin B12 status across the lifespan that may reflect an adaptation to increasing antioxidant demand, while accelerated deficits due to GSH deficiency may contribute to neurodevelopmental and neuropsychiatric disorders.
Data from: Drosophila clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function
Circadian clocks control many self-sustained rhythms in physiology and behavior with approximately 24-hour periodicity. In many organisms, oxidative stress and aging negatively impact the circadian system and sleep. Conversely, loss of the clock decreases resistance to oxidative stress, and may reduce lifespan and speed up brain aging and neurodegeneration. Here we examined the effects of clock disruptions on locomotor aging and longevity in Drosophila. We found that lifespan was similarly reduced in three arrhythmic mutants (ClkAR, cyc0 and tim0) and in wild-type flies under constant light, which stops the clock. In contrast, ClkAR mutants showed significantly faster age-related locomotor deficits (as monitored by startle-induced climbing) than cyc0 and tim0, or than control flies under constant light. Reactive oxygen species accumulated more with age in ClkAR mutant brains, but this did not appear to contribute to the accelerated locomotor decline of the mutant. Clk, but not Cyc, inactivation by RNA interference in the pigment-dispersing factor (PDF)-expressing central pacemaker neurons led to similar loss of climbing performance as ClkAR. Conversely, restoring Clk function in these cells was sufficient to rescue the ClkAR locomotor phenotype, independently of behavioral rhythmicity. Accelerated locomotor decline of the ClkAR mutant required expression of the PDF receptor and correlated to an apparent loss of dopaminergic neurons in the posterior protocerebral lateral 1 (PPL1) clusters. This neuronal loss was rescued when the ClkAR mutation was placed in an apoptosis-deficient background. Impairing dopamine synthesis in a single pair of PPL1 neurons that innervate the mushroom bodies accelerated locomotor decline in otherwise wild-type flies. Our results therefore reveal a novel circadian-independent requirement for Clk in brain circadian neurons to maintain a subset of dopaminergic cells and avoid premature locomotor aging in Drosophila.
Second wave, late-phase neuroinflammation in the brain of aged 5xFAD transgenic Alzheimer's disease model mice iden-tified using macrolaser light sheet microscopy imaging with tissue clearing
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Health & Aging Brain Study: Health Disparities TAU Project
ClinicalTrials.gov study NCT04324541. IPD Sharing: NO. Countries: 1. Publications: 0.
Brain Energy and Aging With Triheptanoin
ClinicalTrials.gov study NCT02679235. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy Study of ChimeriVax™-JE and JE Inactivated Mouse Brain Vaccine in Children of Descending Age
ClinicalTrials.gov study NCT00441259. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Infant Brain Study Follow-Up at 3 and 4 Years of Age
ClinicalTrials.gov study NCT02619006. IPD Sharing: NO. Countries: 0. Publications: 5.
Data from: Decreased brain levels of vitamin B12 in aging, autism and schizophrenia
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Data from: Measures of obesity are associated with MRI markers of brain aging: the Northern Manhattan Study
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.