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80
datasets available to search
ShareScore release 0.9.0
Dataset results
80 results for “CIC”
Gene expression profiles in naïve and activated CD4+ T cells from WT and Capicua (Cic)-deficient mice
GEO Series GSE84125. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Microarray Data of U87 and HEK293 cells expressing CIC and their respective controls
GEO Series GSE123444. Homo sapiens. 4 samples. Type: Expression profiling by array.
Expression data from CIC wild type and knockout cell lines
GEO Series GSE80359. Homo sapiens. 6 samples. Type: Expression profiling by array.
The role of CIC in brain development and neuronal differentiation
GEO Series GSE131302. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Expression of the CIC-DUX4 fusion oncoprotein mirrors human CIC-rearranged sarcoma in a transgenic mouse model (ChIP-Seq)
GEO Series GSE241370. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptomic and Epigenomic Profiles of CIC-knockout and IDH1 mutant cells [cic_chip]
GEO Series GSE189858. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptome analysis of murine T-cell lymphoblastic lymphomas induced by HrasG12V, p53 KO and CIC loss-of-function
GEO Series GSE89952. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
CIC-DUX4 chromatin prolfiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas
<p>CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal rearrangements. CIC-DUX4 displays chromatin binding properties, and is therefore believed to function as an aberrant transcription factor. However, the chromatin remodeling events induced by CIC-DUX4 are not well understood, limiting our ability to identify new mechanism-based therapeutic strategies for these patients. Here we generated a genome wide profile of CIC-DUX4 DNA occupancy and associated chromatin states in human CDS cell models and primary tumors. Combining chromatin profiling, proximity ligation assays, as well as genetic and pharmacological perturbations, we show that CIC-DUX4 operates as a potent transcriptional activator at its binding sites. This property is in contrast with the repressive function of the wild type CIC protein, and is mainly mediated through the direct interaction of CIC-DUX4 with the acetyltransferase p300. In keeping with this, we show p300 to be essential for CDS tumor cell proliferation, and its pharmacological inhibition to significantly impact tumor growth in vitro and in vivo. Taken together, our study elucidates the mechanisms underpinning CIC-DUX4-mediated transcriptional regulation and suggests a potential therapeutic approach for the clinical management of CDS patients. </p>
A Exploratory Study of KWA-0711 in Patients With Chronic Idiopathic Constipation (CIC)
ClinicalTrials.gov study NCT01600001. IPD Sharing: Not stated. Countries: 1. Publications: 0.
RNA sequencing analysis of gene expresssion profiles in Cic-null MZB cells
GEO Series GSE264654. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Flexible multiplatform RNA profiling at the single cell level applied to enriched cancer initiating cells: RNA-Seq CIC data
GEO Series GSE52715. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
RNA Sequencing Analysis of Gene Expression Profiles in Control versus CIC Knockdown T47D Mammospheres
GEO Series GSE142171. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
BCR repertoire analysis of wild-type and Cic-null B-1a cells
GEO Series GSE164147. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
The analysis of gene expression profiles and BCR repertoire in control and Capicua (Cic)-deficient B cells
GEO Series GSE164148. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA Sequencing Analysis of T Cell Receptor Alpha and Beta Chain in Thymic WT versus CIC-deficient CD4+ SP Non-Treg and Treg Cells.
GEO Series GSE173996. Mus musculus. 4 samples. Type: Other.
NINJ2 inhibition increased chemo-sensitivity by decreasing CICs in chemotherapy-resistant gastric cancer
GEO Series GSE171054. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
CIC and ATXN1L knockout gene expression data [NHA]
GEO Series GSE103514. Homo sapiens. 12 samples. Type: Expression profiling by array.
CIC and ATXN1L knockout gene expression data [HEK]
GEO Series GSE103513. Homo sapiens. 18 samples. Type: Expression profiling by array.
CIC and ATXN1L knockout gene expression data
GEO Series GSE103515. Homo sapiens. 30 samples. Type: Expression profiling by array.
RNA Sequencing Analysis of Gene Expression Profiles in Cic-null B-1a and Follicular B (Fo B) cells
GEO Series GSE163455. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.