Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
240
datasets available to search
ShareScore release 0.9.0
Dataset results
240 results for “Cardiotoxicity”
Early Assessment of Anthracycline-induced Cardiotoxicity (CARDIOTOX)
ClinicalTrials.gov study NCT00195897. IPD Sharing: NO. Countries: 1. Publications: 4.
Bisoprolol Administration to Prevent Anthracycline-induced Cardiotoxicity
ClinicalTrials.gov study NCT05175066. IPD Sharing: YES. Countries: 1. Publications: 2.
Data from: Anthracycline induced cardiotoxicity: prospective cohort study from Pakistan.
Open the record for dataset details and reuse information.
A targeted metabolomics-based assay using human induced pluripotent stem cell-derived cardiomyocytes identifies structural and functional cardiotoxicity potential
Open the record for dataset details and reuse information.
Raw in vitro screening data and R scripts for: A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model
<p>Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes are an established model for testing potential chemical hazards. Inter-individual variability in toxicodynamic sensitivity has also been demonstrated <i>in vitro</i>; however, quantitative characterization of the population-wide variability has not been fully explored. We sought to develop a method to address this gap by combining a population-based iPSC-derived cardiomyocyte model with Bayesian concentration-response modeling. A total of 136 compounds, including 44 pharmaceuticals and 82 environmental chemicals, were tested in iPSC-derived cardiomyocytes from 43 non-diseased humans. Hierarchical Bayesian population concentration-response modeling was conducted for five phenotypes reflecting cardiomyocyte function or viability. Toxicodynamic variability was quantified through the derivation of chemical- and phenotype-specific variability factors (TDVF). Toxicokinetic modeling was used for probabilistic <i>in vitro</i>-to-<i>in vivo </i>extrapolation in order to derive population-wide margins of safety (MOS) for pharmaceuticals and margins of exposure (MOE) for environmental chemicals. Pharmaceuticals were found to be active across all phenotypes. Over half of tested environmental chemicals showed activity in at least one phenotype, most commonly positive chronotropy. TDVF estimates for the functional phenotypes were greater than those for cell viability, usually exceeding the generally-assumed default of ~3. Population variability-based MOS for pharmaceuticals were correctly predicted to be relatively narrow, between 10-100; however, MOE for environmental chemicals, based on population exposure estimates, generally exceeded 1000, suggesting they pose little risk at general population exposures even to sensitive sub populations. This study represents a first of its kind human <i>in vitro</i> model that can be used to characterize toxicodynamic population variability in cardiotoxic risk.</p>
99mTc-rhAnnexin V-128 Imaging and Cardiotoxicity in Patients With Early Breast Cancer
ClinicalTrials.gov study NCT02677714. IPD Sharing: NO. Countries: 1. Publications: 0.
Enalapril After Anthracycline Cardiotoxicity
ClinicalTrials.gov study NCT00000547. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dapagliflozin to Prevent Anthracycline-Induced Cardiotoxicity
ClinicalTrials.gov study NCT06888505. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Cardiopulmonary Exercise Testing in Women Who Have HER2-Positive Breast Cancer With Mild Cardiotoxicity
ClinicalTrials.gov study NCT05036252. IPD Sharing: YES. Countries: 1. Publications: 0.
Cardiotoxicity in Breast Cancer Patients Treated With Proton or Photon Radiotherapy: A RadComp Companion Study
ClinicalTrials.gov study NCT04361240. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Determinants of Physical Activity Level in Pediatric Oncological Patients Treated With Cardiotoxic Therapy - a Study Protocol
ClinicalTrials.gov study NCT06256068. IPD Sharing: NO. Countries: 0. Publications: 1.
Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy
ClinicalTrials.gov study NCT04305613. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cardiotoxicity Monitoring With Single-lead Electrocardiogram
ClinicalTrials.gov study NCT05676606. IPD Sharing: NO. Countries: 1. Publications: 0.
Raw in vitro screening data and R scripts for: A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model
Open the record for dataset details and reuse information.
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective [snMultiome]
GEO Series GSE309754. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Sorafenib induces cardiotoxicity through RBM20 mediated alternative splicing of sarcomeric and mitochondrial genes
GEO Series GSE222642. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Highly efficient and multiplexed transcriptome profiling of cardiotoxicity induced by tyrosine kinase inhibitors
GEO Series GSE221595. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Phosphodiesterase 10A inactivation protects against doxorubicin-induced cardiotoxicity and concomitantly inhibits tumor growth
GEO Series GSE224157. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
miRNA Expression Profiles in Isolated Ventricular Cardiomyocytes: Insights into Doxorubicin-Induced Cardiotoxicity
GEO Series GSE263950. Cavia porcellus. 12 samples. Type: Expression profiling by high throughput sequencing.
Alteration of N6-Methyladenosine mRNAMethylation in an hiPSC-CMs Model of TKI-induced cardiotoxicity
GEO Series GSE192913. Homo sapiens. 12 samples. Type: Methylation profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.