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887 results for “Cataract”
FIGURE 5 in The structure of the cataract causing P23T mutant of human gamma-D crystallin
FIGURE 5. Ampelisca jiigurru sp. nov., holotype, female, 7.1 mm, AM P75274, Mrs Watsons Bay, Lizard Island, Great Barrier Reef.
FIGURE 4 in The structure of the cataract causing P23T mutant of human gamma-D crystallin
FIGURE 4. Ampelisca jiigurru sp. nov., holotype, female, 7.1 mm, AM P75274, Mrs Watsons Bay, Lizard Island, Great Barrier Reef, paratype, male, 5.7 mm, AM P71034, near North Point, Lizard Island, Great Barrier Reef.
The lncRNA TUG1 regulates Smac/DIABLO expression by competitively inhibiting miR-29b and modulates the apoptosis of lens epithelial cells in age-related cataracts
<p>As one of the first discovered lncRNAs, TUG1 has been reported to be widely expressed in a variety of tumours. It promotes cell proliferation, differentiation, apoptosis and migration. However, our understanding of its importance in cataracts is limited. This study aims to explore the mechanism by which TUG1 mediates the apoptosis of lens epithelial cells by regulating the miR-29b/Smac axis in age-related cataracts and to identify more strategies for the nonsurgical treatment of cataracts. In this experiment we found TUG1 and Smac were expressed at high levels in age-related cataract (ARC) samples and HLEB3 cells treated with H2O2, while miR-29b expression was decreased. In vitro cell-based experiments confirmed that the downregulation of TUG1 inhibits lens epithelial cell apoptosis. Mechanistically, Smac expression is negatively regulated by miR-29b. TUG1 competitively inhibits miR-29b expression and causes the release of more Smac. In addition, miR-29b reverses the effect of TUG1 on HLE-B3 cells. In conclusion, lncRNATUG1 increases Smac expression by competitively inhibiting miR-29b and promoting the apoptosis of lens epithelial cells in age-related cataracts. This mechanism is the cytological basis of ARC formation. Based on these results, the TUG1-miR29b-Smac axis may be a new molecular pathway to regulate the development of age-related cataracts.</p>
Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery
ClinicalTrials.gov study NCT07291089. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Safety Profile Comparison of Undiluted Intracameral Moxifloxacin vs. Levofloxacin in Cataract Surgery
ClinicalTrials.gov study NCT05741632. IPD Sharing: NO. Countries: 1. Publications: 3.
The Safety of Cataract Removal by Phacoemulsification Surgery in Patients Under Anti-aggregant and Coumadin Treatment
ClinicalTrials.gov study NCT00564356. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exploratory Study of OMS302 Injection in Subjects Undergoing Unilateral Cataract Extraction by Phacoemulsification.
ClinicalTrials.gov study NCT00721695. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Astigmatism Management in Cataract Surgery With the AcrySof Toric Intraocular Lens
ClinicalTrials.gov study NCT01075542. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Wound Integrity for Clear Corneal Cataract Incisions
ClinicalTrials.gov study NCT05242653. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Wavefront Analysis and Contrast Sensitivity After Cataract Surgery With Akreos Advanced Optics Intraocular Lens Implantation
ClinicalTrials.gov study NCT00863759. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Corticosteroid Injection Combined With Cataract Surgery in Diabetic Eyes.
ClinicalTrials.gov study NCT05413330. IPD Sharing: NO. Countries: 1. Publications: 11.
Patient Participation in Free Cataract Surgery
ClinicalTrials.gov study NCT02633865. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Clinical Evaluation of Intraocular Caliper-assisted Capsulotomy for Age-related Cataract
ClinicalTrials.gov study NCT04977115. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bromfenac Versus Dexamethasone After Cataract Surgery
ClinicalTrials.gov study NCT03317847. IPD Sharing: NO. Countries: 1. Publications: 2.
Improved Operation of Low Intraocular Pressure in Phacoemulsification for Patients With High Myopia Complicated With Cataract
ClinicalTrials.gov study NCT05201677. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Cataract Surgery
ClinicalTrials.gov study NCT04100031. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
ClinicalTrials.gov study NCT00326066. IPD Sharing: Not stated. Countries: 5. Publications: 1.
A Decision Aid for Patients With Age-related Cataract
ClinicalTrials.gov study NCT03992807. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Qualitative and Quantitative Endothelium Changes After Cataract Surgery: Ultrasound Phacoemulsification vs Nanolaser Technique
ClinicalTrials.gov study NCT05886283. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Clinical Trial on Anti-inflammatory Effect of Low-Molecular Weight Heparin in Pediatric Cataract Surgery
ClinicalTrials.gov study NCT00986076. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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