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1,052 results for “Cell growth”
PP2A complex disruptor SET prompts widespread hyper-transcription of growth-essential genes in the pancreatic cancer cells
<p>Hyper-activation of the oncogenic transcription reflects the epigenetic plasticity of the cancer cells. SET was described as a nuclear factor that stimulated transcription from the chromatin template. However, the mechanisms of SET-dependent transcription are unknown. Here, we found that over-expression of SET and CDK9 induced very similar transcriptome signatures in multiple cancer cell lines. SET localized in the transcription start site (TSS)-proximal regions and supported the RNA transcription. SET specifically bound the PP2A-C subunit and induced PP2A-A subunit repulsion from the C subunit, which indicated the role of SET as a PP2A-A/C complex disruptor in the TSS-proximal regions. Through blocking PP2A activity, SET assisted CDK9 to maintain Pol II CTD phosphorylation and activated mRNA transcription. Our findings position SET as a key factor that modulates chromatin PP2A activity, promoting the oncogenic transcription in pancreatic cancer.</p>
Representative data accompanying the manuscript: Four-dimensional quantitative analysis of cell plate development in Arabidopsis using lattice light sheet microscopy identifies robust transition points between growth phases
<p>Representative data accompanying the manuscript: Sinclair R, Wang M, Jawaid MZ, Longkumer T, Aaron J, Rossetti B, Wait E, McDonald K, Cox D, Heddleston J, Wilkop T, Drakakaki G. (2024). <em>Four-dimensional quantitative analysis of cell plate development in Arabidopsis using lattice light sheet microscopy identifies robust transition points between growth phases.</em> J Exp Bot. 2024 Mar 4: erae091. doi: 10.1093/jxb/erae091.</p> <p>The data show YFP–RABA2a dynamics in dividing cells of Arabidopsis root tips using lattice light sheet microscopy. Treatments with or without Endosidin 7, a cytokinesis-specific callose deposition inhibitor, are shown.</p> <p>Data: </p> <p>22.3 YFP-RABA2A. </p> <p>23.9 YFP-RABA2A ES7 </p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate the motor disorder and brain pathological injury in mice with cerebral palsy
<p>Supplementary Table 1.The statistics of the pole-climbing experiments and the horizontal network test</p> <p>Supplementary Table 2.Results of Kruskal–Wallis test as presented in pole-climbing experiments and the horizontal network test.</p> <p>Supplementary Figure 1. Identification of human umbilical cord mesenchymal stem cell exosomes (hUC-MSCs-exos)</p> <p>Supplementary Figure 2. Results of horizontal network test and pole-climbing experiments.</p> <p> </p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate themotor disorder and brain pathological injury inmice with cerebral palsy
<p>This research design.</p>
Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure
<p>Spheroids of different composition (100% sensitive, 50% sensitive – 50% resistant, 100% resistant) were initiated from Venus-labeled CAMA-1 and mCherry-labeled CAMA-1_ribociclib_resistant cells and were subjected to 1 uM ribociclib treatment. After 11 days, speroids were harvested, washed and cell suspensions were viably frozen for single cell RNA-seq analysis. </p>
Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction
<p>Expression quantitative trait loci (eQTLs) provide a key bridge between noncoding DNA sequence variants and organismal traits. The effects of eQTLs can differ among tissues, cell types, and cellular states, but these differences are obscured by gene expression measurements in bulk populations. We developed a one-pot approach to map eQTLs in <em>Saccharomyces cerevisiae</em> by single-cell RNA sequencing (scRNA-seq) and applied it to over 100,000 single cells from three crosses. We used scRNA-seq data to genotype each cell, measure gene expression, and classify the cells by cell-cycle stage. We mapped thousands of local and distant eQTLs and identified interactions between eQTL effects and cell-cycle stages. We took advantage of single-cell expression information to identify hundreds of genes with allele-specific effects on expression noise. We used cell-cycle stage classification to map 20 loci that influence cell-cycle progression. One of these loci influenced the expression of genes involved in the mating response. We showed that the effects of this locus arise from a common variant (W82R) in the gene <em>GPA1</em>, which encodes a signaling protein that negatively regulates the mating pathway. The 82R allele increases mating efficiency at the cost of slower cell-cycle progression and is associated with a higher rate of outcrossing in nature. Our results provide a more granular picture of the effects of genetic variants on gene expression and downstream traits.</p>
A 3D printed plastic frame deeply impacts yeast cell growth
<p>Solid State Fermentation (SSF) processes have been explored for yeast growth and protein and metabolites production. However, most of these processes lack standardization. In this work, we present a polylactic acid (PLA) 3D printed matrix that dramatically enhances yeast growth when embedded in liquid media compared to equivalent static cultures, and changes yeast expression patterns at the proteome level. Moreover, differences in sugar assimilation and ethanol production, as the main product of alcoholic fermentation, are observed. Our results suggest that these matrixes may be useful for a vast range of biotechnological applications based on yeast fermentation. Here we submit the proteomic data of this paper.</p>
Sorafenib Treatment in Non-Small Cell Lung Cancer After Failure of Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitor
ClinicalTrials.gov study NCT00922584. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of ASP8273 in Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-Naïve Patients With Non-Small Cell Lung Cancer Harboring EGFR Mutations
ClinicalTrials.gov study NCT02500927. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of 5 Years of Adjuvant Osimertinib in Completely Resected Epidermal Growth Factor Receptor Mutation (EGFRm) Non-small Cell Lung Carcinoma (NSCLC)
ClinicalTrials.gov study NCT05526755. IPD Sharing: YES. Countries: 11. Publications: 1.
Immunotherapy Using Pluripotent Killer-Human Epidermal Growth Factor Receptor-2 (PIK-HER2) Cells for the Treatment of Advanced Gastric Cancer With Liver Metastasis
ClinicalTrials.gov study NCT02632201. IPD Sharing: Not stated. Countries: 1. Publications: 26.
Study to Evaluate Concordance of Detecting EGFR (Epidermal Growth Factor Receptor) Mutation by Circulating Tumour Free DNA Versus Tissues Biopsy in NSCLC (Non-small Cell Lung Cancer).
ClinicalTrials.gov study NCT03562819. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Erlotinib Versus Gemcitabine/Carboplatin in Chemo-naive Stage IIIB/IV Non-Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Exon 19 or 21 Mutation
ClinicalTrials.gov study NCT00874419. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth
ClinicalTrials.gov study NCT04057274. IPD Sharing: YES. Countries: 1. Publications: 4.
Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease Patients
ClinicalTrials.gov study NCT01163825. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Non Small Cell Lung Cancer Trial of Durvalumab and Tremelimumab in Advanced Epidermal Growth Factor Receptor (EGFR) Mutant Disease.
ClinicalTrials.gov study NCT03994393. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Mutations in the Epidermal Growth Factor Receptor(EGFR) Gene in Non-Small Cell Lung Carcinoma (NSCLC) and the Relation to Response of Treatment With Erlotinib
ClinicalTrials.gov study NCT00815971. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vascular Endothelial Growth Factor (VEGF) Imaging Before and During Everolimus Treatment for Renal Cell Carcinoma
ClinicalTrials.gov study NCT01028638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lu
ClinicalTrials.gov study NCT02699606. IPD Sharing: Not stated. Countries: 3. Publications: 1.
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Gr
ClinicalTrials.gov study NCT05099172. IPD Sharing: NO. Countries: 15. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.