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78 results for “Cost of resistance”
Data from: Reverse evolution: selection against costly resistance in disease-free microcosm populations of Paramecium caudatum
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Data from: Type of fitness cost influences the rate of evolution of resistance to transgenic Bt crops
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Data from: The fitness costs of antibiotic resistance mutations
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Data from: Variation in costs of parasite resistance among natural host populations
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Data from: An examination of fitness costs of glyphosate resistance in the common morning glory, Ipomoea purpurea
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The cost effectiveness of surgery for drug resistant temporal lobe epilepsy in the US
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Data from: Temperature-sensitive fitness cost of insecticide resistance in Chinese populations of the diamondback moth Plutella xylostella
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Data from: The genetic basis of the fitness costs of antimicrobial resistance: a meta-analysis approach
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Data from: Costs of walking: differences in egg size and starvation resistance of females between strains of the red flour beetle (Tribolium castaneum) artificially selected for walking ability
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Data from: Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa
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Data from: Lytic phages obscure the cost of antibiotic resistance in Escherichia coli
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Data from: Virus resistance is not costly in a marine alga evolving under multiple environmental stressors
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Data from: Adaptation to parasites and costs of parasite resistance in mutator and non-mutator bacteria
Parasitism creates selection for resistance mechanisms in host populations and is hypothesized to promote increased host evolvability. However, the influence of these traits on host evolution when parasites are no longer present is unclear. We used experimental evolution and whole-genome sequencing of Escherichia coli to determine the effects of past and present exposure to parasitic viruses (phages) on the spread of mutator alleles, resistance and bacterial competitive fitness. We found that mutator alleles spread rapidly during adaptation to any of four different phage species, and this pattern was even more pronounced with multiple phages present simultaneously. However, hypermutability did not detectably accelerate adaptation in the absence of phages and recovery of fitness costs associated with resistance. Several lineages evolved phage resistance through elevated mucoidy, and during subsequent evolution in phage-free conditions they rapidly reverted to non-mucoid, phage-susceptible phenotypes. Genome sequencing revealed that this phenotypic reversion was achieved by additional genetic changes rather than by genotypic reversion of the initial resistance mutations. Insertion sequence (IS) elements played a key role in both the acquisition of resistance and adaptation in the absence of parasites; unlike single nucleotide polymorphisms (SNPs), IS insertions were not more frequent in mutator lineages. Our results provide a genetic explanation for rapid reversion of mucoidy, a phenotype observed in other bacterial species including human pathogens. Moreover, this demonstrates that the types of genetic change underlying adaptation to fitness costs, and consequently the impact of evolvability mechanisms such as increased point-mutation rates, depend critically on the mechanism of resistance.
Rescue Treatment Pattern, Drug Resistance Recurrence, and Direct Medical Costs Associated With Chinese Patients With Chronic Hepatitis B and Drug Resistance to Nucleot(s)Ide Analogue Therapy
ClinicalTrials.gov study NCT02791386. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
ClinicalTrials.gov study NCT01352936. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Adaptation to parasites and costs of parasite resistance in mutator and non-mutator bacteria
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Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
GEO Series GSE35990. Entamoeba histolytica. 8 samples. Type: Expression profiling by array.
Biological cost of rifampicin resistance in Helicobacter pylori
GEO Series GSE25333. Helicobacter pylori 26695. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.