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176 results for “Diagnostic tools”
Data from: Gene transcription in sea otters (Enhydra lutris): development of a diagnostic tool for sea otter and ecosystem health
Gene transcription analysis for diagnosing or monitoring wildlife health requires the ability to distinguish pathophysiological change from natural variation. Herein we describe methodology for the development of quantitative real time polymerase chain reaction (qPCR) assays to measure differential transcript levels of multiple immune-function genes in the sea otter (Enhydra lutris); sea otter specific, qPCR primer sequences for the genes of interest are defined. We establish a "reference" range of transcripts for each gene in a group of clinically healthy captive and free-ranging sea otters. The 10 genes of interest represent multiple physiological systems that play a role in immuno-modulation, inflammation, cell protection, tumor suppression, cellular stress-response, xenobiotic metabolizing enzymes, antioxidant enzymes, and cell-cell adhesion. The cycle threshold (CT) measures for most genes were normally distributed; the complement cytolysis inhibitor was the exception. The relative enumeration of multiple gene transcripts in simple peripheral blood samples expands the diagnostic capability currently available to assess the health of sea otters in situ and provides a better understanding of the state of their environment.
Liquid Biopsy as a Diagnostic and Prognostic Tool for Women and Female Dogs with Breast Cancer
<p>This dataset contains numerous analyses on genetic variants obtained from liquid biopsy of women and dogs with breast cancer (BC). Both core biopsy and plasma samples were processed for next generation sequencing (NGS) assay. The effectiveness of liquid biopsy in the diagnosis and follow-up of women and female dogs with BC was investigated. In this study, 55 and 35 BC samples were collected from women and female dogs, respectively. After obtaining core biopsy and plasma samples, DNA and ctDNA of tumor fragments and plasma were processed and submitted to the Genome Analysis ToolKit (GATK).</p> <p> </p>
Development of preclinical diagnostic tools of hepatobiliary tumors associated with Opisthorchis felineus infection in population of endemic regions
<p>According to the official medical statistics, the incidence of hepatobiliary tumors (including cholangiocarcinoma) in the Tomsk region was 9.31 cases per 100,000 population in 2011-2013, which was twice the average in Russia [Fedorova OS, Kovshirina Yu.V., et al., 2017]. Cholangiocarcinoma is a group of intra- and / or extrahepatic bile ducts cancer with high mortality due to its aggressiveness, lack of specific symptoms and / or prolonged asymptomatic course and resistance to therapy [Bridgewater J, Galle PR, Khan SA et al., 2014]. One of the significant risk factors for liver cancer is the high prevalence of parasitic infection caused by liver fluke O. felineus in Western Siberia, whose carcinogenic potential has been demonstrated in a number of experimental studies in animal models of the disease, as well as in research on autopsy material, surgical data [Gouveia MJ, Pakharukova MY, et al., 2017; Brazhnikov N.A. et al., 2002; Maksimova GA, Pakharukova MY, 2017; Bychkov V.G., 2003; Kovshirina YV, Fedorova OS, Kovshirina AE et al, in press, 2018]. In this regard, it is necessary to develop diagnostic tools allowed timely detection of severe hepatobiliary diseases (including cancer) associated with opisthorchiasis in order to jugulate it and improve the prognosis for patients in endemic regions. In this way, the aim of this project is creation a diagnostic tools for early preclinical diagnostics of the hepatobiliary tumors (cholangiocarcinoma) in patients with chronic O. felineus infection in endemic regions. For these aims a comprehensive fundamental research will be performed, including evaluation of biochemical measures (lactate, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, glucose, direct and indirect bilirubin, high and low density lipoproteins, triacylglycers, as well as low-density lipotropes. Immunological parameters (TGFb) and tumor markers (CA 19-9, СYFRA 21-1) in serum samples obtained from patients with O. felineus infection having periductal fibrosis and without it, patients with cholangiocarcinoma and individuals without opisthorchiasis and bile ducts cancer. Statistical analysis was carried out using the programming language R version 3.6.1. The study results indicate that ultrasound of the liver and biliary system with the assessment of opistorchosis-associated periductal fibrosis together with the determination of biochemical indicators (alkaline phosphatase, direct bilirubin, AST, glucose), as well as oncomarker CA 19-9, as predictors of fibrosis, can be used as an algorithm for early preclinical diagnosis of malignant tumors of the hepatobiliary system (cholangiocarcinoma) against the background of chronic infection O. felineus, in the population of endemic regions.</p>
CGM as Diagnostic Tool in Observing Steroid-Induced Hyperglycemia
ClinicalTrials.gov study NCT06628284. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Magnetocardiography as a Diagnostic Screening Tool for Myocarditis and Other Types of Cardiomyopathy
ClinicalTrials.gov study NCT06689098. IPD Sharing: YES. Countries: 1. Publications: 0.
Role of Pleural Fluid Attenuation Value on CT as a Diagnostic Tool in Traumatic Hemothorax
ClinicalTrials.gov study NCT04098185. IPD Sharing: Not stated. Countries: 0. Publications: 11.
Clinical Validation of Novel Malaria Diagnostic Tools for POC Point-of-Care Testing
ClinicalTrials.gov study NCT06225700. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prostasomes as Diagnostic Tool for Prostate Cancer Detection
ClinicalTrials.gov study NCT03694483. IPD Sharing: NO. Countries: 1. Publications: 0.
Diagnostic Precision of the AI Tool Dermalyzer to Identify Malignant Melanomas in Subjects Seeking Primary Care for Melanoma-suspected Cutaneous Lesions
ClinicalTrials.gov study NCT05172232. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Gene transcription in sea otters (Enhydra lutris): development of a diagnostic tool for sea otter and ecosystem health
Open the record for dataset details and reuse information.
Data from: A molecular diagnostic tool for the preliminary assessment of host-parasitoid associations in biological control programmes for a new invasive pest
Open the record for dataset details and reuse information.
Whole blood Transcriptional Profiles as a Prognostic and Diagnostic Tool in Complete and Incomplete Kawasaki Disease
GEO Series GSE68004. Homo sapiens. 162 samples. Type: Expression profiling by array.
Blood miR-144-3p: A Novel Diagnostic and Therapeutic Tool for Depression
GEO Series GSE209673. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Figure 2 from: Acquah ME, Aboagye F, Ashong Y, Mosi L (2024) Development of a field diagnostic tool for Schistosoma mansoni Praziquantel resistant markers in selected endemic communities. Research Ideas and Outcomes 10: e120899. https://doi.org/10.3897/rio.10.e120899
Figure 2 Study Design: Workflow of the proposed research.
Diagnostic Tools for Identifying Prolonged Grief
ClinicalTrials.gov study NCT05365139. IPD Sharing: NO. Countries: 1. Publications: 0.
A Pilot Study to Explore the Use of Skin Biopsy as Diagnostic Tool in Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
ClinicalTrials.gov study NCT05678127. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Stress Multidetector Computed Tomography (MDCT) an New Diagnostic Tool for Myocardial Disease
ClinicalTrials.gov study NCT00949520. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study on the Use of Traditional Chinese Medicine Diagnostic Tools to Assist in Identifying the Clinical Characteristics of Inflammatory Bowel Disease and Research on Metabolic Plastids of Tongue Coati
ClinicalTrials.gov study NCT07314151. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Development of New Diagnostic Tools in Capsule Endoscopy
ClinicalTrials.gov study NCT06152289. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer
ClinicalTrials.gov study NCT04346225. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.