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224
datasets available to search
ShareScore release 0.9.0
Dataset results
224 results for “Disease Biology”
Identification of Predictive Biomarkers for Response to Biologic Therapies and Tofacitinib in Inflammatory Bowel Disease
ClinicalTrials.gov study NCT03885713. IPD Sharing: Not stated. Countries: 1. Publications: 69.
Biologic Basis for Multiple Sclerosis Disease Progression in RRMS Patients Treated With Gilenya
ClinicalTrials.gov study NCT02137707. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nurse-led Clinic for Patients With Rheumatic Diseases and Biological Treatment
ClinicalTrials.gov study NCT01071447. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease
ClinicalTrials.gov study NCT02285088. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease
ClinicalTrials.gov study NCT02899039. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Identify Clinical, Imaging and Biologic Markers of Parkinson Disease Progression
ClinicalTrials.gov study NCT01141023. IPD Sharing: Not stated. Countries: 11. Publications: 17.
Investigating Neurocognitive, Motor and Biological Effects of MindLenses Professional in Neurological Diseases
ClinicalTrials.gov study NCT05826626. IPD Sharing: NO. Countries: 1. Publications: 12.
Measurement of Distinct Biological Pools of Hydrogen Sulfide in Women With Cardiovascular Disease
ClinicalTrials.gov study NCT02180074. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Biological Determinants of Sputum Rheology in Chronic Airway Diseases
ClinicalTrials.gov study NCT04081740. IPD Sharing: YES. Countries: 1. Publications: 1.
Collection of Human Biological Samples for the Development and Validation of New Methods of Diagnosis and for the Realization of Expertises Diagnostics in the Field of Infectious Diseases and Tropical
ClinicalTrials.gov study NCT03912246. IPD Sharing: NO. Countries: 1. Publications: 14.
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics
ClinicalTrials.gov study NCT04870411. IPD Sharing: NO. Countries: 1. Publications: 5.
Biological Markers for the Diagnosis of Central Nervous System Infective Diseases
ClinicalTrials.gov study NCT02278016. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hypothesizing the Genesis of Infectious Diseases and Epidemics Through an Integrated Systems Biology Approach
ClinicalTrials.gov study NCT05557539. IPD Sharing: NO. Countries: 1. Publications: 0.
Biological Therapy in Patients With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT05599867. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
List of papers reviewed to uncover trends in the use of model systems in infectious disease ecology & evolutionary biology
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Biological subtypes of Alzheimer's disease: a systematic review and meta-analysis
<p><span><b>Objective: </b>We conducted a systematic review and meta-analysis on subtype studies of Alzheimer's disease (AD) based on postmortem and neuroimaging data, with the ultimate goal of advancing our understanding of mechanisms driving heterogeneity in AD.</span></p> <p><span><b>Methods: </b>EMBASE, PubMed and Web of Science databases were consulted until July 2019.</span></p> <p><span><b>Results:</b> Neuropathology and neuroimaging studies have consistently identified three subtypes of AD based on the distribution of tau-related pathology and regional brain atrophy: typical, limbic-predominant, and hippocampal-sparing AD. A fourth subtype, minimal atrophy AD, has been identified in several neuroimaging studies. Typical AD displays tau-related pathology and atrophy both in hippocampus and association cortex, and has a pooled frequency of 55%. Limbic-predominant, hippocampal-sparing, and minimal atrophy AD had a pooled frequency of 21%, 17%, and 15%, respectively. Between-subtype differences were found in age at onset, age at assessment, sex distribution, years of education, global cognitive status, disease duration, APOE e4 genotype, and CSF biomarker levels.</span></p> <p><span><b>Conclusion:</b> We identified two core dimensions of heterogeneity: "typicality" and "severity". We propose that these two dimensions determine individuals' belonging to one of the AD subtypes based on the combination of protective factors, risk factors, and concomitant non-AD brain pathologies. This model is envisioned to aid with framing hypotheses, study design, results interpretation, and understanding mechanisms in future subtype studies. Unraveling the heterogeneity within AD is critical for implementing precision medicine approaches and for ultimately developing successful disease-modifying drugs for AD.</span></p>
Biological assets registered and used to control insects and diseases and their respective dosage per hectare according to the biological target.
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Fig. 2 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 2. Chemical structure of Astragalus polysaccharide (Liu et al., 2020).
Fig. 4 in Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases
Fig. 4. Astragalus spinosus (Alsirhan, 2002).
Fig. 1 in Isosteroidal alkaloids of Fritillaria taipaiensis and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity
Fig. 1. Structures of compounds 1–9.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.