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ShareScore release 0.9.0
Dataset results
204 results for “Drug-resistance”
Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
Objective: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. Methods: We conducted a case-control study consisting of a discovery cohort and a replication cohort independently assessed at two different centres. In each centre patients with idiopathic generalized epilepsy phenotype and generalized spike-wave discharges on EEG were classified as drug-resistant or drug-responsive. EEG changes were classified into pre-defined patterns and compared between the two groups in the discovery cohort. Factors associated with drug resistance in multivariable analysis were tested in the replication cohort. Results: The discovery cohort included 85 patients (29% drug-resistant and 71% drug-responsive). Their median age at assessment was 32 years and 50.6% were female. Multivariable analysis showed that having higher number of seizure types (3 vs. 1: odds ratio [OR]= 31.1, 95% confidence interval [CI] 4.5-214, p<0.001; 3 vs. 2: OR=14.6, 95% CI: 2.3-93.1, p=0.004) and generalized polyspike train (burst of generalized rhythmic spikes lasting less than 1 second) during sleep were associated with drug resistance (OR=10.8, 95% CI: 2.4-49.4, p=0.002). When these factors were tested in the replication cohort of 80 patients (27.5% drug-resistant and 72.5% drug-responsive; 71.3% female; median age 27.5 years), the proportion of patients with generalized polyspike train during sleep was also higher in the drug-resistant group (OR=4.0, 95% CI: 1.35-11.8, p=0.012). Conclusion: Generalized polyspike train during sleep may be an EEG biomarker for drug resistance in adults with idiopathic generalized epilepsy.
The Effect of Probiotic Supplementation in Drug-resistant Epilepsy Patients
ClinicalTrials.gov study NCT03403907. IPD Sharing: NO. Countries: 0. Publications: 3.
A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures
ClinicalTrials.gov study NCT02519439. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy
ClinicalTrials.gov study NCT02495844. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Colistin-rifampin Combination and Colistin Monotherapy in Extensively Drug-resistant Acinetobacter Baumannii
ClinicalTrials.gov study NCT03622918. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
ClinicalTrials.gov study NCT02133872. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03370120. IPD Sharing: YES. Countries: 27. Publications: 0.
An Open-label Extension Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy
ClinicalTrials.gov study NCT02625090. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Phase 3 Study of Adjunctive Ganaxolone in Adults With Drug-resistant Partial Onset Seizures and Open-label Extension
ClinicalTrials.gov study NCT01963208. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Data from: The impact of within-host ecology on the fitness of a drug-resistant parasite
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Data from: Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites
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Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
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Data from: The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
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Data from: The effects of sub-curative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni
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Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets
GEO Series GSE288840. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Identification of gene regulatory networks affected across drug-resistant epilepsies
GEO Series GSE256068. Homo sapiens. 162 samples. Type: Expression profiling by high throughput sequencing.
Janus nanoparticles targeting extracellular polymeric substance achieve flexible elimination of drug-resistant biofilms
GEO Series GSE239411. Staphylococcus aureus. 4 samples. Type: Expression profiling by high throughput sequencing.
MRTF/SRF link the cytoskeleton and hedgehog pathway in drug-resistant basal cell carcinomas
GEO Series GSE78497. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Other.
ANXA1 promotes cell proliferation and drug-resistance in B cell acute lymphoblastic leukemia
GEO Series GSE226449. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells
GEO Series GSE228208. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.