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1,838
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Dataset results
1,838 results for “Endometrial”
Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
ClinicalTrials.gov study NCT03422198. IPD Sharing: NO. Countries: 1. Publications: 31.
Lymph Node Mapping in Patients With Endometrial Cancer
ClinicalTrials.gov study NCT01818739. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feasibility Study Using the Xoft System for the Treatment of Endometrial Cancer
ClinicalTrials.gov study NCT01045187. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma
ClinicalTrials.gov study NCT03395080. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The EndoBARR Trial (Endometrial Bevacizumab, Atezolizumab, Rucaparib)
ClinicalTrials.gov study NCT03694262. IPD Sharing: UNDECIDED. Countries: 1. Publications: 36.
Doxorubicin Hydrochloride, Cisplatin, and Paclitaxel or Carboplatin and Paclitaxel in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer
ClinicalTrials.gov study NCT00063999. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Endometrial Safety of a Low Dose of Vagifem® in Postmenopausal Women With Atrophic Vaginitis
ClinicalTrials.gov study NCT00431132. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometri
ClinicalTrials.gov study NCT00977574. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-
ClinicalTrials.gov study NCT03517449. IPD Sharing: Not stated. Countries: 21. Publications: 5.
Strain-elastography in Endometrial Cancer
ClinicalTrials.gov study NCT06623916. IPD Sharing: NO. Countries: 1. Publications: 1.
Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer
ClinicalTrials.gov study NCT01935934. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer
ClinicalTrials.gov study NCT01307631. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis
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Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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Data from: The embryonic DPPA3 gene stimulates the expression of pregnancy-related genes in bovine endometrial cells
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Association of Peripheral Monocytic-Myeloid-Derived Suppressor Cells with Molecular Subtypes in Single Center Endometrial Cancer Patients Receiving Carboplatin + Paclitaxel/Avelumab (MITO END-3 Trial)
<p><span>The MITO-END3 trial compared carboplatin and paclitaxel (</span><span>CP</span><span>) with avelumab plus carboplatin and paclitaxel (</span><span>CPA)</span><span> as first-line treatment in endometrial cancer (EC) patients and </span><span>demonstrated a significant interaction between avelumab response and mismatch repair status. To investigate prognostic/predictive biomarker, </span><span>twenty-nine MITO-END3-EC patients were evaluated at pre-treatment (B1) and at the end of CP/CPA treatment (B2) for </span><span>peripheral Myeloid derived suppressor cells (MDSC) and Tregs. </span><span>At B2, <span>effector</span> Tregs frequency was significantly higher in patients treated with CPA as compared to CP (p=0.038). Both treatments (CP/CPA) induced significant decrease in peripheral M-MDSC (-5.41%) in TCGA 2-MSI-High as compared to TCGA-category 4 tumors (p=0.004). In accordance, both treatments induced M-MDSCs (+5.34%) in MSS patients as compared to MSI-High patients (p=0.001). Moreover, in a subgroup of patients, </span><span>primary tumors were highly infiltrated by M-MDSCs in MSS as compared to MSI-high ECs. </span><span>A post hoc analysis displayed higher frequeny of M-MDSCs (p=0.020) and lower frequency of CD4+ (p<0.005) at pretreatment in EC patients as compared to healthy donors. </span><span>In conclusion, </span><span>the</span><span> peripheral evaluation of MDSCs and Tregs correlated with molecular features in EC treated with CP/CPA and may add insights in identifying EC patients responder to first line chemo/chemo-immunotherapy. </span></p>
ENID - Endometrial Implants Dataset
<p>ENID (ENdometrial Implants DAtaset) comprises 160 images taken from 100+ gynecologic laparoscopy surgeries and is purposefully created to be utilized for a variety of automatic content analysis problems in the context of Endometriosis recognition. ENID is the result of experiments on reorganizing previously published dataset <a href="http://ftp.itec.aau.at/datasets/GLENDA">GLENDA</a> in terms of visual similarity.</p> <p>The dataset includes region-based annotations of a specific visual endometriosis manifestation: dark endometrial implants. Annotations are created for single video frames, which can contain multiple annotations. Each single annotation is exported as a pixel-based image mask: the annotated regions are colored, while the background is left black. Additionally a particular dataset augmentation is provided: ground truth annotations are tracked over time using the original videos. The tracking results are acquired via kernelized correlation filters (KCF).</p> <p>You are kindly requested to cite the original work that led to the creation of the dataset: <a href="https://doi.org/10.1007/s11042-021-11730-1">https://doi.org/10.1007/s11042-021-11730-1</a>.</p> <p>For the latest updates, please visit the dataset's homepage: <a href="http://ftp.itec.aau.at/datasets/Smoke_cholec80/">http://ftp.itec.aau.at/datasets/ENID</a>.</p>
BMP/SMAD1/5 signaling in the endometrial epithelium is essential for receptivity and early pregnancy
<p>The biological processes that control endometrial receptivity and embryo implantation are critical for the successful outcome of pregnancy. The endometrium is the complex inner lining of the uterine wall that is under the cyclical control of estrogen and progesterone and is a site of intimate contact between mother and blastocyst. The bone morphogenetic signaling (BMP) pathway is a highly conserved signaling pathway that controls key cellular processes throughout pregnancy and exerts intracellular effects via the SMAD1/5 transcription factors. To delineate the endometrial compartment–specific roles of BMP signaling, we generated mice with epithelial-specific conditional deletion of SMAD1/5 using Lactoferrin-icre (Smad1flox/flox;Smad5flox/flox;Lactoferrin-cre, "Smad1/5 cKO"). Histological analysis of the reproductive tracts showed that Smad1/5 cKO mice were developmentally normal and displayed no defects in glandular morphology. In fertility analyses, single SMAD1 or SMAD5 deletion had no effect on fertility; however, double-conditional deletion of SMAD1 and SMAD5 resulted in severe subfertility. Timed mating analyses revealed endometrial receptivity defects in the Smad1/5 cKO mice beginning at 3.5 days post coitum (dpc) that perturbed embryo implantation at 4.5 dpc, as demonstrated by the detection of unattached blastocysts in the uterus, decreased COX2 expression, and FOXO1 cytoplasmic mislocalization. We also found that defects that arose during peri-implantation adversely affected embryonic and decidual development at 5.5 and 6.5 dpc. Thus, uterine epithelial BMP/SMAD1/5 signaling is essential during early pregnancy and SMAD1/5 epithelial-specific deletion has detrimental effects on stromal cell decidualization and pregnancy development.</p>
SEQUENCE OF HYSTEROSCOPIC DIAGNOSIS OF ENDOMETRIAL POLYPS IN PATIENTS WITH INFERTILITY
<p><strong><span>Annotation</span></strong><strong><span>:</span></strong><span> </span></p> <p><span>The established criteria for diagnosing endometrial polyps during hysteroscopy were examined in a cohort of 35 patients presenting with both primary and secondary infertility and exhibiting echographic indications of endometrial polyps. These criteria serve as a guide for appropriately selecting the hysteroscopic treatment technique for endometrial polyps.</span></p> <p><em><span>Key words:endometrial polyps, infertility, hysteroscopy.</span></em></p>
Data from: Poor endometrial proliferation after clomiphene is associated with altered estrogen action
<p>Context: Suboptimal endometrial thickening is associated with lower pregnancy rates and occurs in some infertile women treated with clomiphene.</p> <p>Objective: To examine cellular and molecular differences in the endometrium of women with suboptimal versus optimal endometrial thickening following clomiphene.</p> <p>Design: Translational prospective cohort study from 2018-2020.</p> <p>Setting: University-affiliated clinic.</p> <p>Patients or Participants: Reproductive age women with unexplained infertility treated with 100mg of clomiphene cycle days 3-7 who developed optimal (≥8mm; n=6, controls) or suboptimal (<6mm; n=7, subjects) endometrial thickness.</p> <p>Interventions:<b> </b>Pre-ovulatory blood and endometrial sampling.</p> <p>Main outcome measures:<b> </b>Endometrial tissue architecture, abundance and location of specific proteins, RNA expression, ERa binding.</p> <p>Results: The endometrium of suboptimal subjects compared to optimal controls was characterized by a reduced volume of glandular epithelium (16% vs 24%, P=0.01), decreased immunostaining of markers of proliferation (PCNA, ki67) and angiogenesis (PECAM-1), increased immunostaining of pan-leukocyte marker CD45 and ERb, but decreased ERa immunostaining (all P<0.05). RNASeq identified 398 differentially expressed genes between groups. Pathway analysis of differentially expressed genes indicated reduced proliferation (Z-score= -2.2, P<0.01), decreased angiogenesis (Z-score = -2.87, P<0.001), increased inflammation (Z-score= +2.2, P<0.01), and ERb activation (Z-score= +1.6, P<0.001) in suboptimal subjects. ChIP-seq identified 6 genes bound by ERα that were differentially expressed between groups (P<0.01), some of which may play a role in implantation.</p> <p>Conclusions: Women with suboptimal endometrial thickness after clomiphene exhibit aberrant estrogen receptor expression patterns, architectural changes and altered gene and protein expression, suggesting reduced proliferation and angiogenesis in the setting of increased inflammation.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.