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86 results for “Epistasis”
Data from: The Red Queen lives: epistasis between linked resistance loci
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Data from: Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
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Data from: Plasticity and epistasis strongly affect bacterial fitness after losing multiple metabolic genes
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Data from: Sign epistasis limits evolutionary trade-offs at the confluence of single- and multi-carbon metabolism in Methylobacterium extorquens AM1
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Data from: Fixation of mutators in asexual populations: the role of genetic drift and epistasis
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Data from: Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas
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Extreme positive epistasis for fitness in monosomic yeast strains - part 2
GEO Series GSE276940. Saccharomyces cerevisiae. 4 samples. Type: Expression profiling by high throughput sequencing.
Incipient speciation by divergent adaptation and antagonistic epistasis in yeast
GEO Series GSE6870. Saccharomyces cerevisiae. 8 samples. Type: Expression profiling by array.
Widespread genetic epistasis among cancer genes.
GEO Series GSE58834. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Extreme positive epistasis for fitness in monosomic yeast strains - part 1
GEO Series GSE217944. Saccharomyces cerevisiae. 27 samples. Type: Expression profiling by high throughput sequencing.
Cryptic variation fuels plant phenotypic change through hierarchical epistasis
GEO Series GSE289537. Solanum lycopersicum. 8 samples. Type: Expression profiling by high throughput sequencing.
ITPK1 sensitizes tumor cells to IgA-dependent neutrophil killing in vivo [CRISPR Epistasis]
GEO Series GSE273585. Mus musculus. 18 samples. Type: Other.
Combinatorial in vivo genome editing identifies widespread epistasis and an accessible fitness landscape during lung tumorigenesis
GEO Series GSE281604. Mus musculus. 74 samples. Type: Other.
Mitochondrial - Y Chromosome Epistasis in Drosophila melanogaster
GEO Series GSE155395. Drosophila melanogaster. 72 samples. Type: Expression profiling by high throughput sequencing.
Epistasis between TIFAB and miR-146a, neighboring genes in del(5q) MDS
GEO Series GSE87453. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Epistasis analysis of Runx1 and Gata1 over HoxA3 in hemogenic endothelium
GEO Series GSE25079. Mus musculus. 12 samples. Type: Expression profiling by array.
Data from: Selection biases the prevalence and type of epistasis along adaptive trajectories
The contribution to an organism's phenotype from one genetic locus may depend upon the status of other loci. Such epistatic interactions among loci are now recognized as fundamental to shaping the process of adaptation in evolving populations. Although little is known about the structure of epistasis in most organisms, recent experiments with bacterial populations have concluded that antagonistic interactions abound and tend to de-accelerate the pace of adaptation over time. Here, we use the NK model of fitness landscapes to examine how natural selection biases the mutations that substitute during evolution based on their epistatic interactions. We find that, even when beneficial mutations are rare, these biases are strong and change substantially throughout the course of adaptation. In particular, epistasis is less prevalent than the neutral expectation early in adaptation and much more prevalent later, with a concomitant shift from predominantly antagonistic interactions early in adaptation to synergistic and sign epistasis later in adaptation. We observe the same patterns when re-analyzing data from a recent microbial evolution experiment. These results show that when the order of substitutions is not known, standard methods of analysis may suggest that epistasis retards adaptation when in fact it accelerates it.
Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis
GEO Series GSE35139. Mus musculus. 28 samples. Type: Expression profiling by array.
Data from: Positive epistasis drives the acquisition of multidrug resistance.
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Data from: Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.