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Dataset results
468 results for “HLA”
Screen of ESK1 TCR mimic antibody against a library of HLA-A*02:01 MHC-I peptides
<p>Minigene sequencing of T2 cells sorted for high and low binding to the TCR mimic antibody "ESK1."</p>
High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response: summary statistics
<p>How human genetic variation contributes to vaccine immunogenicity and effectiveness is unclear, particularly in infants from Africa. We undertook genome-wide association analyses of eight vaccine antibody responses in 2,499 infants from three African countries and identified significant associations across the human leukocyte antigen (HLA) locus for five antigens spanning pertussis, diphtheria and hepatitis B vaccines. Using high-resolution HLA typing in 1,706 individuals from 11 African populations we constructed a continental imputation resource to fine-map signals of association across the class II HLA observing genetic variation explaining up to 10% of the observed variance in antibody responses. Using follicular helper T-cell assays, <em>in silico</em> binding, and immune cell eQTL datasets we find evidence of <em>HLA-DRB1</em> expression correlating with serological response and inferred protection from pertussis following vaccination. This work improves our understanding of molecular mechanisms underlying HLA associations that should support vaccine design and development across Africa with wider global relevance.</p>
Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refrac
ClinicalTrials.gov study NCT06986382. IPD Sharing: NO. Countries: 1. Publications: 13.
Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation
ClinicalTrials.gov study NCT02921685. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT01758510. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00673777. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
ClinicalTrials.gov study NCT06682793. IPD Sharing: YES. Countries: 1. Publications: 5.
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Gastric Cancer
ClinicalTrials.gov study NCT00845611. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide
ClinicalTrials.gov study NCT06828796. IPD Sharing: YES. Countries: 1. Publications: 10.
Safety and Efficacy Study of Epitope Peptide To Treat HLA-A*24 Disease Controlled Advanced Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT01950156. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Clofarabine, Cytarabine, and Filgrastim Followed by Infusion of Non-HLA Matched Ex Vivo Expanded Cord Blood Progenitors in Treating Patients With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01031368. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Complement (C1q) Binding to HLA Antibodies in a Solid-phase Immunoassay and Clinical Effect on Platelet Transfusion
ClinicalTrials.gov study NCT02858323. IPD Sharing: Not stated. Countries: 1. Publications: 3.
HLA-A*0201 Restricted Peptide Vaccine Therapy With Gemcitabine With Gemcitabine in Patient Pancreatic Cancer (Phase1)
ClinicalTrials.gov study NCT01266720. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
ClinicalTrials.gov study NCT03587272. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00674258. IPD Sharing: Not stated. Countries: 1. Publications: 5.
rATG Versus rATG Combined With Intravenous Immunoglobulin (IVIG) Induction Immunosuppression in HLA Incompatible Transplantation (INHIBIT)
ClinicalTrials.gov study NCT04302805. IPD Sharing: NO. Countries: 1. Publications: 1.
Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A)
ClinicalTrials.gov study NCT02276820. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
ClinicalTrials.gov study NCT03190941. IPD Sharing: YES. Countries: 1. Publications: 3.
Impact of HLA Evolutionary Divergence and HLA Donor-recipient Molecular Mismatches on Kidney Allograft Rejection
ClinicalTrials.gov study NCT06436586. IPD Sharing: NO. Countries: 1. Publications: 6.
Evaluation of Desensitization Protocols in HLA-incompatible Kidney-transplant Candidates
ClinicalTrials.gov study NCT03507348. IPD Sharing: NO. Countries: 1. Publications: 7.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.