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Dataset results
427 results for “Herpes”
Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes
ClinicalTrials.gov study NCT01658826. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis
ClinicalTrials.gov study NCT00878072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Single-cell Herpes simplex virus type-1 infection of neurons using drop-based microfluidics reveals heterogeneous replication kinetics
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Data from: The herpes simplex virus pUL16 and pUL21 proteins prevent capsids from docking at nuclear pore complexes
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Disease parameters following ocular herpes simplex virus type 1 infection are similar in male and female BALB/C mice
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High temperature induces transcriptomic changes in Crassostrea gigas that hinder progress of ostreid herpes virus (OsHV-1) and promote survival
<p>Of all environmental factors, seawater temperature plays a decisive role in triggering marine diseases. Like fever in vertebrates, high seawater temperature could modulate the host response to pathogens in ectothermic animals. In France, massive mortality of Pacific oysters, <em>Crassostrea gigas</em>, caused by the ostreid herpesvirus 1 (OsHV-1) is markedly reduced when temperatures exceed 24°C in the field. In the present study we assess how high temperature influences the host response to the pathogen by comparing transcriptomes (RNA sequencing) during the course of experimental infection at 21°C (reference) and 29°C. We show that high temperature induced host physiological processes that are unfavorable to the viral infection. Temperature influenced the expression of transcripts related to the immune process and increased the transcription of genes related to the apoptotic process, synaptic signaling and protein processes at 29°C. Concomitantly, the expression of genes associated with catabolism, metabolite transport, macromolecule synthesis and cell growth remained low from the first stage of infection at 29°C. Moreover, viral entry into the host might have been limited at 29°C by changes in extracellular matrix composition and protein abundance. Overall, these results provide new insights into how environmental factors modulate host–pathogen interactions.</p>
Data from: Ancient recombination events between human herpes simplex viruses
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to date contain HSV-1 fragments. Using phylogenomic analyses, we could also show that two main HSV-2 lineages exist. One lineage is mostly restricted to subSaharan Africa whereas the other has reached a global distribution. Interestingly, only the worldwide lineage is characterized by ancient recombination events with HSV-1. Our findings highlight the complexity of HSV-2 evolution, a virus of putative zoonotic origin which later recombined with its human-adapted relative. They also suggest that coinfections with HSV-1 and 2 may have genomic and potentially functional consequences and should therefore be monitored more closely.
Association of Disseminated Cutaneous Herpes Zoster and uncontrolled Diabetes Mellitus type II: A Case Report
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Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection
ClinicalTrials.gov study NCT01915212. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Efficacy and Safety of Fire Needle Therapy Combined With Cortex Phellodendri Compound Fluid Wet Compress for Acute Herpes Zoster: a Randomized Controlled Trial.
ClinicalTrials.gov study NCT06985589. IPD Sharing: NO. Countries: 1. Publications: 6.
Occlusion vs Standard Treatment for the Treatment of Herpes Zoster
ClinicalTrials.gov study NCT04258930. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Safety and Tolerability of Herpes Zoster Vaccine Rheumatologic Patients
ClinicalTrials.gov study NCT03016884. IPD Sharing: NO. Countries: 1. Publications: 13.
Valaciclovir to Prevent Transmission of Herpes Simplex Virus
ClinicalTrials.gov study NCT00001649. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Sol
ClinicalTrials.gov study NCT01254630. IPD Sharing: YES. Countries: 0. Publications: 4.
Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212)
ClinicalTrials.gov study NCT00158483. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adult Volunteers
ClinicalTrials.gov study NCT05245838. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Foscarnet Sodium and Sodium Chloride Injection in Patients With Herpes Zoster
ClinicalTrials.gov study NCT02151240. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster
ClinicalTrials.gov study NCT00831103. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long-Term Oral Acyclovir Usage to Prevent Herpes Zoster Virus Infection After Bone Marrow Transplant
ClinicalTrials.gov study NCT00209352. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Acyclovir Therapy for Genital Herpes Ulcers in HIV Negative African Women
ClinicalTrials.gov study NCT02053142. IPD Sharing: Not stated. Countries: 1. Publications: 31.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.