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151
datasets available to search
ShareScore release 0.9.0
Dataset results
151 results for “High throughput screening”
High throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
GEO Series GSE46483. Trypanosoma brucei brucei. 4 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Transcriptomics Screen of 137 Per- and Polyfluoroalkyl Substances (PFAS) in U-2 OS Cells
GEO Series GSE297135. Homo sapiens. 0 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Screening of Human Induced Pluripotent Stem Cell Cardiomyocytes Predicts Tyrosine Kinase Inhibitor Cardiotoxicity
GEO Series GSE88944. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
High throughput screens identify long non-coding RNA LOUP contributions to NFkB signaling and monocyte differentation.
GEO Series GSE247761. Homo sapiens. 15 samples. Type: Other.
High-throughput screen in post-implantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming
GEO Series GSE164250. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells
GEO Series GSE274318. Homo sapiens. 0 samples. Type: Other.
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
GEO Series GSE270608. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Demonstrating the utility of the ex vivo murine mycobacterial growth inhibition assay (MGIA) for high-throughput screening of tuberculosis vaccine candidates against multiple Mycobacterium tuberculosi
GEO Series GSE224467. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
High throughput CRISPR perturbation screens identify epigenetic regulators impacting primordial germ cell development [CRISPRi]
GEO Series GSE259289. Mus musculus. 6 samples. Type: Other.
High-throughput Drug Screening Identifies Fluoxetine as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE224715. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screening of gene expression in the patient's cholangiocarcinoma biopsy
GEO Series GSE107233. Homo sapiens. 1 samples. Type: Expression profiling by array; Third-party reanalysis.
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
GEO Series GSE42529. Homo sapiens. 12 samples. Type: Expression profiling by array.
SOSHI-seq: a high-throughput screening assay to test the functionality of putative response elements for nuclear hormone receptors.
GEO Series GSE298259. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation
GEO Series GSE143892. Homo sapiens. 25 samples. Type: Other.
Development and validation of a high-throughput screening pipeline of compound libraries to target EMT
GEO Series GSE284656. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
High throughput CRISPR screening identifies genes involved in macrophage viability and inflammatory pathways I
GEO Series GSE138786. synthetic construct; Mus musculus. 5 samples. Type: Other.
Probing the signaling requirements for naïve human pluripotency by high-throughput chemical screening [RNA-seq]
GEO Series GSE153212. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
High-throughput Drug Screening Identifies Ketotifen as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
GEO Series GSE225007. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Data from: High-throughput screening for ligands of the HEPN domain of sacsin
Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), which features the loss of Purkinje neurons in the cerebellum. Although the domain architecture of sacsin suggests that it is a neuronal chaperone assisting in protein quality control, the precise function of sacsin remains elusive. Using fluorescence polarization (FP) assays, we confirmed that the HEPN domain of sacsin binds to nucleotides with low micromolar affinities. FP competition assays with a variety of nucleotides and nucleotide analogs revealed that the binding is primarily mediated by the phosphate groups of nucleotides. A high-throughput screen subsequently identified novel small molecule ligands of HEPN, providing new chemical probes for cell culture studies and drug development. Together, the results are consistent with the HEPN domain contributing to the functional activity of sacsin by binding to nucleotides or other multiply charged anionic compounds in neurons.
A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening
<h1>Pan-Canadian Chemical Library</h1> <p>This Zenodo repository contains the cheap and druglike subset of the Pan-Canadian Chemical Library (PCCL) project. For more information, visit <a href="https://pccl.thesgc.org/" rel="nofollow">https://pccl.thesgc.org</a>.</p> <h2>PCCL library</h2> <p>The PCCL library is splitted by reaction, then by number of heavy atoms. Two types of files are available in zip archives:</p> <ul> <li>The SMILES format files, with the SMILES string and their product name,</li> <li>The CSV format file, with all the information generated during their enumeration: reagents, druglike properties, etc.</li> </ul> <p>Note: Purchasability is defined according to two integers: 1 for products only composed of BB-50 reagents, and 2 for products composed of BB-40 or BB-50 reagents. Read more about the meaning of these reagents groups in the article below.</p> <h2><a href="https://github.com/cbedart/PCCL#citation"></a>Citation</h2> <p>If you find the PCCL useful or if you use it, please cite our paper:</p> <p>Bedart, C. <em>et al.</em> A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening. ChemRxiv (2023).<br>doi:10.26434/chemrxiv-2023-jgbgv<br>This content is a preprint and has not been peer-reviewed.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.