Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
895
datasets available to search
ShareScore release 0.7.1
Dataset results
895 results for “Immunology”
Post-acute immunological and behavioral sequelae in mice after Omicron infection
Open the record for dataset details and reuse information.
Data from: Detecting genes for variation in parasite burden and immunological traits in a wild population: testing the candidate gene approach
Identifying the genes underlying phenotypic variation in natural populations can provide novel insight into the evolutionary process. Here we test the candidate gene approach to identifying loci involved in variation in gastrointestinal parasite burden, in a wild population of Soay sheep. A comprehensive literature review, Gene Ontology databases, and comparative genomics resources were used to generate a list of candidate genes. In a pilot study these candidates, along with 50 random genes, were then sequenced in pools of Soay sheep with low and high gastrointestinal nematode burden. Further candidates were identified from SNPs that were highly differentiated between high and low resistance sheep breeds. A panel of 192 candidate and control SNPs were then typed in 960 individual Soay sheep to examine whether they individually explained variation in parasite burden, as measured as faecal egg count (FEC), as well as two immune measures. The cumulative effect of the candidate and control SNPs were estimated by fitting genetic relationship matrices (GRMs) as random effects in animal models of the three traits. No more significant SNPs were identified in the pilot sequencing experiment and association study than expected by chance. Furthermore, no significant difference was found between the proportions of candidate or control SNPs that were found to be significantly associated with parasite burden/immune measures. No significant effect of the candidate or control gene GRMs was found. There is thus little support for the candidate gene approach to the identification of loci explaining variation in parasitological and immunological traits in this population.
Data for multi-dimensional characterization of cellular states in ovarian cancer reveals clinically relevant immunological subtypes and therapeutic vulnerabilities
<p>The data for figures</p>
Genetic and immunological evaluation of children with inborn errors of immunity and hypoxemic COVID-19 pneumonia
<p><strong><em>Background:</em></strong> SARS-CoV-2 has infected more than 450 million people around the world. In about 10% of cases, the infection leads to hypoxemic pneumonia, which is much rarer in children, while multisystem inflammation is seen almost only in children.</p> <p><strong><em>Methods:</em></strong> We evluated 31 young patients (0.5-19 years) who had both pre-existing inborn errors of immunity (IEI) and were later diagnosed with COVID-19 complications. Whole-exome sequencing was performed, SARS-CoV-2 specific antibodies and autoantibody against type I interferons were measured and plasma inflammatory factors were profiled. We also reviewed COVID-19 disease severity and outcome in IEI patients in the literature.</p> <p><strong><em>Results:</em></strong> A potential genetic cause of the IEI was identified in 28 patients (90.3%). The IgM and IgG-specific antibody response against the spike protein of the virus was positive in 14 (66.6%) of the IEI patients tested. Autoantibodies neutralizing type I interferons were identified in the plasma of two patients (6.8% of tested samples). Five patients fulfilled the diagnostic criteria of multisystem inflammatory syndrome in children (MIS-C). Eleven patients (35.4%) died due to COVID-19 complications showing a 3000 fold higher mortality rate compared to normal COVID-19 death rate in children (0.01%). For the additional 696 IEI patients reported till date, severe presentation of COVID-19 was observed in 23.3% of cases. Furthermore, a 5-fold higher mortality rate was observed, when compared with global infection-fatality reports.</p> <p><strong><em>Conclusions:</em></strong> Elucidating the genetic basis of IEI patients with severe/critical COVID-19 may help to better understand the human innate and adaptive immune response against SARS-CoV-2, which may assist to develop better preventive and therapeutic strategies.</p>
Nannochloropsis spp. as Feed Additive for the Pacific White Shrimp: Effect on Midgut Microbiology, Thermal Shock Resistance and Immunology
<p>This work aimed to evaluate Nannochloropsis spp. as feed additive in the diet of Pacific<br> white shrimp for their effect on midgut microbiology, thermal shock resistance and immunological<br> parameters. Initially, the digestibility of the microalgae meal was assessed, and the apparent<br> digestibility coefficient (ADC) was determined. The ADC was, in general, high in lipids (78.88%)<br> and eicosapentaenoic fatty acid (73.86%). Then, Nannochloropsis spp. were included in diets at four<br> levels (0, 0.5, 1 and 2% inclusion). The shrimp were reared in 500 L clear water tanks containing 20<br> shrimp per tank with an initial weight of 6.05 ± 0.06 g and fed four times a day. Shrimp fed with<br> supplemented diets containing Nannochloropsis spp. (0.5 and 2%) presented higher resistance to<br> thermal shock when compared to the non-supplemented group (control). Shrimp fed with 1 and 2%<br> of algae inclusion had a higher production of reactive oxygen species (ROS) when compared to<br> other treatments. No statistical difference was observed in the immunological parameters and<br> microbiology of the intestinal tract. Thus, the inclusion of Nannochloropsis spp. in shrimp diets at 0.5<br> and 2% levels increases resistance to thermal shock and ROS production in shrimp.</p>
The baseline immunological and hygienic status of pigs impact disease severity of African swine fever
<p>Primary data of manuscript</p>
Robust isolation protocol for mouse leukocytes from blood and liver resident cells for immunology research
<p>Isolation of liver and blood for single-cell RNAsequencing from mouse.</p>
A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates
Open the record for dataset details and reuse information.
Immunological indices and parasites in blackbirds
<p>1. Despite the intensive use of immune indices in immunoecology, whether to interpret the results of immune indices in terms of actual immune competence (i.e., ability to control and clear parasite infections as indicated by high values of immune indices associated with low parasite loads) or current immune activation (pathogenic infection being associated with high parasite load and high values of immune indices) is still an open question. Most studies to date have produced contrasting results focused on the effect of a single parasite species despite the fact that hosts usually harbour a community of parasites that influence one another's impact on host immune response.</p> <p>2. We simultaneously assessed blood parasites, intestinal parasites and ectoparasite loads in male blackbirds and compared these measures to several immune indices to investigate how parasites explain the variation around the mean of these immune indices.</p> <p>3. Parasite loads covaried within hosts. Immune indices better reflected the interacting effects of these parasites than the independent effect of each parasite. Immune indices may therefore be better indicators of ongoing pathogenic infections than immune competence. Furthermore, intestinal parasites explained a significant part of the variance in most immune indices through their interactions with other parasites, suggesting that they have a strong influence in modulating immune function.</p> <p>4. Taking the parasite community into account in immunoecology studies will certainly help increase our understanding of immune indices.</p>
Clinical and Immunological Evaluation of HA in Treatment of Periodontitis
ClinicalTrials.gov study NCT06324474. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Clinical, Virological, Serological and Immunological Characteristics During and Following COVID-19 Hospitalization
ClinicalTrials.gov study NCT05274373. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types
ClinicalTrials.gov study NCT05000294. IPD Sharing: NO. Countries: 1. Publications: 1.
IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.
ClinicalTrials.gov study NCT06166030. IPD Sharing: YES. Countries: 1. Publications: 3.
ERCP-induced and Non-ERCP Induced Acute Pancreatitis: Two Distinct Clinical and Immunological Entities?
ClinicalTrials.gov study NCT02602574. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Evaluation of Immunological Changes and Clinical Efficacy of Specific Immunotherapy With Der p House Dust Mite Allergen in Polysensitized and Monosensitized Patients With Allergic Rhinitis and/or Asth
ClinicalTrials.gov study NCT01795846. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Immunological Parameters Between MRONJ Stages
ClinicalTrials.gov study NCT06420284. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Clinical Study to Evaluate Safety and Immunologic Response of COMBIG-DC, in Patients With Metastatic Kidney Cancer
ClinicalTrials.gov study NCT01525017. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Maraviroc in Immunological Non-Responder (INR) HIV-1-infected Subjects
ClinicalTrials.gov study NCT00884858. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical and Immunological Investigations of Subtypes of Autism
ClinicalTrials.gov study NCT00298246. IPD Sharing: Not stated. Countries: 1. Publications: 16.
The Immunologic Reaction to Polypropylene Mesh in Inguinal Hernioplasty
ClinicalTrials.gov study NCT01090284. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.