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1,183 results for “Insertion”
PLAT Domain Protein 1 (PLAT1/PLAFP) Binds to the Arabidopsis thaliana Plasma Membrane and Inserts a Lipid
<p>Harvest yields depend on the plant's ability to fix carbon and deal with changing environmental conditions. Especially during seasonal and diurnal cycles, the plant must constantly adjust its metabolism according to available resources or external stressors. The metabolic changes that a plant undergoes in response to stress are well understood, but the long-distance signaling mechanisms that facilitate communication throughout the plant are less studied. The phloem is considered the predominant conduit for the bidirectional transport of these signals through metabolites, nucleic acids, proteins, and lipids. Lipid trafficking through the phloem in particular attracted our attention due to its reliance on soluble lipid-binding proteins (LBP) that generate and solubilize otherwise membrane-associated lipids. The Phloem Lipid-Associated Family Protein (PLAFP) from <em>Arabidopsis thaliana </em>is generated in response to abiotic stress as is its lipid-ligand phosphatidic acid (PA). PLAFP is proposed to transport PA through the phloem in response to drought stress. To understand the interactions between PLAFP and PA, almost 100 independent systems comprised of the protein and one PA, or a plasma membrane containing varying amounts of PA, were simulated. In the simulations, PLAFP does bind to the plasma membrane independent of the PA concentration, and it adopts a binding pose, where W41 and R82 penetrate the membrane surface and anchor PLAFP. This triggers a separation of the two loop regions containing W41 and R82. Subsequently, PA does insert into PLAFP's beta-sandwich and multiple amino acids besides W41 and R82 are identified that drive the insertion. Fine-tuning the protein-membrane and protein-PA interface by mutating a selection of these amino acids could allow modulating the signaling sensitivity to the climate the plant is supposed to grow in.</p>
Data from: Critical role of insertion preference for invasion trajectory of transposons
<p>It is unclear how mobile DNA sequences (transposable elements, hereafter TEs) invade eukaryotic genomes and reach stable copy numbers, as transposition can decrease host fitness. This challenge is particularly stark early in the invasion of a TE family at which point hosts may lack the specialized machinery to repress the spread of these TEs. One possibility (in addition to the evolution of host regulation of TEs), is that TE families may evolve to preferentially insert into chromosomal regions that are less likely to impact host fitness. This may allow the mean TE copy number to grow while minimizing the risk for host population extinction. To test this, we constructed simulations to explore how the transposition probability and insertion preference of a TE family influence the evolution of mean TE copy number and host population size, allowing for extinction. We find that the effect of a TE family's insertion preference depends on a host's ability to regulate this TE family. Without host repression, a neutral insertion preference increases the frequency of and decreases the time to population extinction. With host repression, a preference for neutral insertions minimizes the cumulative deleterious load, increases population fitness, and, ultimately, avoids triggering an extinction vortex.</p>
Zebrafish with lyz:EGFP expressing neutrophils: Mesh Well Inserts Z-stack 3
<p>96-well plate z-stack of zebrafish with lyz:EGFP expressing neutrophils acquired with a multi-camera array microscope (MCAM)(Ramona Optics Inc., Durham, NC, USA). Mesh well inserts are used and half of the zebrafish on the plate were injected with csf3r morpholino. The overall z-stack is broken into four files.</p> <p> </p> <p>HDF5 files can be opened using open source Python software: https://docs.xarray.dev/</p>
Zebrafish with lyz:EGFP expressing neutrophils: Mesh Well Inserts Z-stack 2
<p>96-well plate z-stack of zebrafish with lyz:EGFP expressing neutrophils acquired with a multi-camera array microscope (MCAM)(Ramona Optics Inc., Durham, NC, USA). Mesh well inserts are used and half of the zebrafish on the plate were injected with csf3r morpholino. The overall z-stack is broken into four files.</p> <p> </p> <p>HDF5 files can be opened using open source Python software: https://docs.xarray.dev/</p>
Zebrafish with lyz:EGFP expressing neutrophils: Mesh Well Inserts Z-stack 1
<p>96-well plate z-stack of zebrafish with lyz:EGFP expressing neutrophils acquired with a multi-camera array microscope (MCAM)(Ramona Optics Inc., Durham, NC, USA). Mesh well inserts are used and half of the zebrafish on the plate were injected with csf3r morpholino. The overall z-stack is broken into four files.</p> <p> </p> <p>HDF5 files can be opened using open source Python software: https://docs.xarray.dev/</p>
Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(sp3)–H Bonds
<p>Data underlying the figures in the publication "Artificial Metalloenzyme-Catalyzed Enantioselective Amidation via Nitrene Insertion in Unactivated C(<em>sp</em><sup>3</sup>)–H Bonds" published in <em>J. Am. Chem. Soc.</em>, <strong>2023</strong>, <a href="https://doi.org/10.1021/jacs.3c03969">https://doi.org/10.1021/jacs.3c03969</a>.</p> <p>Table of contents:</p> <ol> <li><strong>ja3c03969_si_001.pdf</strong>: General information, experimental section, figures, schemes, tables, and X-ray reports.</li> <li><strong>ja3c03969_raw_data.zip</strong>: Raw data</li> </ol>
Randomized Cross-Over Study of Self-Insertion of Two Placebo Vaginal Film Formulations
ClinicalTrials.gov study NCT04391036. IPD Sharing: NO. Countries: 1. Publications: 3.
Postplacental Intrauterine Device Insertion: A Mixed Methods Assessment of Women's Experience
ClinicalTrials.gov study NCT02312726. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Safety and Efficacy of Dexamethasone Ophthalmic Insert (Dextenza®) in the Management of Clinically Significant Dry Eye
ClinicalTrials.gov study NCT04498468. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate the Safety, Tolerability and Effectiveness of the Renew Insert in Treating Accidental Bowel Leakage
ClinicalTrials.gov study NCT01475474. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparing Peripherally Inserted Central Catheters to Long Peripheral Catheters in Pediatrics
ClinicalTrials.gov study NCT05346406. IPD Sharing: NO. Countries: 1. Publications: 12.
Postplacental Insertion of Levonorgestrel-releasing Intrauterine System (LNG-IUS) After Cesarean vs. Interval Insertion
ClinicalTrials.gov study NCT00635362. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Labor and Delivery Implant Insertion: A Randomized Controlled Trial
ClinicalTrials.gov study NCT02866643. IPD Sharing: NO. Countries: 1. Publications: 20.
Insertion of an Intrauterine Device (IUD) After Medical Abortion
ClinicalTrials.gov study NCT00621543. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion
ClinicalTrials.gov study NCT02391714. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women
ClinicalTrials.gov study NCT01534520. IPD Sharing: NO. Countries: 1. Publications: 1.
Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System
ClinicalTrials.gov study NCT01965899. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye
ClinicalTrials.gov study NCT01684436. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
ClinicalTrials.gov study NCT01539759. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation
ClinicalTrials.gov study NCT03318939. IPD Sharing: NO. Countries: 8. Publications: 1.
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