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462
datasets available to search
ShareScore release 0.9.0
Dataset results
462 results for “Lung injury”
Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury
ClinicalTrials.gov study NCT01581229. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Variable PSV in Acute Lung Injury: Part I and Part II
ClinicalTrials.gov study NCT01683669. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Study in Intensive Care Patients to Investigate the Clinical Effect of Repetitive Orally Inhaled Doses of AP301 on Alveolar Liquid Clearance in Acute Lung Injury
ClinicalTrials.gov study NCT01627613. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)
ClinicalTrials.gov study NCT05304702. IPD Sharing: UNDECIDED. Countries: 1. Publications: 30.
Serum Level of Calpains Product as a Novel Biomarker of Acute Lung Injury Following Cardiopulmonary Bypass
ClinicalTrials.gov study NCT05610475. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Resistive Inspiratory Muscle Training Optimizing Lung Function in Spinal Cord Injury
ClinicalTrials.gov study NCT06547606. IPD Sharing: NO. Countries: 0. Publications: 6.
Thoracic Fluid Content and Acute Lung Injury
ClinicalTrials.gov study NCT01922557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inflammatory Genetic Polymorphism and Acute Lung Injury After Cardiac Surgery
ClinicalTrials.gov study NCT00826072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Different Lung Isolation Devices on Pharyngolaryngeal Injuries After Pulmonary Resection
ClinicalTrials.gov study NCT07117539. IPD Sharing: NO. Countries: 1. Publications: 1.
Minimizing Lung Injury During Laparoscopy in Steep Trendelenburg Position
ClinicalTrials.gov study NCT04900714. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury
ClinicalTrials.gov study NCT00127491. IPD Sharing: NO. Countries: 1. Publications: 5.
A Study of RLS-0071 in Patients With Acute Lung Injury Due to COVID-19 Pneumonia in Early Respiratory Failure
ClinicalTrials.gov study NCT04574869. IPD Sharing: NO. Countries: 1. Publications: 1.
Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury
ClinicalTrials.gov study NCT04511923. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Neutrophil Elastase Inhibitor on Lung Injury After Esophagectomy
ClinicalTrials.gov study NCT01170845. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dataset for Subnormothermic ex vivo lung perfusion attenuates ischemia reperfusion injury from donation after circulatory death donors
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Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation
Open the record for dataset details and reuse information.
Cardioespiratory physiological perturbations after acute smoke-induced lung injury and during extracorporeal membrane oxygenation support in sheep
<p><span><b>Background:</b> Numerous successful therapies developed for human medicine involve animal experimentation. Animal studies that are focused solely on translational potential, may not sufficiently document unexpected outcomes. Considerable amounts of data from such studies could be used to advance veterinary science. For example, sheep are increasingly being used as models of intensive care and therefore, data arising from such models must be published. In this study, the hypothesis is that there is little information describing physiological data from sheep models of intensive care and the author aimed to analyse such data to provide biological information that is currently not available for sheep that received extracorporeal life support (ECLS) following acute smoke-induced lung injury. </span></p> <p><span><b>Methods:</b> Nineteen mechanically ventilated adult ewes undergoing intensive care during evaluation of a form of ECLS (treatment) for acute lung injury were used to collate clinical observations. Eight sheep were injured by acute smoke inhalation prior to treatment (injured/treated), while another eight were not injured but treated (uninjured/treated). Two sheep were injured but not treated (injured/untreated), while one received room air instead of smoke as the injury and was not treated (placebo/untreated). The data were then analysed for 11 physiological categories and compared between the two treated groups.</span></p> <p><span><b>Results:</b> Compared with the baseline, treatment contributed to and exacerbated the deterioration of pulmonary pathology by reducing lung compliance and the arterial oxygen partial pressure to fractional inspired oxygen (PaO<sub>2</sub>/FiO<sub>2</sub>) ratio. The oxygen extraction index changes mirrored those of the PaO<sub>2</sub>/FiO<sub>2</sub> ratio. Decreasing coronary perfusion pressure predicted the severity of cardiopulmonary injury. </span></p> <p><b>Conclusions:</b> These novel observations could help in understanding similar pathology such as that which occurs in animal victims of smoke inhalation from house or bush fires, aspiration pneumonia secondary to tick paralysis and in the management of the severe coronavirus disease 2019 (COVID-19) in humans.</p>
Berberine protects against sepsis-related acute lung injury in rats via the upregulation of the PPAR - Υ signaling pathway, with amelioration at the cellular level - A functional, immune-histological and biochemical study
<p>Aim: To assess the therapeutic effects of berberine in experimentally induced lung sepsis. Examining its effects on selected cytokines, gene and protein expression and the histopathological findings.</p> <p>Results: Berberine significantly reduced the wet/dry lung ratio, the BALF protein, cell, and neutrophils percentage & the BALF cytokines levels. In addition, pretreatment with berberine decreases the myeloperoxidase and MDA levels and decreases gene expression of NFKB, MCP -1 and the ICAM - 1 by RT - PCR analysis. Thus, suggesting an antioxidant and anti-inflammatory mode of the action. Western blot analysis revealed increased PPAR – Υ expression in the berberine pretreated group compared to the CLP group. Histopathological examination revealed improved histopathological parameters, in the berberine pretreated group, compared to the CLP group.</p> <p>Conclusion: Berberine improves the outcome in sepsis via antioxidant and anti-inflammatory effects, modulation of cytokine levels, upregulation of PPAR - Υ protein expression, and histopathological amelioration.</p>
Work of Breathing and Mechanical Ventilation in Acute Lung Injury
ClinicalTrials.gov study NCT00961168. IPD Sharing: Not stated. Countries: 0. Publications: 14.
Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)
ClinicalTrials.gov study NCT07302243. IPD Sharing: NO. Countries: 1. Publications: 0.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.