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Dataset results
175 results for “Membrane protein”
Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant
ClinicalTrials.gov study NCT01164514. IPD Sharing: Not stated. Countries: 1. Publications: 1.
First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor
ClinicalTrials.gov study NCT02661373. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Milk Fat Globule Membrane (MFGM) - Enriched Formula With Reduced Energy and Protein Content on Growth and Development
ClinicalTrials.gov study NCT00624689. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from: Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress
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Mitochondrial and ER membrane protein trafficking CRISPR screens
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Annealing simulations of a lipid membrane with different amounts of transmembrane proteins
<p>soon...</p>
Annealing simulations of a lipid membrane with different transmembrane proteins
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Simulations of a lipid membrane with different amounts of transmembrane proteins at different temperatures
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Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was blocked by acidic lipids and competed by other basic proteins. Further studies revealed that MBP induced damage to neuronal membrane integrity and function by depolarizing the resting membrane potential, increasing the permeability to cations and other molecules, and decreasing the membrane fluidity. At last, artificial liposome vesicle assay showed that MBP directly disturbed acidic lipid bilayer and resulted in increased membrane permeability. These results revealed that MBP induces neurotoxicity through its direct interaction with acidic components on the extracellular surface of neuronal membrane, which may suggest a possible contribution of MBP to the pathogenesis in the CNS disorders with myelin damage.
Data Repository: Fast Single-Particle Tracking of Membrane Proteins Combined with Super-Resolution Imaging of Actin Nanodomains
<p>This repository contains a collection of correlated 2D super-resolution images obtained through single molecule localization microscopy and 3D time series of single particle tracking data of membrane proteins. By utilizing high-speed fluorescent microscopy, we tracked a transmembrane protein – the high-affinity IgE receptor – and an outer-leaflet protein – GPI-anchored protein – at the frame rate of 490 Hz. Subsequently, actin structures of the same cells were captured using a super-resolution microscopy (dSTORM technique). Additionally, this dataset includes Technical Validation to support the transition from live-cell imaging to fixed-cell imaging when adding fixation buffers. </p> <p>The data was classified as “Class I” and “Class II” describing two categories of RBL-2H3 cells. In "Class I", the cells were untransfected. In “Class II”, the cells were transfected to express GFP-GPI-anchored fusion protein. The zip folder names that include “IgE Untreated” include image time series of fluorescently labeled IgE receptors in untreated RBL-2H3 cells and image series of corresponding super-resolution imaging of fluorescently labeled actin filaments of the same cell in “SRImage” folder.</p> <p>The data with folder names including with “IgE Treated” are image time series of fluorescently labeled IgE receptors in either phalloidin- or PMA-treated RBL-2H3 cells and corresponding image series of super-resolution imaging of fluorescently labeled actin filaments in the same cell.</p> <p>Similarly, the data with folder names starting with “GPI Untreated” are image time series of fluorescently labeled GPI-anchored proteins in untreated RBL-2H3 cells and corresponding image series of super-resolution imaging of fluorescently labeled actin filaments in the same cell.</p> <p>The data with folder names starting with “GPI Treated” are image time series of fluorescently labeled GPI-anchored proteins in phalloidin treated RBL-2H3 cells and corresponding image series of super-resolution imaging of fluorescently labeled actin filaments in the same cell.</p> <p>The number within each folder name represents an individual experiment and the corresponding data collected under the same conditions.</p> <p>For all experiments an IR movie was added to monitor the cell morphology during live-cell image and adding initial fixation buffer and it was saved in the tracking file. </p> <p>The HDF5 files of all data are available in the second version of this repository. For each sample, there are two files: "Tracking.h5" and "SuperResolution_actin.h5". The "Tracking" files include two groups: single-particle tracking data and IR images during tracking. The "SuperResolution_actin" files contain two groups: super-resolution images of actin filaments and IR reference images for image registeration and drift correction during data collection. </p> <p> </p> <p> </p> <p> </p>
ArsR transcriptional regulator mediated attenuated mechanism by regulating self and outer membrane protein in Brucella
<p><span>The ArsR family transcriptional regulators are widely distributed in microorganisms, including in the important intracellular pathogen <i>Brucella</i>. ArsR proteins are implicated in numerous biological processes. However, the specific roles of ArsR family members in <i>Brucella</i> remain obscure. Here we show that ArsR3 (BSS2_RS07325) is required for <i>Brucella</i> survival both under stress <i>in vitro</i> conditions and in a murine infection model<i> in vivo</i>. ArsR3 autoregulate its own expression to maintain metal ion homeostasis to benefit bacterial survival. Moreover, ArsR3 also regulates the production of virulence factor outer membrane protein 25D (Omp25D) which is key for the survival of <i>Brucella</i> under stress conditions. Significantly, ArsR3 deletion strain attenuated in a murine infection model<i> in vivo</i>. Altogether, our findings reveal a unique mechanism in which the ArsR family member ArsR3 autoregulates its expression and also modulates Omp25D expression to maintain metal ion homeostasis and virulence in <i>Brucella</i>.</span></p>
Supporting data for protein membrane simulations in "Recalibration of protein interactions in Martini 3"
<p>Coarse-grained molecular dynamics simulations of protein-membrane systems from "Recalibration of protein interactions in Martini 3". Simulations were run with the Martini 3.0 force field, along with two modified versions of Martini 3.0 in which the well-depth, ε, in the Lennard-Jones potential between all protein and water beads was rescaled by a factor <em>λ</em><sub>PW</sub>, ε in the Lennard-Jones potential between all protein beads was rescaled by a factor <em>λ</em><sub>PP</sub>. The simulation files are organized into one tar file for each rescaling approach. The simulation files are in xtc format, and are accompanied by a structure in gro format for system topology and a tpr file to start the simulation.</p>
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
Open the record for dataset details and reuse information.
ArsR transcriptional regulator mediated attenuated mechanism by regulating self and outer membrane protein in Brucella
Open the record for dataset details and reuse information.
Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression
GEO Series GSE162123. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A previously uncharacterized Kidney-Associated Membrane Protein (KAMP) is associated with evolutionary adaptation, energy balance and kidney physiology
GEO Series GSE206860. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation
GEO Series GSE308213. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
Epstein-Barr Virus (EBV)-positive B-cell strain, 28-2: Low v. High latent membrane protein 1 (LMP1)-mRFP expression (miRNA)
GEO Series GSE33972. human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Murid gammaherpesvirus 4; Betapolyomavirus hominis; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by array.
Xrn1 activates transcription, translation and decay of mRNAs encoding membrane proteins
GEO Series GSE109734. Saccharomyces cerevisiae. 19 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of Escherichia coli strains producing exogenous internal membrane proteins
GEO Series GSE109819. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.