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141 results for “Microtubules”
Mass spectrometry of natively decorated doublet microtubule from Tetrahymena thermophila WT and mutants
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Microtubule
Drawing uploaded to scidraw.io on: 12 March 2020
Data from: A mathematical understanding of how cytoplasmic dynein walks on microtubules
Cytoplasmic dynein 1 is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article we formulate, based on physical principles, a mechanical model to describe the stepping behaviour of cytoplasmic dynein walking on microtubules from the cell membrane towards the nucleus. Unlike previous studies on physical models of this nature, we base our formulation on the whole structure of cytoplasmic dynein 1 to include the temporal dynamics of the individual subunits such as the cargo (for example an endosome, vesicle or bead), two rings of six ATPase domains associated with diverse cellular activities (AAA+ rings) and the microtubule binding domains which allow dynein to bind to microtubules. This mathematical framework allows us to examine experimental observations on dynein across a wide range of different species, as well as being able to make predictions on the temporal behaviour of the individual components of dynein not currently experimentally measured. Furthermore, we extend the model framework to include backward stepping, variable step size and dwelling. The power of our model is in its predictive nature; first it reflects recent experimental observations that dynein walks on microtubules using a weakly coordinated stepping pattern with predominantly not passing steps. Second, the model predicts that interhead coordination in the ATP cycle of cytoplasmic dynein is important in order to obtain the alternating stepping patterns and long run lengths seen in experiments.
Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation
<p>Data and metadata associated to the paper </p><p><strong>doi:</strong> https://doi.org/10.1101/2023.10.29.564574</p>
Data for the publication "Mechanical communication within the microtubule through network-based analysis of tubulin dynamics"
<p>Repository containing all the necessary data to replicate the study "Mechanical communication within the microtubule through network-based analysis of tubulin dynamics", published in Biomechanics and Modeling in Mechanobiology (https://doi.org/10.1007/s10237-023-01792-5).</p>
Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery.
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Supplementary for Cross-linker design determines microtubule network organization by opposing motors
<p>This file contains Cytosim version, simulation configuration files and analysis scripts used in Cross-linker design determines microtubule network organization by opposing motors (10.1073/pnas.2206398119). </p>
Figures 15–23 in Cell structure and microtubule organisation during gametogenesis of Ulva mutabilis Føyn (Chlorophyta)
Figures 15–23: Transmission electron micrographs of developing gametangia and complete gametes of Ulva mUtabilis. (15) Metaphase nucleus of developing gametangium. The nuclear envelope (NE) is still intact with gaps only at poles (arrows). Spindle microtubules (MT) traverse the nucleoplasm, but do not radiate out of the centrosome (C), which is attached to the external membrane. Scale bar: 0.5 µm. (16) Developing gametangium, in which first nuclear division is completed. Note that furrowing membranes (arrow) are growing between daughter nuclei (N). Scale bar: 2.6 µm. (17) Advanced stage of gamete formation, showing the furrowing membrane (arrow) development separating two daughter nuclei (N). The centrosome-like structures (C) are not connected to the nuclei, but to the external membrane. Scale bar: 0.7 µm. (18) Developing furrowing membranes and vesicles (probably of dictyosome origin, see white arrow). Note increased number of active dictyosomes (D) and membranes of ER close to developing furrow. Scale bar: 0.8 µm. (19) Fully developed gametangium before gamete release. Gametes are still connected to each other by thin cytoplasmic bridges (arrows). Scale bar: 3 µm. (20) Part of fully developed gamete at high magnification. Basal bodies (BB) of flagella are visible close to surrounding membrane. Scale bar: 0.3 µm. (21) Longitudinal section of gamete, showing nucleus, chloroplast with a pyrenoid (P) and starch grains (S) and one of the two flagella. Note that gamete is still connected to neighbouring gametes (arrows). Scale bar: 1 µm. (22 and 23) Detail of cytoplasmic bridges connecting neighbouring gametes. Note the dark-stained borders of cytoplasmic bridge and microtubules close to membrane. Scale bars: 0.5 and 0.1 µm.
Figures 24–26 in Cell structure and microtubule organisation during gametogenesis of Ulva mutabilis Føyn (Chlorophyta)
Figures 24–26: Advanced stages of gametangia formation of Ulva mUtabilis (before gamete release). (24) Cross-section of fully developed gametangium. Cell wall in conical projection appears broken and opening is plugged by cap of cell wall material. Scale bar: 2.8 µm. (25) Detail of cap. Cell wall appears differentiated with loose fibrillar layers embedded in amorphous matrix. Scale bar: 0.69 µm. (26) Exit pore of gametangium. Cap is not visible, but darkly stained amorphous material appears gathered in pore and below (arrow). Vesicles are observed among the gametes. Scale bar: 1.2 µm.
Force-mediated microtubule stabilization induces global nuclear remodelling in neurons
<p>Data and Metadata associated with a publication </p>
ATG9A facilitates the biogenesis of influenza A virus liquid condensates near the ER by dissociating recycling vesicles from microtubules
<p>Raw Data</p>
ATG9A regulates dissociation of recycling endosomes from microtubules leading to formation of influenza A virus liquid condensates - SUPPLEMENTARY FIGURES
<p>Metadata for the manuscript "ATG9A regulates dissociation of recycling endosomes from microtubules leading to formation of influenza A virus liquid condensates" - Supplementary Figures</p>
Microtubule-Targeted Agent BAL101553 and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT03250299. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: A mathematical understanding of how cytoplasmic dynein walks on microtubules
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Data from: Automated stitching of microtubule centerlines across serial electron tomograms
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Active nematic order and dynamic lane formation of microtubules driven by membrane-bound diffusing motors
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Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules
GEO Series GSE246488. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues
GEO Series GSE128414. Homo sapiens. 31 samples. Type: Expression profiling by high throughput sequencing.
GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization
GEO Series GSE135264. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Polyglutamylation of microtubules drives neuronal remodeling
GEO Series GSE296782. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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