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79
datasets available to search
ShareScore release 0.9.0
Dataset results
79 results for “Mouse behavior”
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
GEO Series GSE173262. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The circadian gene Nr1d1 in the mouse nucleus accumbens modulates social reward and anxiety-related behavior
GEO Series GSE110363. Mus musculus. 23 samples. Type: Expression profiling by array.
Characterization of pain-related behaviors and gene expression profiling of peripheral sensory ganglia of a mouse model of acute ankle sprain
GEO Series GSE230178. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
UBE3A reinstatement restores behavior and proteome in an Angelman syndrome mouse model of imprinting defects
GEO Series GSE284678. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression (palme-affy-mouse-84746)
GEO Series GSE4035. Mus musculus. 24 samples. Type: Expression profiling by array.
ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome
<p>This data package includes excel files containing all raw data needed to reproduce the analyses associated to the following study by D' Addario SL, Rosina E, Massaro Cenere M, Bagni C, Mercuri NB, Ledonne A: "<em>ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome</em>" (preprint doi: https://doi.org/10.1101/2024.02.23.581801). </p>
Data from: Sensory-Behavioral Deficits in Parkinson's Disease: Insights from a 6-OHDA Mouse Model
<table> <tbody> <tr> <td>Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the striatum, predominantly associated with motor symptoms. However, non-motor deficits, particularly sensory symptoms, often precede motor manifestations, offering a potential early diagnostic window. The impact of non-motor deficits on sensation behavior and the underlying mechanisms remains poorly understood. In this study, we examined changes in tactile sensation within a Parkinsonian state by employing a mouse model of PD induced by 6-hydroxydopamine (6-OHDA) to deplete striatal dopamine (DA). Leveraging the conserved mouse whisker system as a model for tactile-sensory stimulation, we conducted psychophysical experiments to assess sensory-driven behavioral performance during a tactile detection task in both the healthy and Parkinson-like states. Our findings reveal that DA depletion induces pronounced alterations in tactile sensation behavior, extending beyond expected motor impairments. We observed diverse behavioral deficits, spanning detection performance, task engagement, and reward accumulation, among lesioned individuals. While subjects with extreme DA depletion consistently showed severe sensory behavioral deficits, others with substantial DA depletion displayed minimal changes in sensory behavior performance. Moreover, some exhibited moderate degradation of behavioral performance, likely stemming from sensory signaling loss rather than motor impairment. The implementation of a sensory detection task is a promising approach to quantify the extent of impairments associated with DA depletion in the animal model. This facilitates the exploration of early non-motor deficits in PD, emphasizing the importance of incorporating sensory assessments in understanding the diverse spectrum of PD symptoms.</td> </tr> </tbody> </table>
Life Span Analysis of Brain Development, Gene Expression and Behavioral Phenotypes in the Ts1Cje, Ts65Dn and Dp16 Mouse Models of Down Syndrome
GEO Series GSE99135. Mus musculus. 128 samples. Type: Expression profiling by array.
Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models
GEO Series GSE138539. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix
GEO Series GSE156965. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDAR complex translation in mouse models of psychiatric disorders
GEO Series GSE166939. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease
GEO Series GSE254835. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Fetal toll-like receptor 3 signalling contributes to the induction of autism-like behaviors in a mouse model of maternal immune activation
GEO Series GSE196151. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4
GEO Series GSE155131. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Designed macrocyclic peptide rescues behavioral impairment and brain pathology in an Alzheimer’s disease mouse model
GEO Series GSE246244. Mus musculus. 71 samples. Type: Expression profiling by high throughput sequencing.
Paternal exposure to methylphenidate induces ADHD-like behavioral phenotypes and altered gene expressions in mouse offspring.
GEO Series GSE211982. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex
GEO Series GSE201991. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome-guided GLP-1 receptor therapy rescues metabolic and behavioral disruptions in a Bardet-Biedl Syndrome mouse model
GEO Series GSE293590. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
VGF-derived TLQP21 peptide ameliorates tumor progression, pain and depression-like behaviors in an orthotopic mouse model of pancreatic ductal adenocarcinoma
GEO Series GSE277090. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.