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674 results for “Notch”
Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling
<p class="MsoNormal"><span>Endogenous </span><span>humoral factors </span><span>that</span><span> link systemic and/or local insulin demand to pancreatic β-cells have not been identified. Here</span><span>,</span><span> we demonstrated that T-cadherin, a unique glycosylphosphatidylinositol-anchored cadherin primarily expressed in vascular endothelial cells and cardiac and skeletal muscle cells, but not in pancreatic β-cells, was secreted as soluble forms and was important for β-cell proliferation. <em>Cdh13</em> (T-cadherin) knockout mice exhibited impaired glucose handling due to attenuated β-cell proliferation under high-fat diet conditions. The gene expression analyses indicated the impairment in cell cycle and Notch signaling in the islets of T-cadherin knockout mice under high-fat diet conditions. In streptozotocin-induced diabetes, the replacement of soluble T-cadherin improved β-cell mass and blood glucose </span><span>levels</span><span> in T-cadherin knockout mice. </span><span>R</span><span>ecombinant soluble T-cadherin upregulated Notch signaling in cultured murine islets. We concluded that soluble T-cadherin could work as an endogenous humoral factor whose signaling pathways including Notch signaling regulate β-cell proliferation under diabetic conditions in mice.</span></p>
Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits EPhys raw data
<p>Shared lineage has diverse effects on patterns of neuronal connectivity. In mammalian cortex, excitatory sister neurons assemble into shared microcircuits, whereas throughout the <em>Drosophila</em> nervous system, Notch-differentiated sister neurons diverge into distinct circuits. Notch-differentiated sister neurons have been observed in vertebrate spinal cord and cerebellum, but whether they integrate into shared or distinct circuits remains unknown. Here we evaluate the connectivity between sister V2a/b neurons in the zebrafish spinal cord. Using an <em>in</em> <em>vivo</em> labeling approach, we identified pairs of sister V2a/b neurons born from individual Vsx1+ progenitors and observed that they have similar axonal trajectories and proximal somata. However, paired whole-cell electrophysiology and optogenetics revealed that sister V2a/b neurons receive input from distinct presynaptic sources, do not communicate with each other, and connect to largely distinct targets. These results resemble the divergent connectivity in <em>Drosophila</em> and represent the first evidence of Notch-differentiated circuit integration in a vertebrate system.</p>
FR019, Middle Archaic, Eva basal notched points
Eva Basal Nothced Points Middle Archaic Catalog #: FR 5/41 P130 Uploaded by Gwyneth Harris Suggested Data Citation: Thompson, Christine, Erin Powers, Gwyneth Harris, and Kevin C. Nolan, 2021. FRHS_FR019, 3D Model .ply file. Digital Exhibit of Fort Recovery Historical Society's Precontact Collection, Fort Recovery Historical Society and Applied Anthropology Laboratories, Ball State University. Source: Objaverse 1.0 / Sketchfab
Hardaway Side Notched
This stone projectile point is known as a Hardaway Side Notched, and it was found at a multi-component site (31WA2199) in eastern Wake County, NC. This type of artifact was used as a spear or dart point and likely was secondarily used as a knife and/or scraping tool. It dates to the late Paleoindian period (c. 8500-7900 BC). This artifact is made from a metavolcanic stone commonly called rhyolite and measures 5.1 cm long, 3.2 cm wide, and 0.6 cm thick. This model was constructed by David Cranford with 61 photos using the Agisoft Metashape software. (Credit: NCDNCR/OSA) Source: Objaverse 1.0 / Sketchfab
Kirk Corner-Notched (690a403)
**Kirk Corner-Notched spear point** Location: Hardaway site (31St4), Stanly County, North Carolina. Period: Early Archaic (7000-6000 BC). Material: metavolcanic rock. Dimensions: length, 55.9 mm; width, 33.4 mm; thickness, 7.9 mm. Notes: Catalog no. 690a403, North Carolina Archaeological Collection, Research Laboratories of Archaeology, University of North Carolina at Chapel Hill. Illustrated in *The Formative Cultures of the Carolina Piedmont*, by Joffre L. Coe, Transactions of the American Philosophical Society vol. 54, pt. 5, 1964, Figure 60. Model by Steve Davis. Source: Objaverse 1.0 / Sketchfab
Prediction of Development of Scapular Notching Following Reverse Total Shoulder Arthroplasty
ClinicalTrials.gov study NCT02052466. IPD Sharing: NO. Countries: 1. Publications: 1.
Notch Inhibitor in Advanced Cancer
ClinicalTrials.gov study NCT01158404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
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Data from: Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
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Clonally related, Notch-differentiated spinal neurons integrate into distinct circuits EPhys raw data
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Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling
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FIGURE 10 in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 10. Map showing the current collecting records of Aetius decollatus. Θ—new record, Ɨ/?—records from literature, question mark indicates that type locality in Sri Lanka is unknown.
FIGURE 7A–D. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 7A–D. Aetius decollatus. A Epigastric sclerite and epigyne, ventral view; B Epigyne showing mating plug (arrow) in the right copulatory opening; C Epigyne cleared, dorsal view; D Epigyne (holotype), dorsal view. Scale bar: A–D: 0.5 mm. Image D by Zoë Simmons.
FIGURE 6A–E. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 6A–E. Aetius decollatus. A Holotype female, dorsal view; B Same, lateral view; C Female habitus (from Pollachi, Tamil Nadu, India), dorsal view; D Same, lateral view; E Female habitus (from Wayanad Wildlife Sanctuary, Kerala, India), with variation in the anterodorsal reddish-orange pattern, dorsolateral view; F Female abdomen, ventral view. Abbreviations: ES—epigastric sclerite, VS—ventral sclerite. Scale bar: A–F: 2 mm. Images A & B by Zoë Simmons.
FIGURE 8A–C. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 8A–C. Aetius decollatus. A Epigyne, ventral view; B Same, dorsal view; C Same, with mating plug in the right copulatory opening, ventral view. Abbreviations: CD—copulatory duct, CO—copulatory opening, FD—fertilisation duct, MP—mating plug. Scale bar: A–C: 0.5 mm.
FIGURE 5A–G. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 5A–G. Aetius decollatus. A Male left palp, prolateral view; B Same, ventral view; C Same, retrolateral view; D Expanded palp with twisted bulb showing tegular neck inserted into the cymbial semi-circular notch, ventral view; E Same, retrolateral view; F Embolus, enlarged, ventral view, G Female left tarsus III, lateral view (arrow indicates paired short ventral spine-like setae). Abbreviations: CN—cymbial semi-circular notch, E—embolus, PR—prolateral ridge, PB—prolateral bulge of tegulum, RTA—retrolateral tibial apophysis, SD—sperm duct, ST—subtegulum, T—tegulum, TN—tegular neck. Scale bars: A–E: 1 mm; F: 0.5mm; G: 0.15 mm.
FIGURE 4A–E. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 4A–E. Aetius decollatus. A Male left palp, prolateral view; B Same, ventral view; C Same, retrolateral view; D Expanded palp with twisted bulb showing tegular neck inserted into the cymbial semi-circular notch, ventro-retrolateral view; E Same, retrolateral view. Scale bar: A–E: 1 mm.
FIGURE 9A–B in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 9A–B. Aetius decollatus. View of the collection sites of fresh materials: A Wayanad Wildlife Sanctuary, Kerala; B Pollachi, Tamil Nadu. Photo credit A–B by Karunnappilli S. Nafin.
FIGURE 3A–E. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 3A–E. Aetius decollatus. A Male habitus, dorsal view; B Female habitus, dorsal view; C Female, frontal view; D Female habitus, lateral view; E Male habitus, lateral view (arrows indicate tufts of long white hairs). Scale bar: A–E: 1 mm.
FIGURE 2A–C. Aetius decollatus. A in n the type species of the genus Aetius O. Pickard-Cambridge, 1896: The first description of male with notes on cymbial notch and mating plug (Araneae: Corinnidae: Castianeirinae)
FIGURE 2A–C. Aetius decollatus. A Male habitus, dorsal view; B Same, ventral view; C Same, lateral view. Abbreviations: ES—epigastric sclerite, IS—inframamillary sclerite, VS—ventral sclerite. Scale bar: A–C: 1 mm.
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Allen Brain Atlas
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