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Dataset results
470 results for “PIVOT”
Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients
ClinicalTrials.gov study NCT01174446. IPD Sharing: Not stated. Countries: 14. Publications: 1.
Respicardia, Inc. Pivotal Trial of the remedē System
ClinicalTrials.gov study NCT01816776. IPD Sharing: Not stated. Countries: 3. Publications: 12.
A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Naturalistic Setting
ClinicalTrials.gov study NCT02520388. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation
ClinicalTrials.gov study NCT04612244. IPD Sharing: NO. Countries: 1. Publications: 2.
12 / 48 wk Pivotal PFT vs PBO in COPD II
ClinicalTrials.gov study NCT00782509. IPD Sharing: Not stated. Countries: 4. Publications: 4.
A Pivotal Subjective Sleep Study of a Nasal Dilator (Breathe Right Tan)
ClinicalTrials.gov study NCT03549117. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pivotal Phase 2b/3 ALVAC/Bivalent gp120/MF59 HIV Vaccine Prevention Safety and Efficacy Study in South Africa
ClinicalTrials.gov study NCT02968849. IPD Sharing: NO. Countries: 1. Publications: 6.
Lucica ® Glycated Albumin-L Clinical Program - Pivotal Study
ClinicalTrials.gov study NCT02489773. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Pivotal role of O-antigenic polysaccharide display in the sensitivity against phage tail-like particles in environmental Pseudomonas kin competition
Open the record for dataset details and reuse information.
Data from: Pivotal effect of early-winter temperatures and snowfall on population growth of alpine Parnassius smintheus butterflies
Geographic range shifts in species' distributions, due to climate change, imply altered dynamics at both their northern and southern range limits, or at upper and lower elevational limits. There is therefore a need to identify specific weather or climate variable(s), and life stages or cohorts on which they act, and how these affect population growth. Identifying such variables permits prediction of population increase or decline under a changing climate, and shifts in a species' geographic range. For relatively well studied groups, such as butterflies, geographic range shifts are well documented, but weather variables and mechanisms causing those shifts are not well known. The Holarctic butterfly genus Parnassius (Papilionidae) inhabits northern and alpine environments subject to variable and extreme weather. As such, Parnassius species are vulnerable not only to long-term changes in average conditions but especially to short-term extreme weather events. We use population growth estimates for the alpine butterfly, Parnassius smintheus, from 21 populations in the Rocky Mountains of Canada, over a 20-year interval, combined with techniques of machine learning (randomForests) and parametric modeling to identify the important weather variables determining population growth. We do this to determine the seasons and life-stages of P. smintheus most affected by climate change. Extreme minimum and maximum temperatures in November, in combination with November snowfall, affect annual population growth most, more so than do mean temperatures in November, and more so than weather at any other time of year. Populations decline both in years with low extreme minimum temperatures in November, and especially in years with high extreme maximum temperatures in November, indicating that overwintering eggs are particularly vulnerable to early-winter weather. Snowfall ameliorates the negative effects of extreme temperatures, particularly for extreme warm events. Results provide insight into biological mechanisms by which over-wintering eggs might be affected by early winter weather. Short-term extreme weather in November, acting on a single pivotal life-stage (egg) is a far better predictor of population change of alpine Parnassius smintheus butterflies than is the general index of climate, the Pacific Decadal Oscillation (PDO).
PIVOT - LUAD (light)
<p>Pre-processed TCGA LUAD data used for PIVOT analysis.</p>
PIVOT - COAD (light)
<p>Pre-processed TCGA COAD data used for PIVOT analysis.</p>
Figure 8 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 8. Spallanzani's observations on the sexual reproduction and regeneration of manure earthworms [Eisenia fetida (Savigny, 1826)] as depicted in his laboratory notebooks (Spallanzani, 2003). A, mating. B, cocoon. C, secondary regeneration of the caudal region.
Figure 7 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 7. Spallanzani's observations on his 'lombrico a batello', or 'boat-worm' (Criodrilus lacuum Hoffmeister, 1845). A, B, respiratory posture, with the head buried in the mud and the tail floating on the water surface. C, close-up of the richly vascular tail. D, E, regeneration of the caudal region and reforming of the anus. A, C–E, reproduced from Spallanzani (2003). B, reproduced from Biagi (1958: 108).
Figure 6 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 6. Circulatory apparatus of the earthworm as depicted in Spallanzani's laboratory notebooks (Spallanzani, 2003). A, mid-body dorsal dissection showing the dorsal vessel (ef) running above the gut and giving off segmentally paired median (xx) and adseptal (rr) branches. B, the richly vascular 'gizzard' (= calciferous glands); (qo) dorsal vessel, 'having two lateral branches which spread blood threads laterally, that by their parallelism do a beautiful work'. C, the ventral nerve cord and branched lateral nerves. D, the subneural vessel and lateroneural blood vessels, giving off branches at internodes and nodes of nerve cord, respectively. E, the ventral blood vessel (ao) and its five paired lateral 'bags' (= oesophageal hearts) (cc, dd, ee, ff and gg) descending from the dorsal vessel: 'blood can very openly be seen filling the bags of the back one after the other, which at that time become bigger and swollen, and this swelling is seen progressing up to the last dorsal bags. If then the earthworm turns its belly, then one can see in the belly bags an equal swelling'. F, the ventral blood vessel and its sinuous course in comparison to the straight course of the subneural vessel, seen in vivo by transparency.
Figure 5 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 5. Body wall of the earthworm as sketched in Spallanzani's laboratory notebooks (Spallanzani, 2003). A, dorsal dissection showing the inner ventral side of body wall after removal of the gut, nerve cord, blood vessels and peritoneum: here, the 'veil' of circular muscles and the underlying longitudinal muscles would be 'a continuous fabric' if they were not interrupted by the four series of ventral chaetae. Such fabric in the 'ephippium' (= clitellum) (rxmo) could not be seen clearly. B, ventral dissection showing, after removal of the gut and other organs, the inner dorsal side of the body wall, with middorsal coelomic pores (cccc) and right dorsolateral chaetae (ou). 'Here the musculature has roughly the same structure as in the belly example.' C, dorsal dissection showing, after removal of the gut, the sinuous ventral vessel (rs) and its intraseptal lateral branches (ce).
Figure 4. Plate 3, figure 8 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 4. Plate 3, figure 8 of Bonnet (1745: partie 2) showing his 'Ver à tuyau des eaux douces' [Tubifex tubifex (Müller, 1774) according to Michaelsen (1900)].
Figure 3. Plate 1, figure 5 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 3. Plate 1, figure 5 of Bonnet (1745: partie 2) showing his 'Ver longue aquatique d'un brun rougeâtre' [Lumbriculus variegatus (Müller, 1774) according to Michaelsen (1900)].
Figure 1 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 1. Front page of the fourth Mémoire of Trembley (1744). Abraham Trembley carried out his observations and experiments on regeneration while employed as tutor to the children of Count Willem Bentinck at Sorgvlied estate, Holland.
Figure 2 in REVIEW How the discovery of oligochaete regeneration during the Enlightenment was pivotal to the advancement of annelid research
Figure 2. Parts of plates 6 and 7 of Trembley (1744) showing two newly discovered microdriles that he used as food for the captive hydra. 'Fig. 3' shows the minute worms named 'anguillettes' and which Réaumur renamed 'mille-pieds à dard', endowed with eyes and a fleshy proboscis, which could float and swim by undulatory motion [the naidid Stylaria lacustris (Linnaeus, 1758)]. 'Figs 2, 4, 6' show the mud-dwelling tubificine worms, which Trembley had noticed bristling on the bottom of ditches and which were also used by him to feed the hydras.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.