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1,281 results for “PREMATURITY”
IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE)
ClinicalTrials.gov study NCT03055806. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Colostrum on Mucosal Immunity in Very Low Birth Weight (VLBWs) Premature Infants
ClinicalTrials.gov study NCT01776268. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia (BPD)
ClinicalTrials.gov study NCT02527798. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dynamics of bacterial operons during genome-wide stresses are influenced by premature terminations and internal promoters
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Data from: Effects of the selective stretch-activated channel blocker GsMtx4 on stretch-induced changes in refractoriness in isolated rat hearts and on ventricular premature beats and arrhythmias after coronary occlusion in swine
Mechanical factors may contribute to ischemic ventricular arrhythmias. GsMtx4 peptide, a selective stretch-activated channel blocker, inhibits stretch-induced atrial arrhythmias. We aimed to assess whether GsMtx4 protects against ventricular ectopy and arrhythmias following coronary occlusion in swine. First, the effects of 170-nM GsMtx4 on the changes in the effective refractory period (ERP) induced by left ventricular (LV) dilatation were assessed in 8 isolated rat hearts. Then, 44 anesthetized, open-chest pigs subjected to 50-min left anterior descending artery occlusion and 2-h reperfusion were blindly allocated to GsMtx4 (57 μg/kg iv. bolus and 3.8 μg/kg/min infusion, calculated to attain the above concentration in plasma) or saline, starting 5-min before occlusion and continuing until after reflow. In rat hearts, LV distension induced progressive reductions in ERP (35±2, 32±2, and 29±2 ms at 0, 20, and 40 mmHg of LV end-diastolic pressure, respectively, P<0.001) that were prevented by GsMTx4 (33±2, 33±2, and 32±2 ms, respectively, P=0.002 for the interaction with LV end-diastolic pressure). Pigs receiving GsMtx4 had similar number of ventricular premature beats during the ischemic period as control pigs (110±28 vs. 103±21, respectively, P=0.842). There were not significant differences among treated and untreated animals in the incidence of ventricular fibrillation (13.6 vs. 22.7%, respectively, P=0.696) or tachycardia (36.4 vs. 50.0%, P=0.361) or in the number of ventricular tachycardia episodes during the occlusion period (1.8±0.7 vs. 5.5±2.6, P=0.323). Thus, GsMtx4 administered under these conditions does not suppress ventricular ectopy following coronary occlusion in swine. Whether it might protect against malignant arrhythmias should be tested in studies powered for these outcomes.
Data from: Population characteristics, mechanisms of primary care and premature mortality in England: a cross-sectional study
Objectives. Health systems with strong primary care tend to have better population outcomes, but in many countries demand for care is growing. We sought to identify mechanisms of primary care that influence premature mortality. Design. We developed a conceptual model of the mechanisms by which primary care influences premature mortality, and undertook a cross-sectional study in which population and primary care variables reflecting the model were used to explain variations in mortality under aged 75 years. The premature standardised mortality ratios (SMRs) for each practice, available from the Department of Health, had been calculated from numbers of deaths in the five years 2006-10. A regression model was undertaken with explanatory variables for the year 2009/10, and repeated to check stability using data for 2008/09 and 2010/11. Setting: All general practices in England were eligible for inclusion, and of the total of 8290, complete data were available for 7858. Results. Population variables, particularly deprivation, were the most powerful predictors of premature mortality, but the mechanisms of primary care depicted in our model also affected mortality. The number of GPs/1000 population and detection of hypertension were negatively associated with mortality. In less deprived practices, continuity of care was also negatively associated with mortality. Conclusions. Greater supply of primary care is associated with lower premature mortality even in a health system that has strong primary care (England). Health systems need to sustain the capacity of primary care to deliver effective care, and should assist primary care providers in identifying and meeting the needs of socio-economically deprived groups.
Emergency Medicine: Life-Saving Strategies and Techniques - Prehospital Emergency Care, Triage Systems, Advanced Card Apologies for the premature response.
<p><span>Emergency medicine is a critical field that plays a pivotal role in saving lives and providing essential care during life-threatening situations. This paper aims to explore the key components of emergency medicine, with a focus on prehospital emergency care, triage systems, and advanced cardiac apologies. Through an in-depth analysis of current practices, strategies, and techniques, this paper provides valuable insights into the life-saving measures employed in emergency medicine.</span></p>
Data from: Plane wave Doppler determination of blood flow in retinopathy of prematurity
<p>Retinopathy of prematurity (ROP) is a disorder affecting low birthweight, preterm neonates. In the preterm eye, the retina is not fully developed and neovascularization may occur at the margin between the developed vascular retina and undeveloped avascular retina. Without timely treatment by laser or intravitreal anti-vascular endothelial growth factor (VEGF) therapy, this can lead to tractional retinal detachment and blindness. Visualization of the retina in regular examinations by indirect ophthalmoscopy is hence the current standard of care, but the exams are stressful and interpretation of images is subjective.</p> <p>The upregulation of VEGF in ROP would suggest an increase in ocular blood flow. In this report, we evaluate the potential of ultrafast plane-wave Doppler ultrasound (PWU) to detect increased flow velocities in the orbital vessels supplying the eye in a gentle exam with objective findings.</p> <p>We imaged both eyes of 50 low-birthweight preterm neonates using 18 MHz PWU. Flow velocity in the central retinal artery (CRA) and vein (CRV), and the short posterior ciliary arteries were determined and values at each ROP Stage compared.</p> <p>We found significantly increased velocities in the CRA and CRV in Stage 3 ROP eyes, where intervention would be considered. We compared multivariate models for identifying Stage 3 eyes comprised solely of clinical factors, solely of Doppler parameters, and clinical plus Doppler parameters. The respective models provided areas under their respective ROC curves of 0.760, 0.812, and 0.904. </p> <p>PWU Doppler represents a gentle, objective means for identifying neonates at risk for ROP that could complement ophthalmoscopy.</p>
Data from: Emerging wild virus of native grass bioenergy feedstock is well established in the Midwestern USA and associated with premature stand senescence
<p>This dataset includes values for the prevalence of switchgrass mosaic virus (Genus Marafivirus, Family Tymoviridae) detected with molecular diagnostics (RT-PCR) in individual Panicum virgatum (switchgrass) plants and in Graminella leafhoppers that feed on them. Surveys were conducted in 15 sites in August 2012. Stands surveyed had been established for some time and represent a range of landscape contexts. Measures of stand height and percent senescence were also collected. Land cover composition surrounding each site was calculated from the USDA-NASS Cropland Data Layer and estimates of drought impact were derived from the US Drought Monitor.</p>
Premature Activation of the HIV-1 Protease is influenced by Polymorphisms in the Hinge Region
<p><strong>Abstract: </strong>HIV-1 protease inhibitors are an essential component of antiretroviral therapy. However, drug resistance is a pervasive issue motivating the persistent search for novel therapies. Recent reports found that when protease activates within the host cell cytosol, it facilitates the pyroptotic killing of infected cells. This has led to speculation that promoting protease activation, rather than inhibiting it, could help to eradicate infected cells and potentially cure HIV-1 infection. Here, we used a nanoscale flow cytometry-based assay to characterize protease resistance mutations and polymorphisms. We quantified protease activity, viral concentration, and premature protease activation and confirmed previous findings that major resistance mutations generally destabilize the protease structure. Intriguingly, we found evidence that common polymorphisms in the hinge domain of protease can influence its susceptibility to premature activation. This suggests that viral heterogeneity could pose a considerable challenge for therapeutic strategies aimed at inducing premature protease activation in the future.</p> <p> </p> <p>Attached is the raw .fcs flow virometry data files and western blot images.</p> <p>In addition, the MIFlowCyt-EV information is attached.</p>
Single-cell atlas of circulating immune cells over the first two months of age in extremely premature infants
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The Hematologic Impact of Umbilical Cord Milking Versus Deferred Cord Clamping in Premature Neonates.
ClinicalTrials.gov study NCT03147846. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Blood Pressure Management in Extremely Premature Infants
ClinicalTrials.gov study NCT00874393. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry
ClinicalTrials.gov study NCT05158751. IPD Sharing: Not stated. Countries: 1. Publications: 30.
Effects of the Different Concentrations of Oral Dextrose Solution Applying With Supportive Positions on Pain During Heel-Stick Sampling in Premature Infants
ClinicalTrials.gov study NCT05177263. IPD Sharing: NO. Countries: 1. Publications: 1.
Hormone Replacement in Young Women With Premature Ovarian Failure
ClinicalTrials.gov study NCT00001951. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes
ClinicalTrials.gov study NCT02469519. IPD Sharing: NO. Countries: 1. Publications: 1.
Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat
ClinicalTrials.gov study NCT01612260. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pain of Premature Babies and RetCam (DOLICAM)
ClinicalTrials.gov study NCT04092127. IPD Sharing: NO. Countries: 1. Publications: 8.
The Merit Study (Manual Expression pRemature InfanTs)
ClinicalTrials.gov study NCT02776332. IPD Sharing: NO. Countries: 1. Publications: 9.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.