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ShareScore release 0.9.0
Dataset results
78 results for “Pathogen evolution”
Data from: Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa
Antibiotic resistance is a growing concern to public health. New treatment strategies may alleviate the situation by slowing down the evolution of resistance. Here, we evaluated sequential treatment protocols using two fully independent laboratory-controlled evolution experiments with the human pathogen Pseudomonas aeruginosa PA14 and two pairs of clinically relevant antibiotics (doripenem/ciprofloxacin and cefsulodin/gentamicin). Our results consistently show that the sequential application of two antibiotics decelerates resistance evolution relative to monotherapy. Sequential treatment enhanced population extinction although we applied antibiotics at sub-lethal dosage. In both experiments, we identified an order-effect of the antibiotics used in the sequential protocol, leading to significant variation in the long-term efficacy of the tested protocols. These variations appear to be caused by asymmetric evolutionary constraints, whereby adaptation to one drug slowed down adaptation to the other drug, but not vice versa. An understanding of such asymmetric constraints may help future development of evolutionary robust treatments against infectious disease.
Data from: Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus
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Data from: Evolution of the exclusively human-pathogen Neisseria gonorrhoeae: human-specific engagement of immunoregulatory Siglecs
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Data from: Evolution of pathogenicity traits in the apple scab fungal pathogen in response to the domestication of its host
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Data from: Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa
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Data from: Microbe-mediated host defence drives the evolution of reduced pathogen virulence
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Data from: Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora
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Data from: The role of the environment in the evolution of tolerance and resistance to a pathogen
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Data from: Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with Pseudomonas aeruginosa cystic fibrosis bacterial isolates
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High nucleotide substitution rates associated with retrotransposon proliferation drive dynamic secretome evolution in smut pathogens
GEO Series GSE206526. Ustilago hordei. 6 samples. Type: Expression profiling by high throughput sequencing.
Evolution and Pathogenic Mechanism of Rice Sheath Blight Pathogen
GEO Series GSE32577. Rhizoctonia solani AG-1 IA. 6 samples. Type: Expression profiling by high throughput sequencing.
Discerning role of a functional arsenic resistance cassette in evolution and adaptation of a rice pathogen
GEO Series GSE163417. Xanthomonas oryzae pv. oryzae. 8 samples. Type: Expression profiling by high throughput sequencing.
Convergent evolution of peptide-based quorum sensing required for virulence in a eukaryotic pathogen
GEO Series GSE73203. Cryptococcus neoformans. 47 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Data from: Rapid evolution of microbe-mediated protection against pathogens in a worm host
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Data from: Adaptation of the pathogen, Pseudomonas syringae during experimental evolution on a native versus alternative host plant
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Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen
GEO Series GSE278513. Leptospira interrogans. 6 samples. Type: Expression profiling by high throughput sequencing.
Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen [paraquat]
GEO Series GSE278514. Leptospira interrogans. 12 samples. Type: Expression profiling by high throughput sequencing.
Genomic, tanscriptomic and metabolimic analyses of Amorphophallus albus provides insights into the evolution and resistance to southern blight pathogen
GEO Series GSE286223. Amorphophallus albus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.