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126,115 results for “Patients”
Clinical outcome for TheraCal LC group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for TheraCal LC group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Clinical outcome for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Radiographic outcomes for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Radiographic outcomes for MTA group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Clinical outcome for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months
<p>Clinical outcome for Biodentine group for postoperative pain, tenderness, and neural sensibility at the patient recall period of 21 days, 3 months, and 12 months</p>
Processed snRNA-seq data from "Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation"
<p>Processed snRNA-seq data from "Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation". All nuclei passed QC and were corrected for background noise using cellBender. Files are in R objects saved in RDS (R Data Serialization) format. This repo contains one Seurat v4 object and one gene-by-cell raw RNA count matrix in sparse matrix format (dgCMatrix).</p>
QC and WGS data on compound heterozygous PRKN-mutant (R275W/dEx8) PD patient
<p>Primary/raw data for QC on the characterisation of an iPSC line from a PD patient (Stem Cell Research)</p>
Data Extraction table summarizing studies in the scoping review on co-creation of patient education materials
<p>Data extraction table for scoping review on best practices for co-creating patient-facing educational materials</p>
Repository of IVD Patient-Specific FE Models
<p>Free repository of 169 PP FE models of the IVD. Resulting cohort from a morphing process as a free-access repository to further empower the scientific community. This initiative underlines our commitment to promoting standardization and facilitating a more comprehensive understanding of the mechanisms underlying IVD degeneration.</p>
Longitudinal observational study of pediatric patients with primary brain tumors: establishment of a hospital-based registry.
<p>Although tumors of the central nervous system (CNS) represent 2 % of all malignancies in general, they cause a disproportionately large morbidity and mortality and are the second most common form of cancer in children and the major solid tumor in childhood in the U.S., occurring in 21.3% of all children with malignant disease. The treatment of brain tumors in children and adolescents has evolved significantly in recent decades. Nowadays, most children with a diagnosis of brain tumor are treated properly and achieve prolonged survival. In order to obtain an overview of the impact of brain tumors, specialized registries, which provide information on all types of brain tumors, have emerged in several countries. Following on the pioneering Japanese and American experiences of specialized national records of brain tumors, other specialized registries were opened in European countries. This project aims to initiate a registry of the epidemiological profile of patients treated for CNS tumors in the Pediatric Cancer Center (CPC) of our hospital from January 2000 to December 2013, at diagnosis and during follow-up, updating information periodically. This data will be recorded in an electronic database capable of storing, retrieving and presenting information of interest. Prospectively recorded epidemiological data of patients diagnosed from January 2014 will be accrued, maintaining the database active to continuously record information on patients with CNS tumors treated in the CPC HIAS. Thus, creating a hospital registry of pediatric patients with CNS tumors. To this end, an instrument of data collection will be created using Google Apps (Google Inc., 2014), a digital platform with capacity for storage, creation and editing of documents and collaboration in real time over the cloud.</p>
Bulk RNA-Seq PBMC data of SLE patients and healthy volunteers/ profiling of 29 individual immune cell types as well as PBMCs of healthy donors
<p>This Zenodo project contains processed gene expression data from two publicly available data sets. It includes the gene expression data of peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) patients as well as healthy volunteers (GSE122459). The project also comprises the bulk RNA-Seq profiling of 29 immune cell types as well as PBMCs of healthy individuals (GSE107011). In both cases, the raw RNA-Seq data was downloaded, aligned and processed. The gene expression data is available in form of a count matrix (GSE107011) or count matrix and transcript-per-million (TPM) values (GSE122459). For the latter, an annotation file is attached. Further details are provided in the information file. </p>
Raw EEG-EOG data used in the publication "Auditory Electrooculogram-based Communication System for ALS Patients in Transition from Locked-in to Complete Locked-in State"
<p>The dataset includes raw EEG and EOG recordings during BCI experiments for three patients: p11, p13, p15, and p16. The structure of the dataset is the following: patient/visit/day.</p> <p>The experiment is described in detail in the publication "Auditory Electrooculogram-based Communication System for ALS Patients in Transition from Locked-in to Complete Locked-in State". The correspondence between raw file and BCI session is reported in the attached pdf file "Supplementary Table S5 Session to Raw File Recordings Correspondence".</p> <p>The datasets include EEG and EOG channels. The data are raw (i.e. non filtered and non processed). Data have been acquired with a sampling rate of 500Hz using active electrodes and the amplifier V-Amp DC (Brain Products, Germany). EOG channels are labeled EOGU, EOGD, EOGR, EOGL namely for EOG up, down, right, left; the location in the 10-20 system are respectively SO1, IO1, LO1, LO2.</p> <p>The data are marked with triggers: for each session two markers indicate start and end of the session; for each trial markers indicate start of baseline, start of presentation of question, start of response time, start of feedback. Each trial was marked in a different way if it was a yes trial belonging to a training or feedback session, a no trial belonging to a training or feedback session, or a trial belonging to a speller session. The markers that have been used are the following:<br> <strong>start</strong> 9<br> <em> yes no speller</em><br> <strong>baseline</strong> 10 11 12<br> <strong>presentation</strong> 5 6 7<br> <strong>response</strong> 4 8 13<br> <strong>feedback</strong> 1 2 3</p> <p><strong>end</strong><strong> </strong> 15</p>
Data to "Choroidal changes in intermediate age-related macular degeneration patients with drusen or pseudodrusen."
<p>This record contains experimental and analysis scripts (written in Matlab) as well as raw and processed data to reproduce the results shown in:</p> <p>Rosa R., Corazza P., Musolino M., Mochi C., Maiello G., Traverso C. E., & Nicolò M. Choroidal changes in intermediate age-related macular degeneration patients with drusen or pseudodrusen. European Journal of Ophthalmology. (in press)</p> <p> </p>
Structural and functional connectomes from 27 schizophrenic patients and 27 matched healthy adults
<p><strong><em>Data Acquisition</em></strong></p> <p>The cohort consists of a total of 27 healthy participants (age 35 ± 6.8 years) and 27 schizophrenic patients (age 41 ± 9.6), scanned in a 3-Tesla MRI scanner (Trio, Siemens Medical, Germany) using a 32-channel head-coil. The schizophrenic patients are from the Service of General Psychiatry at the Lausanne University Hospital (CHUV). All of them were diagnosed with schizophrenic and schizoaffective disorders after meeting the DSM-IV criteria (American Psychiatric Association (2000): Diagnostic and Statistical Manual of Mental Disorders, 4th ed. DSM-IV-TR. American Psychiatric Pub, Arlington, VA22209, USA). The Diagnostic Interview for Genetic Studies assessment was used to recruits the healthy controls (Preisig et al. 1999). 24 out of the 27 schizophrenics were under medication with mean chlorpromazine equivalent dose (CPZ) of 431 ± 288 mg. The written consent was obtained for all subjects - in accordance with institutional guidelines of the Ethics Committee of Clinical Research of the Faculty of Biology and Medicine, University of Lausanne, Switzerland, #82/14, #382/11, #26.4.2005). All subjects were fully anonymised.</p> <p>The session protocol consisted of (1) a magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence sensitive to white/gray matter contrast (1-mm in-plane resolution, 1.2-mm slice thickness), (2) a Diffusion Spectrum Imaging (DSI) sequence (128 diffusion-weighted volumes and a single b0 volume, maximum b-value 8,000 s/mm<sup>2</sup>, 2.2x2.2x3.0 mm voxel size), and (3) a gradient echo EPI sequence sensitive to BOLD contrast (3.3-mm in-plane resolution and slice thickness with a 0.3-mm gap, TE 30 ms, TR 1,920 ms, resulting in 280 images per participant). During the fMRI scan, participants were not engaged in any overt task, and the scan was treated as eyes-open resting-state fMRI (rs-fMRI).</p> <p><strong><em>Data Pre-processing </em></strong></p> <p>Initial signal processing of all MPRAGE, DSI, and rs-fMRI data was performed using the Connectome Mapper pipeline (Daducci et al. 2012). Grey and white matter were segmented from the MPRAGE volume using freesurfer (Desikan<em> </em>et al. 2006) and parcellated into 83 cortical and subcortical areas. The parcels were then further subdivided into 129, 234, 463 and 1015 approximately equally sized parcels according to the Lausanne anatomical atlas following the method proposed by (Cammoun et al. 2012). DSI data were reconstructed following the protocol described by (Wedeen et al. 2005), allowing us to estimate multiple diffusion directions per voxel. The diffusion probability density function was reconstructed as the discrete 3D Fourier transform of the signal modulus. The orientation distribution function (ODF) was calculated as the radial summation of the normalized 3D probability distribution function. Thus, the ODF is defined on a discrete sphere and captures the diffusion intensity in every direction.</p> <p><strong><em>Structural Connectivity</em></strong></p> <p>Structural connectivity matrices were estimated for individual participants using deterministic streamline tractography on reconstructed DSI data, initiating 32 streamline propagations per diffusion direction, per white matter voxel (Wedeen et al. 2008). Structural connectivity between pairs of regions was measured in terms of fiber density, defined as the number of streamlines between the two regions, normalized by the average length of the streamlines and average surface area of the two regions (Hagmann et al. 2008). The goal of this normalization was to compensate for the bias toward longer fibers inherent in the tractography procedure, as well as differences in region size. The number of fibers and fiber length were also included in the dataset. For the quantitative measure of structural connectivity, the generalised fractional anisotropy (gFA, Tuch et al. 2004) and average apparent diffusion coefficient (ADC, Sener et al. 2001) were also computed for each tract.</p> <p> </p> <p><strong><em>Functional Connectivity</em></strong></p> <p>Functional data were pre-processed using routines designed to facilitate subsequent network exploration (Murphy et al. 2009, Power et al. 2012). The first four time points were excluded from subsequent analysis to allow the time series to stabilize. The signal was linearly detrended and further physiological (white-matter and cerebrospinal fluid regressors) and motion artefacts (three translational and three rotational regressors) confounds were regressed. Then, the signal was spatially smoothed and bandpass-filtered between 0.01-0.1 Hz with Hamming windowed sinc FIR filter. To obtain the brain regions for different atlas scales the signal was linearly registered to the MPRAGE image and averaged within a given region (Jenkinson et al. 2012). Functional matrices were obtained by computing Pearson’s correlation between the individual pairs of regions. All of the above was carried out in subject’s native space (Daducci et al. 2012, Griffa et al. 2017).</p> <p>Brain cortical bert freesurfer rendering for the 5 scales of the Lausanne2008 atlas is available on <a href="https://github.com/jvohryzek/bert4lausanne2008">https://github.com/jvohryzek/bert4lausanne2008</a>.</p>
Lung ultrasonography features and risk stratification in 80 patients with COVID-19: a prospective observational cohort study
<p><strong>Background</strong></p> <p>Point-of-care lung ultrasound (LUS) is a promising and pragmatic risk stratification tool in COVID-19. This study describes and compares early LUS characteristics across of range of clinical outcomes.</p> <p><strong>Method</strong></p> <p>Prospective observational study of PCR-confirmed COVID-19 patients in the emergency department (ED) of Lausanne University Hospital. A trained physician recorded LUS images using a standardized protocol. Two experts retrospectively reviewed images blinded to patient outcome. We describe and compare early LUS findings (acquired within 24hours of presentation at the ED) between patient groups based on their outcome at 7-days after inclusion: 1) self-resolving outpatients, 2) hospitalised and 3) intubated/death. The LUS score was used to discriminate between groups.</p> <p><strong>Findings</strong></p> <p>Between March 6 and April 3 2020, we included 80 patients (18 outpatients, 41 hospitalized and 21 intubated/dead). 73 patients (91%) had abnormal LUS (72% outpatients, 95% hospitalised and 100% intubated/death; p=0.004). The proportion of involved zones was lower in outpatients compared with other groups (median 30% [IQR 0-40%], 44% [33-70%] and 70% [50-88%], p<0.001). Predominant abnormal patterns were bilateral and multifocal spread thickening of the pleura with pleural line irregularities (77%), confluent B lines (66%) and pathologic B lines (55%). Posterior inferior zones were more often affected. Median LUS score had a good level of discrimination between outpatients and others with area under the ROC of 0.80 (95% CI 0.66-0.95).</p> <p><strong>Interpretation</strong></p> <p>Systematic LUS is a reliable, cheap and easy-to-use triage tool for the early stratification of risk in COVID-19 patients presenting at emergency departments.</p> <p><strong>Funding</strong></p> <p>Leenaards Foundation</p>
Geriatric CO-mAnagement for Cardiology patients in the Hospital (G-COACH): outcome data
<p>The datasets reports baseline and outcome data from the 'Geriatric CO-mAnagement for Cardiology patients in the Hospital (G-COACH)' experimental study. The study evaluated the effectiveness of a geriatric co-management programme on the cardiac care units of the University Hospitals Leuven. Sample included patients aged 75 years or older. Measurements included: demographic, functional status, cognitive status, depressive symptoms, anxiety symptoms, quality of life, physical performance, readmission rates, survival.</p> <p>Please see Word document for more information.</p> <p>Please see protocols for more information:</p> <p><a href="https://clinicaltrials.gov/ct2/show/NCT02890927">https://clinicaltrials.gov/ct2/show/NCT02890927</a></p> <p><a href="https://bmjopen.bmj.com/content/8/10/e023593">https://bmjopen.bmj.com/content/8/10/e023593</a></p> <p>The evaluation study is available at https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.17093 </p>
Data for "Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: a prospective cohort study"
<p>Data for "Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: a prospective cohort study"</p>
Extensive qPCR analysis reveals altered gene expression in middle ear mucosa from cholesteatoma patients
<p><strong>Abstract</strong></p> <p>The middle ear is a small and hard to reach compartment, limiting the amount of tissue that can be extracted and the possibilities for studying the molecular mechanisms behind diseases like cholesteatoma. In this paper 14 reference gene candidates were evaluated in the middle ear mucosa of cholesteatoma patients and two different control tissues. <em>ACTB</em> and <em>GAPDH</em> were shown to be the optimal genes for the normalisation of target gene expression when investigating middle ear mucosa in multiplex qPCR analysis. Validation of reference genes using <em>c-MYC</em> expression confirmed the suitability of <em>ACTB</em> and <em>GAPDH</em> as reference genes and showed an upregulation of <em>c-MYC</em> in middle ear mucosa during cholesteatoma. The occurrence of participants of the innate immunity, <em>TLR2</em> and <em>TLR4</em>, were analysed in order to compare healthy middle ear mucosa to cholesteatoma. Analysis of <em>TLR2</em> and <em>TLR4</em> showed variable results depending on control tissue used, highlighting the importance of selecting relevant control tissue when investigating causes for disease. It is our belief that a consensus regarding reference genes and control tissue will contribute to the comparability and reproducibility of studies within the field.</p>
A protocol to assess the risk of dementia among patients with coronary artery diseases using CAIDE score-Extended Data
<p>The contents of this extended data file are-<br> 01. Consent form (English & Bengali Version)<br> 02. Interview Questionnaire (English & Bengali Version)<br> These contents will help to address the objectives of the study that attempted to identify the risk of long-term dementia among coronary artery disease patients in Bangladesh.</p>
Dataset for Repeated double cross validation applied to the PCA-LDA classification of SERS spectra: a case study with serum samples from hepatocellular carcinoma patients
<p>This dataset contains all the spectra used in the paper "Repeated double cross validation applied to the PCA-LDA classification of SERS spectra: a case study with serum samples from hepatocellular carcinoma patients", plus the R code to import the TXT (ASCII) files into a dataset, preprocess data, set-up and cross validate the PCA-LDA model and generate the figures shown in the paper.</p> <p>Data are available in 2 different formats: </p> <p>- 1 compressed archive ("dataset.zip") containing all the 144 TXT files (1 file = 1 spectrum) </p> <p>- 1 single CSV file (“dataset.csv”) with all the 144 spectra in the form of a table. The data are structured as follow, with each row being 1 spectrum, preceded by metadata: "acquisition_date", "substrate_batch", "class", "sample_code".</p> <p>The code for R is available as a single file "Rcode.R".</p> <p> </p>
Genome wide Illumina 450K array in AML patients with or without CEBPA mutation
<ul> <li>Num: Row Number</li> <li>Hybridization REF: CpG Reference ID</li> <li>Position: Position in hg19</li> <li>Gene: Entrez Gene Symbol</li> <li>Chrome: Chromosome Number</li> <li>p_vals: P value for t-test between patients with CEBPA and without CEBPA mutation</li> <li>mean_cebpa_mut: mean methylation score for patients with CEBPA mutation</li> <li>mean_no_cebpa_mut: mean methylation score for patients with CEBPA mutation </li> <li> <p>site_status: prediction status for CEBPA sites </p> </li> <li> <p>fdr: fdr p_value </p> </li> </ul>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.