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4,871 results for “Symptoms”
Patient-reported outcomes via electronic health record portal vs. telephone: process and retention data in a pilot trial of anxiety or depression symptoms in epilepsy
<p>Objective: To close gaps between research and clinical practice, tools are needed for efficient pragmatic trial recruitment and patient-reported outcome(PROM) collection. The objective was to assess feasibility and process measures for patient-reported outcome collection in a randomized trial comparing electronic health record(EHR) patient portal questionnaires to telephone interview among adults with epilepsy and anxiety or depression symptoms.</p> <p>Results: Participants were 60% women, 77% White/non-Hispanic, with mean age 42.5 years. Among 15 individuals randomized to EHR portal, 10(67%, CI 41.7-84.8%) met the 6-month retention endpoint, versus 100%(CI 79.6-100%) in the telephone group(p=0.04). EHR outcome collection at 6 months required 11.8 minutes less research staff time per participant than telephone (5.9, CI 3.3-7.7 vs. 17.7, CI 14.1-20.2). Subsequent telephone contact after unsuccessful EHR attempts enabled near complete data collection and still saved staff time.</p> <p>Discussion: Data from this randomized pilot study of pragmatic outcome collection methods for patients with anxiety or depression symptoms in epilepsy includes baseline participant characteristics, recruitment flow resulting from a novel EHR-based, care-embedded recruitment process, and data on retention along with various process measures at 6-months.</p>
Illness perception mediates the relationship between the severity of symptoms and perceived health status in patients with Behcet's disease.
<p><strong>Abstract</strong></p> <p><em>Objective</em>. To investigate the relationship between psychological representations of illness, perceived health status and self-assessment of symptom severity in patients with <strong>Behçet's</strong>Disease – a rare long-term incurable condition with unclear etiology.</p> <p><em>Methods</em>. Using cross-sectional survey design, data on self-administered questionnaires on illness perception, health status, symptoms severity and demographic characteristics were collected from 273 patients with <strong>Behçet's</strong>Disease (age range 18 – 65+). The data were subjected to mediation analysis to test whether cognitive and emotional components of illness perception mediate the relationship between the severity of symptoms and heath status.</p> <p><em>Results</em>. The results support our hypotheses that cognitive components of illness perception (perceived consequences and identity of the illness) mediate the link between symptom activity and pain, whereas emotional components of the illness (emotional representations about the illness) mediate the relationship between disease activity and perceived energy level.</p> <p> <em>Conclusion</em>. The robustness of these mediation effects suggests potential directions for clinical psychologists and health care practitioners in developing support programmes. We supplement our study with Open Access database containing information about type of medication, comorbid mood disorder, detailed measurement of the severity of BD symptomsfor sharing and accumulating multidisciplinary knowledge aiming to support the development of interventions. Addressing psychological aspects ofBD will help to manage complex patients effectively.</p> <p>Database of survey (complete)</p>
Weekly supervised Multilingual Data Set to train Named Entity Recognition for Symptom Extraction
<p>Data Sets were generated using the Weakly Supervised NER pipeline (https://github.com/HUMADEX/Weekly-Supervised-NER-pipline) to train the symptom extraction NER models. </p> <p><strong>Supported Languages and dataset locations for the specific language:</strong></p> <p> English (base language): https://huggingface.co/HUMADEX/english_medical_ner<br> German: https://huggingface.co/HUMADEX/german_medical_ner<br> Italian: https://huggingface.co/HUMADEX/italian_medical_ner<br> Spanish: https://huggingface.co/HUMADEX/spanish_medical_ner<br> Greek: https://huggingface.co/HUMADEX/german_medical_ner<br> Slovenian: https://huggingface.co/HUMADEX/slovenian_medical_ner<br> Polish: https://huggingface.co/HUMADEX/polish_medical_ner<br> Portuguese: https://huggingface.co/HUMADEX/portugese_medical_ner</p> <p> </p> <p><strong>Dataset Building </strong></p> <ul> <li>Data Integration and Preprocessing</li> <li>Data Cleaning</li> <li>Annotation with Stanza's i2b2 Clinical Model </li> <li>Translation into the targeted language</li> <li>Word Alignment </li> <li>Data Augmentation </li> </ul> <p><strong>Acknowledgement</strong><br>This dataset had been created as part of joint research of HUMADEX research group (https://www.linkedin.com/company/101563689/) and has received funding by the European Union Horizon Europe Research and Innovation Program project SMILE (grant number 101080923) and Marie Skłodowska-Curie Actions (MSCA) Doctoral Networks, project BosomShield ((rant number 101073222). Responsibility for the information and views expressed herein lies entirely with the authors.</p> <p><strong>Authors:</strong><br>dr. Izidor Mlakar, Rigona Sallauka, dr. Umut Arioz, dr. Matej Rojc</p> <p><strong>Please cite as:</strong></p> <p><span>Article title: Weakly-Supervised Multilingual Medical NER For Symptom Extraction For Low-Resource Languages</span><br><span>Doi: 10.20944/preprints202504.1356.v1</span><br><span>Website: </span><a title="https://www.preprints.org/manuscript/202504.1356/v1" href="https://www.preprints.org/manuscript/202504.1356/v1">https://www.preprints.org/manuscript/202504.1356/v1</a></p>
Supplemental Materials Eikelboom et al. Neuropsychiatric and cognitive symptoms across the Alzheimer's disease clinical spectrum
<p>The objective of this study was to investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of amyloid-<em>β</em> positive individuals across the Alzheimer's disease (AD) clinical spectrum. In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had 1) a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia, and 2) were amyloid-<em>β</em> positive (A+). We measured NPS with the Neuropsychiatric Inventory (NPI), examining total scores and the presence of specific NPI domains. Cognition was assessed across five cognitive domains and with the MMSE. We examined trajectories including model based trends for NPS and cognitive functioning over time. We used linear mixed models to relate baseline NPI scores to cognitive functioning at baseline (whole-sample) and longitudinal time-points (subsample n=520, Mean=1.8 [SD=0.7] years follow-up). We included 1,524 amyloid-β positive individuals from the Amsterdam Dementia Cohort with A+ SCD (n=113), A+ MCI (n=321), or A+ AD dementia (n=1,090). NPS were prevalent across all clinical AD stages (≥1 NPS 81.4% in SCD, 81.2% in MCI, 88.7% in dementia; ≥1 clinically relevant NPS 54.0% in SCD, 50.5% in MCI, 66.0% in dementia). Cognitive functioning showed an uniform gradual decline; while in contrast, large intra-individual heterogeneity of NPS was observed over time across all AD groups. At baseline, we found associations between NPS and cognition in dementia that were most pronounced for NPI total scores and MMSE (range <em>β</em>=0.18 to 0.11, FDR-adjusted <em>p</em><0.05), while there were no cross-sectional relationships in SCD and MCI (range <em>β</em>=-0.32 to 0.36, all FDR-adjusted <em>p</em>>0.05). There were no associations between baseline NPS and cognitive functioning over time in any clinical stage (range <em>β</em>=-0.13 to 0.44, all FDR-adjusted <em>p</em>>0.05). NPS and cognitive symptoms are both prevalent across the AD continuum, but show a different evolution during the course of the disease.</p>
Improving neuropsychiatric symptoms following stroke using virtual reality: A case report
<p>Post-stroke cognitive impairment occurs frequently in patients with stroke, with a 20% to 80% prevalence. Anxiety is common after stroke, and is associated with a poorer quality of life. The use of standard relaxation techniques in treating anxiety in patients undergoing post-stroke rehabilitation have shown some positive effects, whereas virtual reality seems to have a role in the treatment of anxiety disorders, especially when associated to neurological damage. A 50-year-old woman, smokers, affected by hypertension and right ischemic stroke in the chronic phase (i.e., after 12 months by cerebrovascular event), came to our observation for a severe anxiety state and a mild cognitive deficit, mainly involving attention and visuo-executive processes, besides a mild left hemiparesis. Anxiety in a patient with ischemic stroke. Standard relaxation techniques alone in a common clinical setting or the same psychological approach in an immersive virtual environment (i.e., Computer Assisted Rehabilitation Environment – CAREN). The patient's cognitive and psychological profile, with regard to attention processes, mood, anxiety, and coping strategies, were evaluated before and after the 2 different trainings. A significant improvement in the functional and behavioral outcomes were observed only at the end of the combined approach.The immersive virtual reality environment CAREN might be useful to improve cognitive and psychological status, with regard to anxiety symptoms, in post-stroke individuals.</p>
Dataset for Symptoms of performance degradation during multi-annual drought: a large-sample, multi-model study
<p>This dataset contains the data described in the journal article "Symptoms of performance degradation during multi-annual drought: a large-sample, multi-model study" (Trotter et al., 2023, <strong>DOI: </strong>10.1029/2021WR031845)</p>
Data set supplementing "Characteristics of Users and Nonusers of Symptom Checkers in Germany: Cross-Sectional Survey Study"
<p>This is the data set used to conduct the analyses in the article published by the Journal of Medical Internet Research under the title "Characteristics of Users and Nonusers of Symptom Checkers in Germany: Cross-Sectional Survey Study" (<a href="https://doi.org/10.2196/46231">https://doi.org/10.2196/46231</a>)</p> <p>This data set contains information collected of 1,084 respondents about their awareness, use, and usefulness of symptom checkers and several individual characteristics. </p>
Adverse childhood events and clinical manifestation of anxiety symptoms in Greek adolescents during COVID-19 pandemic
<p><strong>Background: </strong>Adverse Childhood Experiences (ACEs) are linked to the development of Anxiety in Adolescence. According to recent studies, the pandemic COVID-19 is a novel ACE that has increased Anxiety among adolescents. This study aims to investigate the relationship between Adverse Childhood Experiences (ACEs) and COVID-19 in the development of Anxiety in Adolescence. <strong>Methods: </strong>A cross-sectional study with a community sample of 248 boys and girls aged 12 to 15 years (Mean: 13.50 years) from five High Schools in Eastern Attica were conducted. A total of four questionnaires were used: 1) Demographic Questionnaire, 2) State-Trait-Anxiety-Inventory for Children – STAIC, 3) Adverse Childhood Experiences Scale, and 4) COVID-19 Impact Scale. <strong>Results: </strong>The results demonstrated a strong correlation between the total number of adverse childhood experiences (ACEs) and Anxiety (Trait and State) in adolescence (Trait Anxiety: rho=.37, p0.001; State Anxiety: rho=.29, p0.001). Girls scored substantially higher on Trait Anxiety (U = 4353, p 0.001) and State Anxiety (U = 5822.5, p = 0.014) than boys. Girls also demonstrated more significant Anxiety than boys. The number of adverse childhood experiences was found to be significantly related to the impact of COVID-19 (=0.025, p 0.001). <strong>Conclusions: </strong>The present study's findings can be used to design and implement future effective, preventive, and therapeutic programs for adolescents with anxiety symptoms who were exposed to a variety of Adverse Childhood Experiences and the COVID-19 pandemic during their adolescence.</p>
A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not Hospitalized
ClinicalTrials.gov study NCT05799495. IPD Sharing: YES. Countries: 1. Publications: 1.
Treatment and Recovery Monitoring of Post TBI Symptoms
ClinicalTrials.gov study NCT02426749. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms
ClinicalTrials.gov study NCT02028754. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Improving Negative Symptoms of Psychosis In Real-world Environments
ClinicalTrials.gov study NCT02170051. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Antihistamines on Ureteral Stent-Related Symptoms
ClinicalTrials.gov study NCT04726345. IPD Sharing: NO. Countries: 1. Publications: 8.
Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients
ClinicalTrials.gov study NCT02466685. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
ClinicalTrials.gov study NCT03849066. IPD Sharing: NO. Countries: 1. Publications: 13.
Efficacy, Safety, and Tolerability of SPD489 in Adults With Schizophrenia and Predominant Negative Symptoms
ClinicalTrials.gov study NCT00922272. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial
ClinicalTrials.gov study NCT03892967. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Impact of Seed Cycling on Menstrual Regularity, Dysmenorrhea, and Premenstrual Symptoms
ClinicalTrials.gov study NCT07052500. IPD Sharing: NO. Countries: 1. Publications: 7.
Posterior Tibial Nerve Stimulation (PTNS) Plus Mirabegron to Treat Refractory OAB Symptoms (PTNS-M Study)
ClinicalTrials.gov study NCT04907032. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder
ClinicalTrials.gov study NCT00689104. IPD Sharing: YES. Countries: 30. Publications: 3.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.