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706
datasets available to search
ShareScore release 0.9.0
Dataset results
706 results for “adult humans”
A Proof of Concept Study of GSK3640254 in Human Immunodeficiency Virus-1 (HIV-1) Infected Treatment-naive Adults
ClinicalTrials.gov study NCT03784079. IPD Sharing: YES. Countries: 6. Publications: 1.
Study of Human Regular U-500 Insulin in Adult Participants With Type 2 Diabetes
ClinicalTrials.gov study NCT01774968. IPD Sharing: Not stated. Countries: 2. Publications: 3.
A Study to Evaluate the Antiviral Effect, Safety and Tolerability of GSK3810109A in Viremic Human Immunodeficiency Virus (HIV)-1 Infected Adults
ClinicalTrials.gov study NCT04871113. IPD Sharing: YES. Countries: 6. Publications: 1.
Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
ClinicalTrials.gov study NCT03299049. IPD Sharing: YES. Countries: 13. Publications: 8.
Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
ClinicalTrials.gov study NCT00122681. IPD Sharing: YES. Countries: 14. Publications: 19.
Data from: Sustainability management of short-lived freshwater fish in human-altered ecosystems should focus on adult survival
<p>Fish populations globally are susceptible to endangerment through exploitation and habitat loss. We present theoretical simulations to explore how reduced adult survival (age truncation) might affect short-lived freshwater fish species in human-altered contemporary environments. Our simulations evaluate two hypothetical "average fish" and five example fish species of age 1 or age 2 maturity. From a population equilibrium baseline representing a natural, unaltered environment we impose systematic reductions in adult survival and quantify how age truncation affects the causes of variation in population growth rate. We estimate the relative contributions to population growth rate arising from simulated temporal variation in age-specific vital rates and population structure. At equilibrium and irrespective of example species, population structure (first adult age class) and survival probability of the first two adult age classes are the most important determinants of population growth. As adult survival decreases, the first reproductive age class becomes increasingly important to variation in population growth. All simulated examples show the same general pattern of change with age truncation as known for exploited, longer-lived fish species in marine and freshwater environments. This implies age truncation is a general potential concern for fish biodiversity across life history strategies and ecosystems. Managers of short-lived, freshwater fishes in contemporary environments often focus on supporting reproduction to ensure population persistence. However, a strong focus on water management to support reproduction may reduce adult survival. Sustainability management needs a focus on mitigating adult mortality in human-altered ecosystems. A watershed spatial extent embracing land and water uses may be necessary to identify and mitigate causes of age truncation in freshwater species. Achieving higher adult survival will require paradigm transformations in society and government about water management priorities.</p>
Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults: Exp1 dataset
<p>Dataset from Exp1 in "Proulx, Sébastien, Sheynin, Yasha, Hess, Robert, & Farivar, Reza. (2020). Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults (in preparation).</p> <p>Metadata included in the 'data' variable of the exp1Data.mat file.</p>
Data from: Early-life disease exposure and associations with adult survival, cause of death, and reproductive success in preindustrial humans
A leading hypothesis proposes that increased human life span since 1850 has resulted from decreased exposure to childhood infections, which has reduced chronic inflammation and later-life mortality rates, particularly from cardiovascular disease, stroke, and cancer. Early-life cohort mortality rate often predicts later-life survival in humans, but such associations could arise from factors other than disease exposure. Additionally, the impact of early-life disease exposure on reproduction remains unknown, and thus previous work ignores a major component of fitness through which selection acts upon life-history strategy. We collected data from seven 18th- and 19th-century Finnish populations experiencing naturally varying mortality and fertility levels. We quantified early-life disease exposure as the detrended child mortality rate from infectious diseases during an individual's first 5 y, controlling for important social factors. We found no support for an association between early-life disease exposure and all-cause mortality risk after age 15 or 50. We also found no link between early-life disease exposure and probability of death specifically from cardiovascular disease, stroke, or cancer. Independent of survival, there was no evidence to support associations between early-life disease exposure and any of several aspects of reproductive performance, including lifetime reproductive success and age at first birth, in either males or females. Our results do not support the prevailing assertion that exposure to infectious diseases in early life has long-lasting associations with later-life all-cause mortality risk or mortality putatively linked to chronic inflammation. Variation in adulthood conditions could therefore be the most likely source of recent increases in adult life span.
Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults: Exp2 dataset
<p>Dataset from Exp2 in "Proulx, Sébastien, Sheynin, Yasha, Hess, Robert, & Farivar, Reza. (2020). Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults (in preparation).</p> <p>Data was collected in 3-min measures: 2 consecutive pre-deprivation and 2 consecutive immediate post-deprivation.</p> <p>The 'data' variable from the exp3Data.mat file stores percept durations that were logged then averaged within measures.</p> <p>Metadata is included in the data and dataTot variable structure.</p>
Cell Atlas at Single-Nuclei Resolution of the Adult Human Adrenal Gland and Adrenocortical Adenomas
<p><strong>Abstract</strong></p> <p>The human adrenal glands are highly dynamic endocrine organs that are involved in the secretion of various hormones such as steroids and catecholamines. Here we present a single-nuclei and spatial transcriptomic analysis of healthy adult human adrenal glands to provide a complete adrenal gland atlas. With this, we show how such an atlas can be taken advantage when studying adrenocortical diseases, such as adrenocortical adenomas (ACA). Using nornal adrenal as reference, we showed a high intra-tumoural heterogeneity in the single-nuclei transcriptome of ACA, revealing the presence of specific cell populations associated with cortisol secretion and genetic background.</p> <p> </p> <p><strong>Data content</strong></p> <p>This dataset contains the two Visium replicates (NAG-7A and NAG-7B) processed using Space Ranger (spaceranger-1.0.0).</p> <p> </p>
Human vocalization corpus: recordings of infant-directed and adult-directed speech and song in 21 societies
<p>This repository contains a corpus of 1615 audio recordings of speech and song collected in 21 societies, first reported in Moser et al. (2020; <a href="https://www.biorxiv.org/content/10.1101/2020.04.09.032995v5">bioRxiv</a>) and later published in Hilton & Moser et al. (2022; <a href="https://doi.org/10.1038/s41562-022-01410-x">Nature Human Behaviour</a>). For assistance using any of this, contact Cody Moser (<a href="mailto:cmoser2@ucmerced.edu">cmoser2@ucmerced.edu</a>), Courtney Hilton (<a href="mailto:courtney.hilton@auckland.ac.nz">courtney.hilton@auckland.ac.nz</a>), and Samuel Mehr (<a href="mailto:mehr@hey.com">mehr@hey.com</a>).</p> <p>Two versions of the audio are included: raw audio (`IDS-corpus-raw.zip`) and audio that was edited to prepare the recordings for automatic acoustic feature extraction (`IDS-corpus-edited.zip`). `IDS-textGrids.zip` contains annotation files from Praat's silence detection method, which were manually reviewed for accuracy. These files are used with the audio extraction scripts associated with the project (see code linked in paper) to build the edited audio files.</p> <p>`IDS-fieldsites.csv` contains some fieldsite-level metadata; additional metadata is in the Supplementary Information of the paper.</p> <p>In the two .zip archives, filenames have the format XXXYYZ.wav, where "XXX" is a fieldsite code, "YY" is a participant number, and "Z" is a vocalization type.</p> <p>Fieldsite codes are:</p> <blockquote> <p>MBE: Mbendjele BaYaka<br> HAD: Hadza<br> NYA: Nyangatom<br> TOP: Toposa<br> BEJ: Beijing<br> JEN: Jenu Kurubas<br> MEN: Mentawai Islanders<br> KRA: Krakow<br> LIM: Rural Poland<br> TUR: Turku<br> USD: San Diego<br> TOR: Toronto<br> VAN: Tannese Vanuatuans<br> PNG: Enga<br> WEL: Wellington<br> ARA: Arawak<br> TSI: Tsimane<br> SPA: Sápara & Achuar<br> QUE: Quechua<br> ACO: Afrocolombians<br> MES: Colombian Mestizos</p> </blockquote> <p>Participant numbers are padded integers, starting with 01, and are unique within fieldsites.</p> <p>Vocalization types are:</p> <blockquote> <p>A: infant-directed song<br> B: infant-directed speech<br> C: adult-directed song<br> D: adult-directed speech </p> </blockquote> <p>In a few cases, participants vocalized in a different language than was expected, given the primary language of their fieldsite (e.g., when the participant was multilingual, or if they sang a song that contains multiple languages, as in The Beatles' "Michelle"). The file `IDS-unexpectedLanguages.csv` at <a href="https://github.com/themusiclab/infant-speech-song/blob/main/data/IDS-unexpectedLanguages.csv">https://github.com/themusiclab/infant-speech-song/blob/main/data/IDS-unexpectedLanguages.csv</a> contains an inventory of these examples from the English-speaking fieldsites. This issue only affects a small minority of the recordings, as it was typically avoided by the researchers collecting the recordings. </p>
Safety, Tolerability, and Biosignature of Humanized Prebiotics in Healthy Adults
ClinicalTrials.gov study NCT06068894. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretrovi
ClinicalTrials.gov study NCT04840199. IPD Sharing: YES. Countries: 1. Publications: 0.
Study to Determine and Compare Plasma and Intrapulmonary Concentrations of WCK 4873 in Healthy Adult Human Subjects
ClinicalTrials.gov study NCT02453529. IPD Sharing: Not stated. Countries: 1. Publications: 1.
First-in-human, Study of MATTISSE® Tissue Engineering Chamber in Adult Female Patients Undergoing Breast Reconstruction After Mastectomy for Cancer
ClinicalTrials.gov study NCT05460780. IPD Sharing: NO. Countries: 2. Publications: 20.
A Strep Throat Controlled Human Infection Trial in Healthy Adults
ClinicalTrials.gov study NCT06992141. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety, Tolerability and Immunogenicity Study of Different Vaccine Schedules With Ad26.Mos.HIV and Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults
ClinicalTrials.gov study NCT02685020. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Human Papilloma Virus Vaccine Consistency and Non-inferiority Trial in Young Adult Women With GSK Bio HPV-16/18
ClinicalTrials.gov study NCT00169494. IPD Sharing: YES. Countries: 6. Publications: 1.
A FIRST IN HUMAN TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF SARS-CoV-2 UQSC2 VACCINE IN HEALTHY ADULTS.
ClinicalTrials.gov study NCT05775887. IPD Sharing: NO. Countries: 1. Publications: 1.
Influenza A H3N2 Human Challenge Study in Healthy Adult Volunteers
ClinicalTrials.gov study NCT02594189. IPD Sharing: Not stated. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.