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Dataset results
674 results for “brain disease”
A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation
<p>Deep brain stimulation (DBS) is indicated when motor disturbances in patients with idiopathic Parkinson's disease (PD) are refractory to current treatment options and significantly impair quality of life. However, post-DBS rehabilitation is essential, with particular regard to gait. Rhythmic auditory stimulation (RAS)-assisted treadmill gait rehabilitation within conventional physiotherapy program plays a major role in gait recovery. We explored the effects of a monthly RAS-assisted treadmill training within a conventional physiotherapy program on gait performance and gait-related EEG dynamics (while walking on the RAS-aided treadmill) in PD patients with (<em>n</em> = 10) and without DBS (<em>n</em> = 10). Patients with DBS achieved superior results than those without DBS concerning gait velocity, overall motor performance, and the timed velocity and self-confidence in balance, sit-to-stand (and vice versa) and walking, whereas both groups improved in dynamic and static balance, overall cognitive performance, and the fear of falling. The difference in motor outcomes between the two groups was paralleled by a stronger remodulation of gait cycle-related beta oscillations in patients with DBS as compared to those without DBS. Our work suggests that RAS-assisted gait training plus conventional physiotherapy is a useful strategy to improve gait performance in PD patients with and without DBS. Interestingly, patients with DBS may benefit more from this approach owing to a more focused and dynamic re-configuration of sensorimotor network beta oscillations related to gait secondary to the association between RAS-treadmill, conventional physiotherapy, and DBS. Actually, the coupling of these approaches may help restoring a residually altered beta-band response profile despite DBS intervention, thus better tailoring the gait rehabilitation of these PD patients.</p>
Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease
<p>Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem control and PD brain tissue. We found a dramatic association of oligodendrocytes and oligodendrocyte precursor cells with PD-linked risk loci and reported several dysregulated genes and pathways, including regulation of tau-protein kinase activity, regulation of inclusion body assembly and protein processing involved in protein targeting to mitochondria.</p>
Cognitive Training and Brain Stimulation in Prodromal Alzheimer's Disease
ClinicalTrials.gov study NCT04265378. IPD Sharing: NO. Countries: 1. Publications: 2.
Effects of Deep Brain Stimulation in Parkinson's Disease
ClinicalTrials.gov study NCT00855621. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease
ClinicalTrials.gov study NCT05707663. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Evaluate Temporary Blood Brain Barrier Disruption in Patients With Parkinson's Disease Dementia
ClinicalTrials.gov study NCT03608553. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Impact of Deep Brain Stimulation of Subthalamic Nucleus on the Hepatic Glucose Production in Parkinson's Disease
ClinicalTrials.gov study NCT00663312. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
ClinicalTrials.gov study NCT04121858. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study to Evaluate the Impact of MABT5102A on Brain Amyloid Load and Related Biomarkers in Patients With Mild to Moderate Alzheimer's Disease
ClinicalTrials.gov study NCT01397578. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Functional Magnetic Resonance Imaging (fMRI) During Deep Brain Stimulation (DBS) to Treat Parkinson's Disease
ClinicalTrials.gov study NCT01809613. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Deep Brain Stimulation (DBS) for Parkinson's Disease International Study
ClinicalTrials.gov study NCT02937688. IPD Sharing: NO. Countries: 2. Publications: 1.
Brain Imaging in Elderly People and Individuals With Alzheimer's Disease
ClinicalTrials.gov study NCT00001917. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Cardiac Rehabilitation in Congenital Heart Disease: Effects on Brain and Cognitive Functions
ClinicalTrials.gov study NCT05195788. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation
ClinicalTrials.gov study NCT07187739. IPD Sharing: NO. Countries: 1. Publications: 2.
Clinical Trial to Evaluate the Efficacy and Security of Deep Brain Stimulation in Alzheimer´s Disease
ClinicalTrials.gov study NCT03290274. IPD Sharing: Not stated. Countries: 1. Publications: 1.
P-glycoprotein Function in Brain Diseases
ClinicalTrials.gov study NCT00677885. IPD Sharing: Not stated. Countries: 1. Publications: 3.
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
ClinicalTrials.gov study NCT00478491. IPD Sharing: Not stated. Countries: 1. Publications: 5.
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
ClinicalTrials.gov study NCT04396873. IPD Sharing: YES. Countries: 1. Publications: 0.
Non-Invasive Brain Stimulation for the Treatment of Parkinson´s Disease-related Pain
ClinicalTrials.gov study NCT04651699. IPD Sharing: YES. Countries: 1. Publications: 11.
Deep Brain Stimulation (DBS) For Parkinson's Disease: Caudal Zona Incerta Versus Subthalamic Nucleus
ClinicalTrials.gov study NCT00888095. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.