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192
datasets available to search
ShareScore release 0.9.0
Dataset results
192 results for “cellular senescence”
UHRF1 is an upstream regulator of DNMT1-mediated cellular senescence
GEO Series GSE80322. Homo sapiens. 12 samples. Type: Expression profiling by array.
Decreased estrogen level in ovariectomized mice causes an increase in oxidative stress in osteal macrophages leading to development of cellular senescence [scRNA-seq]
GEO Series GSE275976. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
BRAF inhibition leads to oxidative phosphorylation and cellular senescence in human melanoma cells
GEO Series GSE58721. Homo sapiens. 14 samples. Type: Expression profiling by array.
Multileveled reduction of p21 expression by Linc-ASEN represses cellular senescence [ChIRP-seq]
GEO Series GSE128396. Homo sapiens. 1 samples. Type: Other.
Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFV600E-induced Cellular Senescence in Human Melanocytes
GEO Series GSE255546. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Interferon Mediated Bronchial Epithelium Cellular Senescence in Chronic Obstructive Pulmonary Disease
GEO Series GSE256448. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis
GEO Series GSE247760. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Cellular senescence contributes to spontaneous repair of rat meniscus
GEO Series GSE268970. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Decreased SRSF7 expression induces cellular senescence via generating MDM2 variants
GEO Series GSE230443. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch
GEO Series GSE124109. Rattus norvegicus. 30 samples. Type: Expression profiling by high throughput sequencing.
A small molecule that promotes cellular senescence prevents fibrogenesis and tumorigenesis
<p>Uncontrolled proliferative diseases such as fibrosis or cancer can be fatal. We previously found that a compound containing the chromone scaffold (SC), ONG41008, had potent anti-fibrogenic effects associated with EMT or cell cycle control resembling tumorigenesis. We investigated the effects of ONG41008 on tumor cells and compared these effects with those in pathogenic myofibroblasts. Stimulation of A549 (lung carcinoma epithelial cells) or PANC1 (pancreatic ductal carcinoma cells) with ONG41008 resulted in robust cellular senescence, indicating dysregulated cell proliferation is common to fibrotic cells and tumor cells. The senescence was followed by multinucleation, a manifestation of mitotic slippage. There were significant upregulation of expression and rapid nuclear translocation of p-TP53 and p16 in the treated cancer cells which thereafter died after 72hr confirmed by 6-day live imaging. ONG41008 exhibited a comparable senogenic potential to that of dasatinib. Interestingly, ONG41008 was only able to activate caspase3,7 in comparison with quercetin and fisetin also containing SC in A549. ONG41008 did not seem to be essentially toxic to normal human lung fibroblasts or primary prostate epithelial cells, suggesting ONG41008 can distinguish the intracellular microenvironment between normal cells and aged or diseased cells. This effect might occur as a result of the increased NAD/NADH ratio because ONG41008 restored this important metabolic ratio in cancer cells.</p> <p>Taken together, this is the first study to demonstrate that a small molecule can arrest uncontrolled proliferation during fibrogenesis or tumorigenesis via both senogenic and senolytic potential. ONG41008 could be a potential drug for a broad range of fibrotic or tumorigenic diseases.</p>
Cellular Senescence and COVID-19 Long-Hauler Syndrome
ClinicalTrials.gov study NCT04903132. IPD Sharing: NO. Countries: 1. Publications: 0.
Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors
ClinicalTrials.gov study NCT07114614. IPD Sharing: NO. Countries: 1. Publications: 0.
IN UTERO SMOKING AND PREMATURE CELLULAR SENESCENCE
ClinicalTrials.gov study NCT01865435. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Naked mole rat cells are protected from cellular senescence via Wnt/β-catenin-promoted cholesterol metabolism
GEO Series GSE147871. Heterocephalus glaber. 2 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation analysis of cellular senescence
GEO Series GSE227160. Homo sapiens. 48 samples. Type: Methylation profiling by genome tiling array.
The androgen receptor-lncRNASAT1-Akt-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells
GEO Series GSE162711. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-loop formation, replication stress and cellular senescence
GEO Series GSE120371. Homo sapiens. 4 samples. Type: Other.
Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cells’ Decidualization and Inhibit Their Migration
GEO Series GSE299492. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension, Healthy Life Improvement, and Cellular Senescence Delay
GEO Series GSE262770. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.